Selected Article


Nephrotoxic Effects of Pesticides


Pesticidesare used extensively throughout the world and, in recent years, their use hasincreased considerably. Pesticides are responsible for several adverse effectson human health, and they represent a potential risk to human. Liver and kidneyare firstly most harmed tissues by pesticides, because pesticides are removedfrom the body by being metabolized in the liver and kidney main road. A broad rangeof pesticides, including organophosphates, organochlorines, carbamates,pyrethroids and triazine herbicides have been shown to cause renal damage anddysfunction in animal toxicity studies.The most commonly reported pesticidesimplicated in human renal damage are organophosphates, though other pesticidesare known to be nephrotoxic at high levels. Pesticide poisoning case studies,animal models, and in vitro laboratory research provide evidence for a damagingeffect of both acute and chronic pesticide exposure on renal function Yet, theimpact of long-term pesticide exposure on the human kidney remains unknown.Evidence suggests that pesticide exposure may harm the kidneys throughoxidative stress and resulting cell damage. Acute tubular necrosis has alsobeen seen in animal studies of pesticide nephrotoxicity, along with otherevidence of renal damage from pesticide exposure. Commonly observed renalsymptoms in pesticide poisoning include acute tubular necrosis, hematuria, andproteinuria. Clinically, acute kidney injury is a frequent outcome of pesticidepoisoning among humans, and is associated with subsequent renal disease.Chronic effects of pesticides on kidney: Albuminurrhea, increased ureacreatinine levels, decreased secretory function Because of potential healthrisks, pesticides should be used consciously and under supervision. Keywords:Nephrotoxic,Pesticides, Poisoning