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Oil palm is the most productive oil-bearing crop. Although it is planted on only 5% of the total world vegetable oil acreage, palm oil accounts for 33% of vegetable oil and 45% of edible oil worldwide, but increased cultivation competes with dwindlin...
Despite the success of genome-wide association studies (GWAS) in detecting a large number of loci for complex phenotypes such as rheumatoid arthritis (RA) susceptibility, the lack of information on the causal genes leaves important challenges to inte...
The human X and Y chromosomes evolved from an ordinary pair of autosomes, but millions of years ago genetic decay ravaged the Y chromosome, and only three per cent of its ancestral genes survived. We reconstructed the evolution of the Y chromosome ac...
Ross, Mark T;Grafham, Darren V;Coffey, Alison J;Scherer, Steven;McLay, Kirsten;Muzny, Donna;Platzer, Matthias;Howell, Gareth R;Burrows, Christine;Bird, Christine P;Frankish, Adam;Lovell, Frances L;Howe, Kevin L;Ashurst, Jennifer L;Fulton, Robert S;Sudbrak, Ralf;Wen, Gaiping;Jones, Matthew C;Hurles, Matthew E;Andrews, T Daniel;Scott, Carol E;Searle, Stephen;Ramser, Juliane;Whittaker, Adam;Deadman, Rebecca;Carter, Nigel P;Hunt, Sarah E;Chen, Rui;Cree, Andrew;Gunaratne, Preethi;Havlak, Paul;Hodgson, Anne;Metzker, Michael L;Richards, Stephen;Scott, Graham;Steffen, David;Sodergren, Erica;Wheeler, David A;Worley, Kim C;Ainscough, Rachael;Ambrose, Kerrie D;Ansari-Lari, M Ali;Aradhya, Swaroop;Ashwell, Robert I S;Babbage, Anne K;Bagguley, Claire L;Ballabio, Andrea;Banerjee, Ruby;Barker, Gary E;Barlow, Karen F;Barrett, Ian P;Bates, Karen N;Beare, David M;Beasley, Helen;Beasley, Oliver;Beck, Alfred;Bethel, Graeme;Blechschmidt, Karin;Brady, Nicola;Bray-Allen, Sarah;Bridgeman, Anne M;Brown, Andrew J;Brown, Mary J;Bonnin, David;Bruford, Elspeth A;Buhay, Christian;Burch, Paula;Burford, Deborah;Burgess, Joanne;Burrill, Wayne;Burton, John;Bye, Jackie M;Carder, Carol;Carrel, Laura;Chako, Joseph;Chapman, Joanne C;Chavez, Dean;Chen, Ellson;Chen, Guan;Chen, Yuan;Chen, Zhijian;Chinault, Craig;Ciccodicola, Alfredo;Clark, Sue Y;Clarke, Graham;Clee, Chris M;Clegg, Sheila;Clerc-Blankenburg, Kerstin;Clifford, Karen;Cobley, Vicky;Cole, Charlotte G;Conquer, Jen S;Corby, Nicole;Connor, Richard E;David, Robert;Davies, Joy;Davis, Clay;Davis, John;Delgado, Oliver;Deshazo, Denise;Dhami, Pawandeep;Ding, Yan;Dinh, Huyen;Dodsworth, Steve;Draper, Heather;Dugan-Rocha, Shannon;Dunham, Andrew;Dunn, Matthew;Durbin, K James;Dutta, Ireena;Eades, Tamsin;Ellwood, Matthew;Emery-Cohen, Alexandra;Errington, Helen;Evans, Kathryn L;Faulkner, Louisa;Francis, Fiona;Frankland, John;Fraser, Audrey E;Galgoczy, Petra;Gilbert, James;Gill, Rachel;Glöckner, Gernot;Gregory, Simon G;Gribble, Susan;Griffiths, Coline;Grocock, Russell;Gu, Yanghong;Gwilliam, Rhian;Hamilton, Cerissa;Hart, Elizabeth A;Hawes, Alicia;Heath, Paul D;Heitmann, Katja;Hennig, Steffen;Hernandez, Judith;Hinzmann, Bernd;Ho, Sarah;Hoffs, Michael;Howden, Phillip J;Huckle, Elizabeth J;Hume, Jennifer;Hunt, Paul J;Hunt, Adrienne R;Isherwood, Judith;Jacob, Leni;Johnson, David;Jones, Sally;de Jong, Pieter J;Joseph, Shirin S;Keenan, Stephen;Kelly, Susan;Kershaw, Joanne K;Khan, Ziad;Kioschis, Petra;Klages, Sven;Knights, Andrew J;Kosiura, Anna;Kovar-Smith, Christie;Laird, Gavin K;Langford, Cordelia;Lawlor, Stephanie;Leversha, Margaret;Lewis, Lora;Liu, Wen;Lloyd, Christine;Lloyd, David M;Loulseged, Hermela;Loveland, Jane E;Lovell, Jamieson D;Lozado, Ryan;Lu, Jing;Lyne, Rachael;Ma, Jie;Maheshwari, Manjula;Matthews, Lucy H;McDowall, Jennifer;McLaren, Stuart;McMurray, Amanda;Meidl, Patrick;Meitinger, Thomas;Milne, Sarah;Miner, George;Mistry, Shailesh L;Morgan, Margaret;Morris, Sidney;Müller, Ines;Mullikin, James C;Nguyen, Ngoc;Nordsiek, Gabriele;Nyakatura, Gerald;O'Dell, Christopher N;Okwuonu, Geoffery;Palmer, Sophie;Pandian, Richard;Parker, David;Parrish, Julia;Pasternak, Shiran;Patel, Dina;Pearce, Alex V;Pearson, Danita M;Pelan, Sarah E;Perez, Lesette;Porter, Keith M;Ramsey, Yvonne;Reichwald, Kathrin;Rhodes, Susan;Ridler, Kerry A;Schlessinger, David;Schueler, Mary G;Sehra, Harminder K;Shaw-Smith, Charles;Shen, Hua;Sheridan, Elizabeth M;Shownkeen, Ratna;Skuce, Carl D;Smith, Michelle L;Sotheran, Elizabeth C;Steingruber, Helen E;Steward, Charles A;Storey, Roy;Swann, R Mark;Swarbreck, David;Tabor, Paul E;Taudien, Stefan;Taylor, Tineace;Teague, Brian;Thomas, Karen;Thorpe, Andrea;Timms, Kirsten;Tracey, Alan;Trevanion, Steve;Tromans, Anthony C;d'Urso, Michele;Verduzco, Daniel;Villasana, Donna;Waldron, Lenee;Wall, Melanie;Wang, Qiaoyan;Warren, James;Warry, Georgina L;Wei, Xuehong;West, Anthony;Whitehead, Siobhan L;Whiteley, Mathew N;Wilkinson, Jane E;Willey, David L;Williams, Gabrielle;Williams, Leanne;Williamson, Angela;Williamson, Helen;Wilming, Laurens;Woodmansey, Rebecca L;Wray, Paul W;Yen, Jennifer;Zhang, Jingkun;Zhou, Jianling;Zoghbi, Huda;Zorilla, Sara;Buck, David;Reinhardt, Richard;Poustka, Annemarie;Rosenthal, André;Lehrach, Hans;Meindl, Alfons;Minx, Patrick J;Hillier, Ladeana W;Willard, Huntington F;Wilson, Richard K;Waterston, Robert H;Rice, Catherine M;Vaudin, Mark;Coulson, Alan;Nelson, David L;Weinstock, George;Sulston, John E;Durbin, Richard;Hubbard, Tim;Gibbs, Richard A;Beck, Stephan;Rogers, Jane;Bentley, David R
The human X chromosome has a unique biology that was shaped by its evolution as the sex chromosome shared by males and females. We have determined 99.3% of the euchromatic sequence of the X chromosome. Our analysis illustrates the autosomal origin of...
We report an improved draft nucleotide sequence of the 2.3-gigabase genome of maize, an important crop plant and model for biological research. Over 32,000 genes were predicted, of which 99.8% were placed on reference chromosomes. Nearly 85% of the g...
Myelodysplastic syndromes (MDS) are hematopoietic stem cell disorders that often progress to chemotherapy-resistant secondary acute myeloid leukemia (sAML). We used whole-genome sequencing to perform an unbiased comprehensive screen to discover the s...