Natural killer (NK) cells are a critical component in the innate immune response against disease. NK cell function is tightly regulated by specific cytokine and activation/inhibitory receptor signalling, leading to diverse effector responses. Like al...
Dexmedetomidine (DMET) is a sedative, analgesic and anxiolytic with minimum adverse respiratory effects. An LC-MS/MS bioanalytical method has been developed and validated to accurately measure DMET concentrations in samples of human plasma. The metho...
MicroRNAs (miRNAs) are highly conserved ∼22 nt small noncoding RNAs that bind partially complementary sequences in target transcripts. MicroRNAs regulate both translation and transcript stability, and play important roles in development, cellular hom...
Stafford, Lesley;Sinclair, Michelle;Turner, Jane;Newman, Louise;Wakefield, Claire;Krishnasamy, Mei;Mann, G Bruce;Gilham, Leslie;Mason, Kylie;Rauch, Paula;Cannell, Julia;Schofield, Penelope Parents with cancer have high rates of psychological morbidity, and their children are at risk of poor psychosocial outcomes, particularly in the context of parental distress and poor family communication. Parents express concerns about the impact of...
DsbA catalyses disulfide bond formation in secreted and outer membrane proteins in bacteria. In pathogens, DsbA is a major facilitator of virulence constituting a target for antivirulence antimicrobial development. However, many pathogens encode mult...
Zheng, Yang;Wang, Zhao;Ding, Xu;Dong, Yibo;Zhang, Wei;Zhang, Wei;Zhong, Yi;Gu, Wenyi;Wu, Yunong;Song, Xiaomeng Head and neck squamous cell carcinoma (HNSCC) is characterized by high mortality and low survival rates. As an epidermal growth factor receptor (EGFR) inhibitor, Erlotinib has been approved for treatment of various tumours. PF-03084014 is a selective...
Whiplash associated disorders (WAD) are the most common non-hospitalised injury resulting from a motor vehicle crash. Approximately 50% of individuals with WAD experience on-going pain and disability. Results from intervention trials for individuals ...
Li, Jie;Watterson, Daniel;Chang, Chiung-Wen;Che, Xiao-Yan;Li, Xiao-Quan;Ericsson, Daniel J.;Qiu, Li-Wen;Cai, Jian-Piao;Chen, Jing;Fry, Scott R.;Cheung, Stacey T. M.;Cooper, Matthew A.;Young, Paul R.;Kobe, Bostjan Understanding the molecular basis of the neutralizing antibody response to dengue virus (DENV) is an essential component in the design and development of effective vaccines and immunotherapeutics. Here we present the structure of a cross-reactive, ne...
Tracing the temporal dynamics of pathogens is crucial for developing strategies to detect and limit disease emergence. Canine parvovirus (CPV-2) is an enteric virus causing morbidity and mortality in dogs around the globe. Previous work in Australia ...
Genetic polymorphisms in the fat mass and obesity-associated (FTO) gene have been strongly associated with obesity in humans. The cellular level of FTO is tightly regulated, with alterations in its expression influencing energy metabolism, food intak...
