: Large-scale in-silico statistical mutagenesis analysis sheds light on the deleteriousness landscape of the human proteome
: Rational antibiotic design: in silico structural comparison of the functional cavities of penicillin-binding proteins and ß-lactamases.
The class of ß-lactam antibiotics has proven highly efficient in targeting bacterial penicillin-binding proteins (PBP) leading to the blocking of the bacterial cell wall synthesis. However, the benefit of these drugs is limited because of bacterial r...
In this paper, we show how the adequate use of the intrinsic symmetry of a system when setting up its model structure can avoid unwanted biases in the parameter optimization phase. The playground of our analysis is the prediction of protein thermodyn...
Distinct lymphocyte subpopulations display discrete metabolic profiles and are differently affected by metabolic resource variations, making the analysis of lymphocyte survival in a complex tissue in response to metabolic stress highly challenging. H...