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Introduction
To identify genetic factors contributing to type 2 diabetes (T2D), we performed large-scale meta-analyses by using a custom ∼50,000 SNP genotyping array (the ITMAT-Broad-CARe array) with ∼2000 candidate genes in 39 multiethnic population-based studie...
The following dialogue is between two fictional voices that concerns the phenomenological aspects of two closely related and marginal sub-genres: photographs of ships and photographs taken aboard them by their crews. Whereas the first category is def...
Dupuis, Josee;Langenberg, Claudia;Prokopenko, Inga;Saxena, Richa;Soranzo, Nicole;Jackson, Anne U.;Wheeler, Eleanor;Glazer, Nicole L.;Bouatia-Naji, Nabila;Gloyn, Anna L.;Lindgren, Cecilia M.;Magi, Reedik;Morris, Andrew P.;Randall, Joshua;Johnson, Toby;Elliott, Paul;Rybin, Denis;Thorleifsson, Gudmar;Steinthorsdottir, Valgerdur;Henneman, Peter;Grallert, Harald;Dehghan, Abbas;Hottenga, Jouke Jan;Franklin, Christopher S.;Navarro, Pau;Song, Kijoung;Goel, Anuj;Perry, John R. B.;Egan, Josephine M.;Lajunen, Taina;Grarup, Niels;Sparso, Thomas;Doney, Alex;Voight, Benjamin F.;Stringham, Heather M.;Li, Man;Kanoni, Stavroula;Shrader, Peter;Cavalcanti-Proenca, Christine;Kumari, Meena;Qi, Lu;Timpson, Nicholas J.;Gieger, Christian;Zabena, Carina;Rocheleau, Ghislain;Ingelsson, Erik;An, Ping;O;&;apos;Connell, Jeffrey;Luan, Jian;&;apos;an;Elliott, Amanda;McCarroll, Steven A.;Payne, Felicity;Roccasecca, Rosa Maria;Pattou, Francois;Sethupathy, Praveen;Ardlie, Kristin;Ariyurek, Yavuz;Balkau, Beverley;Barter, Philip;Beilby, John P.;Ben-Shlomo, Yoav;Benediktsson, Rafn;Bennett, Amanda J.;Bergmann, Sven;Bochud, Murielle;Boerwinkle, Eric;Bonnefond, Amelie;Bonnycastle, Lori L.;Borch-Johnsen, Knut;Boettcher, Yvonne;Brunner, Eric;Bumpstead, Suzannah J.;Charpentier, Guillaume;Chen, Yii-Der Ida;Chines, Peter;Clarke, Robert;Coin, Lachlan J. M.;Cooper, Matthew N.;Cornelis, Marilyn;Crawford, Gabe;Crisponi, Laura;Day, Ian N. M.;de Geus, Eco J. C.;Delplanque, Jerome;Dina, Christian;Erdos, Michael R.;Fedson, Annette C.;Fischer-Rosinsky, Antje;Forouhi, Nita G.;Fox, Caroline S.;Frants, Rune;Franzosi, Maria Grazia;Galan, Pilar;Goodarzi, Mark O.;Graessler, Juergen;Groves, Christopher J.;Grundy, Scott;Gwilliam, Rhian;Gyllensten, Ulf;Hadjadj, Samy;Hallmans, Goeran;Hammond, Naomi;Han, Xijing;Hartikainen, Anna-Liisa;Hassanali, Neelam;Hayward, Caroline;Heath, Simon C.;Hercberg, Serge;Herder, Christian;Hicks, Andrew A.;Hillman, David R.;Hingorani, Aroon D.;Hofman, Albert;Hui, Jennie;Hung, Joe;Isomaa, Bo;Johnson, Paul R. V.;Jorgensen, Torben;Jula, Antti;Kaakinen, Marika;Kaprio, Jaakko;Kesaniemi, Y. Antero;Kivimaki, Mika;Knight, Beatrice;Koskinen, Seppo;Kovacs, Peter;Kyvik, Kirsten Ohm;Lathrop, G. Mark;Lawlor, Debbie A.;Le Bacquer, Olivier;Lecoeur, Cecile;Li, Yun;Lyssenko, Valeriya;Mahley, Robert;Mangino, Massimo;Manning, Alisa K.;Teresa Martinez-Larrad, Maria;McAteer, Jarred B.;McCulloch, Laura J.;McPherson, Ruth;Meisinger, Christa;Melzer, David;Meyre, David;Mitchell, Braxton D.;Morken, Mario A.;Mukherjee, Sutapa;Naitza, Silvia;Narisu, Narisu;Neville, Matthew J.;Oostra, Ben A.;Orru, Marco;Pakyz, Ruth;Palmer, Colin N. A.;Paolisso, Giuseppe;Pattaro, Cristian;Pearson, Daniel;Peden, John F.;Pedersen, Nancy L.;Perola, Markus;Pfeiffer, Andreas F. H.;Pichler, Irene;Polasek, Ozren;Posthuma, Danielle;Potter, Simon C.;Pouta, Anneli;Province, Michael A.;Psaty, Bruce M.;Rathmann, Wolfgang;Rayner, Nigel W.;Rice, Kenneth;Ripatti, Samuli;Rivadeneira, Fernando;Roden, Michael;Rolandsson, Olov;Sandbaek, Annelli;Sandhu, Manjinder;Sanna, Serena;Sayer, Avan Aihie;Scheet, Paul;Scott, Laura J.;Seedorf, Udo;Sharp, Stephen J.;Shields, Beverley;Sigurosson, Gunnar;Sijbrands, Eric J. G.;Silveira, Angela;Simpson, Laila;Singleton, Andrew;Smith, Nicholas L.;Sovio, Ulla;Swift, Amy;Syddall, Holly;Syvanen, Ann-Christine;Tanaka, Toshiko;Thorand, Barbara;Tichet, Jean;Tonjes, Anke;Tuomi, Tiinamaija;Uitterlinden, Andre G.;van Dijk, Ko Willems;van Hoek, Mandy;Varma, Dhiraj;Visvikis-Siest, Sophie;Vitart, Veronique;Vogelzangs, Nicole;Waeber, Gerard;Wagner, Peter J.;Walley, Andrew;Walters, G. Bragi;Ward, Kim L.;Watkins, Hugh;Weedon, Michael N.;Wild, Sarah H.;Willemsen, Gonneke;Witteman, Jaqueline C. M.;Yarnell, John W. G.;Zeggini, Eleftheria;Zelenika, Diana;Zethelius, Bjorn;Zhai, Guangju;Zhao, Jing Hua;Zillikens, M. Carola;Borecki, Ingrid B.;Loos, Ruth J. F.;Meneton, Pierre;Magnusson, Patrik K. E.;Nathan, David M.;Williams, Gordon H.;Hattersley, Andrew T.;Silander, Kaisa;Salomaa, Veikko;Smith, George Davey;Bornstein, Stefan R.;Schwarz, Peter;Spranger, Joachim;Karpe, Fredrik;Shuldiner, Alan R.;Cooper, Cyrus;Dedoussis, George V.;Serrano-Rios, Manuel;Morris, Andrew D.;Lind, Lars;Palmer, Lyle J.;Hu, Frank B.;Franks, Paul W.;Ebrahim, Shah;Marmot, Michael;Kao, W. H. Linda;Pankow, James S.;Sampson, Michael J.;Kuusisto, Johanna;Laakso, Markku;Hansen, Torben;Pedersen, Oluf;Pramstaller, Peter Paul;Wichmann, H. Erich;Illig, Thomas;Rudan, Igor;Wright, Alan F.;Stumvoll, Michael;Campbell, Harry;Wilson, James F.;Bergman, Richard N.;Buchanan, Thomas A.;Collins, Francis S.;Mohlke, Karen L.;Tuomilehto, Jaakko;Valle, Timo T.;Altshuler, David;Rotter, Jerome I.;Siscovick, David S.;Penninx, Brenda W. J. H.;Boomsma, Dorret I.;Deloukas, Panos;Spector, Timothy D.;Frayling, Timothy M.;Ferrucci, Luigi;Kong, Augustine;Thorsteinsdottir, Unnur;Stefansson, Kari;van Duijn, Cornelia M.;Aulchenko, Yurii S.;Cao, Antonio;Scuteri, Angelo;Schlessinger, David;Uda, Manuela;Ruokonen, Aimo;Jarvelin, Marjo-Riitta;Waterworth, Dawn M.;Vollenweider, Peter;Peltonen, Leena;Mooser, Vincent;Abecasis, Goncalo R.;Wareham, Nicholas J.;Sladek, Robert;Froguel, Philippe;Watanabe, Richard M.;Meigs, James B.;Groop, Leif;Boehnke, Michael;McCarthy, Mark I.;Florez, Jose C.;Barroso, Ines
Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and indices of beta-cell function...
Peden, John F.;Hopewell, Jemma C.;Saleheen, Danish;Chambers, John C.;Hager, Jorg;Soranzo, Nicole;Collins, Rory;Danesh, John;Elliott, Paul;Farrall, Martin;Stirrups, Kathy;Zhang, Weihua;Hamsten, Anders;Parish, Sarah;Lathrop, Mark;Watkins, Hugh;Clarke, Robert;Deloukas, Panos;Kooner, Jaspal S.;Goel, Anuj;Ongen, Halit;Strawbridge, Rona J.;Heath, Simon;Malarstig, Anders;Helgadottir, Anna;Ohrvik, John;Murtaza, Muhammed;Potter, Simon;Hunt, Sarah E.;Delepine, Marc;Jalilzadeh, Shapour;Axelsson, Tomas;Syvanen, Ann-Christine;Gwilliam, Rhian;Bumpstead, Suzannah;Gray, Emma;Edkins, Sarah;Folkersen, Lasse;Kyriakou, Theodosios;Franco-Cereceda, Anders;Gabrielsen, Anders;Seedorf, Udo;Eriksson, Per;Offer, Alison;Bowman, Louise;Sleight, Peter;Armitage, Jane;Peto, Richard;Abecasis, Goncalo;Ahmed, Nabeel;Caulfield, Mark;Donnelly, Peter;Froguel, Philippe;Kooner, Angad S.;McCarthy, Mark I.;Samani, Nilesh J.;Scott, James;Sehmi, Joban;Silveira, Angela;Hellenius, Mai-Lis;van;&;apos;t Hooft, Ferdinand M.;Olsson, Gunnar;Rust, Stephan;Assmann, Gerd;Barlera, Simona;Tognoni, Gianni;Franzosi, Maria Grazia;Linksted, Pamela;Green, Fiona R.;Rasheed, Asif;Zaidi, Moazzam;Shah, Nabi;Samuel, Maria;Mallick, Nadeem H.;Azhar, Muhammad;Zaman, Khan S.;Samad, Abdus;Ishaq, Mohammad;Gardezi, Ali R.;Memon, Fazal-ur-Rehman;Frossard, Philippe M.;Spector, Tim;Peltonen, Leena;Nieminen, Markku S.;Sinisalo, Juha;Salomaa, Veikko;Ripatti, Samuli;Bennett, Derrick;Leander, Karin;Gigante, Bruna;de Faire, Ulf;Pietri, Silvia;Gori, Francesca;Marchioli, Roberto;Sivapalaratnam, Suthesh;Kastelein, John J. P.;Trip, Mieke D.;Theodoraki, Eirini V.;Dedoussis, George V.;Engert, Jamie C.;Yusuf, Salim;Anand, Sonia S.
Genome-wide association studies have identified 11 common variants convincingly associated with coronary artery disease (CAD)(1-7), a modest number considering the apparent heritability of CAD(8). All of these variants have been discovered in Europea...
Speliotes, Elizabeth K.;Willer, Cristen J.;Berndt, Sonja I.;Monda, Keri L.;Thorleifsson, Gudmar;Jackson, Anne U.;Allen, Hana Lango;Lindgren, Cecilia M.;Luan, Jian;&;apos;an;Maegi, Reedik;Randall, Joshua C.;Vedantam, Sailaja;Winkler, Thomas W.;Qi, Lu;Workalemahu, Tsegaselassie;Heid, Iris M.;Steinthorsdottir, Valgerdur;Stringham, Heather M.;Weedon, Michael N.;Wheeler, Eleanor;Wood, Andrew R.;Ferreira, Teresa;Weyant, Robert J.;Segre, Ayellet V.;Estrada, Karol;Liang, Liming;Nemesh, James;Park, Ju-Hyun;Gustafsson, Stefan;Kilpelaenen, Tuomas O.;Yang, Jian;Bouatia-Naji, Nabila;Esko, Tonu;Feitosa, Mary F.;Kutalik, Zoltan;Mangino, Massimo;Raychaudhuri, Soumya;Scherag, Andre;Smith, Albert Vernon;Welch, Ryan;Zhao, Jing Hua;Aben, Katja K.;Absher, Devin M.;Amin, Najaf;Dixon, Anna L.;Fisher, Eva;Glazer, Nicole L.;Goddard, Michael E.;Heard-Costa, Nancy L.;Hoesel, Volker;Hottenga, Jouke-Jan;Johansson, Asa;Johnson, Toby;Ketkar, Shamika;Lamina, Claudia;Li, Shengxu;Moffatt, Miriam F.;Myers, Richard H.;Narisu, Narisu;Perry, John R. B.;Peters, Marjolein J.;Preuss, Michael;Ripatti, Samuli;Rivadeneira, Fernando;Sandholt, Camilla;Scott, Laura J.;Timpson, Nicholas J.;Tyrer, Jonathan P.;van Wingerden, Sophie;Watanabe, Richard M.;White, Charles C.;Wiklund, Fredrik;Barlassina, Christina;Chasman, Daniel I.;Cooper, Matthew N.;Jansson, John-Olov;Lawrence, Robert W.;Pellikka, Niina;Prokopenko, Inga;Shi, Jianxin;Thiering, Elisabeth;Alavere, Helene;Alibrandi, Maria T. S.;Almgren, Peter;Arnold, Alice M.;Aspelund, Thor;Atwood, Larry D.;Balkau, Beverley;Balmforth, Anthony J.;Bennett, Amanda J.;Ben-Shlomo, Yoav;Bergman, Richard N.;Bergmann, Sven;Biebermann, Heike;Blakemore, Alexandra I. F.;Boes, Tanja;Bonnycastle, Lori L.;Bornstein, Stefan R.;Brown, Morris J.;Buchanan, Thomas A.;Busonero, Fabio;Campbell, Harry;Cappuccio, Francesco P.;Cavalcanti-Proenca, Christine;Chen, Yii-Der Ida;Chen, Chih-Mei;Chines, Peter S.;Clarke, Robert;Coin, Lachlan;Connell, John;Day, Ian N. M.;den Heijer, Martin;Duan, Jubao;Ebrahim, Shah;Elliott, Paul;Elosua, Roberto;Eiriksdottir, Gudny;Erdos, Michael R.;Eriksson, Johan G.;Facheris, Maurizio F.;Felix, Stephan B.;Fischer-Posovszky, Pamela;Folsom, Aaron R.;Friedrich, Nele;Freimer, Nelson B.;Fu, Mao;Gaget, Stefan;Gejman, Pablo V.;Geus, Eco J. C.;Gieger, Christian;Gjesing, Anette P.;Goel, Anuj;Goyette, Philippe;Grallert, Harald;Graessler, Juergen;Greenawalt, Danielle M.;Groves, Christopher J.;Gudnason, Vilmundur;Guiducci, Candace;Hartikainen, Anna-Liisa;Hassanali, Neelam;Hall, Alistair S.;Havulinna, Aki S.;Hayward, Caroline;Heath, Andrew C.;Hengstenberg, Christian;Hicks, Andrew A.;Hinney, Anke;Hofman, Albert;Homuth, Georg;Hui, Jennie;Igl, Wilmar;Iribarren, Carlos;Isomaa, Bo;Jacobs, Kevin B.;Jarick, Ivonne;Jewell, Elizabeth;John, Ulrich;Jorgensen, Torben;Jousilahti, Pekka;Jula, Antti;Kaakinen, Marika;Kajantie, Eero;Kaplan, Lee M.;Kathiresan, Sekar;Kettunen, Johannes;Kinnunen, Leena;Knowles, Joshua W.;Kolcic, Ivana;Koenig, Inke R.;Koskinen, Seppo;Kovacs, Peter;Kuusisto, Johanna;Kraft, Peter;Kvaloy, Kirsti;Laitinen, Jaana;Lantieri, Olivier;Lanzani, Chiara;Launer, Lenore J.;Lecoeur, Cecile;Lehtimaeki, Terho;Lettre, Guillaume;Liu, Jianjun;Lokki, Marja-Liisa;Lorentzon, Mattias;Luben, Robert N.;Ludwig, Barbara;Manunta, Paolo;Marek, Diana;Marre, Michel;Martin, Nicholas G.;McArdle, Wendy L.;McCarthy, Anne;McKnight, Barbara;Meitinger, Thomas;Melander, Olle;Meyre, David;Midthjell, Kristian;Montgomery, Grant W.;Morken, Mario A.;Morris, Andrew P.;Mulic, Rosanda;Ngwa, Julius S.;Nelis, Mari;Neville, Matt J.;Nyholt, Dale R.;O;&;apos;Donnell, Christopher J.;O;&;apos;Rahilly, Stephen;Ong, Ken K.;Oostra, Ben;Pare, Guillaume;Parker, Alex N.;Perola, Markus;Pichler, Irene;Pietilaeinen, Kirsi H.;Platou, Carl G. P.;Polasek, Ozren;Pouta, Anneli;Rafelt, Suzanne;Raitakari, Olli;Rayner, Nigel W.;Ridderstrale, Martin;Rief, Winfried;Ruokonen, Aimo;Robertson, Neil R.;Rzehak, Peter;Salomaa, Veikko;Sanders, Alan R.;Sandhu, Manjinder S.;Sanna, Serena;Saramies, Jouko;Savolainen, Markku J.;Scherag, Susann;Schipf, Sabine;Schreiber, Stefan;Schunkert, Heribert;Silander, Kaisa;Sinisalo, Juha;Siscovick, David S.;Smit, Jan H.;Soranzo, Nicole;Sovio, Ulla;Stephens, Jonathan;Surakka, Ida;Swift, Amy J.;Tammesoo, Mari-Liis;Tardif, Jean-Claude;Teder-Laving, Maris;Teslovich, Tanya M.;Thompson, John R.;Thomson, Brian;Toenjes, Anke;Tuomi, Tiinamaija;van Meurs, Joyce B. J.;van Ommen, Gert-Jan;Vatin, Vincent;Viikari, Jorma;Visvikis-Siest, Sophie;Vitart, Veronique;Vogel, Carla I. G.;Voight, Benjamin F.;Waite, Lindsay L.;Wallaschofski, Henri;Walters, G. Bragi;Widen, Elisabeth;Wiegand, Susanna;Wild, Sarah H.;Willemsen, Gonneke;Witte, Daniel R.;Witteman, Jacqueline C.;Xu, Jianfeng;Zhang, Qunyuan;Zgaga, Lina;Ziegler, Andreas;Zitting, Paavo;Beilby, John P.;Farooqi, I. Sadaf;Hebebrand, Johannes;Huikuri, Heikki V.;James, Alan L.;Kaehoenen, Mika;Levinson, Douglas F.;Macciardi, Fabio;Nieminen, Markku S.;Ohlsson, Claes;Palmer, Lyle J.;Ridker, Paul M.;Stumvoll, Michael;Beckmann, Jacques S.;Boeing, Heiner;Boerwinkle, Eric;Boomsma, Dorret I.;Caulfield, Mark J.;Chanock, Stephen J.;Collins, Francis S.;Cupples, L. Adrienne;Smith, George Davey;Erdmann, Jeanette;Froguel, Philippe;Greonberg, Henrik;Gyllensten, Ulf;Hall, Per;Hansen, Torben;Harris, Tamara B.;Hattersley, Andrew T.;Hayes, Richard B.;Heinrich, Joachim;Hu, Frank B.;Hveem, Kristian;Illig, Thomas;Jarvelin, Marjo-Riitta;Kaprio, Jaakko;Karpe, Fredrik;Khaw, Kay-Tee;Kiemeney, Lambertus A.;Krude, Heiko;Laakso, Markku;Lawlor, Debbie A.;Metspalu, Andres;Munroe, Patricia B.;Ouwehand, Willem H.;Pedersen, Oluf;Penninx, Brenda W.;Peters, Annette;Pramstaller, Peter P.;Quertermous, Thomas;Reinehr, Thomas;Rissanen, Aila;Rudan, Igor;Samani, Nilesh J.;Schwarz, Peter E. H.;Shuldiner, Alan R.;Spector, Timothy D.;Tuomilehto, Jaakko;Uda, Manuela;Uitterlinden, Andre;Valle, Timo T.;Wabitsch, Martin;Waeber, Gerard;Wareham, Nicholas J.;Watkins, Hugh;Wilson, James F.;Wright, Alan F.;Zillikens, M. Carola;Chatterjee, Nilanjan;McCarroll, Steven A.;Purcell, Shaun;Schadt, Eric E.;Visscher, Peter M.;Assimes, Themistocles L.;Borecki, Ingrid B.;Deloukas, Panos;Fox, Caroline S.;Groop, Leif C.;Haritunians, Talin;Hunter, David J.;Kaplan, Robert C.;Mohlke, Karen L.;O;&;apos;Connell, Jeffrey R.;Peltonen, Leena;Schlessinger, David;Strachan, David P.;van Duijn, Cornelia M.;Wichmann, H-Erich;Frayling, Timothy M.;Thorsteinsdottir, Unnur;Abecasis, Goncalo R.;Barroso, Ines;Boehnke, Michael;Stefansson, Kari;North, Kari E.;McCarthy, Mark I.;Hirschhorn, Joel N.;Ingelsson, Erik;Loos, Ruth J. F.
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and similar to 2.8 million SNPs in up...
Objective: To quantify genetic overlap between migraine and ischemic stroke (IS) with respect to common genetic variation. Methods: We applied 4 different approaches to large-scale meta-analyses of genome-wide data on migraine (23,285 cases and 95,42...