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Holmes, Michael V;Dale, Caroline E;Zuccolo, Luisa;Silverwood, Richard J;Guo, Yiran;Ye, Zheng;Prieto-Merino, David;Dehghan, Abbas;Trompet, Stella;Wong, Andrew;Cavadino, Alana;Drogan, Dagmar;Padmanabhan, Sandosh;Li, Shanshan;Yesupriya, Ajay;Leusink, Maarten;Sundstrom, Johan;Hubacek, Jaroslav A;Pikhart, Hynek;Swerdlow, Daniel I;Panayiotou, Andrie G;Borinskaya, Svetlana A;Finan, Chris;Shah, Sonia;Kuchenbaecker, Karoline Bernhardine;Shah, Tina;Engmann, Jorgen;Folkersen, Lasse;Eriksson, Per;Ricceri, Fulvio;Melander, Olle;Sacerdote, Carlotta;Gamble, Dale M;Rayaprolu, Sruti;Ross, Owen A;McLachlan, Stela;Vikhireva, Olga;Sluijs, Ivonne;Scott, Robert;Adamkova, Vera;Flicker, Leon;Bockxmeer, Frank M van;Power, Christine;Marques-Vidal, Pedro;Meade, Tom;Marmot, Michael G;Ferro, Jose M;Paulos-Pinheiro, Sofia;Humphries, Steve E;Talmud, Philippa J;Mateo Leach, Irene;Verweij, Niek;Linneberg, Allan;Skaaby, Tea;Doevendans, Pieter A;Cramer, Maarten J;van der Harst, Pim;Klungel, Olaf H;Dowling, Nicole F;Dominiczak, Anna F;Kumari, Meena;Nicolaides, Andrew N;Weikert, Cornelia;Boeing, Heiner;Ebrahim, Shah;Gaunt, Tom R;Price, Jackie F;Lannfelt, Lars;Peasey, Anne;Kubinova, Ruzena;Pajak, Andrzej;Malyutina, Sofia;Voevoda, Mikhail I;Tamosiunas, Abdonas;Maitland-van der Zee, Anke H;Norman, Paul E;Hankey, Graeme J;Bergmann, Manuela M;Hofman, Albert;Franco, Oscar H;Cooper, Jackie;Palmen, Jutta;Spiering, Wilko;de Jong, Pim A;Kuh, Diana;Hardy, Rebecca;Uitterlinden, Andre G;Ikram, M Arfan;Ford, Ian;Hyppönen, Elina;Almeida, Osvaldo P;Wareham, Nicholas John;Khaw, Kay-Tee;Hamsten, Anders;Husemoen, Lise Lotte N;Tjønneland, Anne;Tolstrup, Janne S;Rimm, Eric;Beulens, Joline WJ;Verschuren, WM Monique;Onland-Moret, N Charlotte;Hofker, Marten H;Wannamethee, S Goya;Whincup, Peter H;Morris, Richard;Vicente, Astrid M;Watkins, Hugh;Farrall, Martin;Jukema, J Wouter;Meschia, James;Cupples, L Adrienne;Sharp, Stephen John;Fornage, Myriam;Kooperberg, Charles;LaCroix, Andrea Z;Dai, James Y;Lanktree, Matthew B;Siscovick, David S;Jorgenson, Eric;Spring, Bonnie;Coresh, Josef;Li, Yun R;Buxbaum, Sarah G;Schreiner, Pamela J;Ellison, R Curtis;Tsai, Michael Y;Patel, Sanjay R;Redline, Susan;Johnson, Andrew D;Hoogeveen, Ron C;Hakonarson, Hakon;Rotter, Jerome I;Boerwinkle, Eric;de Bakker, Paul IW;Kivimaki, Mika;Asselbergs, Folkert W;Sattar, Naveed;Lawlor, Debbie A;Whittaker, John;Davey Smith, George;Mukamal, Kenneth;Psaty, Bruce M;Wilson, James G;Lange, Leslie A;Hamidovic, Ajna;Hingorani, Aroon D;Nordestgaard, Børge G;Bobak, Martin;Leon, David A;Langenberg, Claudia;Palmer, Tom M;Reiner, Alex P;Keating, Brendan J;Dudbridge, Frank;Casas, Juan P;InterAct Consortium,
OBJECTIVE: To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease. DESIGN: Mendelian randomisation meta-analysis of 56 epidemiological studies. PA...
Holmes, Michael V;Dale, Caroline E;Zuccolo, Luisa;Silverwood, Richard J;Guo, Yiran;Ye, Zheng;Prieto-Merino, David;Dehghan, Abbas;Trompet, Stella;Wong, Andrew;Cavadino, Alana;Drogan, Dagmar;Padmanabhan, Sandosh;Li, Shanshan;Yesupriya, Ajay;Leusink, Maarten;Sundstrom, Johan;Hubacek, Jaroslav A;Pikhart, Hynek;Swerdlow, Daniel I;Panayiotou, Andrie G;Borinskaya, Svetlana A;Finan, Chris;Shah, Sonia;Kuchenbaecker, Karoline Bernhardine;Shah, Tina;Engmann, Jorgen;Folkersen, Lasse;Eriksson, Per;Ricceri, Fulvio;Melander, Olle;Sacerdote, Carlotta;Gamble, Dale M;Rayaprolu, Sruti;Ross, Owen A;McLachlan, Stela;Vikhireva, Olga;Sluijs, Ivonne;Scott, Robert;Adamkova, Vera;Flicker, Leon;Bockxmeer, Frank M van;Power, Christine;Marques-Vidal, Pedro;Meade, Tom;Marmot, Michael G;Ferro, Jose M;Paulos-Pinheiro, Sofia;Humphries, Steve E;Talmud, Philippa J;Mateo Leach, Irene;Verweij, Niek;Linneberg, Allan;Skaaby, Tea;Doevendans, Pieter A;Cramer, Maarten J;van der Harst, Pim;Klungel, Olaf H;Dowling, Nicole F;Dominiczak, Anna F;Kumari, Meena;Nicolaides, Andrew N;Weikert, Cornelia;Boeing, Heiner;Ebrahim, Shah;Gaunt, Tom R;Price, Jackie F;Lannfelt, Lars;Peasey, Anne;Kubinova, Ruzena;Pajak, Andrzej;Malyutina, Sofia;Voevoda, Mikhail I;Tamosiunas, Abdonas;Maitland-van der Zee, Anke H;Norman, Paul E;Hankey, Graeme J;Bergmann, Manuela M;Hofman, Albert;Franco, Oscar H;Cooper, Jackie;Palmen, Jutta;Spiering, Wilko;de Jong, Pim A;Kuh, Diana;Hardy, Rebecca;Uitterlinden, Andre G;Ikram, M Arfan;Ford, Ian;Hyppönen, Elina;Almeida, Osvaldo P;Wareham, Nicholas John;Khaw, Kay-Tee;Hamsten, Anders;Husemoen, Lise Lotte N;Tjønneland, Anne;Tolstrup, Janne S;Rimm, Eric;Beulens, Joline WJ;Verschuren, WM Monique;Onland-Moret, N Charlotte;Hofker, Marten H;Wannamethee, S Goya;Whincup, Peter H;Morris, Richard;Vicente, Astrid M;Watkins, Hugh;Farrall, Martin;Jukema, J Wouter;Meschia, James;Cupples, L Adrienne;Sharp, Stephen John;Fornage, Myriam;Kooperberg, Charles;LaCroix, Andrea Z;Dai, James Y;Lanktree, Matthew B;Siscovick, David S;Jorgenson, Eric;Spring, Bonnie;Coresh, Josef;Li, Yun R;Buxbaum, Sarah G;Schreiner, Pamela J;Ellison, R Curtis;Tsai, Michael Y;Patel, Sanjay R;Redline, Susan;Johnson, Andrew D;Hoogeveen, Ron C;Hakonarson, Hakon;Rotter, Jerome I;Boerwinkle, Eric;de Bakker, Paul IW;Kivimaki, Mika;Asselbergs, Folkert W;Sattar, Naveed;Lawlor, Debbie A;Whittaker, John;Davey Smith, George;Mukamal, Kenneth;Psaty, Bruce M;Wilson, James G;Lange, Leslie A;Hamidovic, Ajna;Hingorani, Aroon D;Nordestgaard, Børge G;Bobak, Martin;Leon, David A;Langenberg, Claudia;Palmer, Tom M;Reiner, Alex P;Keating, Brendan J;Dudbridge, Frank;Casas, Juan P;InterAct Consortium,
OBJECTIVE: To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease. DESIGN: Mendelian randomisation meta-analysis of 56 epidemiological studies. PA...
Asselbergs, Folkert W.;Guo, Yiran;van Iperen, Erik P. A.;Sivapalaratnam, Suthesh;Tragante, Vinicius;Lanktree, Matthew B.;Lange, Leslie A.;Almoguera, Berta;Appelman, Yolande E.;Barnard, John;Baumert, Jens;Beitelshees, Amber L.;Bhangale, Tushar R.;Chen, Yii-Der Ida;Gaunt, Tom R.;Gong, Yan;Hopewell, Jemma C.;Johnson, Toby;Kleber, Marcus E.;Langaee, Taimour Y.;Li, Mingyao;Li, Yun R.;Liu, Kiang;McDonough, Caitrin W.;Meijs, Matthijs El.;Middelberg, Rita P. S.;Musunuru, Kiran;Nelson, Christopher P.;O'Connell, Jeffery R.;Padmanabhan, Sandosh;Pankow, James S.;Pankratz, Nathan;Rafelt, Suzanne;Rajagopalan, Ramakrishnan;Romaine, Simon P. R.;Schork, Nicholas J.;Shaffer, Jonathan;Shen, Haiqing;Smith, Erin N.;Tischfield, Sam E.;van der Most, Peter J.;van Vliet-Ostaptchouk, Jana V.;Verweij, Niek;Volcik, Kelly A.;Zhang, Li;Bailey, Kent R.;Bailey, Kristian M.;Bauer, Florianne;Boer, Jolanda M. A.;Braund, Peter S.;Burt, Amber;Burton, Paul R.;Buxbaum, Sarah G.;Chen, Wei;Cooper-DeHoff, Rhonda M.;Cupples, L. Adrienne;deJong, Jonas S.;Delles, Christian;Duggan, David;Fornage, Myriam;Furlong, Clement E.;Glazer, Nicole;Gums, John G.;Hastie, Claire;Holmes, Michael V.;Illig, Thomas;Kirkland, Susan A.;Kivimaki, Mika;Klein, Ronald;Klein, Barbara E.;Kooperberg, Charles;Kottke-Marchant, Kandice;Kumari, Meena;LaCroix, Andrea Z.;Mallela, Laya;Murugesan, Gurunathan;Ordovas, Jose;Ouwehand, Willem H.;Post, Wendy S.;Saxena, Richa;Scharnagl, Hubert;Schreiner, Pamela J.;Shah, Tina;Shields, Denis C.;Shimbo, Daichi;Srinivasan, Sathanur R.;Stolk, Ronald P.;Swerdlow, Daniel I.;Taylor, Herman A.;Topo, Eric J.;Toskala, Elina;van Pelt, Joost L.;van Setten, Jessica;Yusuf, Salim;Whittaker, John C.;Zwinderman, A. H.;Anand, Sonia S.;Balmforth, Anthony J.;Berenson, Gerald S.;Bezzina, Connie R.;Boehm, Bernhard O.;Boerwinkle, Eric;Casas, Juan P.;Caulfield, Mark J.;Clarke, Robert;Connell, John M.;Cruickshanks, Karen J.;Davidson, Karina W.;Day, Ian N. M.;de Bakker, Paul I. W.;Doevendans, Pieter A.;Dominiczak, Anna E.;Hall, Alistair S.;Hartman, Catharina A.;Hengstenberg, Christian;Hillege, Hans L.;Hofker, Marten H.;Humphries, Steve E.;Jarvik, Gail P.;Johnson, Julie A.;Kaess, Bernhard M.;Kathiresan, Sekar;Koenig, Wolfgang;Lawlor, Debbie A.;Maerz, Winfried;Melander, Olle;Mitchell, Braxton D.;Montgomery, Grant W.;Munroe, Patricia B.;Murray, Sarah S.;Newhouse, Stephen J.;Onland-Moret, N. Charlotte;Poulter, Neil;Psaty, Bruce;Redline, Susan;Rich, Stephen S.;Rotter, Jerome I.;Schunkert, Heribert;Sever, Peter;Shuldiner, Alan R.;Silverstein, Roy L.;Stanton, Alice;Thorand, Barbara;Trip, Mieke D.;Tsai, Michael Y.;van der Harst, Pim;van der Schoot, Ellen;van der Schouw, Yvonne T.;Verschuren, W. M. Monique;Watkins, Hugh;Wilde, Arthur A. M.;Wolffenbuttel, Bruce H. R.;Whitfield, John B.;Hovingh, G. Kees;Ballantyne, Christie M.;Wijmenga, Cisca;Reilly, Muredach P.;Martin, Nicholas G.;Wilson, James G.;Rader, Daniel J.;Samani, Nilesh J.;Reiner, Alex P.;Hegele, Robert A.;Kastelein, John J. P.;Hingorani, Aroon D.;Talmud, Philippa J.;Hakonarson, Hakon;Elbers, Clara C.;Keating, Brendan J.;Drenos, Fotios
Genome-wide association studies (GWASs) have identified many SNPs underlying variations in plasma-lipid levels. We explore whether additional loci associated with plasma-lipid phenotypes, such as high-density lipoprotein cholesterol (HDL-C), low-dens...
Asselbergs, Folkert W.;Guo, Yiran;van Iperen, Erik P. A.;Sivapalaratnam, Suthesh;Tragante, Vinicius;Lanktree, Matthew B.;Lange, Leslie A.;Almoguera, Berta;Appelman, Yolande E.;Barnard, John;Baumert, Jens;Beitelshees, Amber L.;Bhangale, Tushar R.;Chen, Yii-Der Ida;Gaunt, Tom R.;Gong, Yan;Hopewell, Jemma C.;Johnson, Toby;Kleber, Marcus E.;Langaee, Taimour Y.;Li, Mingyao;Li, Yun R.;Liu, Kiang;McDonough, Caitrin W.;Meijs, Matthijs El.;Middelberg, Rita P. S.;Musunuru, Kiran;Nelson, Christopher P.;O'Connell, Jeffery R.;Padmanabhan, Sandosh;Pankow, James S.;Pankratz, Nathan;Rafelt, Suzanne;Rajagopalan, Ramakrishnan;Romaine, Simon P. R.;Schork, Nicholas J.;Shaffer, Jonathan;Shen, Haiqing;Smith, Erin N.;Tischfield, Sam E.;van der Most, Peter J.;van Vliet-Ostaptchouk, Jana V.;Verweij, Niek;Volcik, Kelly A.;Zhang, Li;Bailey, Kent R.;Bailey, Kristian M.;Bauer, Florianne;Boer, Jolanda M. A.;Braund, Peter S.;Burt, Amber;Burton, Paul R.;Buxbaum, Sarah G.;Chen, Wei;Cooper-DeHoff, Rhonda M.;Cupples, L. Adrienne;deJong, Jonas S.;Delles, Christian;Duggan, David;Fornage, Myriam;Furlong, Clement E.;Glazer, Nicole;Gums, John G.;Hastie, Claire;Holmes, Michael V.;Illig, Thomas;Kirkland, Susan A.;Kivimaki, Mika;Klein, Ronald;Klein, Barbara E.;Kooperberg, Charles;Kottke-Marchant, Kandice;Kumari, Meena;LaCroix, Andrea Z.;Mallela, Laya;Murugesan, Gurunathan;Ordovas, Jose;Ouwehand, Willem H.;Post, Wendy S.;Saxena, Richa;Scharnagl, Hubert;Schreiner, Pamela J.;Shah, Tina;Shields, Denis C.;Shimbo, Daichi;Srinivasan, Sathanur R.;Stolk, Ronald P.;Swerdlow, Daniel I.;Taylor, Herman A.;Topo, Eric J.;Toskala, Elina;van Pelt, Joost L.;van Setten, Jessica;Yusuf, Salim;Whittaker, John C.;Zwinderman, A. H.;Anand, Sonia S.;Balmforth, Anthony J.;Berenson, Gerald S.;Bezzina, Connie R.;Boehm, Bernhard O.;Boerwinkle, Eric;Casas, Juan P.;Caulfield, Mark J.;Clarke, Robert;Connell, John M.;Cruickshanks, Karen J.;Davidson, Karina W.;Day, Ian N. M.;de Bakker, Paul I. W.;Doevendans, Pieter A.;Dominiczak, Anna E.;Hall, Alistair S.;Hartman, Catharina A.;Hengstenberg, Christian;Hillege, Hans L.;Hofker, Marten H.;Humphries, Steve E.;Jarvik, Gail P.;Johnson, Julie A.;Kaess, Bernhard M.;Kathiresan, Sekar;Koenig, Wolfgang;Lawlor, Debbie A.;Maerz, Winfried;Melander, Olle;Mitchell, Braxton D.;Montgomery, Grant W.;Munroe, Patricia B.;Murray, Sarah S.;Newhouse, Stephen J.;Onland-Moret, N. Charlotte;Poulter, Neil;Psaty, Bruce;Redline, Susan;Rich, Stephen S.;Rotter, Jerome I.;Schunkert, Heribert;Sever, Peter;Shuldiner, Alan R.;Silverstein, Roy L.;Stanton, Alice;Thorand, Barbara;Trip, Mieke D.;Tsai, Michael Y.;van der Harst, Pim;van der Schoot, Ellen;van der Schouw, Yvonne T.;Verschuren, W. M. Monique;Watkins, Hugh;Wilde, Arthur A. M.;Wolffenbuttel, Bruce H. R.;Whitfield, John B.;Hovingh, G. Kees;Ballantyne, Christie M.;Wijmenga, Cisca;Reilly, Muredach P.;Martin, Nicholas G.;Wilson, James G.;Rader, Daniel J.;Samani, Nilesh J.;Reiner, Alex P.;Hegele, Robert A.;Kastelein, John J. P.;Hingorani, Aroon D.;Talmud, Philippa J.;Hakonarson, Hakon;Elbers, Clara C.;Keating, Brendan J.;Drenos, Fotios
Genome-wide association studies (GWASs) have identified many SNPs underlying variations in plasma-lipid levels. We explore whether additional loci associated with plasma-lipid phenotypes, such as high-density lipoprotein cholesterol (HDL-C), low-dens...
Flannick, Jason;Fuchsberger, Christian;Mahajan, Anubha;Teslovich, Tanya M.;Agarwala, Vineeta;Gaulton, Kyle J.;Caulkins, Lizz;Koesterer, Ryan;Ma, Clement;Moutsianas, Loukas;McCarthy, Davis J.;Rivas, Manuel A.;Perry, John R.B.;Sim, Xueling;Blackwell, Thomas W.;Robertson, Neil R.;Rayner, N. William;Cingolani, Pablo;Locke, Adam E.;Tajes, Juan Fernandez;Highland, Heather M.;Dupuis, Josée;Chines, Peter S.;Lindgren, Cecilia M.;Hartl, Christopher;Jackson, Anne U.;Chen, Han;Huyghe, Jeroen R.;Van De Bunt, Martijn;Pearson, Richard D.;Kumar, Ashish;Müller-Nurasyid, Martina;Grarup, Niels;Stringham, Heather M.;Gamazon, Eric R.;Lee, Jaehoon;Chen, Yuhui;Scott, Robert A.;Below, Jennifer E.;Chen, Peng;Huang, Jinyan;Go, Min Jin;Stitzel, Michael L.;Pasko, Dorota;Parker, Stephen C.J.;Varga, Tibor V.;Green, Todd;Beer, Nicola L.;Day-Williams, Aaron G.;Ferreira, Teresa;Fingerlin, Tasha;Horikoshi, Momoko;Hu, Cheng;Huh, Iksoo;Ikram, Mohammad Kamran;Kim, Bong-Jo;Kim, Yongkang;Kim, Young Jin;Kwon, Min-Seok;Lee, Juyoung;Lee, Selyeong;Lin, Keng-Han;Maxwell, Taylor J.;Nagai, Yoshihiko;Wang, Xu;Welch, Ryan P.;Yoon, Joon;Zhang, Weihua;Barzilai, Nir;Voight, Benjamin F.;Han, Bok-Ghee;Jenkinson, Christopher P.;Kuulasmaa, Teemu;Kuusisto, Johanna;Manning, Alisa;Ng, Maggie C.Y.;Palmer, Nicholette D.;Balkau, Beverley;Stančáková, Alena;Abboud, Hanna E.;Boeing, Heiner;Giedraitis, Vilmantas;Prabhakaran, Dorairaj;Gottesman, Omri;Scott, James;Carey, Jason;Kwan, Phoenix;Grant, George;Smith, Joshua D.;Neale, Benjamin M.;Purcell, Shaun;Butterworth, Adam S.;Howson, Joanna M.M.;Lee, Heung Man;Lu, Yingchang;Kwak, Soo-Heon;Zhao, Wei;Danesh, John;Lam, Vincent K.L.;Park, Kyong Soo;Saleheen, Danish;So, Wing Yee;Tam, Claudia H.T.;Afzal, Uzma;Aguilar, David;Arya, Rector;Aung, Tin;Chan, Edmund;Navarro, Carmen;Cheng, Ching-Yu;Palli, Domenico;Correa, Adolfo;Curran, Joanne E.;Rybin, Dennis;Farook, Vidya S.;Fowler, Sharon P.;Freedman, Barry I.;Griswold, Michael;Hale, Daniel Esten;Hicks, Pamela J.;Khor, Chiea-Chuen;Kumar, Satish;Lehne, Benjamin;Thuillier, Dorothée;Lim, Wei Yen;Liu, Jianjun;Loh, Marie;Musani, Solomon K.;Puppala, Sobha;Scott, William R.;Yengo, Loïc;Tan, Sian-Tsung;Taylor, Herman A.;Thameem, Farook;Wilson, Gregory;Wong, Tien Yin;Njølstad, Pål Rasmus;Levy, Jonathan C.;Mangino, Massimo;Bonnycastle, Lori L.;Schwarzmayr, Thomas;Fadista, João;Surdulescu, Gabriela L.;Herder, Christian;Groves, Christopher J.;Wieland, Thomas;Bork-Jensen, Jette;Brandslund, Ivan;Christensen, Cramer;Koistinen, Heikki A.;Doney, Alex S.F.;Kinnunen, Leena;Esko, Tõnu;Farmer, Andrew J.;Hakaste, Liisa;Hodgkiss, Dylan;Kravic, Jasmina;Lyssenko, Valeriya;Hollensted, Mette;Jørgensen, Marit E.;Jørgensen, Torben;Ladenvall, Claes;Justesen, Johanne Marie;Käräjämäki, Annemari;Kriebel, Jennifer;Rathmann, Wolfgang;Lannfelt, Lars;Lauritzen, Torsten;Narisu, Narisu;Linneberg, Allan;Melander, Olle;Milani, Lili;Neville, Matt;Orho-Melander, Marju;Qi, Lu;Qi, Qibin;Roden, Michael;Rolandsson, Olov;Swift, Amy;Rosengren, Anders H.;Stirrups, Kathleen;Wood, Andrew R.;Mihailov, Evelin;Blancher, Christine;Carneiro, Mauricio O.;Maguire, Jared;Poplin, Ryan;Shakir, Khalid;Fennell, Timothy;DePristo, Mark;De Angelis, Martin Hrabé;Deloukas, Panos;Gjesing, Anette P.;Jun, Goo;Nilsson, Peter M.;Murphy, Jacquelyn;Onofrio, Robert;Thorand, Barbara;Hansen, Torben;Meisinger, Christa;Hu, Frank B.;Isomaa, Bo;Karpe, Fredrik;Liang, Liming;Peters, Annette;Huth, Cornelia;O'Rahilly, Stephen P.;Palmer, Colin N.A.;Pedersen, Oluf;Rauramaa, Rainer;Tuomilehto, Jaakko;Salomaa, Veikko;Watanabe, Richard M.;Syvänen, Ann-Christine;Bergman, Richard N.;Bharadwaj, Dwaipayan;Bottinger, Erwin P.;Cho, Yoon Shin;Chandak, Giriraj R.;Chan, Juliana C.N.;Chia, Kee Seng;Daly, Mark J.;Ebrahim, Shah B.;Langenberg, Claudia;Elliott, Paul;Jablonski, Kathleen A.;Lehman, Donna M.;Jia, Weiping;Ma, Ronald C.W.;Pollin, Toni I.;Sandhu, Manjinder;Tandon, Nikhil;Froguel, Philippe;Barroso, Inês;Teo, Yik Ying;Zeggini, Eleftheria;Loos, Ruth J.F.;Small, Kerrin S.;Ried, Janina S.;DeFronzo, Ralph A.;Grallert, Harald;Glaser, Benjamin;Metspalu, Andres;Wareham, Nicholas J.;Walker, Mark;Banks, Eric;Gieger, Christian;Ingelsson, Erik;Im, Hae Kyung;Illig, Thomas;Franks, Paul W.;Buck, Gemma;Trakalo, Joseph;Buck, David;Prokopenko, Inga;Mägi, Reedik;Lind, Lars;Farjoun, Yossi;Owen, Katharine R.;Gloyn, Anna L.;Strauch, Konstantin;Tuomi, Tiinamaija;Kooner, Jaspal Singh;Lee, Jong-Young;Park, Taesung;Donnelly, Peter;Morris, Andrew D.;Hattersley, Andrew T.;Bowden, Donald W.;Collins, Francis S.;Atzmon, Gil;Chambers, John C.;Spector, Timothy D.;Laakso, Markku;Strom, Tim M.;Bell, Graeme I.;Blangero, John;Duggirala, Ravindranath;Tai, Eshyong;McVean, Gilean;Hanis, Craig L.;Wilson, James G.;Seielstad, Mark;Frayling, Timothy M.;Meigs, James B.;Cox, Nancy J.;Sladek, Rob;Lander, Eric S.;Gabriel, Stacey;Mohlke, Karen L.;Meitinger, Thomas;Groop, Leif;Abecasis, Goncalo;Scott, Laura J.;Morris, Andrew P.;Kang, Hyun Min;Altshuler, David;Burtt, Noël P.;Florez, Jose C.;Boehnke, Michael;McCarthy, Mark I.
To investigate the genetic basis of type 2 diabetes (T2D) to high resolution, the GoT2D and T2D-GENES consortia catalogued variation from whole-genome sequencing of 2,657 European individuals and exome sequencing of 12,940 individuals of multiple anc...
Flannick, Jason;Fuchsberger, Christian;Mahajan, Anubha;Teslovich, Tanya M.;Agarwala, Vineeta;Gaulton, Kyle J.;Caulkins, Lizz;Koesterer, Ryan;Ma, Clement;Moutsianas, Loukas;McCarthy, Davis J.;Rivas, Manuel A.;Perry, John R.B.;Sim, Xueling;Blackwell, Thomas W.;Robertson, Neil R.;Rayner, N. William;Cingolani, Pablo;Locke, Adam E.;Tajes, Juan Fernandez;Highland, Heather M.;Dupuis, Josée;Chines, Peter S.;Lindgren, Cecilia M.;Hartl, Christopher;Jackson, Anne U.;Chen, Han;Huyghe, Jeroen R.;Van De Bunt, Martijn;Pearson, Richard D.;Kumar, Ashish;Müller-Nurasyid, Martina;Grarup, Niels;Stringham, Heather M.;Gamazon, Eric R.;Lee, Jaehoon;Chen, Yuhui;Scott, Robert A.;Below, Jennifer E.;Chen, Peng;Huang, Jinyan;Go, Min Jin;Stitzel, Michael L.;Pasko, Dorota;Parker, Stephen C.J.;Varga, Tibor V.;Green, Todd;Beer, Nicola L.;Day-Williams, Aaron G.;Ferreira, Teresa;Fingerlin, Tasha;Horikoshi, Momoko;Hu, Cheng;Huh, Iksoo;Ikram, Mohammad Kamran;Kim, Bong-Jo;Kim, Yongkang;Kim, Young Jin;Kwon, Min-Seok;Lee, Juyoung;Lee, Selyeong;Lin, Keng-Han;Maxwell, Taylor J.;Nagai, Yoshihiko;Wang, Xu;Welch, Ryan P.;Yoon, Joon;Zhang, Weihua;Barzilai, Nir;Voight, Benjamin F.;Han, Bok-Ghee;Jenkinson, Christopher P.;Kuulasmaa, Teemu;Kuusisto, Johanna;Manning, Alisa;Ng, Maggie C.Y.;Palmer, Nicholette D.;Balkau, Beverley;Stančáková, Alena;Abboud, Hanna E.;Boeing, Heiner;Giedraitis, Vilmantas;Prabhakaran, Dorairaj;Gottesman, Omri;Scott, James;Carey, Jason;Kwan, Phoenix;Grant, George;Smith, Joshua D.;Neale, Benjamin M.;Purcell, Shaun;Butterworth, Adam S.;Howson, Joanna M.M.;Lee, Heung Man;Lu, Yingchang;Kwak, Soo-Heon;Zhao, Wei;Danesh, John;Lam, Vincent K.L.;Park, Kyong Soo;Saleheen, Danish;So, Wing Yee;Tam, Claudia H.T.;Afzal, Uzma;Aguilar, David;Arya, Rector;Aung, Tin;Chan, Edmund;Navarro, Carmen;Cheng, Ching-Yu;Palli, Domenico;Correa, Adolfo;Curran, Joanne E.;Rybin, Dennis;Farook, Vidya S.;Fowler, Sharon P.;Freedman, Barry I.;Griswold, Michael;Hale, Daniel Esten;Hicks, Pamela J.;Khor, Chiea-Chuen;Kumar, Satish;Lehne, Benjamin;Thuillier, Dorothée;Lim, Wei Yen;Liu, Jianjun;Loh, Marie;Musani, Solomon K.;Puppala, Sobha;Scott, William R.;Yengo, Loïc;Tan, Sian-Tsung;Taylor, Herman A.;Thameem, Farook;Wilson, Gregory;Wong, Tien Yin;Njølstad, Pål Rasmus;Levy, Jonathan C.;Mangino, Massimo;Bonnycastle, Lori L.;Schwarzmayr, Thomas;Fadista, João;Surdulescu, Gabriela L.;Herder, Christian;Groves, Christopher J.;Wieland, Thomas;Bork-Jensen, Jette;Brandslund, Ivan;Christensen, Cramer;Koistinen, Heikki A.;Doney, Alex S.F.;Kinnunen, Leena;Esko, Tõnu;Farmer, Andrew J.;Hakaste, Liisa;Hodgkiss, Dylan;Kravic, Jasmina;Lyssenko, Valeriya;Hollensted, Mette;Jørgensen, Marit E.;Jørgensen, Torben;Ladenvall, Claes;Justesen, Johanne Marie;Käräjämäki, Annemari;Kriebel, Jennifer;Rathmann, Wolfgang;Lannfelt, Lars;Lauritzen, Torsten;Narisu, Narisu;Linneberg, Allan;Melander, Olle;Milani, Lili;Neville, Matt;Orho-Melander, Marju;Qi, Lu;Qi, Qibin;Roden, Michael;Rolandsson, Olov;Swift, Amy;Rosengren, Anders H.;Stirrups, Kathleen;Wood, Andrew R.;Mihailov, Evelin;Blancher, Christine;Carneiro, Mauricio O.;Maguire, Jared;Poplin, Ryan;Shakir, Khalid;Fennell, Timothy;DePristo, Mark;De Angelis, Martin Hrabé;Deloukas, Panos;Gjesing, Anette P.;Jun, Goo;Nilsson, Peter M.;Murphy, Jacquelyn;Onofrio, Robert;Thorand, Barbara;Hansen, Torben;Meisinger, Christa;Hu, Frank B.;Isomaa, Bo;Karpe, Fredrik;Liang, Liming;Peters, Annette;Huth, Cornelia;O'Rahilly, Stephen P.;Palmer, Colin N.A.;Pedersen, Oluf;Rauramaa, Rainer;Tuomilehto, Jaakko;Salomaa, Veikko;Watanabe, Richard M.;Syvänen, Ann-Christine;Bergman, Richard N.;Bharadwaj, Dwaipayan;Bottinger, Erwin P.;Cho, Yoon Shin;Chandak, Giriraj R.;Chan, Juliana C.N.;Chia, Kee Seng;Daly, Mark J.;Ebrahim, Shah B.;Langenberg, Claudia;Elliott, Paul;Jablonski, Kathleen A.;Lehman, Donna M.;Jia, Weiping;Ma, Ronald C.W.;Pollin, Toni I.;Sandhu, Manjinder;Tandon, Nikhil;Froguel, Philippe;Barroso, Inês;Teo, Yik Ying;Zeggini, Eleftheria;Loos, Ruth J.F.;Small, Kerrin S.;Ried, Janina S.;DeFronzo, Ralph A.;Grallert, Harald;Glaser, Benjamin;Metspalu, Andres;Wareham, Nicholas J.;Walker, Mark;Banks, Eric;Gieger, Christian;Ingelsson, Erik;Im, Hae Kyung;Illig, Thomas;Franks, Paul W.;Buck, Gemma;Trakalo, Joseph;Buck, David;Prokopenko, Inga;Mägi, Reedik;Lind, Lars;Farjoun, Yossi;Owen, Katharine R.;Gloyn, Anna L.;Strauch, Konstantin;Tuomi, Tiinamaija;Kooner, Jaspal Singh;Lee, Jong-Young;Park, Taesung;Donnelly, Peter;Morris, Andrew D.;Hattersley, Andrew T.;Bowden, Donald W.;Collins, Francis S.;Atzmon, Gil;Chambers, John C.;Spector, Timothy D.;Laakso, Markku;Strom, Tim M.;Bell, Graeme I.;Blangero, John;Duggirala, Ravindranath;Tai, Eshyong;McVean, Gilean;Hanis, Craig L.;Wilson, James G.;Seielstad, Mark;Frayling, Timothy M.;Meigs, James B.;Cox, Nancy J.;Sladek, Rob;Lander, Eric S.;Gabriel, Stacey;Mohlke, Karen L.;Meitinger, Thomas;Groop, Leif;Abecasis, Goncalo;Scott, Laura J.;Morris, Andrew P.;Kang, Hyun Min;Altshuler, David;Burtt, Noël P.;Florez, Jose C.;Boehnke, Michael;McCarthy, Mark I.
To investigate the genetic basis of type 2 diabetes (T2D) to high resolution, the GoT2D and T2D-GENES consortia catalogued variation from whole-genome sequencing of 2,657 European individuals and exome sequencing of 12,940 individuals of multiple anc...
Asselbergs, Folkert W.;Guo, Yiran;van Iperen, Erik P. A.;Sivapalaratnam, Suthesh;Tragante, Vinicius;Lanktree, Matthew B.;Lange, Leslie A.;Almoguera, Berta;Appelman, Yolande E.;Barnard, John;Baumert, Jens;Beitelshees, Amber L.;Bhangale, Tushar R.;Chen, Yii-Der Ida;Gaunt, Tom R.;Gong, Yan;Hopewell, Jemma C.;Johnson, Toby;Kleber, Marcus E.;Langaee, Taimour Y.;Li, Mingyao;Li, Yun R.;Liu, Kiang;McDonough, Caitrin W.;Meijs, Matthijs El.;Middelberg, Rita P. S.;Musunuru, Kiran;Nelson, Christopher P.;O'Connell, Jeffery R.;Padmanabhan, Sandosh;Pankow, James S.;Pankratz, Nathan;Rafelt, Suzanne;Rajagopalan, Ramakrishnan;Romaine, Simon P. R.;Schork, Nicholas J.;Shaffer, Jonathan;Shen, Haiqing;Smith, Erin N.;Tischfield, Sam E.;van der Most, Peter J.;van Vliet-Ostaptchouk, Jana V.;Verweij, Niek;Volcik, Kelly A.;Zhang, Li;Bailey, Kent R.;Bailey, Kristian M.;Bauer, Florianne;Boer, Jolanda M. A.;Braund, Peter S.;Burt, Amber;Burton, Paul R.;Buxbaum, Sarah G.;Chen, Wei;Cooper-DeHoff, Rhonda M.;Cupples, L. Adrienne;deJong, Jonas S.;Delles, Christian;Duggan, David;Fornage, Myriam;Furlong, Clement E.;Glazer, Nicole;Gums, John G.;Hastie, Claire;Holmes, Michael V.;Illig, Thomas;Kirkland, Susan A.;Kivimaki, Mika;Klein, Ronald;Klein, Barbara E.;Kooperberg, Charles;Kottke-Marchant, Kandice;Kumari, Meena;LaCroix, Andrea Z.;Mallela, Laya;Murugesan, Gurunathan;Ordovas, Jose;Ouwehand, Willem H.;Post, Wendy S.;Saxena, Richa;Scharnagl, Hubert;Schreiner, Pamela J.;Shah, Tina;Shields, Denis C.;Shimbo, Daichi;Srinivasan, Sathanur R.;Stolk, Ronald P.;Swerdlow, Daniel I.;Taylor, Herman A.;Topo, Eric J.;Toskala, Elina;van Pelt, Joost L.;van Setten, Jessica;Yusuf, Salim;Whittaker, John C.;Zwinderman, A. H.;Anand, Sonia S.;Balmforth, Anthony J.;Berenson, Gerald S.;Bezzina, Connie R.;Boehm, Bernhard O.;Boerwinkle, Eric;Casas, Juan P.;Caulfield, Mark J.;Clarke, Robert;Connell, John M.;Cruickshanks, Karen J.;Davidson, Karina W.;Day, Ian N. M.;de Bakker, Paul I. W.;Doevendans, Pieter A.;Dominiczak, Anna E.;Hall, Alistair S.;Hartman, Catharina A.;Hengstenberg, Christian;Hillege, Hans L.;Hofker, Marten H.;Humphries, Steve E.;Jarvik, Gail P.;Johnson, Julie A.;Kaess, Bernhard M.;Kathiresan, Sekar;Koenig, Wolfgang;Lawlor, Debbie A.;Maerz, Winfried;Melander, Olle;Mitchell, Braxton D.;Montgomery, Grant W.;Munroe, Patricia B.;Murray, Sarah S.;Newhouse, Stephen J.;Onland-Moret, N. Charlotte;Poulter, Neil;Psaty, Bruce;Redline, Susan;Rich, Stephen S.;Rotter, Jerome I.;Schunkert, Heribert;Sever, Peter;Shuldiner, Alan R.;Silverstein, Roy L.;Stanton, Alice;Thorand, Barbara;Trip, Mieke D.;Tsai, Michael Y.;van der Harst, Pim;van der Schoot, Ellen;van der Schouw, Yvonne T.;Verschuren, W. M. Monique;Watkins, Hugh;Wilde, Arthur A. M.;Wolffenbuttel, Bruce H. R.;Whitfield, John B.;Hovingh, G. Kees;Ballantyne, Christie M.;Wijmenga, Cisca;Reilly, Muredach P.;Martin, Nicholas G.;Wilson, James G.;Rader, Daniel J.;Samani, Nilesh J.;Reiner, Alex P.;Hegele, Robert A.;Kastelein, John J. P.;Hingorani, Aroon D.;Talmud, Philippa J.;Hakonarson, Hakon;Elbers, Clara C.;Keating, Brendan J.;Drenos, Fotios
Genome-wide association studies (GWASs) have identified many SNPs underlying variations in plasma-lipid levels. We explore whether additional loci associated with plasma-lipid phenotypes, such as high-density lipoprotein cholesterol (HDL-C), low-dens...
Flannick, Jason;Fuchsberger, Christian;Mahajan, Anubha;Teslovich, Tanya M.;Agarwala, Vineeta;Gaulton, Kyle J.;Caulkins, Lizz;Koesterer, Ryan;Ma, Clement;Moutsianas, Loukas;McCarthy, Davis J.;Rivas, Manuel A.;Perry, John R.B.;Sim, Xueling;Blackwell, Thomas W.;Robertson, Neil R.;Rayner, N. William;Cingolani, Pablo;Locke, Adam E.;Tajes, Juan Fernandez;Highland, Heather M.;Dupuis, Josée;Chines, Peter S.;Lindgren, Cecilia M.;Hartl, Christopher;Jackson, Anne U.;Chen, Han;Huyghe, Jeroen R.;Van De Bunt, Martijn;Pearson, Richard D.;Kumar, Ashish;Müller-Nurasyid, Martina;Grarup, Niels;Stringham, Heather M.;Gamazon, Eric R.;Lee, Jaehoon;Chen, Yuhui;Scott, Robert A.;Below, Jennifer E.;Chen, Peng;Huang, Jinyan;Go, Min Jin;Stitzel, Michael L.;Pasko, Dorota;Parker, Stephen C.J.;Varga, Tibor V.;Green, Todd;Beer, Nicola L.;Day-Williams, Aaron G.;Ferreira, Teresa;Fingerlin, Tasha;Horikoshi, Momoko;Hu, Cheng;Huh, Iksoo;Ikram, Mohammad Kamran;Kim, Bong-Jo;Kim, Yongkang;Kim, Young Jin;Kwon, Min-Seok;Lee, Juyoung;Lee, Selyeong;Lin, Keng-Han;Maxwell, Taylor J.;Nagai, Yoshihiko;Wang, Xu;Welch, Ryan P.;Yoon, Joon;Zhang, Weihua;Barzilai, Nir;Voight, Benjamin F.;Han, Bok-Ghee;Jenkinson, Christopher P.;Kuulasmaa, Teemu;Kuusisto, Johanna;Manning, Alisa;Ng, Maggie C.Y.;Palmer, Nicholette D.;Balkau, Beverley;Stančáková, Alena;Abboud, Hanna E.;Boeing, Heiner;Giedraitis, Vilmantas;Prabhakaran, Dorairaj;Gottesman, Omri;Scott, James;Carey, Jason;Kwan, Phoenix;Grant, George;Smith, Joshua D.;Neale, Benjamin M.;Purcell, Shaun;Butterworth, Adam S.;Howson, Joanna M.M.;Lee, Heung Man;Lu, Yingchang;Kwak, Soo-Heon;Zhao, Wei;Danesh, John;Lam, Vincent K.L.;Park, Kyong Soo;Saleheen, Danish;So, Wing Yee;Tam, Claudia H.T.;Afzal, Uzma;Aguilar, David;Arya, Rector;Aung, Tin;Chan, Edmund;Navarro, Carmen;Cheng, Ching-Yu;Palli, Domenico;Correa, Adolfo;Curran, Joanne E.;Rybin, Dennis;Farook, Vidya S.;Fowler, Sharon P.;Freedman, Barry I.;Griswold, Michael;Hale, Daniel Esten;Hicks, Pamela J.;Khor, Chiea-Chuen;Kumar, Satish;Lehne, Benjamin;Thuillier, Dorothée;Lim, Wei Yen;Liu, Jianjun;Loh, Marie;Musani, Solomon K.;Puppala, Sobha;Scott, William R.;Yengo, Loïc;Tan, Sian-Tsung;Taylor, Herman A.;Thameem, Farook;Wilson, Gregory;Wong, Tien Yin;Njølstad, Pål Rasmus;Levy, Jonathan C.;Mangino, Massimo;Bonnycastle, Lori L.;Schwarzmayr, Thomas;Fadista, João;Surdulescu, Gabriela L.;Herder, Christian;Groves, Christopher J.;Wieland, Thomas;Bork-Jensen, Jette;Brandslund, Ivan;Christensen, Cramer;Koistinen, Heikki A.;Doney, Alex S.F.;Kinnunen, Leena;Esko, Tõnu;Farmer, Andrew J.;Hakaste, Liisa;Hodgkiss, Dylan;Kravic, Jasmina;Lyssenko, Valeriya;Hollensted, Mette;Jørgensen, Marit E.;Jørgensen, Torben;Ladenvall, Claes;Justesen, Johanne Marie;Käräjämäki, Annemari;Kriebel, Jennifer;Rathmann, Wolfgang;Lannfelt, Lars;Lauritzen, Torsten;Narisu, Narisu;Linneberg, Allan;Melander, Olle;Milani, Lili;Neville, Matt;Orho-Melander, Marju;Qi, Lu;Qi, Qibin;Roden, Michael;Rolandsson, Olov;Swift, Amy;Rosengren, Anders H.;Stirrups, Kathleen;Wood, Andrew R.;Mihailov, Evelin;Blancher, Christine;Carneiro, Mauricio O.;Maguire, Jared;Poplin, Ryan;Shakir, Khalid;Fennell, Timothy;DePristo, Mark;De Angelis, Martin Hrabé;Deloukas, Panos;Gjesing, Anette P.;Jun, Goo;Nilsson, Peter M.;Murphy, Jacquelyn;Onofrio, Robert;Thorand, Barbara;Hansen, Torben;Meisinger, Christa;Hu, Frank B.;Isomaa, Bo;Karpe, Fredrik;Liang, Liming;Peters, Annette;Huth, Cornelia;O'Rahilly, Stephen P.;Palmer, Colin N.A.;Pedersen, Oluf;Rauramaa, Rainer;Tuomilehto, Jaakko;Salomaa, Veikko;Watanabe, Richard M.;Syvänen, Ann-Christine;Bergman, Richard N.;Bharadwaj, Dwaipayan;Bottinger, Erwin P.;Cho, Yoon Shin;Chandak, Giriraj R.;Chan, Juliana C.N.;Chia, Kee Seng;Daly, Mark J.;Ebrahim, Shah B.;Langenberg, Claudia;Elliott, Paul;Jablonski, Kathleen A.;Lehman, Donna M.;Jia, Weiping;Ma, Ronald C.W.;Pollin, Toni I.;Sandhu, Manjinder;Tandon, Nikhil;Froguel, Philippe;Barroso, Inês;Teo, Yik Ying;Zeggini, Eleftheria;Loos, Ruth J.F.;Small, Kerrin S.;Ried, Janina S.;DeFronzo, Ralph A.;Grallert, Harald;Glaser, Benjamin;Metspalu, Andres;Wareham, Nicholas J.;Walker, Mark;Banks, Eric;