ARTICLES
6 Article(s)
Document(s)
Title
Introduction: Identification of blood-based metabolic changes might provide early and easy-to-obtain biomarkers. Methods: We included 127 AD patients and 121 controls with CSF-biomarker-confirmed diagnosis (cut-off tau/A$\beta_{42}$: 0.52). Mass spec...
Graff, Mariaelisa;Scott, Robert A.;Justice, Anne E.;Young, Kristin L.;Feitosa, Mary F.;Barata, Llilda;Winkler, Thomas W.;Chu, Audrey Y.;Mahajan, Anubha;Hadley, David;Xue, Luting;Workalemahu, Tsegaselassie;Heard-Costa, Nancy L.;den Hoed, Marcel;Ahluwalia, Tarunveer S.;Qi, Qibin;Ngwa, Julius S.;Renström, Frida;Quaye, Lydia;Eicher, John D.;Hayes, James E.;Cornelis, Marilyn;Kutalik, Zoltan;Lim, Elise;Luan, Jian’an;Huffman, Jennifer E.;Zhang, Weihua;Zhao, Wei;Griffin, Paula J.;Haller, Toomas;Ahmad, Shafqat;Marques-Vidal, Pedro M.;Bien, Stephanie;Yengo, Loic;Teumer, Alexander;Smith, Albert Vernon;Kumari, Meena;Harder, Marie Neergaard;Justesen, Johanne Marie;Kleber, Marcus E.;Hollensted, Mette;Lohman, Kurt;Rivera, Natalia V.;Whitfield, John B.;Zhao, Jing Hua;Stringham, Heather M.;Lyytikäinen, Leo-Pekka;Huppertz, Charlotte;Willemsen, Gonneke;Peyrot, Wouter J.;Wu, Ying;Kristiansson, Kati;Demirkan, Ayse;Fornage, Myriam;Hassinen, Maija;Bielak, Lawrence F.;Cadby, Gemma;Tanaka, Toshiko;Mägi, Reedik;van der Most, Peter J.;Jackson, Anne U.;Bragg-Gresham, Jennifer L.;Vitart, Veronique;Marten, Jonathan;Navarro, Pau;Bellis, Claire;Pasko, Dorota;Johansson, Åsa;Snitker, Søren;Cheng, Yu-Ching;Eriksson, Joel;Lim, Unhee;Aadahl, Mette;Adair, Linda S.;Amin, Najaf;Balkau, Beverley;Auvinen, Juha;Beilby, John;Bergman, Richard N.;Bergmann, Sven;Bertoni, Alain G.;Blangero, John;Bonnefond, Amélie;Bonnycastle, Lori L.;Borja, Judith B.;Brage, Søren;Busonero, Fabio;Buyske, Steve;Campbell, Harry;Chines, Peter S.;Collins, Francis S.;Corre, Tanguy;Smith, George Davey;Delgado, Graciela E.;Dueker, Nicole;Dörr, Marcus;Ebeling, Tapani;Eiriksdottir, Gudny;Esko, Tõnu;Faul, Jessica D.;Fu, Mao;Færch, Kristine;Gieger, Christian;Gläser, Sven;Gong, Jian;Gordon-Larsen, Penny;Grallert, Harald;Grammer, Tanja B.;Grarup, Niels;van Grootheest, Gerard;Harald, Kennet;Hastie, Nicholas D.;Havulinna, Aki S.;Hernandez, Dena;Hindorff, Lucia;Hocking, Lynne J.;Holmens, Oddgeir L.;Holzapfel, Christina;Hottenga, Jouke Jan;Huang, Jie;Huang, Tao;Hui, Jennie;Huth, Cornelia;Hutri-Kähönen, Nina;James, Alan L.;Jansson, John-Olov;Jhun, Min A.;Juonala, Markus;Kinnunen, Leena;Koistinen, Heikki A.;Kolcic, Ivana;Komulainen, Pirjo;Kuusisto, Johanna;Kvaløy, Kirsti;Kähönen, Mika;Lakka, Timo A.;Launer, Lenore J.;Lehne, Benjamin;Lindgren, Cecilia M.;Lorentzon, Mattias;Luben, Robert;Marre, Michel;Milaneschi, Yuri;Monda, Keri L.;Montgomery, Grant W.;De Moor, Marleen H. M.;Mulas, Antonella;Müller-Nurasyid, Martina;Musk, A. W.;Männikkö, Reija;Männistö, Satu;Narisu, Narisu;Nauck, Matthias;Nettleton, Jennifer A.;Nolte, Ilja M.;Oldehinkel, Albertine J.;Olden, Matthias;Ong, Ken K.;Padmanabhan, Sandosh;Paternoster, Lavinia;Perez, Jeremiah;Perola, Markus;Peters, Annette;Peters, Ulrike;Peyser, Patricia A.;Prokopenko, Inga;Puolijoki, Hannu;Raitakari, Olli T.;Rankinen, Tuomo;Rasmussen-Torvik, Laura J.;Rawal, Rajesh;Ridker, Paul M.;Rose, Lynda M.;Rudan, Igor;Sarti, Cinzia;Sarzynski, Mark A.;Savonen, Kai;Scott, William R.;Sanna, Serena;Shuldiner, Alan R.;Sidney, Steve;Silbernagel, Günther;Smith, Blair H.;Smith, Jennifer A.;Snieder, Harold;Stančáková, Alena;Sternfeld, Barbara;Swift, Amy J.;Tammelin, Tuija;Tan, Sian-Tsung;Thorand, Barbara;Thuillier, Dorothée;Vandenput, Liesbeth;Vestergaard, Henrik;van Vliet-Ostaptchouk, Jana V.;Vohl, Marie-Claude;Völker, Uwe;Waeber, Gérard;Walker, Mark;Wild, Sarah;Wong, Andrew;Wright, Alan F.;Zillikens, M. Carola;Zubair, Niha;Haiman, Christopher A.;Lemarchand, Loic;Gyllensten, Ulf;Ohlsson, Claes;Hofman, Albert;Rivadeneira, Fernando;Uitterlinden, André G.;Pérusse, Louis;Wilson, James F.;Hayward, Caroline;Polasek, Ozren;Cucca, Francesco;Hveem, Kristian;Hartman, Catharina A.;Tönjes, Anke;Bandinelli, Stefania;Palmer, Lyle J.;Kardia, Sharon L. R.;Rauramaa, Rainer;Sørensen, Thorkild I. A.;Tuomilehto, Jaakko;Salomaa, Veikko;Penninx, Brenda W. J. H.;de Geus, Eco J. C.;Boomsma, Dorret I.;Lehtimäki, Terho;Mangino, Massimo;Laakso, Markku;Bouchard, Claude;Martin, Nicholas G.;Kuh, Diana;Liu, Yongmei;Linneberg, Allan;März, Winfried;Strauch, Konstantin;Kivimäki, Mika;Harris, Tamara B.;Gudnason, Vilmundur;Völzke, Henry;Qi, Lu;Järvelin, Marjo-Riitta;Chambers, John C.;Kooner, Jaspal S.;Froguel, Philippe;Kooperberg, Charles;Vollenweider, Peter;Hallmans, Göran;Hansen, Torben;Pedersen, Oluf;Metspalu, Andres;Wareham, Nicholas J.;Langenberg, Claudia;Weir, David R.;Porteous, David J.;Boerwinkle, Eric;Chasman, Daniel I.;Abecasis, Gonçalo R.;Barroso, Inês;McCarthy, Mark I.;Frayling, Timothy M.;O’Connell, Jeffrey R.;van Duijn, Cornelia M.;Boehnke, Michael;Heid, Iris M.;Mohlke, Karen L.;Strachan, David P.;Fox, Caroline S.;Liu, Ching-Ti;Hirschhorn, Joel N.;Klein, Robert J.;Johnson, Andrew D.;Borecki, Ingrid B.;Franks, Paul W.;North, Kari E.;Cupples, L. Adrienne;Loos, Ruth J. F.;Kilpeläinen, Tuomas O.
Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumfer...
Graff, Mariaelisa;Scott, Robert A.;Justice, Anne E.;Young, Kristin L.;Feitosa, Mary F.;Barata, Llilda;Winkler, Thomas W.;Chu, Audrey Y.;Mahajan, Anubha;Hadley, David;Xue, Luting;Workalemahu, Tsegaselassie;Heard-Costa, Nancy L.;den Hoed, Marcel;Ahluwalia, Tarunveer S.;Qi, Qibin;Ngwa, Julius S.;Renström, Frida;Quaye, Lydia;Eicher, John D.;Hayes, James E.;Cornelis, Marilyn;Kutalik, Zoltan;Lim, Elise;Luan, Jian’an;Huffman, Jennifer E.;Zhang, Weihua;Zhao, Wei;Griffin, Paula J.;Haller, Toomas;Ahmad, Shafqat;Marques-Vidal, Pedro M.;Bien, Stephanie;Yengo, Loic;Teumer, Alexander;Smith, Albert Vernon;Kumari, Meena;Harder, Marie Neergaard;Justesen, Johanne Marie;Kleber, Marcus E.;Hollensted, Mette;Lohman, Kurt;Rivera, Natalia V.;Whitfield, John B.;Zhao, Jing Hua;Stringham, Heather M.;Lyytikäinen, Leo-Pekka;Huppertz, Charlotte;Willemsen, Gonneke;Peyrot, Wouter J.;Wu, Ying;Kristiansson, Kati;Demirkan, Ayse;Fornage, Myriam;Hassinen, Maija;Bielak, Lawrence F.;Cadby, Gemma;Tanaka, Toshiko;Mägi, Reedik;van der Most, Peter J.;Jackson, Anne U.;Bragg-Gresham, Jennifer L.;Vitart, Veronique;Marten, Jonathan;Navarro, Pau;Bellis, Claire;Pasko, Dorota;Johansson, Åsa;Snitker, Søren;Cheng, Yu-Ching;Eriksson, Joel;Lim, Unhee;Aadahl, Mette;Adair, Linda S.;Amin, Najaf;Balkau, Beverley;Auvinen, Juha;Beilby, John;Bergman, Richard N.;Bergmann, Sven;Bertoni, Alain G.;Blangero, John;Bonnefond, Amélie;Bonnycastle, Lori L.;Borja, Judith B.;Brage, Søren;Busonero, Fabio;Buyske, Steve;Campbell, Harry;Chines, Peter S.;Collins, Francis S.;Corre, Tanguy;Smith, George Davey;Delgado, Graciela E.;Dueker, Nicole;Dörr, Marcus;Ebeling, Tapani;Eiriksdottir, Gudny;Esko, Tõnu;Faul, Jessica D.;Fu, Mao;Færch, Kristine;Gieger, Christian;Gläser, Sven;Gong, Jian;Gordon-Larsen, Penny;Grallert, Harald;Grammer, Tanja B.;Grarup, Niels;van Grootheest, Gerard;Harald, Kennet;Hastie, Nicholas D.;Havulinna, Aki S.;Hernandez, Dena;Hindorff, Lucia;Hocking, Lynne J.;Holmens, Oddgeir L.;Holzapfel, Christina;Hottenga, Jouke Jan;Huang, Jie;Huang, Tao;Hui, Jennie;Huth, Cornelia;Hutri-Kähönen, Nina;James, Alan L.;Jansson, John-Olov;Jhun, Min A.;Juonala, Markus;Kinnunen, Leena;Koistinen, Heikki A.;Kolcic, Ivana;Komulainen, Pirjo;Kuusisto, Johanna;Kvaløy, Kirsti;Kähönen, Mika;Lakka, Timo A.;Launer, Lenore J.;Lehne, Benjamin;Lindgren, Cecilia M.;Lorentzon, Mattias;Luben, Robert;Marre, Michel;Milaneschi, Yuri;Monda, Keri L.;Montgomery, Grant W.;De Moor, Marleen H. M.;Mulas, Antonella;Müller-Nurasyid, Martina;Musk, A. W.;Männikkö, Reija;Männistö, Satu;Narisu, Narisu;Nauck, Matthias;Nettleton, Jennifer A.;Nolte, Ilja M.;Oldehinkel, Albertine J.;Olden, Matthias;Ong, Ken K.;Padmanabhan, Sandosh;Paternoster, Lavinia;Perez, Jeremiah;Perola, Markus;Peters, Annette;Peters, Ulrike;Peyser, Patricia A.;Prokopenko, Inga;Puolijoki, Hannu;Raitakari, Olli T.;Rankinen, Tuomo;Rasmussen-Torvik, Laura J.;Rawal, Rajesh;Ridker, Paul M.;Rose, Lynda M.;Rudan, Igor;Sarti, Cinzia;Sarzynski, Mark A.;Savonen, Kai;Scott, William R.;Sanna, Serena;Shuldiner, Alan R.;Sidney, Steve;Silbernagel, Günther;Smith, Blair H.;Smith, Jennifer A.;Snieder, Harold;Stančáková, Alena;Sternfeld, Barbara;Swift, Amy J.;Tammelin, Tuija;Tan, Sian-Tsung;Thorand, Barbara;Thuillier, Dorothée;Vandenput, Liesbeth;Vestergaard, Henrik;van Vliet-Ostaptchouk, Jana V.;Vohl, Marie-Claude;Völker, Uwe;Waeber, Gérard;Walker, Mark;Wild, Sarah;Wong, Andrew;Wright, Alan F.;Zillikens, M. Carola;Zubair, Niha;Haiman, Christopher A.;Lemarchand, Loic;Gyllensten, Ulf;Ohlsson, Claes;Hofman, Albert;Rivadeneira, Fernando;Uitterlinden, André G.;Pérusse, Louis;Wilson, James F.;Hayward, Caroline;Polasek, Ozren;Cucca, Francesco;Hveem, Kristian;Hartman, Catharina A.;Tönjes, Anke;Bandinelli, Stefania;Palmer, Lyle J.;Kardia, Sharon L. R.;Rauramaa, Rainer;Sørensen, Thorkild I. A.;Tuomilehto, Jaakko;Salomaa, Veikko;Penninx, Brenda W. J. H.;de Geus, Eco J. C.;Boomsma, Dorret I.;Lehtimäki, Terho;Mangino, Massimo;Laakso, Markku;Bouchard, Claude;Martin, Nicholas G.;Kuh, Diana;Liu, Yongmei;Linneberg, Allan;März, Winfried;Strauch, Konstantin;Kivimäki, Mika;Harris, Tamara B.;Gudnason, Vilmundur;Völzke, Henry;Qi, Lu;Järvelin, Marjo-Riitta;Chambers, John C.;Kooner, Jaspal S.;Froguel, Philippe;Kooperberg, Charles;Vollenweider, Peter;Hallmans, Göran;Hansen, Torben;Pedersen, Oluf;Metspalu, Andres;Wareham, Nicholas J.;Langenberg, Claudia;Weir, David R.;Porteous, David J.;Boerwinkle, Eric;Chasman, Daniel I.;Abecasis, Gonçalo R.;Barroso, Inês;McCarthy, Mark I.;Frayling, Timothy M.;O’Connell, Jeffrey R.;van Duijn, Cornelia M.;Boehnke, Michael;Heid, Iris M.;Mohlke, Karen L.;Strachan, David P.;Fox, Caroline S.;Liu, Ching-Ti;Hirschhorn, Joel N.;Klein, Robert J.;Johnson, Andrew D.;Borecki, Ingrid B.;Franks, Paul W.;North, Kari E.;Cupples, L. Adrienne;Loos, Ruth J. F.;Kilpeläinen, Tuomas O.
Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumfer...
Ikram, M. Arfan;Fornage, Myriam;Smith, Albert V.;Seshadri, Sudha;Schmidt, Reinhold;Debette, Stéphanie;Vrooman, Henri A.;Sigurdsson, Sigurdur;Ropele, Stefan;Taal, H. Rob;Mook-Kanamori, Dennis O.;Coker, Laura H.;Longstreth, W. T.;Niessen, Wiro J.;DeStefano, Anita L.;Beiser, Alexa;Zijdenbos, Alex P.;Struchalin, Maksim;Jack, Clifford R.;Rivadeneira, Fernando;Uitterlinden, Andre G.;Knopman, David S.;Hartikainen, Anna-Liisa;Pennell, Craig E.;Thiering, Elisabeth;Steegers, Eric A. P.;Hakonarson, Hakon;Heinrich, Joachim;Palmer, Lyle J.;Jarvelin, Marjo-Riitta;McCarthy, Mark I.;Grant, Struan F. A.;Pourcain, Beate St;Timpson, Nicholas J.;Smith, George Davey;Sovio, Ulla;Nalls, Mike A.;Au, Rhoda;Hofman, Albert;Gudnason, Haukur;van der Lugt, Aad;Harris, Tamara B.;Meeks, William M.;Vernooij, Meike W.;van Buchem, Mark A.;Catellier, Diane;Jaddoe, Vincent W. V.;Gudnason, Vilmundur;Windham, B. Gwen;Wolf, Philip A.;van Duijn, Cornelia M.;Mosley, Thomas H.;Schmidt, Helena;Launer, Lenore J.;Breteler, Monique M. B.;DeCarli, Charles;Adair, Linda S.;Ang, Wei;Atalay, Mustafa;van Beijsterveldt, Toos;Bergen, Nienke;Benke, Kelly;Berry, Diane;Coin, Lachlan;Davis, Oliver S. P.;Elliott, Paul;Flexeder, Claudia;Frayling, Tim;Gaillard, Romy;Groen-Blokhuis, Maria;Goh, Liang-Kee;Haworth, Claire M. A.;Hadley, Dexter;Hedebrand, Johannes;Hinney, Anke;Hirschhorn, Joel N.;Holloway, John W.;Holst, Claus;Jan Hottenga, Jouke;Horikoshi, Momoko;Huikari, Ville;Hypponen, Elina;Kilpeläinen, Tuomas O.;Kirin, Mirna;Kowgier, Matthew;Lakka, Hanna-Maaria;Lange, Leslie A.;Lawlor, Debbie A.;Lehtimäki, Terho;Lewin, Alex;Lindgren, Cecilia;Lindi, Virpi;Maggi, Reedik;Marsh, Julie;Middeldorp, Christel;Millwood, Iona;Murray, Jeffrey C.;Nivard, Michel;Nohr, Ellen Aagaard;Ntalla, Ioanna;Oken, Emily;Panoutsopoulou, Kalliope;Pararajasingham, Jennifer;Rodriguez, Alina;Salem, Rany M.;Sebert, Sylvain;Siitonen, Niina;Strachan, David P.;Teo, Yik-Ying;Valcárcel, Beatriz;Willemsen, Gonneke;Zeggini, Eleftheria;Boomsma, Dorret I.;Cooper, Cyrus;Gillman, Matthew;Hocher, Berthold;Lakka, Timo A.;Mohlke, Karen L.;Dedoussis, George V.;Ong, Ken K.;Pearson, Ewan R.;Price, Thomas S.;Power, Chris;Raitakari, Olli T.;Saw, Seang-Mei;Scherag, Andre;Simell, Olli;Sørensen, Thorkild I. A.;Wilson, James F.
During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect differ...
Escott-Price, Valentina;Bellenguez, Céline;Wang, Li-San;Choi, Seung-Hoan;Harold, Denise;Jones, Lesley;Holmans, Peter;Gerrish, Amy;Vedernikov, Alexey;Richards, Alexander;DeStefano, Anita L.;Lambert, Jean-Charles;Ibrahim-Verbaas, Carla A.;Naj, Adam C.;Sims, Rebecca;Jun, Gyungah;Bis, Joshua C.;Beecham, Gary W.;Grenier-Boley, Benjamin;Russo, Giancarlo;Thornton-Wells, Tricia A.;Denning, Nicola;Smith, Albert V.;Chouraki, Vincent;Thomas, Charlene;Ikram, M. Arfan;Zelenika, Diana;Vardarajan, Badri N.;Kamatani, Yoichiro;Lin, Chiao-Feng;Schmidt, Helena;Kunkle, Brian;Dunstan, Melanie L.;Vronskaya, Maria;Johnson, Andrew D.;Ruiz, Agustin;Bihoreau, Marie-Thérèse;Reitz, Christiane;Pasquier, Florence;Hollingworth, Paul;Hanon, Olivier;Fitzpatrick, Annette L.;Buxbaum, Joseph D.;Campion, Dominique;Crane, Paul K.;Baldwin, Clinton;Becker, Tim;Gudnason, Vilmundur;Cruchaga, Carlos;Craig, David;Amin, Najaf;Berr, Claudine;Lopez, Oscar L.;De Jager, Philip L.;Deramecourt, Vincent;Johnston, Janet A.;Evans, Denis;Lovestone, Simon;Letenneur, Luc;Hernández, Isabel;Rubinsztein, David C.;Eiriksdottir, Gudny;Sleegers, Kristel;Goate, Alison M.;Fiévet, Nathalie;Huentelman, Matthew J.;Gill, Michael;Brown, Kristelle;Kamboh, M. Ilyas;Keller, Lina;Barberger-Gateau, Pascale;McGuinness, Bernadette;Larson, Eric B.;Myers, Amanda J.;Dufouil, Carole;Todd, Stephen;Wallon, David;Love, Seth;Rogaeva, Ekaterina;Gallacher, John;George-Hyslop, Peter St;Clarimon, Jordi;Lleo, Alberto;Bayer, Anthony;Tsuang, Debby W.;Yu, Lei;Tsolaki, Magda;Bossù, Paola;Spalletta, Gianfranco;Proitsi, Petra;Collinge, John;Sorbi, Sandro;Garcia, Florentino Sanchez;Fox, Nick C.;Hardy, John;Naranjo, Maria Candida Deniz;Bosco, Paolo;Clarke, Robert;Brayne, Carol;Galimberti, Daniela;Scarpini, Elio;Bonuccelli, Ubaldo;Mancuso, Michelangelo;Siciliano, Gabriele;Moebus, Susanne;Mecocci, Patrizia;Zompo, Maria Del;Maier, Wolfgang;Hampel, Harald;Pilotto, Alberto;Frank-García, Ana;Panza, Francesco;Solfrizzi, Vincenzo;Caffarra, Paolo;Nacmias, Benedetta;Perry, William;Mayhaus, Manuel;Lannfelt, Lars;Hakonarson, Hakon;Pichler, Sabrina;Carrasquillo, Minerva M.;Ingelsson, Martin;Beekly, Duane;Alvarez, Victoria;Zou, Fanggeng;Valladares, Otto;Younkin, Steven G.;Coto, Eliecer;Hamilton-Nelson, Kara L.;Gu, Wei;Razquin, Cristina;Pastor, Pau;Mateo, Ignacio;Owen, Michael J.;Faber, Kelley M.;Jonsson, Palmi V.;Combarros, Onofre;O'Donovan, Michael C.;Cantwell, Laura B.;Soininen, Hilkka;Blacker, Deborah;Mead, Simon;Mosley, Thomas H.;Bennett, David A.;Harris, Tamara B.;Fratiglioni, Laura;Holmes, Clive;de Bruijn, Renee F. A. G.;Passmore, Peter;Montine, Thomas J.;Bettens, Karolien;Rotter, Jerome I.;Brice, Alexis;Morgan, Kevin;Foroud, Tatiana M.;Kukull, Walter A.;Hannequin, Didier;Powell, John F.;Nalls, Michael A.;Ritchie, Karen;Lunetta, Kathryn L.;Kauwe, John S. K.;Boerwinkle, Eric;Riemenschneider, Matthias;Boada, Mercè;Hiltunen, Mikko;Martin, Eden R.;Schmidt, Reinhold;Rujescu, Dan;Dartigues, Jean-François;Mayeux, Richard;Tzourio, Christophe;Hofman, Albert;Nöthen, Markus M.;Graff, Caroline;Psaty, Bruce M.;Haines, Jonathan L.;Lathrop, Mark;Pericak-Vance, Margaret A.;Launer, Lenore J.;Van Broeckhoven, Christine;Farrer, Lindsay A.;van Duijn, Cornelia M.;Ramirez, Alfredo;Seshadri, Sudha;Schellenberg, Gerard D.;Amouyel, Philippe;Williams, Julie
Background: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, usi...
Background: Chronic mucus hypersecretion (CMH) is associated with an increased frequency of respiratory infections, excess lung function decline, and increased hospitalisation and mortality rates in the general population. It is associated with smoki...