Developments in genome-wide association studies and the increasing availability of summary genetic association data have made application of Mendelian randomization relatively straightforward. However, obtaining reliable results from a Mendelian rand...

Zheng, Jie;Erzurumluoglu, A. Mesut;Elsworth, Benjamin L.;Kemp, John P.;Howe, Laurence;Haycock, Philip C.;Hemani, Gibran;Tansey, Katherine;Laurin, Charles;St Pourcain, Beate;Warrington, Nicole M.;Finucane, Hilary K.;Price, Alkes L.;Bulik-Sullivan, Brendan K.;Anttila, Verneri;Paternoster, Lavinia;Gaunt, Tom R.;Evans, David M.;Neale, Benjamin M. Motivation: LD score regression is a reliable and efficient method of using genome-wide association study (GWAS) summary-level results data to estimate the SNP heritability of complex traits and diseases, partition this heritability into functional c...

Zheng, Jie;Erzurumluoglu, A. Mesut;Elsworth, Benjamin L.;Kemp, John P.;Howe, Laurence;Haycock, Philip C.;Hemani, Gibran;Tansey, Katherine;Laurin, Charles;St Pourcain, Beate;Warrington, Nicole M.;Finucane, Hilary K.;Price, Alkes L.;Bulik-Sullivan, Brendan K.;Anttila, Verneri;Paternoster, Lavinia;Gaunt, Tom R.;Evans, David M.;Neale, Benjamin M. Motivation: LD score regression is a reliable and efficient method of using genome-wide association study (GWAS) summary-level results data to estimate the SNP heritability of complex traits and diseases, partition this heritability into functional c...

Zheng, Jie;Erzurumluoglu, A. Mesut;Elsworth, Benjamin L.;Kemp, John P.;Howe, Laurence;Haycock, Philip C.;Hemani, Gibran;Tansey, Katherine;Laurin, Charles;St Pourcain, Beate;Warrington, Nicole M.;Finucane, Hilary K.;Price, Alkes L.;Bulik-Sullivan, Brendan K.;Anttila, Verneri;Paternoster, Lavinia;Gaunt, Tom R.;Evans, David M.;Neale, Benjamin M. Motivation: LD score regression is a reliable and efficient method of using genome-wide association study (GWAS) summary-level results data to estimate the SNP heritability of complex traits and diseases, partition this heritability into functional c...

Zheng, Jie;Erzurumluoglu, A. Mesut;Elsworth, Benjamin L.;Kemp, John P.;Howe, Laurence;Haycock, Philip C.;Hemani, Gibran;Tansey, Katherine;Laurin, Charles;St Pourcain, Beate;Warrington, Nicole M.;Finucane, Hilary K.;Price, Alkes L.;Bulik-Sullivan, Brendan K.;Anttila, Verneri;Paternoster, Lavinia;Gaunt, Tom R.;Evans, David M.;Neale, Benjamin M. Motivation: LD score regression is a reliable and efficient method of using genome-wide association study (GWAS) summary-level results data to estimate the SNP heritability of complex traits and diseases, partition this heritability into functional c...

Zheng, Jie;Erzurumluoglu, A. Mesut;Elsworth, Benjamin L.;Kemp, John P.;Howe, Laurence;Haycock, Philip C.;Hemani, Gibran;Tansey, Katherine;Laurin, Charles;St Pourcain, Beate;Warrington, Nicole M.;Finucane, Hilary K.;Price, Alkes L.;Bulik-Sullivan, Brendan K.;Anttila, Verneri;Paternoster, Lavinia;Gaunt, Tom R.;Evans, David M.;Neale, Benjamin M. Motivation: LD score regression is a reliable and efficient method of using genome-wide association study (GWAS) summary-level results data to estimate the SNP heritability of complex traits and diseases, partition this heritability into functional c...

Zheng, Jie;Erzurumluoglu, A. Mesut;Elsworth, Benjamin L.;Kemp, John P.;Howe, Laurence;Haycock, Philip C.;Hemani, Gibran;Tansey, Katherine;Laurin, Charles;St Pourcain, Beate;Warrington, Nicole M.;Finucane, Hilary K.;Price, Alkes L.;Bulik-Sullivan, Brendan K.;Anttila, Verneri;Paternoster, Lavinia;Gaunt, Tom R.;Evans, David M.;Neale, Benjamin M. Motivation: LD score regression is a reliable and efficient method of using genome-wide association study (GWAS) summary-level results data to estimate the SNP heritability of complex traits and diseases, partition this heritability into functional c...

Zheng, Jie;Erzurumluoglu, A. Mesut;Elsworth, Benjamin L.;Kemp, John P.;Howe, Laurence;Haycock, Philip C.;Hemani, Gibran;Tansey, Katherine;Laurin, Charles;St Pourcain, Beate;Warrington, Nicole M.;Finucane, Hilary K.;Price, Alkes L.;Bulik-Sullivan, Brendan K.;Anttila, Verneri;Paternoster, Lavinia;Gaunt, Tom R.;Evans, David M.;Neale, Benjamin M. Motivation: LD score regression is a reliable and efficient method of using genome-wide association study (GWAS) summary-level results data to estimate the SNP heritability of complex traits and diseases, partition this heritability into functional c...

Zheng, Jie;Erzurumluoglu, A. Mesut;Elsworth, Benjamin L.;Kemp, John P.;Howe, Laurence;Haycock, Philip C.;Hemani, Gibran;Tansey, Katherine;Laurin, Charles;St Pourcain, Beate;Warrington, Nicole M.;Finucane, Hilary K.;Price, Alkes L.;Bulik-Sullivan, Brendan K.;Anttila, Verneri;Paternoster, Lavinia;Gaunt, Tom R.;Evans, David M.;Neale, Benjamin M. Motivation: LD score regression is a reliable and efficient method of using genome-wide association study (GWAS) summary-level results data to estimate the SNP heritability of complex traits and diseases, partition this heritability into functional c...

Developments in genome-wide association studies and the increasing availability of summary genetic association data have made application of Mendelian randomization relatively straightforward. However, obtaining reliable results from a Mendelian rand...