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Title
While there have been studies exploring regulatory variation in one or more tissues, the complexity of tissue-specificity in multiple primary tissues is not yet well understood. We explore in depth the role of cis-regulatory variation in three human ...
AIMS: To determine the prevalence of diabetes mellitus and pre-diabetes (impaired fasting glucose and impaired glucose tolerance) in adults in Sri Lanka. Projections for the year 2030 and factors associated with diabetes and pre-diabetes are also pre...
We present an approximate conditional and joint association analysis that can use summary-level statistics from a meta-analysis of genome-wide association studies (GWAS) and estimated linkage disequilibrium (LD) from a reference sample with individua...
Scott, R.A.;Lagou, V.;Welch, R.P.;Wheeler, E.;Montasser, M.E.;Luan, J.;Mägi, R.;Strawbridge, R.J.;Rehnberg, E.;Gustafsson, S.;Kanoni, S.;Rasmussen-Torvik, L.J.;Yengo, L.;Lecoeur, C.;Shungin, D.;Sanna, S.;Sidore, C.;Johnson, P.C.;Jukema, J.W.;Johnson, T.;Mahajan, A.;Verweij, N.;Thorleifsson, G.;Hottenga, J.J.;Shah, S.;Smith, A.V.;Sennblad, B.;Gieger, C.;Salo, P.;Perola, M.;Timpson, N.J.;Evans, D.M.;Pourcain, B.S.;Wu, Y.;Andrews, J.S.;Hui, J.;Bielak, L.F.;Zhao, W.;Horikoshi, M.;Navarro, P.;Isaacs, A.;O'Connell, J.R.;Stirrups, K.;Vitart, V.;Hayward, C.;Esko, T.;Mihailov, E.;Fraser, R.M.;Fall, T.;Voight, B.F.;Raychaudhuri, S.;Chen, H.;Lindgren, C.M.;Morris, A.P.;Rayner, N.W.;Robertson, N.;Rybin, D.;Liu, C.T.;Beckmann, J.S.;Willems, S.M.;Chines, P.S.;Jackson, A.U.;Kang, H.M.;Stringham, H.M.;Song, K.;Tanaka, T.;Peden, J.F.;Goel, A.;Hicks, A.A.;An, P.;Müller-Nurasyid, M.;Franco-Cereceda, A.;Folkersen, L.;Marullo, L.;Jansen, H.;Oldehinkel, A.J.;Bruinenberg, M.;Pankow, J.S.;North, K.E.;Forouhi, N.G.;Loos, R.J.;Edkins, S.;Varga, T.V.;Hallmans, G.;Oksa, H.;Antonella, M.;Nagaraja, R.;Trompet, S.;Ford, I.;Bakker, S.J.;Kong, A.;Kumari, M.;Gigante, B.;Herder, C.;Munroe, P.B.;Caulfield, M.;Antti, J.;Mangino, M.;Small, K.;Miljkovic, I.;Liu, Y.;Atalay, M.;Kiess, W.;James, A.L.;Rivadeneira, F.;Uitterlinden, A.G.;Palmer, C.N.;Doney, A.S.;Willemsen, G.;Smit, J.H.;Campbell, S.;Polasek, O.;Bonnycastle, L.L.;Hercberg, S.;Dimitriou, M.;Bolton, J.L.;Fowkes, G.R.;Kovacs, P.;Lindström, J.;Zemunik, T.;Bandinelli, S.;Wild, S.H.;Basart, H.V.;Rathmann, W.;Grallert, H.;Maerz, W.;Maerz, W.;Kleber, M.E.;Boehm, B.O.;Peters, A.;Pramstaller, P.P.;Province, M.A.;Borecki, I.B.;Hastie, N.D.;Rudan, I.;Campbell, H.;Watkins, H.;Farrall, M.;Stumvoll, M.;Ferrucci, L.;Waterworth, D.M.;Bergman, R.N.;Collins, F.S.;Tuomilehto, J.;Watanabe, R.M.;de Geus, E.J.;Penninx, B.W.;Hofman, A.;Oostra, B.A.;Psaty, B.M.;Vollenweider, P.;Wilson, J.F.;Wright, A.F.;Hovingh, G.K.;Metspalu, A.;Uusitupa, M.;Magnusson, P.K.;Kyvik, K.O.;Kaprio, J.;Price, J.F.;Dedoussis, G.V.;Deloukas, P.;Meneton, P.;Lind, L.;Boehnke, M.;Shuldiner, A.R.;van Duijn, C.M.;Morris, A.D.;Toenjes, A.;Peyser, P.A.;Beilby, J.P.;Körner, A.;Kuusisto, J.;Laakso, M.;Bornstein, S.R.;Schwarz, P.E.;Lakka, T.A.;Rauramaa, R.;Adair, L.S.;Smith, G.D.;Spector, T.D.;Illig, T.;de Faire, U.;Hamsten, A.;Gudnason, V.;Kivimaki, M.;Hingorani, A.;Keinanen-Kiukaanniemi, S.M.;Saaristo, T.E.;Boomsma, D.I.;Stefansson, K.;van der Harst, P.;Dupuis, J.;Pedersen, N.L.;Sattar, N.;Harris, T.B.;Cucca, F.;Ripatti, S.;Salomaa, V.;Mohlke, K.L.;Balkau, B.;Froguel, P.;Pouta, A.;Jarvelin, M.R.;Wareham, N.J.;Bouatia-Naji, N.;McCarthy, M.I.;Franks, P.W.;Meigs, J.B.;Teslovich, T.M.;Florez, J.C.;Langenberg, C.;Ingelsson, E.;Prokopenko, I.;Barroso, I.
Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci influencing glycemic traits t...
Scott, R.A.;Lagou, V.;Welch, R.P.;Wheeler, E.;Montasser, M.E.;Luan, J.;Mägi, R.;Strawbridge, R.J.;Rehnberg, E.;Gustafsson, S.;Kanoni, S.;Rasmussen-Torvik, L.J.;Yengo, L.;Lecoeur, C.;Shungin, D.;Sanna, S.;Sidore, C.;Johnson, P.C.;Jukema, J.W.;Johnson, T.;Mahajan, A.;Verweij, N.;Thorleifsson, G.;Hottenga, J.J.;Shah, S.;Smith, A.V.;Sennblad, B.;Gieger, C.;Salo, P.;Perola, M.;Timpson, N.J.;Evans, D.M.;Pourcain, B.S.;Wu, Y.;Andrews, J.S.;Hui, J.;Bielak, L.F.;Zhao, W.;Horikoshi, M.;Navarro, P.;Isaacs, A.;O'Connell, J.R.;Stirrups, K.;Vitart, V.;Hayward, C.;Esko, T.;Mihailov, E.;Fraser, R.M.;Fall, T.;Voight, B.F.;Raychaudhuri, S.;Chen, H.;Lindgren, C.M.;Morris, A.P.;Rayner, N.W.;Robertson, N.;Rybin, D.;Liu, C.T.;Beckmann, J.S.;Willems, S.M.;Chines, P.S.;Jackson, A.U.;Kang, H.M.;Stringham, H.M.;Song, K.;Tanaka, T.;Peden, J.F.;Goel, A.;Hicks, A.A.;An, P.;Müller-Nurasyid, M.;Franco-Cereceda, A.;Folkersen, L.;Marullo, L.;Jansen, H.;Oldehinkel, A.J.;Bruinenberg, M.;Pankow, J.S.;North, K.E.;Forouhi, N.G.;Loos, R.J.;Edkins, S.;Varga, T.V.;Hallmans, G.;Oksa, H.;Antonella, M.;Nagaraja, R.;Trompet, S.;Ford, I.;Bakker, S.J.;Kong, A.;Kumari, M.;Gigante, B.;Herder, C.;Munroe, P.B.;Caulfield, M.;Antti, J.;Mangino, M.;Small, K.;Miljkovic, I.;Liu, Y.;Atalay, M.;Kiess, W.;James, A.L.;Rivadeneira, F.;Uitterlinden, A.G.;Palmer, C.N.;Doney, A.S.;Willemsen, G.;Smit, J.H.;Campbell, S.;Polasek, O.;Bonnycastle, L.L.;Hercberg, S.;Dimitriou, M.;Bolton, J.L.;Fowkes, G.R.;Kovacs, P.;Lindström, J.;Zemunik, T.;Bandinelli, S.;Wild, S.H.;Basart, H.V.;Rathmann, W.;Grallert, H.;Maerz, W.;Maerz, W.;Kleber, M.E.;Boehm, B.O.;Peters, A.;Pramstaller, P.P.;Province, M.A.;Borecki, I.B.;Hastie, N.D.;Rudan, I.;Campbell, H.;Watkins, H.;Farrall, M.;Stumvoll, M.;Ferrucci, L.;Waterworth, D.M.;Bergman, R.N.;Collins, F.S.;Tuomilehto, J.;Watanabe, R.M.;de Geus, E.J.;Penninx, B.W.;Hofman, A.;Oostra, B.A.;Psaty, B.M.;Vollenweider, P.;Wilson, J.F.;Wright, A.F.;Hovingh, G.K.;Metspalu, A.;Uusitupa, M.;Magnusson, P.K.;Kyvik, K.O.;Kaprio, J.;Price, J.F.;Dedoussis, G.V.;Deloukas, P.;Meneton, P.;Lind, L.;Boehnke, M.;Shuldiner, A.R.;van Duijn, C.M.;Morris, A.D.;Toenjes, A.;Peyser, P.A.;Beilby, J.P.;Körner, A.;Kuusisto, J.;Laakso, M.;Bornstein, S.R.;Schwarz, P.E.;Lakka, T.A.;Rauramaa, R.;Adair, L.S.;Smith, G.D.;Spector, T.D.;Illig, T.;de Faire, U.;Hamsten, A.;Gudnason, V.;Kivimaki, M.;Hingorani, A.;Keinanen-Kiukaanniemi, S.M.;Saaristo, T.E.;Boomsma, D.I.;Stefansson, K.;van der Harst, P.;Dupuis, J.;Pedersen, N.L.;Sattar, N.;Harris, T.B.;Cucca, F.;Ripatti, S.;Salomaa, V.;Mohlke, K.L.;Balkau, B.;Froguel, P.;Pouta, A.;Jarvelin, M.R.;Wareham, N.J.;Bouatia-Naji, N.;McCarthy, M.I.;Franks, P.W.;Meigs, J.B.;Teslovich, T.M.;Florez, J.C.;Langenberg, C.;Ingelsson, E.;Prokopenko, I.;Barroso, I.
Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci influencing glycemic traits t...
Scott, R.A.;Lagou, V.;Welch, R.P.;Wheeler, E.;Montasser, M.E.;Luan, J.;Mägi, R.;Strawbridge, R.J.;Rehnberg, E.;Gustafsson, S.;Kanoni, S.;Rasmussen-Torvik, L.J.;Yengo, L.;Lecoeur, C.;Shungin, D.;Sanna, S.;Sidore, C.;Johnson, P.C.;Jukema, J.W.;Johnson, T.;Mahajan, A.;Verweij, N.;Thorleifsson, G.;Hottenga, J.J.;Shah, S.;Smith, A.V.;Sennblad, B.;Gieger, C.;Salo, P.;Perola, M.;Timpson, N.J.;Evans, D.M.;Pourcain, B.S.;Wu, Y.;Andrews, J.S.;Hui, J.;Bielak, L.F.;Zhao, W.;Horikoshi, M.;Navarro, P.;Isaacs, A.;O'Connell, J.R.;Stirrups, K.;Vitart, V.;Hayward, C.;Esko, T.;Mihailov, E.;Fraser, R.M.;Fall, T.;Voight, B.F.;Raychaudhuri, S.;Chen, H.;Lindgren, C.M.;Morris, A.P.;Rayner, N.W.;Robertson, N.;Rybin, D.;Liu, C.T.;Beckmann, J.S.;Willems, S.M.;Chines, P.S.;Jackson, A.U.;Kang, H.M.;Stringham, H.M.;Song, K.;Tanaka, T.;Peden, J.F.;Goel, A.;Hicks, A.A.;An, P.;Müller-Nurasyid, M.;Franco-Cereceda, A.;Folkersen, L.;Marullo, L.;Jansen, H.;Oldehinkel, A.J.;Bruinenberg, M.;Pankow, J.S.;North, K.E.;Forouhi, N.G.;Loos, R.J.;Edkins, S.;Varga, T.V.;Hallmans, G.;Oksa, H.;Antonella, M.;Nagaraja, R.;Trompet, S.;Ford, I.;Bakker, S.J.;Kong, A.;Kumari, M.;Gigante, B.;Herder, C.;Munroe, P.B.;Caulfield, M.;Antti, J.;Mangino, M.;Small, K.;Miljkovic, I.;Liu, Y.;Atalay, M.;Kiess, W.;James, A.L.;Rivadeneira, F.;Uitterlinden, A.G.;Palmer, C.N.;Doney, A.S.;Willemsen, G.;Smit, J.H.;Campbell, S.;Polasek, O.;Bonnycastle, L.L.;Hercberg, S.;Dimitriou, M.;Bolton, J.L.;Fowkes, G.R.;Kovacs, P.;Lindström, J.;Zemunik, T.;Bandinelli, S.;Wild, S.H.;Basart, H.V.;Rathmann, W.;Grallert, H.;Maerz, W.;Maerz, W.;Kleber, M.E.;Boehm, B.O.;Peters, A.;Pramstaller, P.P.;Province, M.A.;Borecki, I.B.;Hastie, N.D.;Rudan, I.;Campbell, H.;Watkins, H.;Farrall, M.;Stumvoll, M.;Ferrucci, L.;Waterworth, D.M.;Bergman, R.N.;Collins, F.S.;Tuomilehto, J.;Watanabe, R.M.;de Geus, E.J.;Penninx, B.W.;Hofman, A.;Oostra, B.A.;Psaty, B.M.;Vollenweider, P.;Wilson, J.F.;Wright, A.F.;Hovingh, G.K.;Metspalu, A.;Uusitupa, M.;Magnusson, P.K.;Kyvik, K.O.;Kaprio, J.;Price, J.F.;Dedoussis, G.V.;Deloukas, P.;Meneton, P.;Lind, L.;Boehnke, M.;Shuldiner, A.R.;van Duijn, C.M.;Morris, A.D.;Toenjes, A.;Peyser, P.A.;Beilby, J.P.;Körner, A.;Kuusisto, J.;Laakso, M.;Bornstein, S.R.;Schwarz, P.E.;Lakka, T.A.;Rauramaa, R.;Adair, L.S.;Smith, G.D.;Spector, T.D.;Illig, T.;de Faire, U.;Hamsten, A.;Gudnason, V.;Kivimaki, M.;Hingorani, A.;Keinanen-Kiukaanniemi, S.M.;Saaristo, T.E.;Boomsma, D.I.;Stefansson, K.;van der Harst, P.;Dupuis, J.;Pedersen, N.L.;Sattar, N.;Harris, T.B.;Cucca, F.;Ripatti, S.;Salomaa, V.;Mohlke, K.L.;Balkau, B.;Froguel, P.;Pouta, A.;Jarvelin, M.R.;Wareham, N.J.;Bouatia-Naji, N.;McCarthy, M.I.;Franks, P.W.;Meigs, J.B.;Teslovich, T.M.;Florez, J.C.;Langenberg, C.;Ingelsson, E.;Prokopenko, I.;Barroso, I.
Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci influencing glycemic traits t...
Scott, R.A.;Lagou, V.;Welch, R.P.;Wheeler, E.;Montasser, M.E.;Luan, J.;Mägi, R.;Strawbridge, R.J.;Rehnberg, E.;Gustafsson, S.;Kanoni, S.;Rasmussen-Torvik, L.J.;Yengo, L.;Lecoeur, C.;Shungin, D.;Sanna, S.;Sidore, C.;Johnson, P.C.;Jukema, J.W.;Johnson, T.;Mahajan, A.;Verweij, N.;Thorleifsson, G.;Hottenga, J.J.;Shah, S.;Smith, A.V.;Sennblad, B.;Gieger, C.;Salo, P.;Perola, M.;Timpson, N.J.;Evans, D.M.;Pourcain, B.S.;Wu, Y.;Andrews, J.S.;Hui, J.;Bielak, L.F.;Zhao, W.;Horikoshi, M.;Navarro, P.;Isaacs, A.;O'Connell, J.R.;Stirrups, K.;Vitart, V.;Hayward, C.;Esko, T.;Mihailov, E.;Fraser, R.M.;Fall, T.;Voight, B.F.;Raychaudhuri, S.;Chen, H.;Lindgren, C.M.;Morris, A.P.;Rayner, N.W.;Robertson, N.;Rybin, D.;Liu, C.T.;Beckmann, J.S.;Willems, S.M.;Chines, P.S.;Jackson, A.U.;Kang, H.M.;Stringham, H.M.;Song, K.;Tanaka, T.;Peden, J.F.;Goel, A.;Hicks, A.A.;An, P.;Müller-Nurasyid, M.;Franco-Cereceda, A.;Folkersen, L.;Marullo, L.;Jansen, H.;Oldehinkel, A.J.;Bruinenberg, M.;Pankow, J.S.;North, K.E.;Forouhi, N.G.;Loos, R.J.;Edkins, S.;Varga, T.V.;Hallmans, G.;Oksa, H.;Antonella, M.;Nagaraja, R.;Trompet, S.;Ford, I.;Bakker, S.J.;Kong, A.;Kumari, M.;Gigante, B.;Herder, C.;Munroe, P.B.;Caulfield, M.;Antti, J.;Mangino, M.;Small, K.;Miljkovic, I.;Liu, Y.;Atalay, M.;Kiess, W.;James, A.L.;Rivadeneira, F.;Uitterlinden, A.G.;Palmer, C.N.;Doney, A.S.;Willemsen, G.;Smit, J.H.;Campbell, S.;Polasek, O.;Bonnycastle, L.L.;Hercberg, S.;Dimitriou, M.;Bolton, J.L.;Fowkes, G.R.;Kovacs, P.;Lindström, J.;Zemunik, T.;Bandinelli, S.;Wild, S.H.;Basart, H.V.;Rathmann, W.;Grallert, H.;Maerz, W.;Maerz, W.;Kleber, M.E.;Boehm, B.O.;Peters, A.;Pramstaller, P.P.;Province, M.A.;Borecki, I.B.;Hastie, N.D.;Rudan, I.;Campbell, H.;Watkins, H.;Farrall, M.;Stumvoll, M.;Ferrucci, L.;Waterworth, D.M.;Bergman, R.N.;Collins, F.S.;Tuomilehto, J.;Watanabe, R.M.;de Geus, E.J.;Penninx, B.W.;Hofman, A.;Oostra, B.A.;Psaty, B.M.;Vollenweider, P.;Wilson, J.F.;Wright, A.F.;Hovingh, G.K.;Metspalu, A.;Uusitupa, M.;Magnusson, P.K.;Kyvik, K.O.;Kaprio, J.;Price, J.F.;Dedoussis, G.V.;Deloukas, P.;Meneton, P.;Lind, L.;Boehnke, M.;Shuldiner, A.R.;van Duijn, C.M.;Morris, A.D.;Toenjes, A.;Peyser, P.A.;Beilby, J.P.;Körner, A.;Kuusisto, J.;Laakso, M.;Bornstein, S.R.;Schwarz, P.E.;Lakka, T.A.;Rauramaa, R.;Adair, L.S.;Smith, G.D.;Spector, T.D.;Illig, T.;de Faire, U.;Hamsten, A.;Gudnason, V.;Kivimaki, M.;Hingorani, A.;Keinanen-Kiukaanniemi, S.M.;Saaristo, T.E.;Boomsma, D.I.;Stefansson, K.;van der Harst, P.;Dupuis, J.;Pedersen, N.L.;Sattar, N.;Harris, T.B.;Cucca, F.;Ripatti, S.;Salomaa, V.;Mohlke, K.L.;Balkau, B.;Froguel, P.;Pouta, A.;Jarvelin, M.R.;Wareham, N.J.;Bouatia-Naji, N.;McCarthy, M.I.;Franks, P.W.;Meigs, J.B.;Teslovich, T.M.;Florez, J.C.;Langenberg, C.;Ingelsson, E.;Prokopenko, I.;Barroso, I.
Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci influencing glycemic traits t...