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Wellcome Trust Case Control Consortium;;Cardon, Lon R;;Craddock, Nick;;Deloukas, Panos;;Duncanson, Audrey;;Kwiatkowski, Dominic P;;McCarthy, Mark I;;Ouwehand, Willem H;;Samani, Nilesh J;;Todd, John A;;Donnelly, Peter;;Barrett, Jeffrey C;;Davison, Dan;;Easton, Doug;;Evans, David;;Leung, Hin-Tak;;Marchini, Jonathan L;;Morris, Andrew P;;Spencer, Chris CA;;Tobin, Martin D;;Attwood, Antony P;;Boorman, James P;;Cant, Barbara;;Everson, Ursula;;Hussey, Judith M;;Jolley, Jennifer D;;Knight, Alexandra S;;Koch, Kerstin;;Meech, Elizabeth;;Nutland, Sarah;;Prowse, Christopher V;;Stevens, Helen E;;Taylor, Niall C;;Walters, Graham R;;Walker, Neil M;;Watkins, Nicholas A;;Winzer, Thilo;;Jones, Richard W;;McArdle, Wendy L;;Ring, Susan M;;Strachan, David P;;Pembrey, Marcus;;Breen, Gerome;;St Clair, David;;Caesar, Sian;;Gordon-Smith, Katherine;;Jones, Lisa;;Fraser, Christine;;Green, Elain K;;Grozeva, Detelina;;Hamshere, Marian L;;Holmans, Peter A;;Jones, Ian R;;Kirov, George;;Moskvina, Valentina;;Nikolov, Ivan;;O'Donovan, Michael C;;Owen, Michael J;;Collier, David A;;Elkin, Amanda;;Farmer, Anne;;Williamson, Richard;;McGuffin, Peter;;Young, Allan H;;Ferrier, I Nicol;;Ball, Stephen G;;Balmforth, Anthony J;;Barrett, Jennifer H;;Bishop, D Timothy;;Iles, Mark M;;Maqbool, Azhar;;Yudasheve, Nadira;;Hall, Alistair S;;Braund, Peter S;;Dixon, Richard J;;Mangino, Massimo;;Stevens, Suzanne;;Thompson, John R;;Bredin, Francesca;;Tremelling, Mark;;Parkes, Miles;;Drummond, Hazel;;Lees, Charles W;;Nimmo, Elaine R;;Satsangi, Jack;;Fisher, Sheila A;;Forbes, Alistair;;Lewis, Cathryn M;;Onnie, Clive M;;Prescott, Natalie J;;Sanderson, Jeremy;;Mathew, Christopher G;;Barbour, Jamie;;Mohiuddin, M Khalid;;Todhunter, Catherine E;;Mansfield, John C;;Ahmad, Tariq;;Cummings, Fraser R;;Jewell, Derek P;;Webster, John;;Brown, Morris J;;Lathrop, G Mark;;Connell, John;;Dominiczak, Anna;;Marcano, Carolina A Braga;;Burke, Beverley;;Dobson, Richard;;Gungadoo, Johannie;;Lee, Kate L;;Munroe, Patricia B;;Newhouse, Stephen J;;Onipinla, Abiodun;;Wallace, Chris;;Xue, Mingzhan;;Caulfield, Mark;;Farrall, Martin;;Barton, Anne;;Bruce, Ian N;;Donovan, Hannah;;Eyre, Steve;;Gilbert, Paul D;;Hider, Samantha L;;Hinks, Anne M;;John, Sally L;;Potter, Catherine;;Silman, Alan J;;Symmons, Deborah PM;;Thomson, Wendy;;Worthington, Jane;;Dunger, David B;;Widmer, Barry;;Frayling, Timothy M;;Freathy, Rachel M;;Lango, Hana;;Perry, John RB;;Shields, Beverley M;;Weedon, Michael N;;Hattersley, Andrew T;;Elliott, Kate S;;Groves, Christopher J;;Lindgren, Cecilia M;;Rayner, Nigel W;;Timpson, Nicholas J;;Zeggini, Eleftheria;;Newport, Melanie;;Sirugo, Giorgio;;Lynons, Emily;;Vannberg, Fredrik;;Brown, Matthew A;;Franklyn, Jayne A;;Heward;;Simmonds, Matthew J;;Hill, Adrian VS;;Bradbury, Linda A;;Farrar, Claire;;Pointon, Jennifer J;;Wordsmith, Paul;;Gough, Stephen CL;;Seal, Sheila;;Stratton, Michael R;;Rahman, Nazneen;;Ban, Maria;;Goris, An; 31949;;Sawcer, Stephen J;;Compston, Alistair;;Conway, David;;Jallow, Muminatou;;Bumpstead, Suzannah J;;Chaney, Amy;;Downes, Kate;;Ghori, Mohammed JR;;Gwilliam, Rhian;;Inouye, Michael;;Keniry, Andrew;;King, Emma;;McGinnis, Ralph;;Potter, Simon;;Ravindrarajah, Rathi;;Whittaker, Pamela;;Withers, David;;Easton, Doug;;Pereira-Gale, Joanne;;Hallgrimsdottir, Ingilef B;;Howie, Bryan N;;Su, Zhan;;Teo, Yik Ying;;Vukcevic, Damjan;;Bentley, David;;Caulfield, Mark;;Mathew, Christopher G;;Worthington, Jane;
There is increasing evidence that genome-wide association ( GWA) studies represent a powerful approach to the identification of genes involved in common human diseases. We describe a joint GWA study ( using the Affymetrix GeneChip 500K Mapping Array ...
Romagnoni, Alberto;;Jegou, Simon;;Van Steen, Kristel; 58783;;Wainrib, Gilles;;Hugot, Jean-Pierre;;Peyrin-Biroulet, Laurent;;Chamaillard, Mathias;;Colombel, Jean-Frederick;;Cottone, Mario;;D'Amato, Mauro;;D'Inca, Renata;;Halfvarson, Jonas;;Henderson, Paul;;Karban, Amir;;Kennedy, Nicholas A;;Khan, Mohammed Azam;;Lemann, Marc;;Levine, Arie;;Massey, Dunecan;;Milla, Monica;;Ng, Sok Meng Evelyn;;Oikonomou, Ioannis;;Peeters, Harald;;Proctor, Deborah D;;Rahier, Jean-Francois;;Rutgeerts, Paul;;Seibold, Frank;;Stronati, Laura;;Taylor, Kirstin M;;Torkvist, Leif;;Ublick, Kullak;;Van Limbergen, Johan;;Van Gossum, Andre;;Vatn, Morten H;;Zhang, Hu;;Zhang, Wei;;Andrews, Jane M;;Bampton, Peter A;;Barclay, Murray;;Florin, Timothy H;;Gearry, Richard;;Krishnaprasad, Krupa;;Lawrance, Ian C;;Mahy, Gillian;;Montgomery, Grant W;;Radford-Smith, Graham;;Roberts, Rebecca L;;Simms, Lisa A;;Hanigan, Katherine;;Croft, Anthony;;Amininijad, Leila;;Cleynen, Isabelle; 43487;;Dewit, Olivier;;Franchimont, Denis;;Georges, Michel;;Laukens, Debby;;Theatre, Emilie;;Vermeire, Severine; 3938;;Aumais, Guy;;Baidoo, Leonard;;Barrie, Arthur M;;Beck, Karen;;Bernard, Edmond-Jean;;Binion, David G;;Bitton, Alain;;Brant, Steve R;;Cho, Judy H;;Cohen, Albert;;Croitoru, Kenneth;;Daly, Mark J;;Datta, Lisa W;;Deslandres, Colette;;Duerr, Richard H;;Dutridge, Debra;;Ferguson, John;;Fultz, Joann;;Goyette, Philippe;;Greenberg, Gordon R;;Haritunians, Talin;;Jobin, Gilles;;Katz, Seymour;;Lahaie, Raymond G;;McGovern, Dermot P;;Nelson, Linda;;Ng, Sok Meng;;Ning, Kaida;;Pare, Pierre;;Regueiro, Miguel D;;Rioux, John D;;Ruggiero, Elizabeth;;Schumm, L Philip;;Schwartz, Marc;;Scott, Regan;;Sharma, Yashoda;;Silverberg, Mark S;;Spears, Denise;;Steinhart, A Hillary;;Stempak, Joanne M;;Swoger, Jason M;;Tsagarelis, Constantina;;Zhang, Clarence;;Zhao, Hongyu;;Aerts, Jan; 69827;;Ahmad, Tariq;;Arbury, Hazel;;Attwood, Anthony;;Auton, Adam;;Ball, Stephen G;;Balmforth, Anthony J;;Barnes, Chris;;Barrett, Jeffrey C;;Barroso, Ines;;Barton, Anne;;Bennett, Amanda J;;Bhaskar, Sanjeev;;Blaszczyk, Katarzyna;;Bowes, John;;Brand, Oliver J;;Braund, Peter S;;Bredin, Francesca;;Breen, Gerome;;Brown, Morris J;;Bruce, Ian N;;Bull, Jaswinder;;Burren, Oliver S;;Burton, John;;Byrnes, Jake;;Caesar, Sian;;Cardin, Niall;;Clee, Chris M;;Coffey, Alison J;;Mc Connell, John;;Conrad, Donald F;;Cooper, Jason D;;Dominiczak, Anna F;;Downes, Kate;;Drummond, Hazel E;;Dudakia, Darshna;;Dunham, Andrew;;Ebbs, Bernadette;;Eccles, Diana;;Edkins, Sarah;;Edwards, Cathryn;;Elliot, Anna;;Emery, Paul;;Evans, David M;;Evans, Gareth;;Eyre, Steve;;Farmer, Anne;;Ferrier, I Nicol;;Flynn, Edward;;Forbes, Alistair;;Forty, Liz;;Franklyn, Jayne A;;Frayling, Timothy M;;Freathy, Rachel M;;Giannoulatou, Eleni;;Gibbs, Polly;;Gilbert, Paul;;Gordon-Smith, Katherine;;Gray, Emma;;Green, Elaine;;Groves, Chris J;;Grozeva, Detelina;;Gwilliam, Rhian;;Hall, Anita;;Hammond, Naomi;;Hardy, Matt;;Harrison, Pile;;Hassanali, Neelam;;Hebaishi, Husam;;Hines, Sarah;;Hinks, Anne;;Hitman, Graham A;;Hocking, Lynne;;Holmes, Chris;;Howard, Eleanor;;Howard, Philip;;Howson, Joanna MM;;Hughes, Debbie;;Hunt, Sarah;;Isaacs, John D;;Jain, Mahim;;Jewell, Derek P;;Johnson, Toby;;Jolley, Jennifer D;;Jones, Ian R;;Jones, Lisa A;;Kirov, George;;Langford, Cordelia F;;Lango-Allen, Hana;;Lathrop, G Mark;;Lee, James;;Lee, Kate L;;Lees, Charlie;;Lewis, Kevin;;Lindgren, Cecilia M;;Maisuria-Armer, Meeta;;Maller, Julian;;Mansfield, John;;Marchini, Jonathan L;;Martin, Paul;;Massey, Dunecan CO;;McArdle, Wendy L;;McGuffin, Peter;;McLay, Kirsten E;;McVean, Gil;;Mentzer, Alex;;Mimmack, Michael L;;Morgan, Ann E;;Morris, Andrew P;;Mowat, Craig;;Munroe, Patricia B;;Myers, Simon;;Newman, William;;Nimmo, Elaine R;;O'Donovan, Michael C;;Onipinla, Abiodun;;Ovington, Nigel R;;Owen, Michael J;;Palin, Kimmo;;Palotie, Aarno;;Parnell, Kirstie;;Pearson, Richard;;Pernet, David;;Perry, John RB;;Phillips, Anne;;Plagnol, Vincent;;Prescott, Natalie J;;Prokopenko, Inga;;Quail, Michael A;;Rafelt, Suzanne;;Rayner, Nigel W;;Reid, David M;;Renwick, Anthony;;Ring, Susan M;;Robertson, Neil;;Robson, Samuel;;Russell, Ellie;;St Clair, David;;Sambrook, Jennifer G;;Sanderson, Jeremy D;;Sawcer, Stephen J;;Schuilenburg, Helen;;Scott, Carol E;;Scott, Richard;;Seal, Sheila;;Shaw-Hawkins, Sue;;Shields, Beverley M;;Simmonds, Matthew J;;Smyth, Debbie J;;Somaskantharajah, Elilan;;Spanova, Katarina;;Steer, Sophia;;Stephens, Jonathan;;Stevens, Helen E;;Stirrups, Kathy;;Stone, Millicent A;;Strachan, David P;;Su, Zhan;;Symmons, Deborah PM;;Thompson, John R;;Thomson, Wendy;;Tobin, Martin D;;Travers, Mary E;;Turnbull, Clare;;Vukcevic, Damjan;;Wain, Louise;;Walker, Mark;;Walker, Neil M;;Wallace, Chris;;Warren-Perry, Margaret;;Watkins, Nicholas A;;Webster, John;;Weedon, Michael N;;Wilson, Anthony G;;Woodburn, Matthew;;Wordsworth, B Paul;;Yau, Chris;;Young, Allan H;;Zeggini, Eleftheria;;Brown, Matthew A;;Burton, Paul R;;Caulfield, Mark J;;Compston, Alastair;;Farrall, Martin;;Gough, Stephen CL;;Hall, Alistair S;;Hattersley, Andrew T;;Hill, Adrian VS;;Mathew, Christopher G;;Pembrey, Marcus;;Satsangi, Jack;;Stratton, Michael R;;Worthington, Jane;;Hurles, Matthew E;;Duncanson, Audrey;;Ouwehand, Willem H;;Parkes, Miles;;Rahman, Nazneen;;Todd, John A;;Samani, Nilesh J;;Kwiatkowski, Dominic P;;McCarthy, Mark;;Craddock, Nick;;Deloukas, Panos;;Donnelly, Peter;;Blackwell, Jenefer M;;Bramon, Elvira;;Casas, Juan P;;Corvin, Aiden;;Jankowski, Janusz;;Markus, Hugh S;;Palmer, Colin NA;;Plomin, Robert;;Rautanen, Anna;;Trembath, Richard C;;Viswanathan, Ananth C;;Wood, Nicholas W;;Spencer, Chris CA;;Band, Gavin;;Bellenguez, Celine;;Freeman, Colin;;Hellenthal, Garrett;;Pirinen, Matti;;Strange, Amy;;Blackburn, Hannah;;Bumpstead, Suzannah J;;Dronov, Serge;;Gillman, Matthew;;Jayakumar, Alagurevathi;;McCann, Owen T;;Liddle, Jennifer;;Potter, Simon C;;Ravindrarajah, Radhi;;Ricketts, Michelle;;Waller, Matthew;;Weston, Paul;;Widaa, Sara;;Whittaker, Pamela;
Crohn Disease (CD) is a complex genetic disorder for which more than 140 genes have been identified using genome wide association studies (GWAS). However, the genetic architecture of the trait remains largely unknown. The recent development of machin...
Background: Methotrexate (MTX) remains the cornerstone for therapy for rheumatoid arthritis yet research shows that non-adherence is significant and correlates with response to therapy.
Despite the success of genome-wide association studies (GWAS) in detecting a large number of loci for complex phenotypes such as rheumatoid arthritis (RA) susceptibility, the lack of information on the causal genes leaves important challenges to inte...
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Objective: To investigate whether antidrug antibodies and/or drug non-trough levels predict the long-term treatment response in a large cohort of patients with rheumatoid arthritis (RA) treated with adalimumab or etanercept and to identify factors in...