ARTICLES
29 Article(s)
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Document(s)
Title
Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of...
Parkinson’s disease (PD) exhibits systemic effects on human metabolism with emerging roles for the gut microbiome. Here, we integrated longitudinal metabolome data from 30 drug-naïve, de-novo PD patients and 30 matched controls with constraint-based ...
Holmes, Michael V;Dale, Caroline E;Zuccolo, Luisa;Silverwood, Richard J;Guo, Yiran;Ye, Zheng;Prieto-Merino, David;Dehghan, Abbas;Trompet, Stella;Wong, Andrew;Cavadino, Alana;Drogan, Dagmar;Padmanabhan, Sandosh;Li, Shanshan;Yesupriya, Ajay;Leusink, Maarten;Sundstrom, Johan;Hubacek, Jaroslav A;Pikhart, Hynek;Swerdlow, Daniel I;Panayiotou, Andrie G;Borinskaya, Svetlana A;Finan, Chris;Shah, Sonia;Kuchenbaecker, Karoline;Shah, Tina;Engmann, Jorgen;Folkersen, Lasse;Eriksson, Per;Ricceri, Fulvio;Melander, Olle;Sacerdote, Carlotta;Gamble, Dale M;Rayaprolu, Sruti;Ross, Owen A;McLachlan, Stela;Vikhireva, Olga;Sluijs, Ivonne;Scott, Robert;Adamkova, Vera;Flicker, Leon;Bockxmeer, Frank M van;Power, Christine;Marques-Vidal, Pedro;Meade, Tom;Marmot, Michael G;Ferro, Jose M;Paulos-Pinheiro, Sofia;Humphries, Steve E;Talmud, Philippa J;Mateo Leach, Irene;Verweij, Niek;Linneberg, Allan;Skaaby, Tea;Doevendans, Pieter A;Cramer, Maarten J;van der Harst, Pim;Klungel, Olaf H;Dowling, Nicole F;Dominiczak, Anna F;Kumari, Meena;Nicolaides, Andrew N;Weikert, Cornelia;Boeing, Heiner;Ebrahim, Shah;Gaunt, Tom R;Price, Jackie F;Lannfelt, Lars;Peasey, Anne;Kubinova, Ruzena;Pajak, Andrzej;Malyutina, Sofia;Voevoda, Mikhail I;Tamosiunas, Abdonas;Maitland-van der Zee, Anke H;Norman, Paul E;Hankey, Graeme J;Bergmann, Manuela M;Hofman, Albert;Franco, Oscar H;Cooper, Jackie;Palmen, Jutta;Spiering, Wilko;de Jong, Pim A;Kuh, Diana;Hardy, Rebecca;Uitterlinden, Andre G;Ikram, M Arfan;Ford, Ian;Hyppönen, Elina;Almeida, Osvaldo P;Wareham, Nicholas;Khaw, Kay-Tee;Hamsten, Anders;Husemoen, Lise Lotte N;Tjønneland, Anne;Tolstrup, Janne S;Rimm, Eric;Beulens, Joline WJ;Verschuren, WM Monique;Onland-Moret, N Charlotte;Hofker, Marten H;Wannamethee, S Goya;Whincup, Peter H;Morris, Richard;Vicente, Astrid M;Watkins, Hugh;Farrall, Martin;Jukema, J Wouter;Meschia, James;Cupples, L Adrienne;Sharp, Stephen;Fornage, Myriam;Kooperberg, Charles;LaCroix, Andrea Z;Dai, James Y;Lanktree, Matthew B;Siscovick, David S;Jorgenson, Eric;Spring, Bonnie;Coresh, Josef;Li, Yun R;Buxbaum, Sarah G;Schreiner, Pamela J;Ellison, R Curtis;Tsai, Michael Y;Patel, Sanjay R;Redline, Susan;Johnson, Andrew D;Hoogeveen, Ron C;Hakonarson, Hakon;Rotter, Jerome I;Boerwinkle, Eric;de Bakker, Paul IW;Kivimaki, Mika;Asselbergs, Folkert W;Sattar, Naveed;Lawlor, Debbie A;Whittaker, John;Davey Smith, George;Mukamal, Kenneth;Psaty, Bruce M;Wilson, James G;Lange, Leslie A;Hamidovic, Ajna;Hingorani, Aroon D;Nordestgaard, Børge G;Bobak, Martin;Leon, David A;Langenberg, Claudia;Palmer, Tom M;Reiner, Alex P;Keating, Brendan J;Dudbridge, Frank;Casas, Juan P;InterAct Consortium,
OBJECTIVE: To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease. DESIGN: Mendelian randomisation meta-analysis of 56 epidemiological studies. PA...
Holmes, Michael V;Dale, Caroline E;Zuccolo, Luisa;Silverwood, Richard J;Guo, Yiran;Ye, Zheng;Prieto-Merino, David;Dehghan, Abbas;Trompet, Stella;Wong, Andrew;Cavadino, Alana;Drogan, Dagmar;Padmanabhan, Sandosh;Li, Shanshan;Yesupriya, Ajay;Leusink, Maarten;Sundstrom, Johan;Hubacek, Jaroslav A;Pikhart, Hynek;Swerdlow, Daniel I;Panayiotou, Andrie G;Borinskaya, Svetlana A;Finan, Chris;Shah, Sonia;Kuchenbaecker, Karoline;Shah, Tina;Engmann, Jorgen;Folkersen, Lasse;Eriksson, Per;Ricceri, Fulvio;Melander, Olle;Sacerdote, Carlotta;Gamble, Dale M;Rayaprolu, Sruti;Ross, Owen A;McLachlan, Stela;Vikhireva, Olga;Sluijs, Ivonne;Scott, Robert;Adamkova, Vera;Flicker, Leon;Bockxmeer, Frank M van;Power, Christine;Marques-Vidal, Pedro;Meade, Tom;Marmot, Michael G;Ferro, Jose M;Paulos-Pinheiro, Sofia;Humphries, Steve E;Talmud, Philippa J;Mateo Leach, Irene;Verweij, Niek;Linneberg, Allan;Skaaby, Tea;Doevendans, Pieter A;Cramer, Maarten J;van der Harst, Pim;Klungel, Olaf H;Dowling, Nicole F;Dominiczak, Anna F;Kumari, Meena;Nicolaides, Andrew N;Weikert, Cornelia;Boeing, Heiner;Ebrahim, Shah;Gaunt, Tom R;Price, Jackie F;Lannfelt, Lars;Peasey, Anne;Kubinova, Ruzena;Pajak, Andrzej;Malyutina, Sofia;Voevoda, Mikhail I;Tamosiunas, Abdonas;Maitland-van der Zee, Anke H;Norman, Paul E;Hankey, Graeme J;Bergmann, Manuela M;Hofman, Albert;Franco, Oscar H;Cooper, Jackie;Palmen, Jutta;Spiering, Wilko;de Jong, Pim A;Kuh, Diana;Hardy, Rebecca;Uitterlinden, Andre G;Ikram, M Arfan;Ford, Ian;Hyppönen, Elina;Almeida, Osvaldo P;Wareham, Nicholas;Khaw, Kay-Tee;Hamsten, Anders;Husemoen, Lise Lotte N;Tjønneland, Anne;Tolstrup, Janne S;Rimm, Eric;Beulens, Joline WJ;Verschuren, WM Monique;Onland-Moret, N Charlotte;Hofker, Marten H;Wannamethee, S Goya;Whincup, Peter H;Morris, Richard;Vicente, Astrid M;Watkins, Hugh;Farrall, Martin;Jukema, J Wouter;Meschia, James;Cupples, L Adrienne;Sharp, Stephen;Fornage, Myriam;Kooperberg, Charles;LaCroix, Andrea Z;Dai, James Y;Lanktree, Matthew B;Siscovick, David S;Jorgenson, Eric;Spring, Bonnie;Coresh, Josef;Li, Yun R;Buxbaum, Sarah G;Schreiner, Pamela J;Ellison, R Curtis;Tsai, Michael Y;Patel, Sanjay R;Redline, Susan;Johnson, Andrew D;Hoogeveen, Ron C;Hakonarson, Hakon;Rotter, Jerome I;Boerwinkle, Eric;de Bakker, Paul IW;Kivimaki, Mika;Asselbergs, Folkert W;Sattar, Naveed;Lawlor, Debbie A;Whittaker, John;Davey Smith, George;Mukamal, Kenneth;Psaty, Bruce M;Wilson, James G;Lange, Leslie A;Hamidovic, Ajna;Hingorani, Aroon D;Nordestgaard, Børge G;Bobak, Martin;Leon, David A;Langenberg, Claudia;Palmer, Tom M;Reiner, Alex P;Keating, Brendan J;Dudbridge, Frank;Casas, Juan P;InterAct Consortium,
OBJECTIVE: To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease. DESIGN: Mendelian randomisation meta-analysis of 56 epidemiological studies. PA...
Holmes, Michael V;Dale, Caroline E;Zuccolo, Luisa;Silverwood, Richard J;Guo, Yiran;Ye, Zheng;Prieto-Merino, David;Dehghan, Abbas;Trompet, Stella;Wong, Andrew;Cavadino, Alana;Drogan, Dagmar;Padmanabhan, Sandosh;Li, Shanshan;Yesupriya, Ajay;Leusink, Maarten;Sundstrom, Johan;Hubacek, Jaroslav A;Pikhart, Hynek;Swerdlow, Daniel I;Panayiotou, Andrie G;Borinskaya, Svetlana A;Finan, Chris;Shah, Sonia;Kuchenbaecker, Karoline;Shah, Tina;Engmann, Jorgen;Folkersen, Lasse;Eriksson, Per;Ricceri, Fulvio;Melander, Olle;Sacerdote, Carlotta;Gamble, Dale M;Rayaprolu, Sruti;Ross, Owen A;McLachlan, Stela;Vikhireva, Olga;Sluijs, Ivonne;Scott, Robert;Adamkova, Vera;Flicker, Leon;Bockxmeer, Frank M van;Power, Christine;Marques-Vidal, Pedro;Meade, Tom;Marmot, Michael G;Ferro, Jose M;Paulos-Pinheiro, Sofia;Humphries, Steve E;Talmud, Philippa J;Mateo Leach, Irene;Verweij, Niek;Linneberg, Allan;Skaaby, Tea;Doevendans, Pieter A;Cramer, Maarten J;van der Harst, Pim;Klungel, Olaf H;Dowling, Nicole F;Dominiczak, Anna F;Kumari, Meena;Nicolaides, Andrew N;Weikert, Cornelia;Boeing, Heiner;Ebrahim, Shah;Gaunt, Tom R;Price, Jackie F;Lannfelt, Lars;Peasey, Anne;Kubinova, Ruzena;Pajak, Andrzej;Malyutina, Sofia;Voevoda, Mikhail I;Tamosiunas, Abdonas;Maitland-van der Zee, Anke H;Norman, Paul E;Hankey, Graeme J;Bergmann, Manuela M;Hofman, Albert;Franco, Oscar H;Cooper, Jackie;Palmen, Jutta;Spiering, Wilko;de Jong, Pim A;Kuh, Diana;Hardy, Rebecca;Uitterlinden, Andre G;Ikram, M Arfan;Ford, Ian;Hyppönen, Elina;Almeida, Osvaldo P;Wareham, Nicholas;Khaw, Kay-Tee;Hamsten, Anders;Husemoen, Lise Lotte N;Tjønneland, Anne;Tolstrup, Janne S;Rimm, Eric;Beulens, Joline WJ;Verschuren, WM Monique;Onland-Moret, N Charlotte;Hofker, Marten H;Wannamethee, S Goya;Whincup, Peter H;Morris, Richard;Vicente, Astrid M;Watkins, Hugh;Farrall, Martin;Jukema, J Wouter;Meschia, James;Cupples, L Adrienne;Sharp, Stephen;Fornage, Myriam;Kooperberg, Charles;LaCroix, Andrea Z;Dai, James Y;Lanktree, Matthew B;Siscovick, David S;Jorgenson, Eric;Spring, Bonnie;Coresh, Josef;Li, Yun R;Buxbaum, Sarah G;Schreiner, Pamela J;Ellison, R Curtis;Tsai, Michael Y;Patel, Sanjay R;Redline, Susan;Johnson, Andrew D;Hoogeveen, Ron C;Hakonarson, Hakon;Rotter, Jerome I;Boerwinkle, Eric;de Bakker, Paul IW;Kivimaki, Mika;Asselbergs, Folkert W;Sattar, Naveed;Lawlor, Debbie A;Whittaker, John;Davey Smith, George;Mukamal, Kenneth;Psaty, Bruce M;Wilson, James G;Lange, Leslie A;Hamidovic, Ajna;Hingorani, Aroon D;Nordestgaard, Børge G;Bobak, Martin;Leon, David A;Langenberg, Claudia;Palmer, Tom M;Reiner, Alex P;Keating, Brendan J;Dudbridge, Frank;Casas, Juan P;InterAct Consortium,
OBJECTIVE: To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease. DESIGN: Mendelian randomisation meta-analysis of 56 epidemiological studies. PA...
Parkinson’s disease (PD) exhibits systemic effects on human metabolism with emerging roles for the gut microbiome. Here, we integrated longitudinal metabolome data from 30 drug-naïve, de-novo PD patients and 30 matched controls with constraint-based ...
Holmes, Michael V;Dale, Caroline E;Zuccolo, Luisa;Silverwood, Richard J;Guo, Yiran;Ye, Zheng;Prieto-Merino, David;Dehghan, Abbas;Trompet, Stella;Wong, Andrew;Cavadino, Alana;Drogan, Dagmar;Padmanabhan, Sandosh;Li, Shanshan;Yesupriya, Ajay;Leusink, Maarten;Sundstrom, Johan;Hubacek, Jaroslav A;Pikhart, Hynek;Swerdlow, Daniel I;Panayiotou, Andrie G;Borinskaya, Svetlana A;Finan, Chris;Shah, Sonia;Kuchenbaecker, Karoline;Shah, Tina;Engmann, Jorgen;Folkersen, Lasse;Eriksson, Per;Ricceri, Fulvio;Melander, Olle;Sacerdote, Carlotta;Gamble, Dale M;Rayaprolu, Sruti;Ross, Owen A;McLachlan, Stela;Vikhireva, Olga;Sluijs, Ivonne;Scott, Robert;Adamkova, Vera;Flicker, Leon;Bockxmeer, Frank M van;Power, Christine;Marques-Vidal, Pedro;Meade, Tom;Marmot, Michael G;Ferro, Jose M;Paulos-Pinheiro, Sofia;Humphries, Steve E;Talmud, Philippa J;Mateo Leach, Irene;Verweij, Niek;Linneberg, Allan;Skaaby, Tea;Doevendans, Pieter A;Cramer, Maarten J;van der Harst, Pim;Klungel, Olaf H;Dowling, Nicole F;Dominiczak, Anna F;Kumari, Meena;Nicolaides, Andrew N;Weikert, Cornelia;Boeing, Heiner;Ebrahim, Shah;Gaunt, Tom R;Price, Jackie F;Lannfelt, Lars;Peasey, Anne;Kubinova, Ruzena;Pajak, Andrzej;Malyutina, Sofia;Voevoda, Mikhail I;Tamosiunas, Abdonas;Maitland-van der Zee, Anke H;Norman, Paul E;Hankey, Graeme J;Bergmann, Manuela M;Hofman, Albert;Franco, Oscar H;Cooper, Jackie;Palmen, Jutta;Spiering, Wilko;de Jong, Pim A;Kuh, Diana;Hardy, Rebecca;Uitterlinden, Andre G;Ikram, M Arfan;Ford, Ian;Hyppönen, Elina;Almeida, Osvaldo P;Wareham, Nicholas;Khaw, Kay-Tee;Hamsten, Anders;Husemoen, Lise Lotte N;Tjønneland, Anne;Tolstrup, Janne S;Rimm, Eric;Beulens, Joline WJ;Verschuren, WM Monique;Onland-Moret, N Charlotte;Hofker, Marten H;Wannamethee, S Goya;Whincup, Peter H;Morris, Richard;Vicente, Astrid M;Watkins, Hugh;Farrall, Martin;Jukema, J Wouter;Meschia, James;Cupples, L Adrienne;Sharp, Stephen;Fornage, Myriam;Kooperberg, Charles;LaCroix, Andrea Z;Dai, James Y;Lanktree, Matthew B;Siscovick, David S;Jorgenson, Eric;Spring, Bonnie;Coresh, Josef;Li, Yun R;Buxbaum, Sarah G;Schreiner, Pamela J;Ellison, R Curtis;Tsai, Michael Y;Patel, Sanjay R;Redline, Susan;Johnson, Andrew D;Hoogeveen, Ron C;Hakonarson, Hakon;Rotter, Jerome I;Boerwinkle, Eric;de Bakker, Paul IW;Kivimaki, Mika;Asselbergs, Folkert W;Sattar, Naveed;Lawlor, Debbie A;Whittaker, John;Davey Smith, George;Mukamal, Kenneth;Psaty, Bruce M;Wilson, James G;Lange, Leslie A;Hamidovic, Ajna;Hingorani, Aroon D;Nordestgaard, Børge G;Bobak, Martin;Leon, David A;Langenberg, Claudia;Palmer, Tom M;Reiner, Alex P;Keating, Brendan J;Dudbridge, Frank;Casas, Juan P;InterAct Consortium,
OBJECTIVE: To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease. DESIGN: Mendelian randomisation meta-analysis of 56 epidemiological studies. PA...