Background Nicotinic acetylcholine receptors (nAChRs) are pentameric proteins that are important drug targets for a variety of diseases including Alzheimer’s, schizophrenia and various forms of epilepsy. One of the most intensively studied nAChR subu...
Diakite, M;Achidi, EA;Achonduh, O;Craik, R;Djimde, AA;Evehe, M-SB;Green, A;Hubbart, C;Ibrahim, M;Jeffreys, A;Khan, BK;Kimani, F;Kwiatkowski, DP;Mbacham, WF;Jezan, SO;Ouedraogo, JB;Rockett, K;Rowlands, K;Tagelsir, N;Tekete, MM;Zongo, I;Ranford-Cartwright, LC Resistance to anti-malarial drugs is a widespread problem for control programmes for this devastating disease. Molecular tests are available for many anti-malarial drugs and are useful tools for the surveillance of drug resistance. However, the corre...
Key, TJ;wrightson;Muller, DC;Murphy, N;Johansson, M;Ferrari, P;Tsildis, KK;Boutron-Rualt, M-C;Clave, F;Dartois, L;Li, K;Kaaks, R;Weikert, C;Bergmann, M;Boeing, H;Tjønneland, A;Overvad, K;Redondo, ML;Agudo, A;Molina-Portillo, E;Altzibar, JM;Cirera, L;Ardanaz, E;Khaw, K-T;Wareham, NJ;Travis, RC;Bamia, C;Orfanos, P;Trichopoulou, A;Palli, D;Pala, V;Tumino, R;Vineis, P;Panico, S;Bueno-de-Mesquita, HB;Verschuren, WMM;Struijk, EA;Peeters, PH;Engström, G;Melander, O;Sund, M;Weiderpass, E;Skeie, G;Lund, E;Norat, T;Gunter, M;Riboli, E;Brennan, P Background Life expectancy is increasing in Europe, yet a substantial proportion of adults still die prematurely before the age of 70 years. We sought to estimate the joint and relative contributions of tobacco smoking, hypertension, obesity, physica...
BACKGROUND: Voice disorders affect patients profoundly, and acoustic tools can potentially measure voice function objectively. Disordered sustained vowels exhibit wide-ranging phenomena, from nearly periodic to highly complex, aperiodic vibrations, a...
Gonem, S;Scadding, A;Soares, M;Singapuri, A;Gustafsson, P;Ohri, C;Range, S;Brightling, CE;Pavord, I;Horsley, A;Siddiqui, S Background: Lung clearance index (LCI) is a measure of abnormal ventilation distribution derived from the multiple breath inert gas washout (MBW) technique. We aimed to determine the clinical utility of LCI in non-CF bronchiectasis, and to assess two...
BACKGROUND: Concurrent diseases, multiple pathologies and multimorbidity patterns are topics of increased interest as the world's population ages. To explore the impact of multimorbidity on affected patients and the consequences for health services, ...
Matsumiya, M;Harris, SA;Satti, I;Stockdale, L;Tanner, R;O'Shea, MK;Tameris, M;Mahomed, H;Hatherill, M;Scriba, TJ;Hanekom, WA;McShane, H;Fletcher, HA Background: Tuberculosis (TB) remains a global health problem, with vaccination likely to be a necessary part of a successful control strategy. Results of the first Phase 2b efficacy trial of a candidate vaccine, MVA85A, evaluated in BCG-vaccinated i...
Puri, T;Chalkidou, A;Roy, A;Henley-Smith, R;Barber, P;Guerrero-Urbano, T;Oakley, R;Simo, R;Jeannon, JP;McGurk, M;Odell, E;O'Doherty, M;Marsden, P Background: Accurate alignment between histopathology slices and positron emission tomography (PET) images is important for radiopharmaceutical validation studies. Limited data is available on the registration accuracy that can be achieved between PE...
Newbury, D;Pettigrew, KA;Frinton, E;Nudel, R;Chan, MTM;Thompson, P;Hayiou-Thomas, ME;Talcott, JB;Stein, J;Monaco, AP;Hulme, C;Snowling, MJ;Paracchini, S Background: Specific Language Impairment (SLI) is a common neurodevelopmental disorder, observed in 5-10% of children. Family and twin studies suggest a strong genetic component, but relatively few candidate genes have been reported to date. A recent...
Background: Identifying factors that improve job satisfaction of new doctors and ease the difficult transition from student to doctor is of great interest to public health agencies. Studies to date have focused primarily on the value of changes to me...
