Dexmedetomidine (DMET) is a sedative, analgesic and anxiolytic with minimum adverse respiratory effects. An LC-MS/MS bioanalytical method has been developed and validated to accurately measure DMET concentrations in samples of human plasma. The metho...
A tetrahydropyranyl acetal bearing a proximal phenyl diazoketone substituent underwent Rh(ii)-catalysed C-H insertion via an 'anomalous' C-O bond-forming, rather than C-C bond-forming, transformation, giving spirocyclic orthoesters. Density functiona...
Wang, Lihua;Guan, Pengfei;Teng, Jiao;Liu, Pan;Chen, Dengke;Xie, Weiyu;Kong, Deli;Zhang, Shengbai;Zhu, Ting;Zhang, Ze;Ma, Evan;Chen, Mingwei;Han, Xiaodong Twin nucleation in a face-centered cubic crystal is believed to be accomplished through the formation of twinning partial dislocations on consecutive atomic planes. Twinning should thus be highly unfavorable in face-centered cubic metals with high tw...
Camargo, Tiago Pacheco;Neves, Ademir;Peralta, Rosely A.;Chaves, Cláudia;Maia, Elene C. P.;Lizarazo-Jaimes, Edgar H.;Gomes, Dawidson A.;Bortolotto, Tiago;Norberto, Douglas R.;Terenzi, Hernán;Tierney, David L.;Schenk, Gerhard Herein, we report the synthesis and characterization of two dinuclear FeIIIZnII complexes [FeIIIZnIILP1] (1) and [FeIIIZnIILP2] (2), in which LP1 and LP2 are conjugated systems containing one and two pyrene groups, respectively, connected via the dia...
Enzymes with a high selectivity are desirable for improving economics of chemical synthesis of enantiopure compounds. To improve enzyme selectivity mutations are often introduced near the catalytic active site. In this compact environment epistatic i...
P25 is one of the most widely used forms of titanium(iv) oxide (TiO2), routinely utilised in dye-sensitised solar cells (DSCs), where it is often employed as a control, in spite of its poorly defined nature and the typically low device efficiency (or...
Extrusion processing of cereal starch granules with high (>50%) amylose content is a promising approach to create nutritionally desirable resistant starch, i.e. starch that escapes digestion in the small intestine. Whilst high amylose content seems t...
A range of endemic Nicotiana species are chewed as a smokeless tobacco by several Aboriginal populations of Australia. In tobacco research, nicotine to nornicotine conversion is important because nornicotine lowers tobacco quality and is detrimental ...
