Study on the preparation and drug release property of Modified PEG-DA based hydrogels
The aim of the present study is todevelop hydroxyapatite modified PEG-DA and PEG-DA/HEMA based hydrogels forrelease of Donepezil HCl for potential treatment of Alzheimer’s disease.[2,2-Dimethoxy-2-phenyl-acetophenone] (Irgacure 651), 1 Hydroxycyclohexyl phenyl ketone (Irgacure184) and 2-Hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone (Irgacure2959) were used as photo-initiators inthe synthesis of hydrogels and hydroxyapatite was used for modifying hydrogels. Fourier transforminfrared spectroscopy (FT-IR), scanning electron microscope (SEM) and digitalmicroscope were utilized to investigate the characteristics properties of hydrogels.Photopolymerization technique was selected to synthesize for hydrogels. Swelling and drug release studies have beenperformed under different pH conditions.
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