Liu, X;Speranza, E;Muñoz-Fontela, C;Haldenby, S;Rickett, N;Garcia-Dorival, I;Fang, Y;Hall, Y;Zekeng, E;Lüdtke, A;Xia, D;Kerber, R;Krumkamp, R;Duraffour, S;Sissoko, D;Kenny, J;Rockliffe, N;Williamson, D;Laws, T;N’Faly, M;Matthews, D;Günther, S;Cossins, A;Sprecher, A;Connor, J;Carroll, M;Hiscox, J Background In 2014, Western Africa experienced an unanticipated explosion of Ebola virus infections. What distinguishes fatal from non-fatal outcomes remains largely unknown, yet is key to optimising personalised treatment strategies. We used transcr...
King, KC;Brockhurst, MA;Vasieva, O;Paterson, S;Betts, A;Ford, SA;Frost, CL;Horsburgh, MJ;Haldenby, S;Hurst, GDD Microbes can defend their host against virulent infections, but direct evidence for the adaptive origin of microbe-mediated protection is lacking. Using experimental evolution of a novel, tripartite interaction, we demonstrate that mildly pathogenic ...
Temperate phages drive genomic diversification in bacterial pathogens. Phage-derived sequences are more common in pathogenic than nonpathogenic taxa and are associated with changes in pathogen virulence. High abundance and mobilization of temperate p...
Carr, DF;Bourgeois, S;Chaponda, M;Takeshita, L;Morris, A;Cornejo Castro, EM;Alfirevic, A;Jones, AR;Rigden, DJ;Haldenby, S;Khoo, S;Lalloo, DG;Heyderman, RS;Dandara, C;Kampira, E;van Oosterhout, JJ;Ssali, F;Munderi, P;Novelli, G;Borgiani, P;Nelson, MR;Holden, A;Deloukas, P;Pirmohamed, M Background: The antiretroviral nevirapine is associated with hypersensitivity reactions in 6%–10% of patients, including hepatotoxicity, maculopapular exanthema, Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Objectives: To unde...
Liu, X;Speranza, E;Muñoz-Fontela, C;Haldenby, S;Rickett, N;Garcia-Dorival, I;Fang, Y;Hall, Y;Zekeng, E;Lüdtke, A;Xia, D;Kerber, R;Krumkamp, R;Duraffour, S;Sissoko, D;Kenny, J;Rockliffe, N;Williamson, D;Laws, T;N’Faly, M;Matthews, D;Günther, S;Cossins, A;Sprecher, A;Connor, J;Carroll, M;Hiscox, J Background In 2014, Western Africa experienced an unanticipated explosion of Ebola virus infections. What distinguishes fatal from non-fatal outcomes remains largely unknown, yet is key to optimising personalised treatment strategies. We used transcr...
Temperate phages drive genomic diversification in bacterial pathogens. Phage-derived sequences are more common in pathogenic than nonpathogenic taxa and are associated with changes in pathogen virulence. High abundance and mobilization of temperate p...
King, KC;Brockhurst, MA;Vasieva, O;Paterson, S;Betts, A;Ford, SA;Frost, CL;Horsburgh, MJ;Haldenby, S;Hurst, GDD Microbes can defend their host against virulent infections, but direct evidence for the adaptive origin of microbe-mediated protection is lacking. Using experimental evolution of a novel, tripartite interaction, we demonstrate that mildly pathogenic ...
Jones, N;Millman, C;van der Es, M;Hukelova, M;Forbes, K;Glover, C;Haldenby, S;Hunter, P;Jackson, K;O'Brien, SJ;Rigby, D;Strachan, N;Williams, NJ;Lake, I This paper introduces a novel method for sampling pathogens in natural environments. It uses fabric boot socks worn over walkers’ shoes allowing collection of composite samples over large areas. Wide area sampling is better suited to studies focussin...
Carr, DF;Bourgeois, S;Chaponda, M;Takeshita, L;Morris, A;Cornejo Castro, EM;Alfirevic, A;Jones, AR;Rigden, DJ;Haldenby, S;Khoo, S;Lalloo, DG;Heyderman, RS;Dandara, C;Kampira, E;van Oosterhout, JJ;Ssali, F;Munderi, P;Novelli, G;Borgiani, P;Nelson, MR;Holden, A;Deloukas, P;Pirmohamed, M Background: The antiretroviral nevirapine is associated with hypersensitivity reactions in 6%–10% of patients, including hepatotoxicity, maculopapular exanthema, Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Objectives: To unde...
Liu, X;Speranza, E;Muñoz-Fontela, C;Haldenby, S;Rickett, N;Garcia-Dorival, I;Fang, Y;Hall, Y;Zekeng, E;Lüdtke, A;Xia, D;Kerber, R;Krumkamp, R;Duraffour, S;Sissoko, D;Kenny, J;Rockliffe, N;Williamson, D;Laws, T;N’Faly, M;Matthews, D;Günther, S;Cossins, A;Sprecher, A;Connor, J;Carroll, M;Hiscox, J Background In 2014, Western Africa experienced an unanticipated explosion of Ebola virus infections. What distinguishes fatal from non-fatal outcomes remains largely unknown, yet is key to optimising personalised treatment strategies. We used transcr...
