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Title
The effect of statins on risk of heart failure (HF) hospitalization and HF death remains uncertain. We aimed to establish whether statins reduce major HF events.We searched Medline, EMBASE, and the Cochrane Central Register of Controlled Trials for r...
Swerdlow, Daniel I;Preiss, David;Kuchenbaecker, Karoline B;Holmes, Michael V;Engmann, Jorgen EL;Shah, Tina;Sofat, Reecha;Stender, Stefan;Johnson, Paul CD;Scott, Robert A;Leusink, Maarten;Verweij, Niek;Sharp, Stephen J;Guo, Yiran;Giambartolomei, Claudia;Chung, Christina;Peasey, Anne;Amuzu, Antoinette;Li, KaWah;Palmen, Jutta;Howard, Philip;Cooper, Jackie A;Drenos, Fotios;Li, Yun R;Lowe, Gordon;Gallacher, John;Stewart, Marlene CW;Tzoulaki, Ioanna;Buxbaum, Sarah G;van der A, Daphne L;Forouhi, Nita G;Onland-Moret, N Charlotte;van der Schouw, Yvonne T;Schnabel, Renate B;Hubacek, Jaroslav A;Kubinova, Ruzena;Baceviciene, Migle;Tamosiunas, Abdonas;Pajak, Andrzej;Topor-Madry, Roman;Stepaniak, Urszula;Malyutina, Sofia;Baldassarre, Damiano;Sennblad, Bengt;Tremoli, Elena;de Faire, Ulf;Veglia, Fabrizio;Ford, Ian;Jukema, J Wouter;Westendorp, Rudi GJ;de Borst, Gert Jan;de Jong, Pim A;Algra, Ale;Spiering, Wilko;Maitland-van der Zee, Anke H;Klungel, Olaf H;de Boer, Anthonius;Doevendans, Pieter A;Eaton, Charles B;Robinson, Jennifer G;Duggan, David;DIAGRAM Consortium;MAGIC Consortium;InterAct Consortium;Kjekshus, John;Downs, John R;Gotto, Antonio M;Keech, Anthony C;Marchioli, Roberto;Tognoni, Gianni;Sever, Peter S;Poulter, Neil R;Waters, David D;Pedersen, Terje R;Amarenco, Pierre;Nakamura, Haruo;McMurray, John JV;Lewsey, James D;Chasman, Daniel I;Ridker, Paul M;Maggioni, Aldo P;Tavazzi, Luigi;Ray, Kausik K;Seshasai, Sreenivasa Rao Kondapally;Manson, JoAnn E;Price, Jackie F;Whincup, Peter H;Morris, Richard W;Lawlor, Debbie A;Smith, George Davey;Ben-Shlomo, Yoav;Schreiner, Pamela J;Fornage, Myriam;Siscovick, David S;Cushman, Mary;Kumari, Meena;Wareham, Nick J;Verschuren, WM Monique;Redline, Susan;Patel, Sanjay R
BACKGROUND:Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the intended drug target. METHODS:We used...
Swerdlow, Daniel I;Preiss, David;Kuchenbaecker, Karoline B;Holmes, Michael V;Engmann, Jorgen E L;Shah, Tina;Sofat, Reecha;Stender, Stefan;Johnson, Paul C D;Scott, Robert A;Leusink, Maarten;Verweij, Niek;Sharp, Stephen J;Guo, Yiran;Giambartolomei, Claudia;Chung, Christina;Peasey, Anne;Amuzu, Antoinette;Li, KaWah;Palmen, Jutta;Howard, Philip;Cooper, Jackie A;Drenos, Fotios;Li, Yun R;Lowe, Gordon;Gallacher, John;Stewart, Marlene C W;Tzoulaki, Ioanna;Buxbaum, Sarah G;van der A, Daphne L;Forouhi, Nita G;Onland-Moret, N Charlotte;van der Schouw, Yvonne T;Schnabel, Renate B;Hubacek, Jaroslav A;Kubinova, Ruzena;Baceviciene, Migle;Tamosiunas, Abdonas;Pajak, Andrzej;Topor-Madry, Roman;Stepaniak, Urszula;Malyutina, Sofia;Baldassarre, Damiano;Sennblad, Bengt;Tremoli, Elena;de Faire, Ulf;Veglia, Fabrizio;Ford, Ian;Jukema, J Wouter;Westendorp, Rudi GJ;de Borst, Gert Jan;de Jong, Pim A;Algra, Ale;Spiering, Wilko;Maitland-van der Zee, Anke H;Klungel, Olaf H;de Boer, Anthonius;Doevendans, Pieter A;Eaton, Charles B;Robinson, Jennifer G;Duggan, David;Kjekshus, John;Downs, John R;Gotto, Antonio M;Keech, Anthony C;Marchioli, Roberto;Tognoni, Gianni;Sever, Peter S;Poulter, Neil R;Waters, David D;Pedersen, Terje R;Amarenco, Pierre;Nakamura, Haruo;McMurray, John J V;Lewsey, James D;Chasman, Daniel I;Ridker, Paul M;Maggioni, Aldo P;Tavazzi, Luigi;Ray, Kausik K;Seshasai, Sreenivasa Rao Kondapally;Manson, JoAnn E;Price, Jackie F;Whincup, Peter H;Morris, Richard W;Lawlor, Debbie A;Smith, George Davey;Ben-Shlomo, Yoav;Schreiner, Pamela J;Fornage, Myriam;Siscovick, David S;Cushman, Mary;Kumari, Meena;Wareham, Nick J;Verschuren, W M Monique;Redline, Susan;Patel, Sanjay R;Whittaker, John C;Hamsten, Anders;Delaney, Joseph A;Dale, Caroline;Gaunt, Tom R;Wong, Andrew;Kuh, Diana;Hardy, Rebecca;Kathiresan, Sekar;Castillo, Berta A;van der Harst, Pim;Brunner, Eric J;Tybjaerg-Hansen, Anne;Marmot, Michael G;Krauss, Ronald M;Tsai, Michael;Coresh, Josef;Hoogeveen, Ronald C;Psaty, Bruce M;Lange, Leslie A;Hakonarson, Hakon;Dudbridge, Frank;Humphries, Steve E;Talmud, Philippa J;Kivimäki, Mika;Timpson, Nicholas J;Langenberg, Claudia;Asselbergs, Folkert W;Voevoda, Mikhail;Bobak, Martin;Pikhart, Hynek;Wilson, James G;Reiner, Alex P;Keating, Brendan J;Hingorani, Aroon D;Sattar, Naveed
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Swerdlow, Daniel I;Preiss, David;Kuchenbaecker, Karoline B;Holmes, Michael V;Engmann, Jorgen E L;Shah, Tina;Sofat, Reecha;Stender, Stefan;Johnson, Paul C D;Scott, Robert A;Leusink, Maarten;Verweij, Niek;Sharp, Stephen J;Guo, Yiran;Giambartolomei, Claudia;Chung, Christina;Peasey, Anne;Amuzu, Antoinette;Li, KaWah;Palmen, Jutta;Howard, Philip;Cooper, Jackie A;Drenos, Fotios;Li, Yun R;Lowe, Gordon;Gallacher, John;Stewart, Marlene C W;Tzoulaki, Ioanna;Buxbaum, Sarah G;van der A, Daphne L;Forouhi, Nita G;Onland-Moret, N Charlotte;van der Schouw, Yvonne T;Schnabel, Renate B;Hubacek, Jaroslav A;Kubinova, Ruzena;Baceviciene, Migle;Tamosiunas, Abdonas;Pajak, Andrzej;Topor-Madry, Roman;Stepaniak, Urszula;Malyutina, Sofia;Baldassarre, Damiano;Sennblad, Bengt;Tremoli, Elena;de Faire, Ulf;Veglia, Fabrizio;Ford, Ian;Jukema, J Wouter;Westendorp, Rudi GJ;de Borst, Gert Jan;de Jong, Pim A;Algra, Ale;Spiering, Wilko;Maitland-van der Zee, Anke H;Klungel, Olaf H;de Boer, Anthonius;Doevendans, Pieter A;Eaton, Charles B;Robinson, Jennifer G;Duggan, David;Kjekshus, John;Downs, John R;Gotto, Antonio M;Keech, Anthony C;Marchioli, Roberto;Tognoni, Gianni;Sever, Peter S;Poulter, Neil R;Waters, David D;Pedersen, Terje R;Amarenco, Pierre;Nakamura, Haruo;McMurray, John J V;Lewsey, James D;Chasman, Daniel I;Ridker, Paul M;Maggioni, Aldo P;Tavazzi, Luigi;Ray, Kausik K;Seshasai, Sreenivasa Rao Kondapally;Manson, JoAnn E;Price, Jackie F;Whincup, Peter H;Morris, Richard W;Lawlor, Debbie A;Smith, George Davey;Ben-Shlomo, Yoav;Schreiner, Pamela J;Fornage, Myriam;Siscovick, David S;Cushman, Mary;Kumari, Meena;Wareham, Nick J;Verschuren, W M Monique;Redline, Susan;Patel, Sanjay R;Whittaker, John C;Hamsten, Anders;Delaney, Joseph A;Dale, Caroline;Gaunt, Tom R;Wong, Andrew;Kuh, Diana;Hardy, Rebecca;Kathiresan, Sekar;Castillo, Berta A;van der Harst, Pim;Brunner, Eric J;Tybjaerg-Hansen, Anne;Marmot, Michael G;Krauss, Ronald M;Tsai, Michael;Coresh, Josef;Hoogeveen, Ronald C;Psaty, Bruce M;Lange, Leslie A;Hakonarson, Hakon;Dudbridge, Frank;Humphries, Steve E;Talmud, Philippa J;Kivimäki, Mika;Timpson, Nicholas J;Langenberg, Claudia;Asselbergs, Folkert W;Voevoda, Mikhail;Bobak, Martin;Pikhart, Hynek;Wilson, James G;Reiner, Alex P;Keating, Brendan J;Hingorani, Aroon D;Sattar, Naveed
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Peden, John F.;Hopewell, Jemma C.;Saleheen, Danish;Chambers, John C.;Hager, Jorg;Soranzo, Nicole;Collins, Rory;Danesh, John;Elliott, Paul;Farrall, Martin;Stirrups, Kathy;Zhang, Weihua;Hamsten, Anders;Parish, Sarah;Lathrop, Mark;Watkins, Hugh;Clarke, Robert;Deloukas, Panos;Kooner, Jaspal S.;Goel, Anuj;Ongen, Halit;Strawbridge, Rona J.;Heath, Simon;Malarstig, Anders;Helgadottir, Anna;Ohrvik, John;Murtaza, Muhammed;Potter, Simon;Hunt, Sarah E.;Delepine, Marc;Jalilzadeh, Shapour;Axelsson, Tomas;Syvanen, Ann-Christine;Gwilliam, Rhian;Bumpstead, Suzannah;Gray, Emma;Edkins, Sarah;Folkersen, Lasse;Kyriakou, Theodosios;Franco-Cereceda, Anders;Gabrielsen, Anders;Seedorf, Udo;Eriksson, Per;Offer, Alison;Bowman, Louise;Sleight, Peter;Armitage, Jane;Peto, Richard;Abecasis, Goncalo;Ahmed, Nabeel;Caulfield, Mark;Donnelly, Peter;Froguel, Philippe;Kooner, Angad S.;McCarthy, Mark I.;Samani, Nilesh J.;Scott, James;Sehmi, Joban;Silveira, Angela;Hellenius, Mai-Lis;van;&;apos;t Hooft, Ferdinand M.;Olsson, Gunnar;Rust, Stephan;Assmann, Gerd;Barlera, Simona;Tognoni, Gianni;Franzosi, Maria Grazia;Linksted, Pamela;Green, Fiona R.;Rasheed, Asif;Zaidi, Moazzam;Shah, Nabi;Samuel, Maria;Mallick, Nadeem H.;Azhar, Muhammad;Zaman, Khan S.;Samad, Abdus;Ishaq, Mohammad;Gardezi, Ali R.;Memon, Fazal-ur-Rehman;Frossard, Philippe M.;Spector, Tim;Peltonen, Leena;Nieminen, Markku S.;Sinisalo, Juha;Salomaa, Veikko;Ripatti, Samuli;Bennett, Derrick;Leander, Karin;Gigante, Bruna;de Faire, Ulf;Pietri, Silvia;Gori, Francesca;Marchioli, Roberto;Sivapalaratnam, Suthesh;Kastelein, John J. P.;Trip, Mieke D.;Theodoraki, Eirini V.;Dedoussis, George V.;Engert, Jamie C.;Yusuf, Salim;Anand, Sonia S.
Genome-wide association studies have identified 11 common variants convincingly associated with coronary artery disease (CAD)(1-7), a modest number considering the apparent heritability of CAD(8). All of these variants have been discovered in Europea...
Aims The effect of statins on risk of heart failure (HF) hospitalization and HF death remains uncertain. We aimed to establish whether statins reduce major HF events. Methods and results We searched Medline, EMBASE, and the Cochrane Central Register ...
Swerdlow, Daniel I;Preiss, David;Kuchenbaecker, Karoline B;Holmes, Michael V;Engmann, Jorgen E L;Shah, Tina;Sofat, Reecha;Stender, Stefan;Johnson, Paul C D;Scott, Robert A;Leusink, Maarten;Verweij, Niek;Sharp, Stephen J;Guo, Yiran;Giambartolomei, Claudia;Chung, Christina;Peasey, Anne;Amuzu, Antoinette;Li, KaWah;Palmen, Jutta;Howard, Philip;Cooper, Jackie A;Drenos, Fotios;Li, Yun R;Lowe, Gordon;Gallacher, John;Stewart, Marlene C W;Tzoulaki, Ioanna;Buxbaum, Sarah G;van der A, Daphne L;Forouhi, Nita G;Onland-Moret, N Charlotte;van der Schouw, Yvonne T;Schnabel, Renate B;Hubacek, Jaroslav A;Kubinova, Ruzena;Baceviciene, Migle;Tamosiunas, Abdonas;Pajak, Andrzej;Topor-Madry, Roman;Stepaniak, Urszula;Malyutina, Sofia;Baldassarre, Damiano;Sennblad, Bengt;Tremoli, Elena;de Faire, Ulf;Veglia, Fabrizio;Ford, Ian;Jukema, J Wouter;Westendorp, Rudi GJ;de Borst, Gert Jan;de Jong, Pim A;Algra, Ale;Spiering, Wilko;Maitland-van der Zee, Anke H;Klungel, Olaf H;de Boer, Anthonius;Doevendans, Pieter A;Eaton, Charles B;Robinson, Jennifer G;Duggan, David;Kjekshus, John;Downs, John R;Gotto, Antonio M;Keech, Anthony C;Marchioli, Roberto;Tognoni, Gianni;Sever, Peter S;Poulter, Neil R;Waters, David D;Pedersen, Terje R;Amarenco, Pierre;Nakamura, Haruo;McMurray, John J V;Lewsey, James D;Chasman, Daniel I;Ridker, Paul M;Maggioni, Aldo P;Tavazzi, Luigi;Ray, Kausik K;Seshasai, Sreenivasa Rao Kondapally;Manson, JoAnn E;Price, Jackie F;Whincup, Peter H;Morris, Richard W;Lawlor, Debbie A;Smith, George Davey;Ben-Shlomo, Yoav;Schreiner, Pamela J;Fornage, Myriam;Siscovick, David S;Cushman, Mary;Kumari, Meena;Wareham, Nick J;Verschuren, W M Monique;Redline, Susan;Patel, Sanjay R;Whittaker, John C;Hamsten, Anders;Delaney, Joseph A;Dale, Caroline;Gaunt, Tom R;Wong, Andrew;Kuh, Diana;Hardy, Rebecca;Kathiresan, Sekar;Castillo, Berta A;van der Harst, Pim;Brunner, Eric J;Tybjaerg-Hansen, Anne;Marmot, Michael G;Krauss, Ronald M;Tsai, Michael;Coresh, Josef;Hoogeveen, Ronald C;Psaty, Bruce M;Lange, Leslie A;Hakonarson, Hakon;Dudbridge, Frank;Humphries, Steve E;Talmud, Philippa J;Kivimäki, Mika;Timpson, Nicholas J;Langenberg, Claudia;Asselbergs, Folkert W;Voevoda, Mikhail;Bobak, Martin;Pikhart, Hynek;Wilson, James G;Reiner, Alex P;Keating, Brendan J;Hingorani, Aroon D;Sattar, Naveed
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Swerdlow, Daniel I;Preiss, David;Kuchenbaecker, Karoline B;Holmes, Michael V;Engmann, Jorgen E L;Shah, Tina;Sofat, Reecha;Stender, Stefan;Johnson, Paul C D;Scott, Robert A;Leusink, Maarten;Verweij, Niek;Sharp, Stephen J;Guo, Yiran;Giambartolomei, Claudia;Chung, Christina;Peasey, Anne;Amuzu, Antoinette;Li, KaWah;Palmen, Jutta;Howard, Philip;Cooper, Jackie A;Drenos, Fotios;Li, Yun R;Lowe, Gordon;Gallacher, John;Stewart, Marlene C W;Tzoulaki, Ioanna;Buxbaum, Sarah G;van der A, Daphne L;Forouhi, Nita G;Onland-Moret, N Charlotte;van der Schouw, Yvonne T;Schnabel, Renate B;Hubacek, Jaroslav A;Kubinova, Ruzena;Baceviciene, Migle;Tamosiunas, Abdonas;Pajak, Andrzej;Topor-Madry, Roman;Stepaniak, Urszula;Malyutina, Sofia;Baldassarre, Damiano;Sennblad, Bengt;Tremoli, Elena;de Faire, Ulf;Veglia, Fabrizio;Ford, Ian;Jukema, J Wouter;Westendorp, Rudi GJ;de Borst, Gert Jan;de Jong, Pim A;Algra, Ale;Spiering, Wilko;Maitland-van der Zee, Anke H;Klungel, Olaf H;de Boer, Anthonius;Doevendans, Pieter A;Eaton, Charles B;Robinson, Jennifer G;Duggan, David;Kjekshus, John;Downs, John R;Gotto, Antonio M;Keech, Anthony C;Marchioli, Roberto;Tognoni, Gianni;Sever, Peter S;Poulter, Neil R;Waters, David D;Pedersen, Terje R;Amarenco, Pierre;Nakamura, Haruo;McMurray, John J V;Lewsey, James D;Chasman, Daniel I;Ridker, Paul M;Maggioni, Aldo P;Tavazzi, Luigi;Ray, Kausik K;Seshasai, Sreenivasa Rao Kondapally;Manson, JoAnn E;Price, Jackie F;Whincup, Peter H;Morris, Richard W;Lawlor, Debbie A;Smith, George Davey;Ben-Shlomo, Yoav;Schreiner, Pamela J;Fornage, Myriam;Siscovick, David S;Cushman, Mary;Kumari, Meena;Wareham, Nick J;Verschuren, W M Monique;Redline, Susan;Patel, Sanjay R;Whittaker, John C;Hamsten, Anders;Delaney, Joseph A;Dale, Caroline;Gaunt, Tom R;Wong, Andrew;Kuh, Diana;Hardy, Rebecca;Kathiresan, Sekar;Castillo, Berta A;van der Harst, Pim;Brunner, Eric J;Tybjaerg-Hansen, Anne;Marmot, Michael G;Krauss, Ronald M;Tsai, Michael;Coresh, Josef;Hoogeveen, Ronald C;Psaty, Bruce M;Lange, Leslie A;Hakonarson, Hakon;Dudbridge, Frank;Humphries, Steve E;Talmud, Philippa J;Kivimäki, Mika;Timpson, Nicholas J;Langenberg, Claudia;Asselbergs, Folkert W;Voevoda, Mikhail;Bobak, Martin;Pikhart, Hynek;Wilson, James G;Reiner, Alex P;Keating, Brendan J;Hingorani, Aroon D;Sattar, Naveed
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Aims The effect of statins on risk of heart failure (HF) hospitalization and HF death remains uncertain. We aimed to establish whether statins reduce major HF events. Methods and results We searched Medline, EMBASE, and the Cochrane Central Register ...