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Holmes, Michael V;Dale, Caroline E;Zuccolo, Luisa;Silverwood, Richard J;Guo, Yiran;Ye, Zheng;Prieto-Merino, David;Dehghan, Abbas;Trompet, Stella;Wong, Andrew;Cavadino, Alana;Drogan, Dagmar;Padmanabhan, Sandosh;Li, Shanshan;Yesupriya, Ajay;Leusink, Maarten;Sundstrom, Johan;Hubacek, Jaroslav A;Pikhart, Hynek;Swerdlow, Daniel I;Panayiotou, Andrie G;Borinskaya, Svetlana A;Finan, Chris;Shah, Sonia;Kuchenbaecker, Karoline;Shah, Tina;Engmann, Jorgen;Folkersen, Lasse;Eriksson, Per;Ricceri, Fulvio;Melander, Olle;Sacerdote, Carlotta;Gamble, Dale M;Rayaprolu, Sruti;Ross, Owen A;McLachlan, Stela;Vikhireva, Olga;Sluijs, Ivonne;Scott, Robert;Adamkova, Vera;Flicker, Leon;Bockxmeer, Frank M van;Power, Christine;Marques-Vidal, Pedro;Meade, Tom;Marmot, Michael G;Ferro, Jose M;Paulos-Pinheiro, Sofia;Humphries, Steve E;Talmud, Philippa J;Mateo Leach, Irene;Verweij, Niek;Linneberg, Allan;Skaaby, Tea;Doevendans, Pieter A;Cramer, Maarten J;van der Harst, Pim;Klungel, Olaf H;Dowling, Nicole F;Dominiczak, Anna F;Kumari, Meena;Nicolaides, Andrew N;Weikert, Cornelia;Boeing, Heiner;Ebrahim, Shah;Gaunt, Tom R;Price, Jackie F;Lannfelt, Lars;Peasey, Anne;Kubinova, Ruzena;Pajak, Andrzej;Malyutina, Sofia;Voevoda, Mikhail I;Tamosiunas, Abdonas;Maitland-van der Zee, Anke H;Norman, Paul E;Hankey, Graeme J;Bergmann, Manuela M;Hofman, Albert;Franco, Oscar H;Cooper, Jackie;Palmen, Jutta;Spiering, Wilko;de Jong, Pim A;Kuh, Diana;Hardy, Rebecca;Uitterlinden, Andre G;Ikram, M Arfan;Ford, Ian;Hyppönen, Elina;Almeida, Osvaldo P;Wareham, Nicholas;Khaw, Kay-Tee;Hamsten, Anders;Husemoen, Lise Lotte N;Tjønneland, Anne;Tolstrup, Janne S;Rimm, Eric;Beulens, Joline WJ;Verschuren, WM Monique;Onland-Moret, N Charlotte;Hofker, Marten H;Wannamethee, S Goya;Whincup, Peter H;Morris, Richard;Vicente, Astrid M;Watkins, Hugh;Farrall, Martin;Jukema, J Wouter;Meschia, James;Cupples, L Adrienne;Sharp, Stephen;Fornage, Myriam;Kooperberg, Charles;LaCroix, Andrea Z;Dai, James Y;Lanktree, Matthew B;Siscovick, David S;Jorgenson, Eric;Spring, Bonnie;Coresh, Josef;Li, Yun R;Buxbaum, Sarah G;Schreiner, Pamela J;Ellison, R Curtis;Tsai, Michael Y;Patel, Sanjay R;Redline, Susan;Johnson, Andrew D;Hoogeveen, Ron C;Hakonarson, Hakon;Rotter, Jerome I;Boerwinkle, Eric;de Bakker, Paul IW;Kivimaki, Mika;Asselbergs, Folkert W;Sattar, Naveed;Lawlor, Debbie A;Whittaker, John;Davey Smith, George;Mukamal, Kenneth;Psaty, Bruce M;Wilson, James G;Lange, Leslie A;Hamidovic, Ajna;Hingorani, Aroon D;Nordestgaard, Børge G;Bobak, Martin;Leon, David A;Langenberg, Claudia;Palmer, Tom M;Reiner, Alex P;Keating, Brendan J;Dudbridge, Frank;Casas, Juan P;InterAct Consortium,
OBJECTIVE: To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease. DESIGN: Mendelian randomisation meta-analysis of 56 epidemiological studies. PA...
Holmes, Michael V;Dale, Caroline E;Zuccolo, Luisa;Silverwood, Richard J;Guo, Yiran;Ye, Zheng;Prieto-Merino, David;Dehghan, Abbas;Trompet, Stella;Wong, Andrew;Cavadino, Alana;Drogan, Dagmar;Padmanabhan, Sandosh;Li, Shanshan;Yesupriya, Ajay;Leusink, Maarten;Sundstrom, Johan;Hubacek, Jaroslav A;Pikhart, Hynek;Swerdlow, Daniel I;Panayiotou, Andrie G;Borinskaya, Svetlana A;Finan, Chris;Shah, Sonia;Kuchenbaecker, Karoline;Shah, Tina;Engmann, Jorgen;Folkersen, Lasse;Eriksson, Per;Ricceri, Fulvio;Melander, Olle;Sacerdote, Carlotta;Gamble, Dale M;Rayaprolu, Sruti;Ross, Owen A;McLachlan, Stela;Vikhireva, Olga;Sluijs, Ivonne;Scott, Robert;Adamkova, Vera;Flicker, Leon;Bockxmeer, Frank M van;Power, Christine;Marques-Vidal, Pedro;Meade, Tom;Marmot, Michael G;Ferro, Jose M;Paulos-Pinheiro, Sofia;Humphries, Steve E;Talmud, Philippa J;Mateo Leach, Irene;Verweij, Niek;Linneberg, Allan;Skaaby, Tea;Doevendans, Pieter A;Cramer, Maarten J;van der Harst, Pim;Klungel, Olaf H;Dowling, Nicole F;Dominiczak, Anna F;Kumari, Meena;Nicolaides, Andrew N;Weikert, Cornelia;Boeing, Heiner;Ebrahim, Shah;Gaunt, Tom R;Price, Jackie F;Lannfelt, Lars;Peasey, Anne;Kubinova, Ruzena;Pajak, Andrzej;Malyutina, Sofia;Voevoda, Mikhail I;Tamosiunas, Abdonas;Maitland-van der Zee, Anke H;Norman, Paul E;Hankey, Graeme J;Bergmann, Manuela M;Hofman, Albert;Franco, Oscar H;Cooper, Jackie;Palmen, Jutta;Spiering, Wilko;de Jong, Pim A;Kuh, Diana;Hardy, Rebecca;Uitterlinden, Andre G;Ikram, M Arfan;Ford, Ian;Hyppönen, Elina;Almeida, Osvaldo P;Wareham, Nicholas;Khaw, Kay-Tee;Hamsten, Anders;Husemoen, Lise Lotte N;Tjønneland, Anne;Tolstrup, Janne S;Rimm, Eric;Beulens, Joline WJ;Verschuren, WM Monique;Onland-Moret, N Charlotte;Hofker, Marten H;Wannamethee, S Goya;Whincup, Peter H;Morris, Richard;Vicente, Astrid M;Watkins, Hugh;Farrall, Martin;Jukema, J Wouter;Meschia, James;Cupples, L Adrienne;Sharp, Stephen;Fornage, Myriam;Kooperberg, Charles;LaCroix, Andrea Z;Dai, James Y;Lanktree, Matthew B;Siscovick, David S;Jorgenson, Eric;Spring, Bonnie;Coresh, Josef;Li, Yun R;Buxbaum, Sarah G;Schreiner, Pamela J;Ellison, R Curtis;Tsai, Michael Y;Patel, Sanjay R;Redline, Susan;Johnson, Andrew D;Hoogeveen, Ron C;Hakonarson, Hakon;Rotter, Jerome I;Boerwinkle, Eric;de Bakker, Paul IW;Kivimaki, Mika;Asselbergs, Folkert W;Sattar, Naveed;Lawlor, Debbie A;Whittaker, John;Davey Smith, George;Mukamal, Kenneth;Psaty, Bruce M;Wilson, James G;Lange, Leslie A;Hamidovic, Ajna;Hingorani, Aroon D;Nordestgaard, Børge G;Bobak, Martin;Leon, David A;Langenberg, Claudia;Palmer, Tom M;Reiner, Alex P;Keating, Brendan J;Dudbridge, Frank;Casas, Juan P;InterAct Consortium,
OBJECTIVE: To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease. DESIGN: Mendelian randomisation meta-analysis of 56 epidemiological studies. PA...
Holmes, Michael V;Dale, Caroline E;Zuccolo, Luisa;Silverwood, Richard J;Guo, Yiran;Ye, Zheng;Prieto-Merino, David;Dehghan, Abbas;Trompet, Stella;Wong, Andrew;Cavadino, Alana;Drogan, Dagmar;Padmanabhan, Sandosh;Li, Shanshan;Yesupriya, Ajay;Leusink, Maarten;Sundstrom, Johan;Hubacek, Jaroslav A;Pikhart, Hynek;Swerdlow, Daniel I;Panayiotou, Andrie G;Borinskaya, Svetlana A;Finan, Chris;Shah, Sonia;Kuchenbaecker, Karoline;Shah, Tina;Engmann, Jorgen;Folkersen, Lasse;Eriksson, Per;Ricceri, Fulvio;Melander, Olle;Sacerdote, Carlotta;Gamble, Dale M;Rayaprolu, Sruti;Ross, Owen A;McLachlan, Stela;Vikhireva, Olga;Sluijs, Ivonne;Scott, Robert;Adamkova, Vera;Flicker, Leon;Bockxmeer, Frank M van;Power, Christine;Marques-Vidal, Pedro;Meade, Tom;Marmot, Michael G;Ferro, Jose M;Paulos-Pinheiro, Sofia;Humphries, Steve E;Talmud, Philippa J;Mateo Leach, Irene;Verweij, Niek;Linneberg, Allan;Skaaby, Tea;Doevendans, Pieter A;Cramer, Maarten J;van der Harst, Pim;Klungel, Olaf H;Dowling, Nicole F;Dominiczak, Anna F;Kumari, Meena;Nicolaides, Andrew N;Weikert, Cornelia;Boeing, Heiner;Ebrahim, Shah;Gaunt, Tom R;Price, Jackie F;Lannfelt, Lars;Peasey, Anne;Kubinova, Ruzena;Pajak, Andrzej;Malyutina, Sofia;Voevoda, Mikhail I;Tamosiunas, Abdonas;Maitland-van der Zee, Anke H;Norman, Paul E;Hankey, Graeme J;Bergmann, Manuela M;Hofman, Albert;Franco, Oscar H;Cooper, Jackie;Palmen, Jutta;Spiering, Wilko;de Jong, Pim A;Kuh, Diana;Hardy, Rebecca;Uitterlinden, Andre G;Ikram, M Arfan;Ford, Ian;Hyppönen, Elina;Almeida, Osvaldo P;Wareham, Nicholas;Khaw, Kay-Tee;Hamsten, Anders;Husemoen, Lise Lotte N;Tjønneland, Anne;Tolstrup, Janne S;Rimm, Eric;Beulens, Joline WJ;Verschuren, WM Monique;Onland-Moret, N Charlotte;Hofker, Marten H;Wannamethee, S Goya;Whincup, Peter H;Morris, Richard;Vicente, Astrid M;Watkins, Hugh;Farrall, Martin;Jukema, J Wouter;Meschia, James;Cupples, L Adrienne;Sharp, Stephen;Fornage, Myriam;Kooperberg, Charles;LaCroix, Andrea Z;Dai, James Y;Lanktree, Matthew B;Siscovick, David S;Jorgenson, Eric;Spring, Bonnie;Coresh, Josef;Li, Yun R;Buxbaum, Sarah G;Schreiner, Pamela J;Ellison, R Curtis;Tsai, Michael Y;Patel, Sanjay R;Redline, Susan;Johnson, Andrew D;Hoogeveen, Ron C;Hakonarson, Hakon;Rotter, Jerome I;Boerwinkle, Eric;de Bakker, Paul IW;Kivimaki, Mika;Asselbergs, Folkert W;Sattar, Naveed;Lawlor, Debbie A;Whittaker, John;Davey Smith, George;Mukamal, Kenneth;Psaty, Bruce M;Wilson, James G;Lange, Leslie A;Hamidovic, Ajna;Hingorani, Aroon D;Nordestgaard, Børge G;Bobak, Martin;Leon, David A;Langenberg, Claudia;Palmer, Tom M;Reiner, Alex P;Keating, Brendan J;Dudbridge, Frank;Casas, Juan P;InterAct Consortium,
OBJECTIVE: To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease. DESIGN: Mendelian randomisation meta-analysis of 56 epidemiological studies. PA...
Holmes, Michael V;Dale, Caroline E;Zuccolo, Luisa;Silverwood, Richard J;Guo, Yiran;Ye, Zheng;Prieto-Merino, David;Dehghan, Abbas;Trompet, Stella;Wong, Andrew;Cavadino, Alana;Drogan, Dagmar;Padmanabhan, Sandosh;Li, Shanshan;Yesupriya, Ajay;Leusink, Maarten;Sundstrom, Johan;Hubacek, Jaroslav A;Pikhart, Hynek;Swerdlow, Daniel I;Panayiotou, Andrie G;Borinskaya, Svetlana A;Finan, Chris;Shah, Sonia;Kuchenbaecker, Karoline;Shah, Tina;Engmann, Jorgen;Folkersen, Lasse;Eriksson, Per;Ricceri, Fulvio;Melander, Olle;Sacerdote, Carlotta;Gamble, Dale M;Rayaprolu, Sruti;Ross, Owen A;McLachlan, Stela;Vikhireva, Olga;Sluijs, Ivonne;Scott, Robert;Adamkova, Vera;Flicker, Leon;Bockxmeer, Frank M van;Power, Christine;Marques-Vidal, Pedro;Meade, Tom;Marmot, Michael G;Ferro, Jose M;Paulos-Pinheiro, Sofia;Humphries, Steve E;Talmud, Philippa J;Mateo Leach, Irene;Verweij, Niek;Linneberg, Allan;Skaaby, Tea;Doevendans, Pieter A;Cramer, Maarten J;van der Harst, Pim;Klungel, Olaf H;Dowling, Nicole F;Dominiczak, Anna F;Kumari, Meena;Nicolaides, Andrew N;Weikert, Cornelia;Boeing, Heiner;Ebrahim, Shah;Gaunt, Tom R;Price, Jackie F;Lannfelt, Lars;Peasey, Anne;Kubinova, Ruzena;Pajak, Andrzej;Malyutina, Sofia;Voevoda, Mikhail I;Tamosiunas, Abdonas;Maitland-van der Zee, Anke H;Norman, Paul E;Hankey, Graeme J;Bergmann, Manuela M;Hofman, Albert;Franco, Oscar H;Cooper, Jackie;Palmen, Jutta;Spiering, Wilko;de Jong, Pim A;Kuh, Diana;Hardy, Rebecca;Uitterlinden, Andre G;Ikram, M Arfan;Ford, Ian;Hyppönen, Elina;Almeida, Osvaldo P;Wareham, Nicholas;Khaw, Kay-Tee;Hamsten, Anders;Husemoen, Lise Lotte N;Tjønneland, Anne;Tolstrup, Janne S;Rimm, Eric;Beulens, Joline WJ;Verschuren, WM Monique;Onland-Moret, N Charlotte;Hofker, Marten H;Wannamethee, S Goya;Whincup, Peter H;Morris, Richard;Vicente, Astrid M;Watkins, Hugh;Farrall, Martin;Jukema, J Wouter;Meschia, James;Cupples, L Adrienne;Sharp, Stephen;Fornage, Myriam;Kooperberg, Charles;LaCroix, Andrea Z;Dai, James Y;Lanktree, Matthew B;Siscovick, David S;Jorgenson, Eric;Spring, Bonnie;Coresh, Josef;Li, Yun R;Buxbaum, Sarah G;Schreiner, Pamela J;Ellison, R Curtis;Tsai, Michael Y;Patel, Sanjay R;Redline, Susan;Johnson, Andrew D;Hoogeveen, Ron C;Hakonarson, Hakon;Rotter, Jerome I;Boerwinkle, Eric;de Bakker, Paul IW;Kivimaki, Mika;Asselbergs, Folkert W;Sattar, Naveed;Lawlor, Debbie A;Whittaker, John;Davey Smith, George;Mukamal, Kenneth;Psaty, Bruce M;Wilson, James G;Lange, Leslie A;Hamidovic, Ajna;Hingorani, Aroon D;Nordestgaard, Børge G;Bobak, Martin;Leon, David A;Langenberg, Claudia;Palmer, Tom M;Reiner, Alex P;Keating, Brendan J;Dudbridge, Frank;Casas, Juan P;InterAct Consortium,
OBJECTIVE: To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease. DESIGN: Mendelian randomisation meta-analysis of 56 epidemiological studies. PA...
Genetic association studies in admixed populations allow us to gain deeper understanding of the genetic architecture of human diseases and traits. However, population stratification, complicated linkage disequilibrium (LD) patterns, and the complex i...
Asselbergs, Folkert W.;Guo, Yiran;van Iperen, Erik P. A.;Sivapalaratnam, Suthesh;Tragante, Vinicius;Lanktree, Matthew B.;Lange, Leslie A.;Almoguera, Berta;Appelman, Yolande E.;Barnard, John;Baumert, Jens;Beitelshees, Amber L.;Bhangale, Tushar R.;Chen, Yii-Der Ida;Gaunt, Tom R.;Gong, Yan;Hopewell, Jemma C.;Johnson, Toby;Kleber, Marcus E.;Langaee, Taimour Y.;Li, Mingyao;Li, Yun R.;Liu, Kiang;McDonough, Caitrin W.;Meijs, Matthijs El.;Middelberg, Rita P. S.;Musunuru, Kiran;Nelson, Christopher P.;O'Connell, Jeffery R.;Padmanabhan, Sandosh;Pankow, James S.;Pankratz, Nathan;Rafelt, Suzanne;Rajagopalan, Ramakrishnan;Romaine, Simon P. R.;Schork, Nicholas J.;Shaffer, Jonathan;Shen, Haiqing;Smith, Erin N.;Tischfield, Sam E.;van der Most, Peter J.;van Vliet-Ostaptchouk, Jana V.;Verweij, Niek;Volcik, Kelly A.;Zhang, Li;Bailey, Kent R.;Bailey, Kristian M.;Bauer, Florianne;Boer, Jolanda M. A.;Braund, Peter S.;Burt, Amber;Burton, Paul R.;Buxbaum, Sarah G.;Chen, Wei;Cooper-DeHoff, Rhonda M.;Cupples, L. Adrienne;deJong, Jonas S.;Delles, Christian;Duggan, David;Fornage, Myriam;Furlong, Clement E.;Glazer, Nicole;Gums, John G.;Hastie, Claire;Holmes, Michael V.;Illig, Thomas;Kirkland, Susan A.;Kivimaki, Mika;Klein, Ronald;Klein, Barbara E.;Kooperberg, Charles;Kottke-Marchant, Kandice;Kumari, Meena;LaCroix, Andrea Z.;Mallela, Laya;Murugesan, Gurunathan;Ordovas, Jose;Ouwehand, Willem H.;Post, Wendy S.;Saxena, Richa;Scharnagl, Hubert;Schreiner, Pamela J.;Shah, Tina;Shields, Denis C.;Shimbo, Daichi;Srinivasan, Sathanur R.;Stolk, Ronald P.;Swerdlow, Daniel I.;Taylor, Herman A.;Topo, Eric J.;Toskala, Elina;van Pelt, Joost L.;van Setten, Jessica;Yusuf, Salim;Whittaker, John C.;Zwinderman, A. H.;Anand, Sonia S.;Balmforth, Anthony J.;Berenson, Gerald S.;Bezzina, Connie R.;Boehm, Bernhard O.;Boerwinkle, Eric;Casas, Juan P.;Caulfield, Mark J.;Clarke, Robert;Connell, John M.;Cruickshanks, Karen J.;Davidson, Karina W.;Day, Ian N. M.;de Bakker, Paul I. W.;Doevendans, Pieter A.;Dominiczak, Anna E.;Hall, Alistair S.;Hartman, Catharina A.;Hengstenberg, Christian;Hillege, Hans L.;Hofker, Marten H.;Humphries, Steve E.;Jarvik, Gail P.;Johnson, Julie A.;Kaess, Bernhard M.;Kathiresan, Sekar;Koenig, Wolfgang;Lawlor, Debbie A.;Maerz, Winfried;Melander, Olle;Mitchell, Braxton D.;Montgomery, Grant W.;Munroe, Patricia B.;Murray, Sarah S.;Newhouse, Stephen J.;Onland-Moret, N. Charlotte;Poulter, Neil;Psaty, Bruce;Redline, Susan;Rich, Stephen S.;Rotter, Jerome I.;Schunkert, Heribert;Sever, Peter;Shuldiner, Alan R.;Silverstein, Roy L.;Stanton, Alice;Thorand, Barbara;Trip, Mieke D.;Tsai, Michael Y.;van der Harst, Pim;van der Schoot, Ellen;van der Schouw, Yvonne T.;Verschuren, W. M. Monique;Watkins, Hugh;Wilde, Arthur A. M.;Wolffenbuttel, Bruce H. R.;Whitfield, John B.;Hovingh, G. Kees;Ballantyne, Christie M.;Wijmenga, Cisca;Reilly, Muredach P.;Martin, Nicholas G.;Wilson, James G.;Rader, Daniel J.;Samani, Nilesh J.;Reiner, Alex P.;Hegele, Robert A.;Kastelein, John J. P.;Hingorani, Aroon D.;Talmud, Philippa J.;Hakonarson, Hakon;Elbers, Clara C.;Keating, Brendan J.;Drenos, Fotios;LifeLines Cohort Study
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Holmes, Michael V;Dale, Caroline E;Zuccolo, Luisa;Silverwood, Richard J;Guo, Yiran;Ye, Zheng;Prieto-Merino, David;Dehghan, Abbas;Trompet, Stella;Wong, Andrew;Cavadino, Alana;Drogan, Dagmar;Padmanabhan, Sandosh;Li, Shanshan;Yesupriya, Ajay;Leusink, Maarten;Sundstrom, Johan;Hubacek, Jaroslav A;Pikhart, Hynek;Swerdlow, Daniel I;Panayiotou, Andrie G;Borinskaya, Svetlana A;Finan, Chris;Shah, Sonia;Kuchenbaecker, Karoline Bernhardine;Shah, Tina;Engmann, Jorgen;Folkersen, Lasse;Eriksson, Per;Ricceri, Fulvio;Melander, Olle;Sacerdote, Carlotta;Gamble, Dale M;Rayaprolu, Sruti;Ross, Owen A;McLachlan, Stela;Vikhireva, Olga;Sluijs, Ivonne;Scott, Robert;Adamkova, Vera;Flicker, Leon;Bockxmeer, Frank M van;Power, Christine;Marques-Vidal, Pedro;Meade, Tom;Marmot, Michael G;Ferro, Jose M;Paulos-Pinheiro, Sofia;Humphries, Steve E;Talmud, Philippa J;Mateo Leach, Irene;Verweij, Niek;Linneberg, Allan;Skaaby, Tea;Doevendans, Pieter A;Cramer, Maarten J;van der Harst, Pim;Klungel, Olaf H;Dowling, Nicole F;Dominiczak, Anna F;Kumari, Meena;Nicolaides, Andrew N;Weikert, Cornelia;Boeing, Heiner;Ebrahim, Shah;Gaunt, Tom R;Price, Jackie F;Lannfelt, Lars;Peasey, Anne;Kubinova, Ruzena;Pajak, Andrzej;Malyutina, Sofia;Voevoda, Mikhail I;Tamosiunas, Abdonas;Maitland-van der Zee, Anke H;Norman, Paul E;Hankey, Graeme J;Bergmann, Manuela M;Hofman, Albert;Franco, Oscar H;Cooper, Jackie;Palmen, Jutta;Spiering, Wilko;de Jong, Pim A;Kuh, Diana;Hardy, Rebecca;Uitterlinden, Andre G;Ikram, M Arfan;Ford, Ian;Hyppönen, Elina;Almeida, Osvaldo P;Wareham, Nicholas John;Khaw, Kay-Tee;Hamsten, Anders;Husemoen, Lise Lotte N;Tjønneland, Anne;Tolstrup, Janne S;Rimm, Eric;Beulens, Joline WJ;Verschuren, WM Monique;Onland-Moret, N Charlotte;Hofker, Marten H;Wannamethee, S Goya;Whincup, Peter H;Morris, Richard;Vicente, Astrid M;Watkins, Hugh;Farrall, Martin;Jukema, J Wouter;Meschia, James;Cupples, L Adrienne;Sharp, Stephen John;Fornage, Myriam;Kooperberg, Charles;LaCroix, Andrea Z;Dai, James Y;Lanktree, Matthew B;Siscovick, David S;Jorgenson, Eric;Spring, Bonnie;Coresh, Josef;Li, Yun R;Buxbaum, Sarah G;Schreiner, Pamela J;Ellison, R Curtis;Tsai, Michael Y;Patel, Sanjay R;Redline, Susan;Johnson, Andrew D;Hoogeveen, Ron C;Hakonarson, Hakon;Rotter, Jerome I;Boerwinkle, Eric;de Bakker, Paul IW;Kivimaki, Mika;Asselbergs, Folkert W;Sattar, Naveed;Lawlor, Debbie A;Whittaker, John;Davey Smith, George;Mukamal, Kenneth;Psaty, Bruce M;Wilson, James G;Lange, Leslie A;Hamidovic, Ajna;Hingorani, Aroon D;Nordestgaard, Børge G;Bobak, Martin;Leon, David A;Langenberg, Claudia;Palmer, Tom M;Reiner, Alex P;Keating, Brendan J;Dudbridge, Frank;Casas, Juan P;InterAct Consortium,
OBJECTIVE: To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease. DESIGN: Mendelian randomisation meta-analysis of 56 epidemiological studies. PA...
Holmes, Michael V;Dale, Caroline E;Zuccolo, Luisa;Silverwood, Richard J;Guo, Yiran;Ye, Zheng;Prieto-Merino, David;Dehghan, Abbas;Trompet, Stella;Wong, Andrew;Cavadino, Alana;Drogan, Dagmar;Padmanabhan, Sandosh;Li, Shanshan;Yesupriya, Ajay;Leusink, Maarten;Sundstrom, Johan;Hubacek, Jaroslav A;Pikhart, Hynek;Swerdlow, Daniel I;Panayiotou, Andrie G;Borinskaya, Svetlana A;Finan, Chris;Shah, Sonia;Kuchenbaecker, Karoline Bernhardine;Shah, Tina;Engmann, Jorgen;Folkersen, Lasse;Eriksson, Per;Ricceri, Fulvio;Melander, Olle;Sacerdote, Carlotta;Gamble, Dale M;Rayaprolu, Sruti;Ross, Owen A;McLachlan, Stela;Vikhireva, Olga;Sluijs, Ivonne;Scott, Robert;Adamkova, Vera;Flicker, Leon;Bockxmeer, Frank M van;Power, Christine;Marques-Vidal, Pedro;Meade, Tom;Marmot, Michael G;Ferro, Jose M;Paulos-Pinheiro, Sofia;Humphries, Steve E;Talmud, Philippa J;Mateo Leach, Irene;Verweij, Niek;Linneberg, Allan;Skaaby, Tea;Doevendans, Pieter A;Cramer, Maarten J;van der Harst, Pim;Klungel, Olaf H;Dowling, Nicole F;Dominiczak, Anna F;Kumari, Meena;Nicolaides, Andrew N;Weikert, Cornelia;Boeing, Heiner;Ebrahim, Shah;Gaunt, Tom R;Price, Jackie F;Lannfelt, Lars;Peasey, Anne;Kubinova, Ruzena;Pajak, Andrzej;Malyutina, Sofia;Voevoda, Mikhail I;Tamosiunas, Abdonas;Maitland-van der Zee, Anke H;Norman, Paul E;Hankey, Graeme J;Bergmann, Manuela M;Hofman, Albert;Franco, Oscar H;Cooper, Jackie;Palmen, Jutta;Spiering, Wilko;de Jong, Pim A;Kuh, Diana;Hardy, Rebecca;Uitterlinden, Andre G;Ikram, M Arfan;Ford, Ian;Hyppönen, Elina;Almeida, Osvaldo P;Wareham, Nicholas John;Khaw, Kay-Tee;Hamsten, Anders;Husemoen, Lise Lotte N;Tjønneland, Anne;Tolstrup, Janne S;Rimm, Eric;Beulens, Joline WJ;Verschuren, WM Monique;Onland-Moret, N Charlotte;Hofker, Marten H;Wannamethee, S Goya;Whincup, Peter H;Morris, Richard;Vicente, Astrid M;Watkins, Hugh;Farrall, Martin;Jukema, J Wouter;Meschia, James;Cupples, L Adrienne;Sharp, Stephen John;Fornage, Myriam;Kooperberg, Charles;LaCroix, Andrea Z;Dai, James Y;Lanktree, Matthew B;Siscovick, David S;Jorgenson, Eric;Spring, Bonnie;Coresh, Josef;Li, Yun R;Buxbaum, Sarah G;Schreiner, Pamela J;Ellison, R Curtis;Tsai, Michael Y;Patel, Sanjay R;Redline, Susan;Johnson, Andrew D;Hoogeveen, Ron C;Hakonarson, Hakon;Rotter, Jerome I;Boerwinkle, Eric;de Bakker, Paul IW;Kivimaki, Mika;Asselbergs, Folkert W;Sattar, Naveed;Lawlor, Debbie A;Whittaker, John;Davey Smith, George;Mukamal, Kenneth;Psaty, Bruce M;Wilson, James G;Lange, Leslie A;Hamidovic, Ajna;Hingorani, Aroon D;Nordestgaard, Børge G;Bobak, Martin;Leon, David A;Langenberg, Claudia;Palmer, Tom M;Reiner, Alex P;Keating, Brendan J;Dudbridge, Frank;Casas, Juan P;InterAct Consortium,
OBJECTIVE: To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease. DESIGN: Mendelian randomisation meta-analysis of 56 epidemiological studies. PA...
Genetic association studies in admixed populations allow us to gain deeper understanding of the genetic architecture of human diseases and traits. However, population stratification, complicated linkage disequilibrium (LD) patterns, and the complex i...
Hypertension is a leading cause of global disease, mortality, and disability. While individuals of African descent suffer a disproportionate burden of hypertension and its complications, they have been underrepresented in genetic studies. To identify...