Selected Article

Title

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

Creator

Flannick, JasonFuchsberger, ChristianMahajan, AnubhaTeslovich, Tanya M.Agarwala, VineetaGaulton, Kyle J.Caulkins, LizzKoesterer, RyanMa, ClementMoutsianas, LoukasMcCarthy, Davis J.Rivas, Manuel A.Perry, John R.B.Sim, XuelingBlackwell, Thomas W.Robertson, Neil R.Rayner, N. WilliamCingolani, PabloLocke, Adam E.Tajes, Juan FernandezHighland, Heather M.Dupuis, JoséeChines, Peter S.Lindgren, Cecilia M.Hartl, ChristopherJackson, Anne U.Chen, HanHuyghe, Jeroen R.Van De Bunt, MartijnPearson, Richard D.Kumar, AshishMüller-Nurasyid, MartinaGrarup, NielsStringham, Heather M.Gamazon, Eric R.Lee, JaehoonChen, YuhuiScott, Robert A.Below, Jennifer E.Chen, PengHuang, JinyanGo, Min JinStitzel, Michael L.Pasko, DorotaParker, Stephen C.J.Varga, Tibor V.Green, ToddBeer, Nicola L.Day-Williams, Aaron G.Ferreira, TeresaFingerlin, TashaHorikoshi, MomokoHu, ChengHuh, IksooIkram, Mohammad KamranKim, Bong-JoKim, YongkangKim, Young JinKwon, Min-SeokLee, JuyoungLee, SelyeongLin, Keng-HanMaxwell, Taylor J.Nagai, YoshihikoWang, XuWelch, Ryan P.Yoon, JoonZhang, WeihuaBarzilai, NirVoight, Benjamin F.Han, Bok-GheeJenkinson, Christopher P.Kuulasmaa, TeemuKuusisto, JohannaManning, AlisaNg, Maggie C.Y.Palmer, Nicholette D.Balkau, BeverleyStančáková, AlenaAbboud, Hanna E.Boeing, HeinerGiedraitis, VilmantasPrabhakaran, DorairajGottesman, OmriScott, JamesCarey, JasonKwan, PhoenixGrant, GeorgeSmith, Joshua D.Neale, Benjamin M.Purcell, ShaunButterworth, Adam S.Howson, Joanna M.M.Lee, Heung ManLu, YingchangKwak, Soo-HeonZhao, WeiDanesh, JohnLam, Vincent K.L.Park, Kyong SooSaleheen, DanishSo, Wing YeeTam, Claudia H.T.Afzal, UzmaAguilar, DavidArya, RectorAung, TinChan, EdmundNavarro, CarmenCheng, Ching-YuPalli, DomenicoCorrea, AdolfoCurran, Joanne E.Rybin, DennisFarook, Vidya S.Fowler, Sharon P.Freedman, Barry I.Griswold, MichaelHale, Daniel EstenHicks, Pamela J.Khor, Chiea-ChuenKumar, SatishLehne, BenjaminThuillier, DorothéeLim, Wei YenLiu, JianjunLoh, MarieMusani, Solomon K.Puppala, SobhaScott, William R.Yengo, LoïcTan, Sian-TsungTaylor, Herman A.Thameem, FarookWilson, GregoryWong, Tien YinNjølstad, Pål RasmusLevy, Jonathan C.Mangino, MassimoBonnycastle, Lori L.Schwarzmayr, ThomasFadista, JoãoSurdulescu, Gabriela L.Herder, ChristianGroves, Christopher J.Wieland, ThomasBork-Jensen, JetteBrandslund, IvanChristensen, CramerKoistinen, Heikki A.Doney, Alex S.F.Kinnunen, LeenaEsko, TõnuFarmer, Andrew J.Hakaste, LiisaHodgkiss, DylanKravic, JasminaLyssenko, ValeriyaHollensted, MetteJørgensen, Marit E.Jørgensen, TorbenLadenvall, ClaesJustesen, Johanne MarieKäräjämäki, AnnemariKriebel, JenniferRathmann, WolfgangLannfelt, LarsLauritzen, TorstenNarisu, NarisuLinneberg, AllanMelander, OlleMilani, LiliNeville, MattOrho-Melander, MarjuQi, LuQi, QibinRoden, MichaelRolandsson, OlovSwift, AmyRosengren, Anders H.Stirrups, KathleenWood, Andrew R.Mihailov, EvelinBlancher, ChristineCarneiro, Mauricio O.Maguire, JaredPoplin, RyanShakir, KhalidFennell, TimothyDePristo, MarkDe Angelis, Martin HrabéDeloukas, PanosGjesing, Anette P.Jun, GooNilsson, Peter M.Murphy, JacquelynOnofrio, RobertThorand, BarbaraHansen, TorbenMeisinger, ChristaHu, Frank B.Isomaa, BoKarpe, FredrikLiang, LimingPeters, AnnetteHuth, CorneliaO'Rahilly, Stephen P.Palmer, Colin N.A.Pedersen, OlufRauramaa, RainerTuomilehto, JaakkoSalomaa, VeikkoWatanabe, Richard M.Syvänen, Ann-ChristineBergman, Richard N.Bharadwaj, DwaipayanBottinger, Erwin P.Cho, Yoon ShinChandak, Giriraj R.Chan, Juliana C.N.Chia, Kee SengDaly, Mark J.Ebrahim, Shah B.Langenberg, ClaudiaElliott, PaulJablonski, Kathleen A.Lehman, Donna M.Jia, WeipingMa, Ronald C.W.Pollin, Toni I.Sandhu, ManjinderTandon, NikhilFroguel, PhilippeBarroso, InêsTeo, Yik YingZeggini, EleftheriaLoos, Ruth J.F.Small, Kerrin S.Ried, Janina S.DeFronzo, Ralph A.Grallert, HaraldGlaser, BenjaminMetspalu, AndresWareham, Nicholas J.Walker, MarkBanks, EricGieger, ChristianIngelsson, ErikIm, Hae KyungIllig, ThomasFranks, Paul W.Buck, GemmaTrakalo, JosephBuck, DavidProkopenko, IngaMägi, ReedikLind, LarsFarjoun, YossiOwen, Katharine R.Gloyn, Anna L.Strauch, KonstantinTuomi, TiinamaijaKooner, Jaspal SinghLee, Jong-YoungPark, TaesungDonnelly, PeterMorris, Andrew D.Hattersley, Andrew T.Bowden, Donald W.Collins, Francis S.Atzmon, GilChambers, John C.Spector, Timothy D.Laakso, MarkkuStrom, Tim M.Bell, Graeme I.Blangero, JohnDuggirala, RavindranathTai, EshyongMcVean, GileanHanis, Craig L.Wilson, James G.Seielstad, MarkFrayling, Timothy M.Meigs, James B.Cox, Nancy J.Sladek, RobLander, Eric S.Gabriel, StaceyMohlke, Karen L.Meitinger, ThomasGroop, LeifAbecasis, GoncaloScott, Laura J.Morris, Andrew P.Kang, Hyun MinAltshuler, DavidBurtt, Noël P.Florez, Jose C.Boehnke, MichaelMcCarthy, Mark I.

Description

To investigate the genetic basis of type 2 diabetes (T2D) to high resolution, the GoT2D and T2D-GENES consortia catalogued variation from whole-genome sequencing of 2,657 European individuals and exome sequencing of 12,940 individuals of multiple ancestries. Over 27M SNPs, indels, and structural variants were identified, including 99% of low-frequency (minor allele frequency [MAF] 0.1-5%) non-coding variants in the whole-genome sequenced individuals and 99.7% of low-frequency coding variants in the whole-exome sequenced individuals. Each variant was tested for association with T2D in the sequenced individuals, and, to increase power, most were tested in larger numbers of individuals (>80% of low-frequency coding variants in ∼82 K Europeans via the exome chip, and ∼90% of low-frequency non-coding variants in ∼44 K Europeans via genotype imputation). The variants, genotypes, and association statistics from these analyses provide the largest reference to date of human genetic information relevant to T2D, for use in activities such as T2D-focused genotype imputation, functional characterization of variants or genes, and other novel analyses to detect associations between sequence variation and T2D.