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Cichlid fishes are famous for large, diverse and replicated adaptive radiations in the Great Lakes of East Africa. To understand the molecular mechanisms underlying cichlid phenotypic diversity, we sequenced the genomes and transcriptomes of five lin...
Global studies of transcript structure and abundance in cancer cells enable the systematic discovery of aberrations that contribute to carcinogenesis, including gene fusions, alternative splice isoforms, and somatic mutations. We developed a systemat...
Exceptionally accurate genome reference sequences have proven to be of great value to microbial researchers. Thus, to date, about 1800 bacterial genome assemblies have been “finished” at great expense with the aid of manual laboratory and computation...
Eliminating the bacterial cloning step has been a major factor in the vastly improved efficiency of massively parallel sequencing approaches. However, this also has made it a technical challenge to produce the modern equivalent of the Fosmid- or BAC-...
Low-cost short read sequencing technology has revolutionized genomics, though it is only just becoming practical for the high-quality de novo assembly of a novel large genome. We describe the Assemblathon 1 competition, which aimed to comprehensively...
Cichlid fishes are famous for large, diverse and replicated adaptive radiations in the Great Lakes of East Africa. To understand the molecular mechanisms underlying cichlid phenotypic diversity, we sequenced the genomes and transcriptomes of five lin...
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Amemiya, Chris T;Alföldi, Jessica;Lee, Alison P;Fan, Shaohua;Philippe, Hervé;Maccallum, Iain;Braasch, Ingo;Manousaki, Tereza;Schneider, Igor;Rohner, Nicolas;Organ, Chris;Chalopin, Domitille;Smith, Jeramiah J;Robinson, Mark;Dorrington, Rosemary A;Gerdol, Marco;Aken, Bronwen;Biscotti, Maria Assunta;Barucca, Marco;Baurain, Denis;Berlin, Aaron M;Blatch, Gregory L;Buonocore, Francesco;Burmester, Thorsten;Campbell, Michael S;Canapa, Adriana;Cannon, John P;Christoffels, Alan;De Moro, Gianluca;Edkins, Adrienne L;Fan, Lin;Fausto, Anna Maria;Feiner, Nathalie;Forconi, Mariko;Gamieldien, Junaid;Gnerre, Sante;Gnirke, Andreas;Goldstone, Jared V;Haerty, Wilfried;Hahn, Mark E;Hesse, Uljana;Hoffmann, Steve;Johnson, Jeremy;Karchner, Sibel I;Kuraku, Shigehiro;Lara, Marcia;Levin, Joshua Z;Litman, Gary W;Mauceli, Evan;Miyake, Tsutomu;Mueller, M Gail;Nelson, David R;Nitsche, Anne;Olmo, Ettore;Ota, Tatsuya;Pallavicini, Alberto;Panji, Sumir;Picone, Barbara;Ponting, Chris P;Prohaska, Sonja J;Przybylski, Dariusz;Saha, Nil Ratan;Ravi, Vydianathan;Ribeiro, Filipe J;Sauka-Spengler, Tatjana;Scapigliati, Giuseppe;Searle, Stephen M J;Sharpe, Ted;Simakov, Oleg;Stadler, Peter F;Stegeman, John J;Sumiyama, Kenta;Tabbaa, Diana;Tafer, Hakim;Turner-Maier, Jason;van Heusden, Peter;White, Simon;Williams, Louise;Yandell, Mark;Brinkmann, Henner;Volff, Jean-Nicolas;Tabin, Clifford J;Shubin, Neil;Schartl, Manfred;Jaffe, David B;Postlethwait, John H;Venkatesh, Byrappa;Di Palma, Federica;Lander, Eric S;Meyer, Axel;Lindblad-Toh, Kerstin
The discovery of a living coelacanth specimen in 1938 was remarkable, as this lineage of lobe-finned fish was thought to have become extinct 70 million years ago. The modern coelacanth looks remarkably similar to many of its ancient relatives, and it...
Although genetic lesions responsible for some mendelian disorders can be rapidly discovered through massively parallel sequencing of whole genomes or exomes, not all diseases readily yield to such efforts. We describe the illustrative case of the sim...
Cichlid fishes are famous for large, diverse and replicated adaptive radiations in the Great Lakes of East Africa. To understand the molecular mechanisms underlying cichlid phenotypic diversity, we sequenced the genomes and transcriptomes of five lin...