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Document(s)
Title
The quest to discover genetic variants that affect the human brain will be accelerated by screening brain images from large populations. Even so, the wealth of information in medical images is often reduced to a single numeric summary, such as a regi...
The degree to which genetic factors influence brain connectivity is beginning to be understood. Large-scale efforts are underway to map the profile of genetic effects in various brain regions. The NIH-funded Human Connectome Project (HCP) is providin...
BACKGROUND: Although case-control approaches are beginning to disentangle schizophrenia's complex polygenic burden, other methods will likely be necessary to fully identify and characterize risk genes. Endophenotypes, traits genetically correlated wi...
Graff, Mariaelisa;Scott, Robert A.;Justice, Anne E.;Young, Kristin L.;Feitosa, Mary F.;Barata, Llilda;Winkler, Thomas W.;Chu, Audrey Y.;Mahajan, Anubha;Hadley, David;Xue, Luting;Workalemahu, Tsegaselassie;Heard-Costa, Nancy L.;den Hoed, Marcel;Ahluwalia, Tarunveer S.;Qi, Qibin;Ngwa, Julius S.;Renström, Frida;Quaye, Lydia;Eicher, John D.;Hayes, James E.;Cornelis, Marilyn;Kutalik, Zoltan;Lim, Elise;Luan, Jian’an;Huffman, Jennifer E.;Zhang, Weihua;Zhao, Wei;Griffin, Paula J.;Haller, Toomas;Ahmad, Shafqat;Marques-Vidal, Pedro M.;Bien, Stephanie;Yengo, Loic;Teumer, Alexander;Smith, Albert Vernon;Kumari, Meena;Harder, Marie Neergaard;Justesen, Johanne Marie;Kleber, Marcus E.;Hollensted, Mette;Lohman, Kurt;Rivera, Natalia V.;Whitfield, John B.;Zhao, Jing Hua;Stringham, Heather M.;Lyytikäinen, Leo-Pekka;Huppertz, Charlotte;Willemsen, Gonneke;Peyrot, Wouter J.;Wu, Ying;Kristiansson, Kati;Demirkan, Ayse;Fornage, Myriam;Hassinen, Maija;Bielak, Lawrence F.;Cadby, Gemma;Tanaka, Toshiko;Mägi, Reedik;van der Most, Peter J.;Jackson, Anne U.;Bragg-Gresham, Jennifer L.;Vitart, Veronique;Marten, Jonathan;Navarro, Pau;Bellis, Claire;Pasko, Dorota;Johansson, Åsa;Snitker, Søren;Cheng, Yu-Ching;Eriksson, Joel;Lim, Unhee;Aadahl, Mette;Adair, Linda S.;Amin, Najaf;Balkau, Beverley;Auvinen, Juha;Beilby, John;Bergman, Richard N.;Bergmann, Sven;Bertoni, Alain G.;Blangero, John;Bonnefond, Amélie;Bonnycastle, Lori L.;Borja, Judith B.;Brage, Søren;Busonero, Fabio;Buyske, Steve;Campbell, Harry;Chines, Peter S.;Collins, Francis S.;Corre, Tanguy;Smith, George Davey;Delgado, Graciela E.;Dueker, Nicole;Dörr, Marcus;Ebeling, Tapani;Eiriksdottir, Gudny;Esko, Tõnu;Faul, Jessica D.;Fu, Mao;Færch, Kristine;Gieger, Christian;Gläser, Sven;Gong, Jian;Gordon-Larsen, Penny;Grallert, Harald;Grammer, Tanja B.;Grarup, Niels;van Grootheest, Gerard;Harald, Kennet;Hastie, Nicholas D.;Havulinna, Aki S.;Hernandez, Dena;Hindorff, Lucia;Hocking, Lynne J.;Holmens, Oddgeir L.;Holzapfel, Christina;Hottenga, Jouke Jan;Huang, Jie;Huang, Tao;Hui, Jennie;Huth, Cornelia;Hutri-Kähönen, Nina;James, Alan L.;Jansson, John-Olov;Jhun, Min A.;Juonala, Markus;Kinnunen, Leena;Koistinen, Heikki A.;Kolcic, Ivana;Komulainen, Pirjo;Kuusisto, Johanna;Kvaløy, Kirsti;Kähönen, Mika;Lakka, Timo A.;Launer, Lenore J.;Lehne, Benjamin;Lindgren, Cecilia M.;Lorentzon, Mattias;Luben, Robert;Marre, Michel;Milaneschi, Yuri;Monda, Keri L.;Montgomery, Grant W.;De Moor, Marleen H. M.;Mulas, Antonella;Müller-Nurasyid, Martina;Musk, A. W.;Männikkö, Reija;Männistö, Satu;Narisu, Narisu;Nauck, Matthias;Nettleton, Jennifer A.;Nolte, Ilja M.;Oldehinkel, Albertine J.;Olden, Matthias;Ong, Ken K.;Padmanabhan, Sandosh;Paternoster, Lavinia;Perez, Jeremiah;Perola, Markus;Peters, Annette;Peters, Ulrike;Peyser, Patricia A.;Prokopenko, Inga;Puolijoki, Hannu;Raitakari, Olli T.;Rankinen, Tuomo;Rasmussen-Torvik, Laura J.;Rawal, Rajesh;Ridker, Paul M.;Rose, Lynda M.;Rudan, Igor;Sarti, Cinzia;Sarzynski, Mark A.;Savonen, Kai;Scott, William R.;Sanna, Serena;Shuldiner, Alan R.;Sidney, Steve;Silbernagel, Günther;Smith, Blair H.;Smith, Jennifer A.;Snieder, Harold;Stančáková, Alena;Sternfeld, Barbara;Swift, Amy J.;Tammelin, Tuija;Tan, Sian-Tsung;Thorand, Barbara;Thuillier, Dorothée;Vandenput, Liesbeth;Vestergaard, Henrik;van Vliet-Ostaptchouk, Jana V.;Vohl, Marie-Claude;Völker, Uwe;Waeber, Gérard;Walker, Mark;Wild, Sarah;Wong, Andrew;Wright, Alan F.;Zillikens, M. Carola;Zubair, Niha;Haiman, Christopher A.;Lemarchand, Loic;Gyllensten, Ulf;Ohlsson, Claes;Hofman, Albert;Rivadeneira, Fernando;Uitterlinden, André G.;Pérusse, Louis;Wilson, James F.;Hayward, Caroline;Polasek, Ozren;Cucca, Francesco;Hveem, Kristian;Hartman, Catharina A.;Tönjes, Anke;Bandinelli, Stefania;Palmer, Lyle J.;Kardia, Sharon L. R.;Rauramaa, Rainer;Sørensen, Thorkild I. A.;Tuomilehto, Jaakko;Salomaa, Veikko;Penninx, Brenda W. J. H.;de Geus, Eco J. C.;Boomsma, Dorret I.;Lehtimäki, Terho;Mangino, Massimo;Laakso, Markku;Bouchard, Claude;Martin, Nicholas G.;Kuh, Diana;Liu, Yongmei;Linneberg, Allan;März, Winfried;Strauch, Konstantin;Kivimäki, Mika;Harris, Tamara B.;Gudnason, Vilmundur;Völzke, Henry;Qi, Lu;Järvelin, Marjo-Riitta;Chambers, John C.;Kooner, Jaspal S.;Froguel, Philippe;Kooperberg, Charles;Vollenweider, Peter;Hallmans, Göran;Hansen, Torben;Pedersen, Oluf;Metspalu, Andres;Wareham, Nicholas J.;Langenberg, Claudia;Weir, David R.;Porteous, David J.;Boerwinkle, Eric;Chasman, Daniel I.;Abecasis, Gonçalo R.;Barroso, Inês;McCarthy, Mark I.;Frayling, Timothy M.;O’Connell, Jeffrey R.;van Duijn, Cornelia M.;Boehnke, Michael;Heid, Iris M.;Mohlke, Karen L.;Strachan, David P.;Fox, Caroline S.;Liu, Ching-Ti;Hirschhorn, Joel N.;Klein, Robert J.;Johnson, Andrew D.;Borecki, Ingrid B.;Franks, Paul W.;North, Kari E.;Cupples, L. Adrienne;Loos, Ruth J. F.;Kilpeläinen, Tuomas O.
Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumfer...
Graff, Mariaelisa;Scott, Robert A.;Justice, Anne E.;Young, Kristin L.;Feitosa, Mary F.;Barata, Llilda;Winkler, Thomas W.;Chu, Audrey Y.;Mahajan, Anubha;Hadley, David;Xue, Luting;Workalemahu, Tsegaselassie;Heard-Costa, Nancy L.;den Hoed, Marcel;Ahluwalia, Tarunveer S.;Qi, Qibin;Ngwa, Julius S.;Renström, Frida;Quaye, Lydia;Eicher, John D.;Hayes, James E.;Cornelis, Marilyn;Kutalik, Zoltan;Lim, Elise;Luan, Jian’an;Huffman, Jennifer E.;Zhang, Weihua;Zhao, Wei;Griffin, Paula J.;Haller, Toomas;Ahmad, Shafqat;Marques-Vidal, Pedro M.;Bien, Stephanie;Yengo, Loic;Teumer, Alexander;Smith, Albert Vernon;Kumari, Meena;Harder, Marie Neergaard;Justesen, Johanne Marie;Kleber, Marcus E.;Hollensted, Mette;Lohman, Kurt;Rivera, Natalia V.;Whitfield, John B.;Zhao, Jing Hua;Stringham, Heather M.;Lyytikäinen, Leo-Pekka;Huppertz, Charlotte;Willemsen, Gonneke;Peyrot, Wouter J.;Wu, Ying;Kristiansson, Kati;Demirkan, Ayse;Fornage, Myriam;Hassinen, Maija;Bielak, Lawrence F.;Cadby, Gemma;Tanaka, Toshiko;Mägi, Reedik;van der Most, Peter J.;Jackson, Anne U.;Bragg-Gresham, Jennifer L.;Vitart, Veronique;Marten, Jonathan;Navarro, Pau;Bellis, Claire;Pasko, Dorota;Johansson, Åsa;Snitker, Søren;Cheng, Yu-Ching;Eriksson, Joel;Lim, Unhee;Aadahl, Mette;Adair, Linda S.;Amin, Najaf;Balkau, Beverley;Auvinen, Juha;Beilby, John;Bergman, Richard N.;Bergmann, Sven;Bertoni, Alain G.;Blangero, John;Bonnefond, Amélie;Bonnycastle, Lori L.;Borja, Judith B.;Brage, Søren;Busonero, Fabio;Buyske, Steve;Campbell, Harry;Chines, Peter S.;Collins, Francis S.;Corre, Tanguy;Smith, George Davey;Delgado, Graciela E.;Dueker, Nicole;Dörr, Marcus;Ebeling, Tapani;Eiriksdottir, Gudny;Esko, Tõnu;Faul, Jessica D.;Fu, Mao;Færch, Kristine;Gieger, Christian;Gläser, Sven;Gong, Jian;Gordon-Larsen, Penny;Grallert, Harald;Grammer, Tanja B.;Grarup, Niels;van Grootheest, Gerard;Harald, Kennet;Hastie, Nicholas D.;Havulinna, Aki S.;Hernandez, Dena;Hindorff, Lucia;Hocking, Lynne J.;Holmens, Oddgeir L.;Holzapfel, Christina;Hottenga, Jouke Jan;Huang, Jie;Huang, Tao;Hui, Jennie;Huth, Cornelia;Hutri-Kähönen, Nina;James, Alan L.;Jansson, John-Olov;Jhun, Min A.;Juonala, Markus;Kinnunen, Leena;Koistinen, Heikki A.;Kolcic, Ivana;Komulainen, Pirjo;Kuusisto, Johanna;Kvaløy, Kirsti;Kähönen, Mika;Lakka, Timo A.;Launer, Lenore J.;Lehne, Benjamin;Lindgren, Cecilia M.;Lorentzon, Mattias;Luben, Robert;Marre, Michel;Milaneschi, Yuri;Monda, Keri L.;Montgomery, Grant W.;De Moor, Marleen H. M.;Mulas, Antonella;Müller-Nurasyid, Martina;Musk, A. W.;Männikkö, Reija;Männistö, Satu;Narisu, Narisu;Nauck, Matthias;Nettleton, Jennifer A.;Nolte, Ilja M.;Oldehinkel, Albertine J.;Olden, Matthias;Ong, Ken K.;Padmanabhan, Sandosh;Paternoster, Lavinia;Perez, Jeremiah;Perola, Markus;Peters, Annette;Peters, Ulrike;Peyser, Patricia A.;Prokopenko, Inga;Puolijoki, Hannu;Raitakari, Olli T.;Rankinen, Tuomo;Rasmussen-Torvik, Laura J.;Rawal, Rajesh;Ridker, Paul M.;Rose, Lynda M.;Rudan, Igor;Sarti, Cinzia;Sarzynski, Mark A.;Savonen, Kai;Scott, William R.;Sanna, Serena;Shuldiner, Alan R.;Sidney, Steve;Silbernagel, Günther;Smith, Blair H.;Smith, Jennifer A.;Snieder, Harold;Stančáková, Alena;Sternfeld, Barbara;Swift, Amy J.;Tammelin, Tuija;Tan, Sian-Tsung;Thorand, Barbara;Thuillier, Dorothée;Vandenput, Liesbeth;Vestergaard, Henrik;van Vliet-Ostaptchouk, Jana V.;Vohl, Marie-Claude;Völker, Uwe;Waeber, Gérard;Walker, Mark;Wild, Sarah;Wong, Andrew;Wright, Alan F.;Zillikens, M. Carola;Zubair, Niha;Haiman, Christopher A.;Lemarchand, Loic;Gyllensten, Ulf;Ohlsson, Claes;Hofman, Albert;Rivadeneira, Fernando;Uitterlinden, André G.;Pérusse, Louis;Wilson, James F.;Hayward, Caroline;Polasek, Ozren;Cucca, Francesco;Hveem, Kristian;Hartman, Catharina A.;Tönjes, Anke;Bandinelli, Stefania;Palmer, Lyle J.;Kardia, Sharon L. R.;Rauramaa, Rainer;Sørensen, Thorkild I. A.;Tuomilehto, Jaakko;Salomaa, Veikko;Penninx, Brenda W. J. H.;de Geus, Eco J. C.;Boomsma, Dorret I.;Lehtimäki, Terho;Mangino, Massimo;Laakso, Markku;Bouchard, Claude;Martin, Nicholas G.;Kuh, Diana;Liu, Yongmei;Linneberg, Allan;März, Winfried;Strauch, Konstantin;Kivimäki, Mika;Harris, Tamara B.;Gudnason, Vilmundur;Völzke, Henry;Qi, Lu;Järvelin, Marjo-Riitta;Chambers, John C.;Kooner, Jaspal S.;Froguel, Philippe;Kooperberg, Charles;Vollenweider, Peter;Hallmans, Göran;Hansen, Torben;Pedersen, Oluf;Metspalu, Andres;Wareham, Nicholas J.;Langenberg, Claudia;Weir, David R.;Porteous, David J.;Boerwinkle, Eric;Chasman, Daniel I.;Abecasis, Gonçalo R.;Barroso, Inês;McCarthy, Mark I.;Frayling, Timothy M.;O’Connell, Jeffrey R.;van Duijn, Cornelia M.;Boehnke, Michael;Heid, Iris M.;Mohlke, Karen L.;Strachan, David P.;Fox, Caroline S.;Liu, Ching-Ti;Hirschhorn, Joel N.;Klein, Robert J.;Johnson, Andrew D.;Borecki, Ingrid B.;Franks, Paul W.;North, Kari E.;Cupples, L. Adrienne;Loos, Ruth J. F.;Kilpeläinen, Tuomas O.
Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumfer...
BACKGROUND: Although case-control approaches are beginning to disentangle schizophrenia's complex polygenic burden, other methods will likely be necessary to fully identify and characterize risk genes. Endophenotypes, traits genetically correlated wi...