ARTICLES
9 Article(s)
Document(s)
Title
Twin cohorts provide a unique advantage for investigations of the role of genetics and environment in the etiology of variation in common complex traits by reducing the variance due to environment, age, and cohort differences. The GenomEUtwin (http:/...
Twin cohorts provide a unique advantage for investigations of the role of genetics and environment in the etiology of variation in common complex traits by reducing the variance due to environment, age, and cohort differences. The GenomEUtwin (http:/...
An increasing number of genome-wide association (GWA) studies are now using the higher resolution 1000 Genomes Project reference panel (1000G) for imputation, with the expectation that 1000G imputation will lead to the discovery of additional associa...
Metabolites are small molecules involved in cellular metabolism, which can be detected in biological samples using metabolomic techniques. Here we present the results of genome-wide association and meta-analyses for variation in the blood serum level...
Metabolites are small molecules involved in cellular metabolism, which can be detected in biological samples using metabolomic techniques. Here we present the results of genome-wide association and meta-analyses for variation in the blood serum level...
Machine learning analysis of neuroimaging data can accurately predict chronological age in healthy people and deviations from healthy brain ageing have been associated with cognitive impairment and disease. Here we sought to further establish the cre...
Twin cohorts provide a unique advantage for investigations of the role of genetics and environment in the etiology of variation in common complex traits by reducing the variance due to environment, age, and cohort differences. The GenomEUtwin (http:/...
Vimaleswaran, Karani S;Cavadino, Alana;Berry, Diane J;Jorde, Rolf;Dieffenbach, Aida Karina;Lu, Chen;Alves, Alexessander Couto;Heerspink, Hiddo J Lambers;Tikkanen, Emmi;Eriksson, Joel;Wong, Andrew;Mangino, Massimo;Jablonski, Kathleen A;Nolte, Ilja M;Houston, Denise K;Ahluwalia, Tarunveer Singh;van der Most, Peter J;Pasko, Dorota;Zgaga, Lina;Thiering, Elisabeth;Vitart, Veronique;Fraser, Ross M;Huffman, Jennifer E;de Boer, Rudolf A;Schöttker, Ben;Saum, Kai-Uwe;McCarthy, Mark I;Dupuis, Josée;Herzig, Karl-Heinz;Sebert, Sylvain;Pouta, Anneli;Laitinen, Jaana;Kleber, Marcus E;Navis, Gerjan;Lorentzon, Mattias;Jameson, Karen;Arden, Nigel;Cooper, Jackie A;Acharya, Jayshree;Hardy, Rebecca;Raitakari, Olli;Ripatti, Samuli;Billings, Liana K;Lahti, Jari;Osmond, Clive;Penninx, Brenda W;Rejnmark, Lars;Lohman, Kurt K;Paternoster, Lavinia;Stolk, Ronald P;Hernandez, Dena G;Byberg, Liisa;Hagström, Emil;Melhus, Håkan;Ingelsson, Erik;Mellström, Dan;Ljunggren, Östen;Tzoulaki, Ioanna;McLachlan, Stela;Theodoratou, Evropi;Tiesler, Carla M T;Jula, Antti;Navarro, Pau;Wright, Alan F;Polasek, Ozren;Wilson, James F;Rudan, Igor;Salomaa, Veikko;Heinrich, Joachim;Campbell, Harry;Price, Jacqueline F;Karlsson, Magnus;Lind, Lars;Michaëlsson, Karl;Bandinelli, Stefania;Frayling, Timothy M;Hartman, Catharina A;Sørensen, Thorkild I A;Kritchevsky, Stephen B;Langdahl, Bente Lomholt;Eriksson, Johan G;Florez, Jose C;Spector, Tim D;Lehtimäki, Terho;Kuh, Diana;Humphries, Steve E;Cooper, Cyrus;Ohlsson, Claes;März, Winfried;de Borst, Martin H;Kumari, Meena;Kivimaki, Mika;Wang, Thomas J;Power, Chris;Brenner, Hermann;Grimnes, Guri;van der Harst, Pim;Snieder, Harold;Hingorani, Aroon D;Pilz, Stefan;Whittaker, John C;Järvelin, Marjo-Riitta;Hyppönen, Elina
Background Low plasma 25-hydroxyvitamin D (25[OH]D) concentration is associated with high arterial blood pressure and hypertension risk, but whether this association is causal is unknown. We used a mendelian randomisation approach to test whether 25(...
The phenotypic effect of some single nucleotide polymorphisms (SNPs) depends on their parental origin. We present a novel approach to detect parent-of-origin effects (POEs) in genome-wide genotype data of unrelated individuals. The method exploits in...