3-[p-[3-(Trifluoromethyl)-3H-diazirin-3-yl]phenyl]alanine has been prepared in 10 steps from p-bromobenzyl alcohol. The alcohol was converted to 3-(alpha-iodo-p-tolyl)-3-(trifluoromethyl)-3H-diazirine, which was used to alkylate N-(diphenylmethylene)...
Document(s)
Title
Pairing effect: Varying the concentration of support electrolyte in the electrochemical EC(2) reduction of 2,6-diphenylpyrylium reveals the presence of ion pairing between the electroactive species and BF(4)(-). Experiment and theory are shown to be ...
An algorithm for simulating coherence selection due to a pulse sequence element consisting of two pulsed field gradients separated by a short collection of pulses and delays is introduced. This algorithm involves computation of the matrix exponential...
This thesis explores the reactivity of amine-boranes with the {Rh(Xantphos)}+ fragment, with the aim of gaining mechanistic insight into the catalytic dehydropolymerisation of the amine-borane H3B∙NMeH2 to yield the polyaminoborane [H2BNMeH]n. Chapte...
This thesis describes investigations into the total asymmetric synthesis of alkaloids from polysubstituted piperidines via iodolactonisation, resulting in the completion of an asymmetric synthesis of pseudodistomin D.
Farnesyl pyrophosphate synthase (FPPS) is a key branch point enzyme in the mevalonate pathway and the main molecular target of nitrogen-containing bisphosphonates (N-BPs), potent inhibitors of osteoclastic activity and the leading drug of choice for ...
BACKGROUND: Group II metabotropic glutamate receptors (mGlu2 and mGlu3, encoded by Grm2 and Grm3) have been the focus of attention as treatment targets for a number of psychiatric conditions. Double knockout mice lacking mGlu2 and mGlu3 (mGlu2/3-/-) ...
The nature of electronic states at the Fermi energy in metallic β-PbO2 has been identified by hard x-ray photoemission spectroscopy (HXPS) combined with x-ray emission spectroscopy and density-functional theory calculations. Pb 6s states are strongly...
We systematically study the design of simple patchy sphere models that reversibly self-assemble into monodisperse icosahedral clusters. We find that the optimal patch width is a compromise between structural specificity (the patches must be narrow en...
After a general introduction about the properties and preparation of organofluorine compounds (Chapter 1), this thesis is divided into two parts focussing on the development of new methods for CâF bond formation (Part A) as well as studies towards ...