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Swerdlow, Daniel I;Preiss, David;Kuchenbaecker, Karoline B;Holmes, Michael V;Engmann, Jorgen E L;Shah, Tina;Sofat, Reecha;Stender, Stefan;Johnson, Paul C D;Scott, Robert A;Leusink, Maarten;Verweij, Niek;Sharp, Stephen J;Guo, Yiran;Giambartolomei, Claudia;Chung, Christina;Peasey, Anne;Amuzu, Antoinette;Li, KaWah;Palmen, Jutta;Howard, Philip;Cooper, Jackie A;Drenos, Fotios;Li, Yun R;Lowe, Gordon;Gallacher, John;Stewart, Marlene C W;Tzoulaki, Ioanna;Buxbaum, Sarah G;van der A, Daphne L;Forouhi, Nita G;Onland-Moret, N Charlotte;van der Schouw, Yvonne T;Schnabel, Renate B;Hubacek, Jaroslav A;Kubinova, Ruzena;Baceviciene, Migle;Tamosiunas, Abdonas;Pajak, Andrzej;Topor-Madry, Roman;Stepaniak, Urszula;Malyutina, Sofia;Baldassarre, Damiano;Sennblad, Bengt;Tremoli, Elena;de Faire, Ulf;Veglia, Fabrizio;Ford, Ian;Jukema, J Wouter;Westendorp, Rudi GJ;de Borst, Gert Jan;de Jong, Pim A;Algra, Ale;Spiering, Wilko;Maitland-van der Zee, Anke H;Klungel, Olaf H;de Boer, Anthonius;Doevendans, Pieter A;Eaton, Charles B;Robinson, Jennifer G;Duggan, David;Kjekshus, John;Downs, John R;Gotto, Antonio M;Keech, Anthony C;Marchioli, Roberto;Tognoni, Gianni;Sever, Peter S;Poulter, Neil R;Waters, David D;Pedersen, Terje R;Amarenco, Pierre;Nakamura, Haruo;McMurray, John J V;Lewsey, James D;Chasman, Daniel I;Ridker, Paul M;Maggioni, Aldo P;Tavazzi, Luigi;Ray, Kausik K;Seshasai, Sreenivasa Rao Kondapally;Manson, JoAnn E;Price, Jackie F;Whincup, Peter H;Morris, Richard W;Lawlor, Debbie A;Smith, George Davey;Ben-Shlomo, Yoav;Schreiner, Pamela J;Fornage, Myriam;Siscovick, David S;Cushman, Mary;Kumari, Meena;Wareham, Nick J;Verschuren, W M Monique;Redline, Susan;Patel, Sanjay R;Whittaker, John C;Hamsten, Anders;Delaney, Joseph A;Dale, Caroline;Gaunt, Tom R;Wong, Andrew;Kuh, Diana;Hardy, Rebecca;Kathiresan, Sekar;Castillo, Berta A;van der Harst, Pim;Brunner, Eric J;Tybjaerg-Hansen, Anne;Marmot, Michael G;Krauss, Ronald M;Tsai, Michael;Coresh, Josef;Hoogeveen, Ronald C;Psaty, Bruce M;Lange, Leslie A;Hakonarson, Hakon;Dudbridge, Frank;Humphries, Steve E;Talmud, Philippa J;Kivimäki, Mika;Timpson, Nicholas J;Langenberg, Claudia;Asselbergs, Folkert W;Voevoda, Mikhail;Bobak, Martin;Pikhart, Hynek;Wilson, James G;Reiner, Alex P;Keating, Brendan J;Hingorani, Aroon D;Sattar, Naveed
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The prognostic impact of hyperuricemia on long-term clinical outcomes in patients with chronic heart failure (HF) has been investigated in observational registries and clinical trials, but the results have been often inconclusive. We examined the pro...
Objectives Rising evidences showed a possible protective role of statins in chronic obstructive pulmonary disease (COPD). We aimed to evaluate in a post-hoc analysis of the GISSI-HF trial the prognostic effect of the use of rosuvastatin in patients w...
Swerdlow, Daniel I;Preiss, David;Kuchenbaecker, Karoline B;Holmes, Michael V;Engmann, Jorgen E L;Shah, Tina;Sofat, Reecha;Stender, Stefan;Johnson, Paul C D;Scott, Robert A;Leusink, Maarten;Verweij, Niek;Sharp, Stephen J;Guo, Yiran;Giambartolomei, Claudia;Chung, Christina;Peasey, Anne;Amuzu, Antoinette;Li, KaWah;Palmen, Jutta;Howard, Philip;Cooper, Jackie A;Drenos, Fotios;Li, Yun R;Lowe, Gordon;Gallacher, John;Stewart, Marlene C W;Tzoulaki, Ioanna;Buxbaum, Sarah G;van der A, Daphne L;Forouhi, Nita G;Onland-Moret, N Charlotte;van der Schouw, Yvonne T;Schnabel, Renate B;Hubacek, Jaroslav A;Kubinova, Ruzena;Baceviciene, Migle;Tamosiunas, Abdonas;Pajak, Andrzej;Topor-Madry, Roman;Stepaniak, Urszula;Malyutina, Sofia;Baldassarre, Damiano;Sennblad, Bengt;Tremoli, Elena;de Faire, Ulf;Veglia, Fabrizio;Ford, Ian;Jukema, J Wouter;Westendorp, Rudi GJ;de Borst, Gert Jan;de Jong, Pim A;Algra, Ale;Spiering, Wilko;Maitland-van der Zee, Anke H;Klungel, Olaf H;de Boer, Anthonius;Doevendans, Pieter A;Eaton, Charles B;Robinson, Jennifer G;Duggan, David;Kjekshus, John;Downs, John R;Gotto, Antonio M;Keech, Anthony C;Marchioli, Roberto;Tognoni, Gianni;Sever, Peter S;Poulter, Neil R;Waters, David D;Pedersen, Terje R;Amarenco, Pierre;Nakamura, Haruo;McMurray, John J V;Lewsey, James D;Chasman, Daniel I;Ridker, Paul M;Maggioni, Aldo P;Tavazzi, Luigi;Ray, Kausik K;Seshasai, Sreenivasa Rao Kondapally;Manson, JoAnn E;Price, Jackie F;Whincup, Peter H;Morris, Richard W;Lawlor, Debbie A;Smith, George Davey;Ben-Shlomo, Yoav;Schreiner, Pamela J;Fornage, Myriam;Siscovick, David S;Cushman, Mary;Kumari, Meena;Wareham, Nick J;Verschuren, W M Monique;Redline, Susan;Patel, Sanjay R;Whittaker, John C;Hamsten, Anders;Delaney, Joseph A;Dale, Caroline;Gaunt, Tom R;Wong, Andrew;Kuh, Diana;Hardy, Rebecca;Kathiresan, Sekar;Castillo, Berta A;van der Harst, Pim;Brunner, Eric J;Tybjaerg-Hansen, Anne;Marmot, Michael G;Krauss, Ronald M;Tsai, Michael;Coresh, Josef;Hoogeveen, Ronald C;Psaty, Bruce M;Lange, Leslie A;Hakonarson, Hakon;Dudbridge, Frank;Humphries, Steve E;Talmud, Philippa J;Kivimäki, Mika;Timpson, Nicholas J;Langenberg, Claudia;Asselbergs, Folkert W;Voevoda, Mikhail;Bobak, Martin;Pikhart, Hynek;Wilson, James G;Reiner, Alex P;Keating, Brendan J;Hingorani, Aroon D;Sattar, Naveed
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Swerdlow, Daniel I;Preiss, David;Kuchenbaecker, Karoline B;Holmes, Michael V;Engmann, Jorgen E L;Shah, Tina;Sofat, Reecha;Stender, Stefan;Johnson, Paul C D;Scott, Robert A;Leusink, Maarten;Verweij, Niek;Sharp, Stephen J;Guo, Yiran;Giambartolomei, Claudia;Chung, Christina;Peasey, Anne;Amuzu, Antoinette;Li, KaWah;Palmen, Jutta;Howard, Philip;Cooper, Jackie A;Drenos, Fotios;Li, Yun R;Lowe, Gordon;Gallacher, John;Stewart, Marlene C W;Tzoulaki, Ioanna;Buxbaum, Sarah G;van der A, Daphne L;Forouhi, Nita G;Onland-Moret, N Charlotte;van der Schouw, Yvonne T;Schnabel, Renate B;Hubacek, Jaroslav A;Kubinova, Ruzena;Baceviciene, Migle;Tamosiunas, Abdonas;Pajak, Andrzej;Topor-Madry, Roman;Stepaniak, Urszula;Malyutina, Sofia;Baldassarre, Damiano;Sennblad, Bengt;Tremoli, Elena;de Faire, Ulf;Veglia, Fabrizio;Ford, Ian;Jukema, J Wouter;Westendorp, Rudi GJ;de Borst, Gert Jan;de Jong, Pim A;Algra, Ale;Spiering, Wilko;Maitland-van der Zee, Anke H;Klungel, Olaf H;de Boer, Anthonius;Doevendans, Pieter A;Eaton, Charles B;Robinson, Jennifer G;Duggan, David;Kjekshus, John;Downs, John R;Gotto, Antonio M;Keech, Anthony C;Marchioli, Roberto;Tognoni, Gianni;Sever, Peter S;Poulter, Neil R;Waters, David D;Pedersen, Terje R;Amarenco, Pierre;Nakamura, Haruo;McMurray, John J V;Lewsey, James D;Chasman, Daniel I;Ridker, Paul M;Maggioni, Aldo P;Tavazzi, Luigi;Ray, Kausik K;Seshasai, Sreenivasa Rao Kondapally;Manson, JoAnn E;Price, Jackie F;Whincup, Peter H;Morris, Richard W;Lawlor, Debbie A;Smith, George Davey;Ben-Shlomo, Yoav;Schreiner, Pamela J;Fornage, Myriam;Siscovick, David S;Cushman, Mary;Kumari, Meena;Wareham, Nick J;Verschuren, W M Monique;Redline, Susan;Patel, Sanjay R;Whittaker, John C;Hamsten, Anders;Delaney, Joseph A;Dale, Caroline;Gaunt, Tom R;Wong, Andrew;Kuh, Diana;Hardy, Rebecca;Kathiresan, Sekar;Castillo, Berta A;van der Harst, Pim;Brunner, Eric J;Tybjaerg-Hansen, Anne;Marmot, Michael G;Krauss, Ronald M;Tsai, Michael;Coresh, Josef;Hoogeveen, Ronald C;Psaty, Bruce M;Lange, Leslie A;Hakonarson, Hakon;Dudbridge, Frank;Humphries, Steve E;Talmud, Philippa J;Kivimäki, Mika;Timpson, Nicholas J;Langenberg, Claudia;Asselbergs, Folkert W;Voevoda, Mikhail;Bobak, Martin;Pikhart, Hynek;Wilson, James G;Reiner, Alex P;Keating, Brendan J;Hingorani, Aroon D;Sattar, Naveed
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Swerdlow, Daniel I;Preiss, David;Kuchenbaecker, Karoline B;Holmes, Michael V;Engmann, Jorgen EL;Shah, Tina;Sofat, Reecha;Stender, Stefan;Johnson, Paul CD;Scott, Robert A;Leusink, Maarten;Verweij, Niek;Sharp, Stephen J;Guo, Yiran;Giambartolomei, Claudia;Chung, Christina;Peasey, Anne;Amuzu, Antoinette;Li, KaWah;Palmen, Jutta;Howard, Philip;Cooper, Jackie A;Drenos, Fotios;Li, Yun R;Lowe, Gordon;Gallacher, John;Stewart, Marlene CW;Tzoulaki, Ioanna;Buxbaum, Sarah G;van der A, Daphne L;Forouhi, Nita G;Onland-Moret, N Charlotte;van der Schouw, Yvonne T;Schnabel, Renate B;Hubacek, Jaroslav A;Kubinova, Ruzena;Baceviciene, Migle;Tamosiunas, Abdonas;Pajak, Andrzej;Topor-Madry, Roman;Stepaniak, Urszula;Malyutina, Sofia;Baldassarre, Damiano;Sennblad, Bengt;Tremoli, Elena;de Faire, Ulf;Veglia, Fabrizio;Ford, Ian;Jukema, J Wouter;Westendorp, Rudi GJ;de Borst, Gert Jan;de Jong, Pim A;Algra, Ale;Spiering, Wilko;Maitland-van der Zee, Anke H;Klungel, Olaf H;de Boer, Anthonius;Doevendans, Pieter A;Eaton, Charles B;Robinson, Jennifer G;Duggan, David;DIAGRAM Consortium;MAGIC Consortium;InterAct Consortium;Kjekshus, John;Downs, John R;Gotto, Antonio M;Keech, Anthony C;Marchioli, Roberto;Tognoni, Gianni;Sever, Peter S;Poulter, Neil R;Waters, David D;Pedersen, Terje R;Amarenco, Pierre;Nakamura, Haruo;McMurray, John JV;Lewsey, James D;Chasman, Daniel I;Ridker, Paul M;Maggioni, Aldo P;Tavazzi, Luigi;Ray, Kausik K;Seshasai, Sreenivasa Rao Kondapally;Manson, JoAnn E;Price, Jackie F;Whincup, Peter H;Morris, Richard W;Lawlor, Debbie A;Smith, George Davey;Ben-Shlomo, Yoav;Schreiner, Pamela J;Fornage, Myriam;Siscovick, David S;Cushman, Mary;Kumari, Meena;Wareham, Nick J;Verschuren, WM Monique;Redline, Susan;Patel, Sanjay R
BACKGROUND:Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the intended drug target. METHODS:We used...
Swerdlow, Daniel I.;Preiss, David;Kuchenbaecker, Karoline B.;Holmes, Michael V.;Engmann, Jorgen E L;Shah, Tina;Sofat, Reecha;Stender, Stefan;Johnson, Paul C D;Scott, Robert A.;Leusink, Maarten;Verweij, Niek;Sharp, Stephen J.;Guo, Yiran;Giambartolomei, Claudia;Chung, Christina;Peasey, Anne;Amuzu, Antoinette;Li, Kawah;Palmen, Jutta;Howard, Philip;Cooper, Jackie A.;Drenos, Fotios;Li, Yun R.;Lowe, Gordon;Gallacher, John;Stewart, Marlene C W;Tzoulaki, Ioanna;Buxbaum, Sarah G.;Van Der A, Daphne L.;Forouhi, Nita G.;Onland-Moret, N. Charlotte;Van Der Schouw, Yvonne T.;Schnabel, Renate B.;Hubacek, Jaroslav A.;Kubinova, Ruzena;Baceviciene, Migle;Tamosiunas, Abdonas;Pajak, Andrzej;Topor-Madry, Romanvan;Stepaniak, Urszula;Malyutina, Sofia;Baldassarre, Damiano;Sennblad, Bengt;Tremoli, Elena;De Faire, Ulf;Veglia, Fabrizio;Ford, Ian;Jukema, J. Wouter;Westendorp, Rudi G J;De Borst, Gert Jan;De Jong, Pim A.;Algra, Ale;Spiering, Wilko;Der Zee, Anke H Maitland Van;Klungel, Olaf H.;De Boer, Anthonius;Doevendans, Pieter A.;Eaton, Charles B.;Robinson, Jennifer G.;Duggan, David;Kjekshus, John;Downs, John R.;Gotto, Antonio M.;Keech, Anthony C.;Marchioli, Roberto;Tognoni, Gianni;Sever, Peter S.;Poulter, Neil R.;Waters, David D.;Pedersen, Terje R.;Amarenco, Pierre;Nakamura, Haruo;McMurray, John J V;Lewsey, James D.;Chasman, Daniel I.;Ridker, Paul M.;Maggioni, Aldo P.;Tavazzi, Luigi;Ray, Kausik K.;Seshasai, Sreenivasa Rao Kondapally;Manson, Joann E.;Price, Jackie F.;Whincup, Peter H.;Morris, Richard W.;Lawlor, Debbie A.;Smith, George Davey;Ben-Shlomo, Yoav;Schreiner, Pamela J.;Fornage, Myriam;Siscovick, David S.;Cushman, Mary;Kumari, Meena;Wareham, Nick J.;Verschuren, W. M Monique;Redline, Susan;Patel, Sanjay R.;Whittaker, John C.;Hamsten, Anders;Delaney, Joseph A.;Dale, Caroline;Gaunt, Tom R.;Wong, Andrew;Kuh, Diana;Hardy, Rebecca;Kathiresan, Sekar;Castillo, Berta A.;Van Der Harst, Pim;Brunner, Eric J.;Tybjaerg-Hansen, Anne;Marmot, Michael G.;Krauss, Ronald M.;Tsai, Michael;Coresh, Josef;Hoogeveen, Ronald C.;Psaty, Bruce M.;Lange, Leslie A.;Hakonarson, Hakon;Dudbridge, Frank;Humphries, Steve E.;Talmud, Philippa J.;Kivimäki, Mika;Timpson, Nicholas J.;Langenberg, Claudia;Asselbergs, Folkert W.;Voevoda, Mikhail;Bobak, Martin;Pikhart, Hynek;Wilson, James G.;Reiner, Alex P.;Keating, Brendan J.;Hingorani, Aroon D.;Sattar, Naveed
Background Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the intended drug target. Methods We used...
Swerdlow, Daniel I.;Preiss, David;Kuchenbaecker, Karoline B.;Holmes, Michael V.;Engmann, Jorgen E L;Shah, Tina;Sofat, Reecha;Stender, Stefan;Johnson, Paul C D;Scott, Robert A.;Leusink, Maarten;Verweij, Niek;Sharp, Stephen J.;Guo, Yiran;Giambartolomei, Claudia;Chung, Christina;Peasey, Anne;Amuzu, Antoinette;Li, Kawah;Palmen, Jutta;Howard, Philip;Cooper, Jackie A.;Drenos, Fotios;Li, Yun R.;Lowe, Gordon;Gallacher, John;Stewart, Marlene C W;Tzoulaki, Ioanna;Buxbaum, Sarah G.;Van Der A, Daphne L.;Forouhi, Nita G.;Onland-Moret, N. Charlotte;Van Der Schouw, Yvonne T.;Schnabel, Renate B.;Hubacek, Jaroslav A.;Kubinova, Ruzena;Baceviciene, Migle;Tamosiunas, Abdonas;Pajak, Andrzej;Topor-Madry, Romanvan;Stepaniak, Urszula;Malyutina, Sofia;Baldassarre, Damiano;Sennblad, Bengt;Tremoli, Elena;De Faire, Ulf;Veglia, Fabrizio;Ford, Ian;Jukema, J. Wouter;Westendorp, Rudi G J;De Borst, Gert Jan;De Jong, Pim A.;Algra, Ale;Spiering, Wilko;Der Zee, Anke H Maitland Van;Klungel, Olaf H.;De Boer, Anthonius;Doevendans, Pieter A.;Eaton, Charles B.;Robinson, Jennifer G.;Duggan, David;Kjekshus, John;Downs, John R.;Gotto, Antonio M.;Keech, Anthony C.;Marchioli, Roberto;Tognoni, Gianni;Sever, Peter S.;Poulter, Neil R.;Waters, David D.;Pedersen, Terje R.;Amarenco, Pierre;Nakamura, Haruo;McMurray, John J V;Lewsey, James D.;Chasman, Daniel I.;Ridker, Paul M.;Maggioni, Aldo P.;Tavazzi, Luigi;Ray, Kausik K.;Seshasai, Sreenivasa Rao Kondapally;Manson, Joann E.;Price, Jackie F.;Whincup, Peter H.;Morris, Richard W.;Lawlor, Debbie A.;Smith, George Davey;Ben-Shlomo, Yoav;Schreiner, Pamela J.;Fornage, Myriam;Siscovick, David S.;Cushman, Mary;Kumari, Meena;Wareham, Nick J.;Verschuren, W. M Monique;Redline, Susan;Patel, Sanjay R.;Whittaker, John C.;Hamsten, Anders;Delaney, Joseph A.;Dale, Caroline;Gaunt, Tom R.;Wong, Andrew;Kuh, Diana;Hardy, Rebecca;Kathiresan, Sekar;Castillo, Berta A.;Van Der Harst, Pim;Brunner, Eric J.;Tybjaerg-Hansen, Anne;Marmot, Michael G.;Krauss, Ronald M.;Tsai, Michael;Coresh, Josef;Hoogeveen, Ronald C.;Psaty, Bruce M.;Lange, Leslie A.;Hakonarson, Hakon;Dudbridge, Frank;Humphries, Steve E.;Talmud, Philippa J.;Kivimäki, Mika;Timpson, Nicholas J.;Langenberg, Claudia;Asselbergs, Folkert W.;Voevoda, Mikhail;Bobak, Martin;Pikhart, Hynek;Wilson, James G.;Reiner, Alex P.;Keating, Brendan J.;Hingorani, Aroon D.;Sattar, Naveed
Background Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the intended drug target. Methods We used...
Aims The effect of statins on risk of heart failure (HF) hospitalization and HF death remains uncertain. We aimed to establish whether statins reduce major HF events. Methods and results We searched Medline, EMBASE, and the Cochrane Central Register ...
Swerdlow, Daniel I.;Preiss, David;Kuchenbaecker, Karoline B.;Holmes, Michael V.;Engmann, Jorgen E L;Shah, Tina;Sofat, Reecha;Stender, Stefan;Johnson, Paul C D;Scott, Robert A.;Leusink, Maarten;Verweij, Niek;Sharp, Stephen J.;Guo, Yiran;Giambartolomei, Claudia;Chung, Christina;Peasey, Anne;Amuzu, Antoinette;Li, Kawah;Palmen, Jutta;Howard, Philip;Cooper, Jackie A.;Drenos, Fotios;Li, Yun R.;Lowe, Gordon;Gallacher, John;Stewart, Marlene C W;Tzoulaki, Ioanna;Buxbaum, Sarah G.;Van Der A, Daphne L.;Forouhi, Nita G.;Onland-Moret, N. Charlotte;Van Der Schouw, Yvonne T.;Schnabel, Renate B.;Hubacek, Jaroslav A.;Kubinova, Ruzena;Baceviciene, Migle;Tamosiunas, Abdonas;Pajak, Andrzej;Topor-Madry, Romanvan;Stepaniak, Urszula;Malyutina, Sofia;Baldassarre, Damiano;Sennblad, Bengt;Tremoli, Elena;De Faire, Ulf;Veglia, Fabrizio;Ford, Ian;Jukema, J. Wouter;Westendorp, Rudi G J;De Borst, Gert Jan;De Jong, Pim A.;Algra, Ale;Spiering, Wilko;Der Zee, Anke H Maitland Van;Klungel, Olaf H.;De Boer, Anthonius;Doevendans, Pieter A.;Eaton, Charles B.;Robinson, Jennifer G.;Duggan, David;Kjekshus, John;Downs, John R.;Gotto, Antonio M.;Keech, Anthony C.;Marchioli, Roberto;Tognoni, Gianni;Sever, Peter S.;Poulter, Neil R.;Waters, David D.;Pedersen, Terje R.;Amarenco, Pierre;Nakamura, Haruo;McMurray, John J V;Lewsey, James D.;Chasman, Daniel I.;Ridker, Paul M.;Maggioni, Aldo P.;Tavazzi, Luigi;Ray, Kausik K.;Seshasai, Sreenivasa Rao Kondapally;Manson, Joann E.;Price, Jackie F.;Whincup, Peter H.;Morris, Richard W.;Lawlor, Debbie A.;Smith, George Davey;Ben-Shlomo, Yoav;Schreiner, Pamela J.;Fornage, Myriam;Siscovick, David S.;Cushman, Mary;Kumari, Meena;Wareham, Nick J.;Verschuren, W. M Monique;Redline, Susan;Patel, Sanjay R.;Whittaker, John C.;Hamsten, Anders;Delaney, Joseph A.;Dale, Caroline;Gaunt, Tom R.;Wong, Andrew;Kuh, Diana;Hardy, Rebecca;Kathiresan, Sekar;Castillo, Berta A.;Van Der Harst, Pim;Brunner, Eric J.;Tybjaerg-Hansen, Anne;Marmot, Michael G.;Krauss, Ronald M.;Tsai, Michael;Coresh, Josef;Hoogeveen, Ronald C.;Psaty, Bruce M.;Lange, Leslie A.;Hakonarson, Hakon;Dudbridge, Frank;Humphries, Steve E.;Talmud, Philippa J.;Kivimäki, Mika;Timpson, Nicholas J.;Langenberg, Claudia;Asselbergs, Folkert W.;Voevoda, Mikhail;Bobak, Martin;Pikhart, Hynek;Wilson, James G.;Reiner, Alex P.;Keating, Brendan J.;Hingorani, Aroon D.;Sattar, Naveed
Background Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the intended drug target. Methods We used...