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Title
Streptococcus pneumoniae is a common nasopharyngeal colonizer, but can also cause life-threatening invasive diseases such as empyema, bacteremia and meningitis. Genetic variation of host and pathogen is known to play a role in invasive pneumococcal d...
van Rheenen, W.;Shatunov, A.;Dekker, A. M.;McLaughlin, R. L.;Diekstra, F. P.;Pulit, S. L.;van der Spek, R. A.;Vosa, U.;de Jong, S.;Robinson, M. R.;Yang, J.;Fogh, I.;van Doormaal, P. T.;Tazelaar, G. H.;Koppers, M.;Blokhuis, A. M.;Sproviero, W.;Jones, A. R.;Kenna, K. P.;van Eijk, K. R.;Harschnitz, O.;Schellevis, R. D.;Brands, W. J.;Medic, J.;Menelaou, A.;Vajda, A.;Ticozzi, N.;Lin, K.;Rogelj, B.;Vrabec, K.;Ravnik-Glavac, M.;Koritnik, B.;Zidar, J.;Leonardis, L.;Groselj, L. D.;Millecamps, S.;Salachas, F.;Meininger, V.;de Carvalho, M.;Pinto, S.;Mora, J. S.;Rojas-Garcia, R.;Polak, M.;Chandran, S.;Colville, S.;Swingler, R.;Morrison, K. E.;Shaw, P. J.;Hardy, J.;Orrell, R. W.;Pittman, A.;Sidle, K.;Fratta, P.;Malaspina, A.;Topp, S.;Petri, S.;Abdulla, S.;Drepper, C.;Sendtner, M.;Meyer, T.;Ophoff, R. A.;Staats, K. A.;Wiedau-Pazos, M.;Lomen-Hoerth, C.;Van Deerlin, V. M.;Trojanowski, J. Q.;Elman, L.;McCluskey, L.;Basak, A. N.;Tunca, C.;Hamzeiy, H.;Parman, Y.;Meitinger, T.;Lichtner, P.;Radivojkov-Blagojevic, M.;Andres, C. R.;Maurel, C.;Bensimon, G.;Landwehrmeyer, B.;Brice, A.;Payan, C. A.;Saker-Delye, S.;Durr, A.;Wood, N. W.;Tittmann, L.;Lieb, W.;Franke, A.;Rietschel, M.;Cichon, S.;Nothen, M. M.;Amouyel, P.;Tzourio, C.;Dartigues, J. F.;Uitterlinden, A. G.;Rivadeneira, F.;Estrada, K.;Hofman, A.;Curtis, C.;Blauw, H. M.;van der Kooi, A. J.;de Visser, M.;Goris, A.;Weber, M.;Shaw, C. E.;Smith, B. N.;Pansarasa, O.;Cereda, C.;Del Bo, R.;Comi, G. P.;D'Alfonso, S.;Bertolin, C.;Soraru, G.;Mazzini, L.;Pensato, V.;Gellera, C.;Tiloca, C.;Ratti, A.;Calvo, A.;Moglia, C.;Brunetti, M.;Arcuti, S.;Capozzo, R.;Zecca, C.;Lunetta, C.;Penco, S.;Riva, N.;Padovani, A.;Filosto, M.;Muller, B.;Stuit, R. J.;Parals Registry,;Slalom Group,;Slap Registry,;Fals Sequencing Consortium,;Slagen Consortium,;Nnipps Study Group,;Blair, I.;Zhang, K.;McCann, E. P.;Fifita, J. A.;Nicholson, G. A.;Rowe, D. B.;Pamphlett, R.;Kiernan, M. C.;Grosskreutz, J.;Witte, O. W.;Ringer, T.;Prell, T.;Stubendorff, B.;Kurth, I.;Hubner, C. A.;Leigh, P. N.;Casale, F.;Chio, A.;Beghi, E.;Pupillo, E.;Tortelli, R.;Logroscino, G.;Powell, J.;Ludolph, A. C.;Weishaupt, J. H.;Robberecht, W.;Van Damme, P.;Franke, L.;Pers, T. H.;Brown, R. H.;Glass, J. D.;Landers, J. E.;Hardiman, O.;Andersen, P. M.;Corcia, P.;Vourc'h, P.;Silani, V.;Wray, N. R.;Visscher, P. M.;de Bakker, P. I.;van Es, M. A.;Pasterkamp, R. J.;Lewis, C. M.;Breen, G.;Al-Chalabi, A.;van den Berg, L. H.;Veldink, J. H.
To elucidate the genetic architecture of amyotrophic lateral sclerosis (ALS) and find associated loci, we assembled a custom imputation reference panel from whole-genome-sequenced patients with ALS and matched controls (n = 1,861). Through imputation...
Background: The use of topiramate (TPM) has been increased among pregnant women. Safety data for TPM in human pregnancy are limited. Recent studies have suggested that exposure to TPM early in gestation has a higher risk of orofacial clefts (OCs), pa...
Liang, C;Alam, I;Albanese, D;Altschuler, G;Andersson, R;Arakawa, T;Archer, J;Arner, E;Arner, P;Babina, M;Baillie, K;Bajic, V;Baker, S;Balic, A;Balwierz, P;Beckhouse, A;Bertin, N;Blake, Ja;Blumenthal, A;Bodega, B;Bonetti, A;Briggs, J;Brombacher, F;Burroughs, M;Califano, A;Cannistraci, C;Carbajo, D;Carninci, P;Chen, Y;Chierici, M;Ciani, Y;Clevers, H;Dalla, E;Daub, C;Davis, C;De Hoon, M;De Lima Morais, D;Dermar, M;Diehl, A;Dimont, E;Dohl, T;Drabros, F;Edge, A;Edinger, M;Ekwall, K;Endoh, M;Enomoto, H;Fagiolini, M;Fairbairn, L;Fang, H;Farach-Carson, Mc;Faulkner, G;Favorov, A;Fisher, M;Forrest, A;Francescatto, M;Freeman, T;Frith, M;Fujita, R;Fukuda, S;Furlanello, C;Furuno, M;Furusawa, J;Geijtenbeek, Tb;Gibson, A;Gingeras, T;Goldowithz, D;Gough, J;Guhl, S;Guler, R;Gustincich, S;Ha, T;Haberle, V;Hamaguchi, M;Hara, M;Harbers, M;Harshbarger, J;Hasegawa, A;Hasegawa, Y;Hashimoto, T;Hayashizaki, Y;Herlyn, M;Heutink, P;Hide, W;Hitchens, K;Ho Sui, S;Hofmann, O;Hoof, I;Hori, F;Hume, D;Huminiecki, L;Iida, K;Ikawa, T;Ishizu, Y;Itoh, M;Jankovic, B;Jia, H;Jorgensen, M;Joshi, A;Jurman, G;Kaczkowski, B;Kai, C;Kaida, K;Kaiho, A;Kajiyama, K;Kanamori-Katayama, M;Kasianov, A;Kasukawa, T;Katayama, S;Kato Ishikawa, S;Kawaguchi, S;Kawai, J;Kawaji, H;Kawamoto, H;Kawamura, Y;Kawashima, T;Kempfle, J;Kenna, T;Kere, J;Khachigian, L;Kitamura, T;Klinken, P;Knox, A;Kojima, M;Kojima, S;Kondo, N;Koseki, H;Koyasu, S;Krampitz, S;Kubosaki, A;Kulakovskiy, I;Kwon, At;Laros, J;Lassmann, T;Lenhard, B;Lennartsson, A;Li, K;Lilji, B;Lipovich, L;Lizio, M;Mackay-Sim, A;Makeev, V;Manabe, R;Mar, J;Marchand, B;Mathelier, A;Medvedeva, Y;Meehan, Tf;Mejhert, N;Meynert, A;Mizuno, Y;Morikawa, H;Morimoto, M;Moro, K;Motakis, E;Motohashi, H;Mummery, C;Mungall, Cj;Murata, M;Nagao Sato, S;Nakachi, Y;Nakahara, F;Nakamura, T;Nakamura, Y;Nakazato, K;Ninomiya Fukuda, N;Nishiyori Sueki, H;Noma, S;Nozaki, T;Ogishima, S;Ohkura, N;Ohmiya, H;Ohno, H;Ohshima, M;Okada-Hatakeyama, M;Okazaki, Y;Orlando, V;Ovchinnikov, D;Pain, A;Passier, R;Persson, H;Piazza, S;Plessy, C;Pradhan-Bhatt, S;Prendergast, J;Rackham, O;Ramilowski, J;Rashid, M;Ravasi, T;Rehli, M;Rizzu, P;Roncador, M;Roy, S;Rye, M;Saijyo, E;Sajantila, A;Saka, A;Sakaguchi, S;Sakai, M;Sandelin, A;Sato, H;Satoh, H;Suzana, S;Alka, S;Schaefer, U;Schmeier, S;Schmidl, C;Schneider, C;Schultes, Ea;Schulze-Tanzil, G;Schwegmann, A;Semple, C;Sengstag, T;Severin, J;Sheng, G;Shimoji, H;Shimoni, Y;Shin, J;Simon, C;Sugiyama, D;Sugiyama, T;Summers, K;Suzuki, H;Suzuki, M;Suzuki, N;Swoboda, R;Hoen P, T;Tagami, M;Takahashi, N;Takai, J;Tanaka, H;Tatsukawa, H;Tatum, Z;Taylor, M;Thompson, M;Toyoda, H;Toyoda, T;Valen, E;Van De Wetering, M;Van Den Berg, L;Van Nimwegen, E;Verardo, R;Vijayan, D;Vitezic, M;Vorontzov, I;Wasserman, W;Watanabe, S;Wells, C;Winteringham, L;Wolvetang, E;Wood, Ej;Yamaguchi, Y;Yamamoto, M;Yoneda, M;Yonekura, Y;Yoshida, S;Young, R;Zabierowski, Se;Zhang, P;Zhao, X;Zucchelli, S;Forrest, Ar;Wagner, Gp
In evolution, body plan complexity increases due to an increase in the number of individualized cell types. Yet, there is very little understanding of the mechanisms that produce this form of organismal complexity. One model for the origin of novel c...
Objectives Several studies focused on the association between alcohol consumption and amyotrophic lateral sclerosis (ALS), although with inconsistent findings. Antioxidants may play a role since lyophilised red wine was found to prolong SOD1 mice lif...