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The membrane proximal external region (MPER) of the HIV-1 Env glycoprotein subunit gp41 is targeted by potent broadly neutralizing antibodies (bnAb) 2F5, 4E10 and 10E8. These antibodies recognize linear epitopes and have been suggested to target the ...
HIV Research for Prevention: AIDS Vaccine, Microbicide, and ARV-based Prevention Science (HIVR4P) was built on a growing consensus that effective HIV prevention requires a combination of approaches and that understanding, analyzing, and debating the ...
HIV Research for Prevention: AIDS Vaccine, Microbicide, and ARV-based Prevention Science (HIVR4P) was built on a growing consensus that effective HIV prevention requires a combination of approaches and that understanding, analyzing, and debating the ...
Brown, Gordon D;Meintjes, Graeme;Kolls, Jay K;Gray, Clive;Horsnell, William;Working Group from the EMBO-AIDS Related Mycoses Workshop,;Achan, Beatrice;Alber, Gottfried;Aloisi, Maria;Armstrong-James, Darius;Beale, Mathew;Bicanic, Tihana;Black, John;Bohjanen, Paul;Botes, Angela;Boulware, David R;Brown, Gordon;Bunjun, Rubina;Carr, William;Casadevall, Arturo;Chang, Christina;Chivero, Ernest;Corcoran, Craig;Cross, Anna;Dawood, Halima;Day, Jeremy;De Bernardis, Flavia;De Jager, Veronique;De Repentigny, Louis;Denning, David;Eschke, Maria;Finkelman, Malcolm;Govender, Nelesh;Gow, Neil;Graham, Lisa;Gryschek, Ronaldo;Hammond-Aryee, Kenneth;Harrison, Tom;Heard, Neil;Hill, Melanie;Hoving, J Claire;Janoff, Edward;Jarvis, Joseph;Kayuni, Sekeleghe;King, Karin;Kolls, Jay;Kullberg, Bart-Jan;Lalloo, David G;Letang, Emilio;Levitz, Stuart;Limper, Andrew;Longley, Nicky;Machiridza, Tendai Rodney;Mahabeer, Yesholata;Martinsons, Neil;Meiring, Susan;Meya, David;Miller, Robert;Molloy, Sile;Morris, Lynn;Mukaremera, Liliane;Musubire, Abdu K;Muzoora, Conrad;Nair, Amy;Nakiwala Kimbowa, Justine;Netea, Mihai;Nielsen, Kirsten;O'hern, Jennifer;Okurut, Samuel;Parker, Arifa;Patterson, Tom;Pennap, Grace;Perfect, John;Prinsloo, Chrisna;Rhein, Joshua;Rolfes, Melissa A;Samuel, Catherine;Schutz, Charlotte;Scriven, James;Sebolai, Olihile M;Sojane, Katlego;Sriruttan, Charlotte;Stead, David;Steyn, Annica;Thawer, Narjis K;Thienemann, Friedrich;Von Hohenberg, Maximilian;Vreulink, Jo-marie;Wessels, Jeannette;Wood, Kathryn;Yang, Yun-liang
The contribution of fungal infections to the morbidity and mortality of HIV-infected individuals is largely unrecognized. A recent meeting highlighted several priorities that need to be urgently addressed, including improved epidemiological surveilla...
The α4β7 integrin is a non-essential HIV-1 adhesion receptor, bound by the gp120 V1V2 domain, facilitating rapid viral dissemination into gut-associated lymphoid tissues. Antibodies blocking this interaction early in infection can improve disease out...
Wibmer, Constantinos Kurt [National Inst. for Communicable Diseases, Johannesburg (South Africa); Univ. of Witwatersrand, Johannesburg (South Africa); National Inst. of Health (NIH), Bethesda, MD (United States)]; Gorman, Jason [National Inst. of Health (NIH), Bethesda, MD (United States)]; Anthony, Colin S. [Univ. of Cape Town and National Health Lab. Service, Cape Town (South Africa)]; Mkhize, Nonhlanhla N. [National Inst. for Communicable Diseases, Johannesburg (South Africa); Univ. of Witwatersrand, Johannesburg (South Africa)]; Druz, Aliaksandr [National Inst. of Health (NIH), Bethesda, MD (United States)]; York, Talita [Univ. of Cape Town and National Health Lab. Service, Cape Town (South Africa)]; Schmidt, Stephen D. [National Inst. of Health (NIH), Bethesda, MD (United States)]; Labuschagne, Phillip [Univ. of the Western Cape, Cape Town (South Africa)]; Louder, Mark K. [National Inst. of Health (NIH), Bethesda, MD (United States)]; Bailer, Robert T. [National Inst. of Health (NIH), Bethesda, MD (United States)]; Abdool Karim, Salim S. [Univ. of KwaZulu-Natal, Durban (South Africa); Columbia Univ., New York, NY (United States)]; Mascola, John R. [National Inst. of Health (NIH), Bethesda, MD (United States)]; Williamson, Carolyn [Univ. of Cape Town and National Health Lab. Service, Cape Town (South Africa); Univ. of KwaZulu-Natal, Durban (South Africa)]; Moore, Penny L. [National Inst. for Communicable Diseases, Johannesburg (South Africa); Univ. of Witwatersrand, Johannesburg (South Africa); Univ. of KwaZulu-Natal, Durban (South Africa)]; Kwong, Peter D. [National Inst. of Health (NIH), Bethesda, MD (United States)]; Morris, Lynn [National Inst. for Communicable Diseases, Johannesburg (South Africa); Univ. of Witwatersrand, Johannesburg (South Africa); Univ. of KwaZulu-Natal, Durban (South Africa)]; Kirchhoff, F. [Ulm Univ. Medical Center (Germany)]
All HIV-1-infected individuals develop strain-specific neutralizing antibodies to their infecting virus, which in some cases mature into broadly neutralizing antibodies. Defining the epitopes of strain-specific antibodies that overlap conserved sites...
Wibmer, Constantinos Kurt [National Inst. for Communicable Diseases, Johannesburg (South Africa); Univ. of Witwatersrand, Johannesburg (South Africa); National Inst. of Health (NIH), Bethesda, MD (United States)]; Gorman, Jason [National Inst. of Health (NIH), Bethesda, MD (United States)]; Anthony, Colin S. [Univ. of Cape Town and National Health Lab. Service, Cape Town (South Africa)]; Mkhize, Nonhlanhla N. [National Inst. for Communicable Diseases, Johannesburg (South Africa); Univ. of Witwatersrand, Johannesburg (South Africa)]; Druz, Aliaksandr [National Inst. of Health (NIH), Bethesda, MD (United States)]; York, Talita [Univ. of Cape Town and National Health Lab. Service, Cape Town (South Africa)]; Schmidt, Stephen D. [National Inst. of Health (NIH), Bethesda, MD (United States)]; Labuschagne, Phillip [Univ. of the Western Cape, Cape Town (South Africa)]; Louder, Mark K. [National Inst. of Health (NIH), Bethesda, MD (United States)]; Bailer, Robert T. [National Inst. of Health (NIH), Bethesda, MD (United States)]; Abdool Karim, Salim S. [Univ. of KwaZulu-Natal, Durban (South Africa); Columbia Univ., New York, NY (United States)]; Mascola, John R. [National Inst. of Health (NIH), Bethesda, MD (United States)]; Williamson, Carolyn [Univ. of Cape Town and National Health Lab. Service, Cape Town (South Africa); Univ. of KwaZulu-Natal, Durban (South Africa)]; Moore, Penny L. [National Inst. for Communicable Diseases, Johannesburg (South Africa); Univ. of Witwatersrand, Johannesburg (South Africa); Univ. of KwaZulu-Natal, Durban (South Africa)]; Kwong, Peter D. [National Inst. of Health (NIH), Bethesda, MD (United States)]; Morris, Lynn [National Inst. for Communicable Diseases, Johannesburg (South Africa); Univ. of Witwatersrand, Johannesburg (South Africa); Univ. of KwaZulu-Natal, Durban (South Africa)]; Kirchhoff, F. [Ulm Univ. Medical Center (Germany)]
All HIV-1-infected individuals develop strain-specific neutralizing antibodies to their infecting virus, which in some cases mature into broadly neutralizing antibodies. Defining the epitopes of strain-specific antibodies that overlap conserved sites...
Wibmer, Constantinos Kurt [Univ. of the Witwatersrand, Johannesburg (South Africa)]; Gorman, Jason [National Inst. of Health (NIH), Bethesda, MD (United States)]; Ozorowski, Gabriel [The Scripps Research Inst., La Jolla, CA (United States)]; Bhiman, Jinal N. [National Inst. for Communicable Diseases (NICD), of the National Health Laboratory Service (NHLS), Johannesburg (South Africa); Univ. of the Witwatersrand, Johannesburg (South Africa)]; Sheward, Daniel J. [Univ. of Cape Town and NHLS, Cape Town (South Africa)]; Elliott, Debra H. [Tulane Univ. Medical Center, New Orleans, LA (United States)]; Rouelle, Julie [Tulane Univ. Medical Center, New Orleans, LA (United States)]; Smira, Ashley [Tulane Univ. Medical Center, New Orleans, LA (United States)]; Joyce, M. Gordon [National Inst. of Health (NIH), Bethesda, MD (United States)]; Ndabambi, Nonkululeko [Univ. of Cape Town and NHLS, Cape Town (South Africa)]; Druz, Aliaksandr [National Inst. of Health (NIH), Bethesda, MD (United States)]; Asokan, Mangai [National Inst. of Health (NIH), Bethesda, MD (United States)]; Burton, Dennis R. [The Scripps Research Inst., La Jolla, CA (United States); Ragon Inst. of Massachusetts General Hospital, MIT and Harvard, Cambridge, MA (United States)]; Connors, Mark [National Inst. of Health (NIH), Bethesda, MD (United States)]; Abdool Karim, Salim S. [Univ. of KwaZulu-Natal, Durban (South Africa); Columbia Univ., New York, NY (United States)]; Mascola, John R. [National Inst. of Health (NIH), Bethesda, MD (United States)]; Robinson, James E. [Tulane Univ. Medical Center, New Orleans, LA (United States)]; Ward, Andrew B. [The Scripps Research Inst., La Jolla, CA (United States)]; Williamson, Carolyn [Univ. of Cape Town and NHLS, Cape Town (South Africa); Univ. of KwaZulu-Natal, Durban (South Africa)]; Kwong, Peter D. [National Inst. of Health (NIH), Bethesda, MD (United States)]; Morris, Lynn [National Inst. for Communicable Diseases (NICD), of the National Health Lab. Service (NHLS), Johannesburg (South Africa); Univ. of the Witwatersrand, Johannesburg (South Africa); Univ. of KwaZulu-Natal, Durban (South Africa)]; Moore, Penny L. [National Inst. for Communicable Diseases (NICD), of the National Health Lab. Service (NHLS), Johannesburg (South Africa); Univ. of the Witwatersrand, Johannesburg (South Africa); Univ. of KwaZulu-Natal, Durban (South Africa)]; Desrosiers, Ronald C. [Univ. of Miami, FL (United States). Miller School of Medicine]
A comprehensive understanding of the regions on HIV-1 envelope trimers targeted by broadly neutralizing antibodies may contribute to rational design of an HIV-1 vaccine. We previously identified a participant in the CAPRISA cohort, CAP248, who develo...