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Title
Genome-wide association studies (GWAS) have transformed our understanding of susceptibility to multiple myeloma (MM), but much of the heritability remains unexplained. We report a new GWAS, a meta-analysis with previous GWAS and a replication series,...
Arking, Dan E;Pulit, Sara L;Crotti, Lia;van der Harst, Pim;Munroe, Patricia B;Koopmann, Tamara T;Sotoodehnia, Nona;Rossin, Elizabeth J;Morley, Michael;Wang, Xinchen;Johnson, Andrew D;Lundby, Alicia;Gudbjartsson, Daníel F;Noseworthy, Peter A;Eijgelsheim, Mark;Bradford, Yuki;Tarasov, Kirill V;Dörr, Marcus;Müller-Nurasyid, Martina;Lahtinen, Annukka M;Nolte, Ilja M;Smith, Albert Vernon;Bis, Joshua C;Isaacs, Aaron;Newhouse, Stephen J;Evans, Daniel S;Post, Wendy S;Waggott, Daryl;Lyytikäinen, Leo-Pekka;Hicks, Andrew A;Eisele, Lewin;Ellinghaus, David;Hayward, Caroline;Navarro, Pau;Ulivi, Sheila;Tanaka, Toshiko;Tester, David J;Chatel, Stéphanie;Gustafsson, Stefan;Kumari, Meena;Morris, Richard W;Naluai, Asa T;Padmanabhan, Sandosh;Kluttig, Alexander;Strohmer, Bernhard;Panayiotou, Andrie G;Torres, Maria;Knoflach, Michael;Hubacek, Jaroslav A;Slowikowski, Kamil;Raychaudhuri, Soumya;Kumar, Runjun D;Harris, Tamara B;Launer, Lenore J;Shuldiner, Alan R;Alonso, Alvaro;Bader, Joel S;Ehret, Georg;Huang, Hailiang;Kao, W H Linda;Strait, James B;Macfarlane, Peter W;Brown, Morris;Caulfield, Mark J;Samani, Nilesh J;Kronenberg, Florian;Willeit, Johann;Smith, Gustav;Greiser, Karin H;Meyer Zu Schwabedissen, Henriette;Werdan, Karl;Carella, Massimo;Zelante, Leopoldo;Heckbert, Susan R;Psaty, Bruce M;Rotter, Jerome I;Kolcic, Ivana;Polašek, Ozren;Wright, Alan F;Griffin, Maura;Daly, Mark J;Arnar, David O;Hólm, Hilma;Thorsteinsdottir, Unnur;Denny, Joshua C;Roden, Dan M;Zuvich, Rebecca L;Emilsson, Valur;Plump, Andrew S;Larson, Martin G;O'Donnell, Christopher J;Yin, Xiaoyan;Bobbo, Marco;D'Adamo, Adamo P;Iorio, Annamaria;Sinagra, Gianfranco;Carracedo, Angel;Cummings, Steven R;Nalls, Michael A;Jula, Antti;Kontula, Kimmo K;Marjamaa, Annukka;Oikarinen, Lasse;Perola, Markus;Porthan, Kimmo;Erbel, Raimund;Hoffmann, Per;Jöckel, Karl-Heinz;Kälsch, Hagen;Nöthen, Markus M;den Hoed, Marcel;Loos, Ruth J F;Thelle, Dag S;Gieger, Christian;Meitinger, Thomas;Perz, Siegfried;Peters, Annette;Prucha, Hanna;Sinner, Moritz F;Waldenberger, Melanie;de Boer, Rudolf A;Franke, Lude;van der Vleuten, Pieter A;Beckmann, Britt Maria;Martens, Eimo;Bardai, Abdennasser;Hofman, Nynke;Wilde, Arthur A M;Behr, Elijah R;Dalageorgou, Chrysoula;Giudicessi, John R;Medeiros-Domingo, Argelia;Barc, Julien;Kyndt, Florence;Probst, Vincent;Ghidoni, Alice;Insolia, Roberto;Hamilton, Robert M;Scherer, Stephen W;Brandimarto, Jeffrey;Margulies, Kenneth;Moravec, Christine E;Fabiola, NN;Fuchsberger, Christian;O'Connell, Jeffrey R;Lee, Wai K;Watt, Graham C M;Campbell, Harry;Wild, Sarah H;El Mokhtari, Nour E;Frey, Norbert;Asselbergs, Folkert W;Leach, Irene Mateo;Navis, Gerjan;van den Berg, Maarten P;van Veldhuisen, Dirk J;Kellis, Manolis;Krijthe, Bouwe P;Franco, Oscar H;Hofman, Albert;Kors, Jan A;Uitterlinden, André G;Witteman, Jacqueline C M;Kedenko, Lyudmyla;Lamina, Claudia;Oostra, Ben A;Abecasis, Gonçalo R;Lakatta, Edward G;Mulas, Antonella;Orrú, Marco;Schlessinger, David;Uda, Manuela;Markus, Marcello R P;Völker, Uwe;Snieder, Harold;Spector, Timothy D;Arnlöv, Johan;Lind, Lars;Sundström, Johan;Syvänen, Ann-Christine;Kivimaki, Mika;Kähönen, Mika;Mononen, Nina;Raitakari, Olli T;Viikari, Jorma S;Adamkova, Vera;Kiechl, Stefan;Brion, Maria;Nicolaides, Andrew N;Paulweber, Bernhard;Haerting, Johannes;Dominiczak, Anna F;Nyberg, Fredrik;Whincup, Peter H;Hingorani, Aroon D;Schott, Jean-Jacques;Bezzina, Connie R;Ingelsson, Erik;Ferrucci, Luigi;Gasparini, Paolo;Wilson, James F;Rudan, Igor;Franke, Andre;Mühleisen, Thomas W;Pramstaller, Peter P;Lehtimäki, Terho J;Paterson, Andrew D;Parsa, Afshin;Liu, Yongmei;van Duijn, Cornelia M;Siscovick, David S;Gudnason, Vilmundur;Jamshidi, Yalda;Salomaa, Veikko;Felix, Stephan B;Sanna, Serena;Ritchie, Marylyn D;Stricker, Bruno H;Stefansson, Kari;Boyer, Laurie A;Cappola, Thomas P;Olsen, Jesper V;Lage, Kasper;Schwartz, Peter J;Kääb, Stefan;Chakravarti, Aravinda;Ackerman, Michael J;Pfeufer, Arne;de Bakker, Paul I W;Newton-Cheh, Christopher
The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentiall...
OBJECTIVES: To identify germ line variants contributing to the development of monoclonal gammopathy of undetermined significance (MGUS), an asymptomatic premalignant precursor for multiple myeloma (MM).METHODS: We conducted the first genomewide assoc...
Several susceptibility loci for classical Hodgkin lymphoma have been reported. However, much of the heritable risk is unknown. Here, we perform a meta-analysis of two existing genome-wide association studies, a new genome-wide association study, and ...
To identify risk variants for multiple myeloma, we conducted a genome-wide association study of 1,675 individuals with multiple myeloma and 5,903 control subjects. We identified risk loci for multiple myeloma at 3p22.1 (rs1052501 in ULK4; odds ratio ...
Genome-wide association studies (GWAS) have provided strong evidence for inherited predisposition to childhood acute lymphoblastic leukaemia (ALL) identifying a number of risk loci. We have previously shown common SNPs at 9p21.3 influence ALL risk. T...
Stitziel, Nathan O.;Stirrups, Kathleen E.;Masca, Nicholas G D;Erdmann, Jeanette;Ferrario, Paola G.;König, Inke R.;Weeke, Peter E.;Webb, Thomas R.;Auer, Paul L.;Schick, Ursula M.;Lu, Yingchang;Zhang, He;Dube, Marie Pierre;Goel, Anuj;Farrall, Martin;Peloso, Gina M.;Won, Hong Hee;Do, Ron;Van Iperen, Erik;Kanoni, Stavroula;Kruppa, Jochen;Mahajan, Anubha;Scott, Robert A.;Willenborg, Christina;Braund, Peter S.;Van Capelleveen, Julian C.;Doney, Alex S F;Donnelly, Louise A.;Asselta, Rosanna;Merlini, Piera A.;Duga, Stefano;Marziliano, Nicola;Denny, Josh C.;Shaffer, Christian M.;El-Mokhtari, Nour Eddine;Franke, Andre;Gottesman, Omri;Heilmann, Stefanie;Hengstenberg, Christian;Hoffmann, Per;Holmen, Oddgeir L.;Hveem, Kristian;Jansson, Jan Håkan;Jöckel, Karl Heinz;Kessler, Thorsten;Kriebel, Jennifer;Laugwitz, Karl L.;Marouli, Eirini;Martinelli, Nicola;McCarthy, Mark I.;Van Zuydam, Natalie R.;Meisinger, Christa;Esko, Tõnu;Mihailov, Evelin;Escher, Stefan A.;Alver, Maris;Moebus, Susanne;Morris, Andrew D.;Müller-Nurasyid, Martina;Nikpay, Majid;Olivieri, Oliviero;Perreault, Louis Philippe Lemieux;AlQarawi, Alaa;Robertson, Neil R.;Akinsanya, Karen O.;Reilly, Dermot F.;Vogt, Thomas F.;Yin, Wu;Asselbergs, Folkert W.;Kooperberg, Charles;Jackson, Rebecca D.;Stahl, Eli;Strauch, Konstantin;Varga, Tibor V.;Waldenberger, Melanie;Zeng, Lingyao;Kraja, Aldi T.;Liu, Chunyu;Ehret, Georg B.;Newton-Cheh, Christopher;Chasman, Daniel I.;Chowdhury, Rajiv;Ferrario, Marco;Ford, Ian;Jukema, J. Wouter;Kee, Frank;Kuulasmaa, Kari;Nordestgaard, Børge G.;Perola, Markus;Saleheen, Danish;Sattar, Naveed;Surendran, Praveen;Tregouet, David;Young, Robin;Howson, Joanna M M;Butterworth, Adam S.;Danesh, John;Ardissino, Diego;Bottinger, Erwin P.;Erbel, Raimund;Franks, Paul W.;Girelli, Domenico;Hall, Alistair S.;Hovingh, G. Kees;Kastrati, Adnan;Lieb, Wolfgang;Meitinger, Thomas;Kraus, William E.;Shah, Svati H.;McPherson, Ruth;Orho-Melander, Marju;Melander, Olle;Metspalu, Andres;Palmer, Colin N A;Peters, Annette;Rader, Daniel J.;Reilly, Muredach P.;Loos, Ruth J F;Reiner, Alex P.;Roden, Dan M.;Tardif, Jean Claude;Thompson, John R.;Wareham, Nicholas J.;Watkins, Hugh;Willer, Cristen J.;Kathiresan, Sekar;Deloukas, Panos;Samani, Nilesh J.;Schunkert, Heribert
BACKGROUND: The discovery of low-frequency coding variants affecting the risk of coronary artery disease has facilitated the identification of therapeutic targets. METHODS: Through DNA genotyping, we tested 54,003 coding-sequence variants covering 13...
To further our understanding of inherited susceptibility to Hodgkin lymphoma (HL), we performed a meta-analysis of seven genome-wide association studies totalling 5,325 HL cases and 22,423 controls. We identify five new HL risk loci at 6p21.31 (rs649...
Chromosomal aberrations (CAs) in human peripheral blood lymphocytes (PBL) measured with the conventional cytogenetic assay have been used for human biomonitoring of genotoxic exposure for decades. CA frequency in peripheral blood is a marker of cance...