Familial breast and ovarian cancers are often defective in homologous recombination (HR) due to mutations in the BRCA1 or BRCA2 genes. Cisplatin chemotherapy or poly(ADP-ribose) polymerase (PARP) inhibitors were tested for these tumors in clinical tr...
Document(s)
Title
Purpose Previous studies indicate a possible inverse relationship between prostate-specific antigen (PSA) and body mass index (BMI), and a positive relationship between PSA and age. We investigated the associations between age, BMI, PSA, and screen-d...
In this thesis, C-F bond activation and C-F bond construction under platinum and iridium catalysis is described.Chapter 1 provides a general introduction on the use of transition metal catalysis for the formation and activation of Csp³-F bonds in org...
A highly significant structure is observed in the Λ+cK−π+π+ mass spectrum, where the Λ+c baryon is reconstructed in the decay mode pK−π+. The structure is consistent with originating from a weakly decaying particle, identified as the doubly charmed b...
Anthropogenic warming could well drive depletion of oceanic oxygen in the future. Important insight into the relationship between de-oxygenation and warming can be gleaned from the geological record, but evidence is limited because few ocean oxygenat...
A systematic multi-isotopic and trace element characterization of U.S. Geological Survey reference materials has been carried out at the Pacific Centre for Isotopic and Geochemical Research, University of British Columbia. Values of 176Hf/177Hf are r...
This paper chronicles the progress in wireless information transmission and reception, and discusses future trends in radiowave propagation research. Since the conception of wireless transmission, a number of pioneers have successfully understood and...
BACKGROUND: In certain diseases clinical experts may judge that the intervention with the best prospects is the addition of two treatments to the standard of care. This can either be tested with a simple randomized trial of combination versus standar...