Mura-Jornet, Isidora;Pimentel, Carolina;Dantas, Gisele P. M.;Petry, María Virginia;González-Acuña, Daniel;Barbosa, Andrés;Lowther, Andrew D.;Kovacs, Kit M.;Poulin, Elie;Vianna, Juliana A. Background: Historical factors, demography, reproduction and dispersal are crucial in determining the genetic structure of seabirds. In the Antarctic marine environment, penguins are a major component of the avian biomass, dominant predators and impo...
Guillaumet Adkins, Amy;Richter, Julia;Odero, Maria D.;Sandoval, Juan;Agirre, Xabi;Catala, Albert;Esteller, Manel;Prósper, Felipe;Calasanz, María José;Buño, Ismael;Kwo, Mi;Court, Franck;Siebert, Reiner;Monk, David Background: Wilms tumor 1 (WT1) is over-expressed in numerous cancers with respect to normal cells, and has either a tumor suppressor or oncogenic role depending on cellular context. This gene is associated with numerous alternatively spliced transcr...
We isolate and culture carcinoma-associated fibroblasts (CAFs) from primary tumour (CAFpt), CAFs from corresponding synchronous liver metastasis (CAFlm) as well as normal colonic fibroblasts (NCF) from the same patient. From these cultures, condition...
The fruit fly Drosophila melanogaster is a powerful model system for the study of innate immunity in vector insects as well as mammals. For vector insects, it is particularly important to understand all aspects of their antiviral immune defenses, whi...
Compositional data consist of vectors of proportions normalized to a constant sum from a basis of unobserved counts. The sum constraint makes inference on correlations between unconstrained features challenging due to the information loss from normal...
A constellation of metabolic disorders, including obesity, dysregulated lipids, and elevations in blood glucose levels, has been associated with cardiovascular disease and diabetes. Analysis of data from recently published genome-wide association stu...
Human primary glioblastomas (GBM) often harbor mutations within the epidermal growth factor receptor (EGFR). Treatment of EGFR-mutant GBM cell lines with the EGFR/HER2 tyrosine kinase inhibitor lapatinib can effectively induce cell death in these mod...
Recent advances in reconstruction and analytical methods for signaling networks have spurred the development of large-scale models that incorporate fully functional and biologically relevant features. An extended reconstruction of the human Toll-like...
Guillaumet Adkins, Amy;Richter, Julia;Odero, Maria D.;Sandoval, Juan;Agirre, Xabi;Catala, Albert;Esteller, Manel;Prósper, Felipe;Calasanz, María José;Buño, Ismael;Kwo, Mi;Court, Franck;Siebert, Reiner;Monk, David Background: Wilms tumor 1 (WT1) is over-expressed in numerous cancers with respect to normal cells, and has either a tumor suppressor or oncogenic role depending on cellular context. This gene is associated with numerous alternatively spliced transcr...
