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Abstract Background Increasing use of zebrafish in drug discovery and mechanistic toxicology demands knowledge of cytochrome P450 (CYP) gene regulation and function. CYP enzymes catalyze oxidative transformation leading to activation or inactivation ...
Amemiya, Chris T;Alföldi, Jessica;Lee, Alison P;Fan, Shaohua;Philippe, Hervé;Maccallum, Iain;Braasch, Ingo;Manousaki, Tereza;Schneider, Igor;Rohner, Nicolas;Organ, Chris;Chalopin, Domitille;Smith, Jeramiah J;Robinson, Mark;Dorrington, Rosemary A;Gerdol, Marco;Aken, Bronwen;Biscotti, Maria Assunta;Barucca, Marco;Baurain, Denis;Berlin, Aaron M;Blatch, Gregory L;Buonocore, Francesco;Burmester, Thorsten;Campbell, Michael S;Canapa, Adriana;Cannon, John P;Christoffels, Alan;De Moro, Gianluca;Edkins, Adrienne L;Fan, Lin;Fausto, Anna Maria;Feiner, Nathalie;Forconi, Mariko;Gamieldien, Junaid;Gnerre, Sante;Gnirke, Andreas;Goldstone, Jared V;Haerty, Wilfried;Hahn, Mark E;Hesse, Uljana;Hoffmann, Steve;Johnson, Jeremy;Karchner, Sibel I;Kuraku, Shigehiro;Lara, Marcia;Levin, Joshua Z;Litman, Gary W;Mauceli, Evan;Miyake, Tsutomu;Mueller, M Gail;Nelson, David R;Nitsche, Anne;Olmo, Ettore;Ota, Tatsuya;Pallavicini, Alberto;Panji, Sumir;Picone, Barbara;Ponting, Chris P;Prohaska, Sonja J;Przybylski, Dariusz;Saha, Nil Ratan;Ravi, Vydianathan;Ribeiro, Filipe J;Sauka-Spengler, Tatjana;Scapigliati, Giuseppe;Searle, Stephen M J;Sharpe, Ted;Simakov, Oleg;Stadler, Peter F;Stegeman, John J;Sumiyama, Kenta;Tabbaa, Diana;Tafer, Hakim;Turner-Maier, Jason;van Heusden, Peter;White, Simon;Williams, Louise;Yandell, Mark;Brinkmann, Henner;Volff, Jean-Nicolas;Tabin, Clifford J;Shubin, Neil;Schartl, Manfred;Jaffe, David B;Postlethwait, John H;Venkatesh, Byrappa;Di Palma, Federica;Lander, Eric S;Meyer, Axel;Lindblad-Toh, Kerstin
The discovery of a living coelacanth specimen in 1938 was remarkable, as this lineage of lobe-finned fish was thought to have become extinct 70 million years ago. The modern coelacanth looks remarkably similar to many of its ancient relatives, and it...
Background: Zebrafish express five cytochrome P450 1 genes: CYP1A, CYP1B1, CYP1C1, CYP1C2, inducible by aryl hydrocarbon receptor agonists, and CYP1D1, a constitutively expressed CYP1A-like gene. We examined substrate selectivity of CYP1s expressed i...
Background: Zebrafish express five cytochrome P450 1 genes: CYP1A, CYP1B1, CYP1C1, CYP1C2, inducible by aryl hydrocarbon receptor agonists, and CYP1D1, a constitutively expressed CYP1A-like gene. We examined substrate selectivity of CYP1s expressed i...
Background: Zebrafish express five cytochrome P450 1 genes: CYP1A, CYP1B1, CYP1C1, CYP1C2, inducible by aryl hydrocarbon receptor agonists, and CYP1D1, a constitutively expressed CYP1A-like gene. We examined substrate selectivity of CYP1s expressed i...
Background: Zebrafish express five cytochrome P450 1 genes: CYP1A, CYP1B1, CYP1C1, CYP1C2, inducible by aryl hydrocarbon receptor agonists, and CYP1D1, a constitutively expressed CYP1A-like gene. We examined substrate selectivity of CYP1s expressed i...
Background: Zebrafish express five cytochrome P450 1 genes: CYP1A, CYP1B1, CYP1C1, CYP1C2, inducible by aryl hydrocarbon receptor agonists, and CYP1D1, a constitutively expressed CYP1A-like gene. We examined substrate selectivity of CYP1s expressed i...
Background: Zebrafish express five cytochrome P450 1 genes: CYP1A, CYP1B1, CYP1C1, CYP1C2, inducible by aryl hydrocarbon receptor agonists, and CYP1D1, a constitutively expressed CYP1A-like gene. We examined substrate selectivity of CYP1s expressed i...
Background: Zebrafish express five cytochrome P450 1 genes: CYP1A, CYP1B1, CYP1C1, CYP1C2, inducible by aryl hydrocarbon receptor agonists, and CYP1D1, a constitutively expressed CYP1A-like gene. We examined substrate selectivity of CYP1s expressed i...
Background: Zebrafish express five cytochrome P450 1 genes: CYP1A, CYP1B1, CYP1C1, CYP1C2, inducible by aryl hydrocarbon receptor agonists, and CYP1D1, a constitutively expressed CYP1A-like gene. We examined substrate selectivity of CYP1s expressed i...