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Fuchsberger, Christian;Flannick, Jason;Teslovich, Tanya M;Mahajan, Anubha;Agarwala, Vineeta;Gaulton, Kyle J;Ma, Clement;Fontanillas, Pierre;Moutsianas, Loukas;McCarthy, Davis J;Rivas, Manuel A;Perry, John RB;Sim, Xueling;Blackwell, Thomas W;Robertson, Neil R;Rayner, N William;Cingolani, Pablo;Locke, Adam E;Tajes, Juan Fernandez;Highland, Heather M;Dupuis, Josee;Chines, Peter S;Lindgren, Cecilia M;Hartl, Christopher;Jackson, Anne U;Chen, Han;Huyghe, Jeroen R;van de Bunt, Martijn;Pearson, Richard D;Kumar, Ashish;Mueller-Nurasyid, Martina;Grarup, Niels;Stringham, Heather M;Gamazon, Eric R;Lee, Jaehoon;Chen, Yuhui;Scott, Robert A;Below, Jennifer E;Chen, Peng;Huang, Jinyan;Go, Min Jin;Stitzel, Michael L;Pasko, Dorota;Parker, Stephen CJ;Varga, Tibor V;Green, Todd;Beer, Nicola L;Day-Williams, Aaron G;Ferreira, Teresa;Fingerlin, Tasha;Horikoshi, Momoko;Hu, Cheng;Huh, Iksoo;Ikram, Mohammad Kamran;Kim, Bong-Jo;Kim, Yongkang;Kim, Young Jin;Kwon, Min-Seok;Lee, Juyoung;Lee, Selyeong;Lin, Keng-Han;Maxwell, Taylor J;Nagai, Yoshihiko;Wang, Xu;Welch, Ryan P;Yoon, Joon;Zhang, Weihua;Barzilai, Nir;Voight, Benjamin F;Han, Bok-Ghee;Jenkinson, Christopher P;Kuulasmaa, Teemu;Kuusisto, Johanna;Manning, Alisa;Ng, Maggie CY;Palmer, Nicholette D;Balkau, Beverley;Stancakova, Alena;Abboud, Hanna E;Boeing, Heiner;Giedraitis, Vilmantas;Prabhakaran, Dorairaj;Gottesman, Omri;Scott, James;Carey, Jason;Kwan, Phoenix;Grant, George;Smith, Joshua D;Neale, Benjamin M;Purcell, Shaun;Butterworth, Adam S;Howson, Joanna MM;Lee, Heung Man;Lu, Yingchang;Kwak, Soo-Heon;Zhao, Wei;Danesh, John;Lam, Vincent KL;Park, Kyong Soo;Saleheen, Danish;So, Wing Yee;Tam, Claudia HT;Afzal, Uzma;Aguilar, David;Arya, Rector;Aung, Tin;Chan, Edmund;Navarro, Carmen;Cheng, Ching-Yu;Palli, Domenico;Correa, Adolfo;Curran, Joanne E;Rybin, Denis;Farook, Vidya S;Fowler, Sharon P;Freedman, Barry I;Griswold, Michael;Hale, Daniel Esten;Hicks, Pamela J;Khor, Chiea-Chuen;Kumar, Satish;Lehne, Benjamin;Thuillier, Dorothee;Lim, Wei Yen;Liu, Jianjun;van der Schouw, Yvonne T;Loh, Marie;Musani, Solomon K;Puppala, Sobha;Scott, William R;Yengo, Loic;Tan, Sian-Tsung;Jr, Taylor Herman A;Thameem, Farook;Sr, Wilson Gregory;Wong, Tien Yin;Njolstad, Pal Rasmus;Levy, Jonathan C;Mangino, Massimo;Bonnycastle, Lori L;Schwarzmayr, Thomas;Fadista, Joao;Surdulescu, Gabriela L;Herder, Christian;Groves, Christopher J;Wieland, Thomas;Bork-Jensen, Jette;Brandslund, Ivan;Christensen, Cramer;Koistinen, Heikki A;Doney, Alex SF;Kinnunen, Leena;Esko, Tonu;Farmer, Andrew J;Hakaste, Liisa;Hodgkiss, Dylan;Kravic, Jasmina;Lyssenko, Valeriya;Hollensted, Mette;Jorgensen, Marit E;Jorgensen, Torben;Ladenvall, Claes;Justesen, Johanne Marie;Karajamaki, Annemari;Kriebel, Jennifer;Rathmann, Wolfgang;Lannfelt, Lars;Lauritzen, Torsten;Narisu, Narisu;Linneberg, Allan;Melander, Olle;Milani, Lili;Neville, Matt;Orho-Melander, Marju;Qi, Lu;Qi, Qibin;Roden, Michael;Rolandsson, Olov;Swift, Amy;Rosengren, Anders H;Stirrups, Kathleen;Wood, Andrew R;Mihailov, Evelin;Blancher, Christine;Carneiro, Mauricio O;Maguire, Jared;Poplin, Ryan;Shakir, Khalid;Fennell, Timothy;DePristo, Mark;de Angelis, Martin Hrabe;Deloukas, Panos;Gjesing, Anette P;Jun, Goo;Nilsson, Peter;Murphy, Jacquelyn;Onofrio, Robert;Thorand, Barbara;Hansen, Torben;Meisinger, Christa;Hu, Frank B;Isomaa, Bo;Karpe, Fredrik;Liang, Liming;Peters, Annette;Huth, Cornelia;O'Rahilly, Stephen P;Palmer, Colin NA;Pedersen, Oluf;Rauramaa, Rainer;Tuomilehto, Jaakko;Salomaa, Veikko;Watanabe, Richard M;Syvanen, Ann-Christine;Bergman, Richard N;Bharadwaj, Dwaipayan;Bottinger, Erwin P;Cho, Yoon Shin;Chandak, Giriraj R;Chan, Juliana CN;Chia, Kee Seng;Daly, Mark J;Ebrahim, Shah B;Langenberg, Claudia;Elliott, Paul;Jablonski, Kathleen A;Lehman, Donna M;Jia, Weiping;Ma, Ronald CW;Pollin, Toni I;Sandhu, Manjinder;Tandon, Nikhil;Froguel, Philippe;Barroso, Ines;Teo, Yik Ying;Zeggini, Eleftheria;Loos, Ruth JF;Small, Kerrin S;Ried, Janina S;DeFronzo, Ralph A;Grallert, Harald;Glaser, Benjamin;Metspalu, Andres;Wareham, Nicholas J;Walker, Mark;Banks, Eric;Gieger, Christian;Ingelsson, Erik;Im, Hae Kyung;Illig, Thomas;Franks, Paul W;Buck, Gemma;Trakalo, Joseph;Buck, David;Prokopenko, Inga;Magi, Reedik;Lind, Lars;Farjoun, Yossi;Owen, Katharine R;Gloyn, Anna L;Strauch, Konstantin;Tuomi, Tiinamaija;Kooner, Jaspal Singh;Lee, Jong-Young;Park, Taesung;Donnelly, Peter;Morris, Andrew D;Hattersley, Andrew T;Bowden, Donald W;Collins, Francis S;Atzmon, Gil;Chambers, John C;Spector, Timothy D;Laakso, Markku;Strom, Tim M;Bell, Graeme I;Blangero, John;Duggirala, Ravindranath;Tai, E Shyong;McVean, Gilean;Hanis, Craig L;Wilson, James G;Seielstad, Mark;Frayling, Timothy M;Meigs, James B;Cox, Nancy J;Sladek, Rob;Lander, Eric S;Gabriel, Stacey;Burtt, Noel P;Mohlke, Karen L;Meitinger, Thomas;Groop, Leif;Abecasis, Goncalo;Florez, Jose C;Scott, Laura J;Morris, Andrew P;Kang, Hyun Min;Boehnke, Michael;Altshuler, David;McCarthy, Mark I
Schumann, Gunter;Coin, Lachlan J.;Lourdusamy, Anbarasu;Charoen, Pimphen;Berger, Karen H.;Stacey, David;Desrivieres, Sylvane;Aliev, Fazil A.;Khan, Anokhi A.;Amin, Najaf;Aulchenko, Yurii S.;Bakalkin, Georgy;Bakker, Stephan J.;Balkau, Beverley;Beulens, Joline W.;Bilbao, Ainhoa;de Boer, Rudolf A.;Beury, Delphine;Bots, Michiel L.;Breetvelt, Elemi J.;Cauchi, Stephane;Cavalcanti-Proenca, Christine;Chambers, John C.;Clarke, Toni-Kim;Dahmen, Norbert;de Geus, Eco J.;Dick, Danielle;Ducci, Francesca;Easton, Alanna;Edenberg, Howard J.;Esk, Tonu;Fernandez-Medarde, Alberto;Foroud, Tatiana;Freimer, Nelson B.;Girault, Jean-Antoine;Grobbee, Diederick E.;Guarrera, Simonetta;Gudbjartsson, Daniel F.;Hartikainen, Anna-Liisa;Heath, Andrew C.;Hesselbrock, Victor;Hofman, Albert;Hottenga, Jouke-Jan;Isohanni, Matti K.;Kaprio, Jaakko;Khaw, Kay-Tee;Kuehnel, Brigitte;Laitinen, Jaana;Lobbens, Stephane;Luan, Jian;&;apos;an;Mangino, Massimo;Maroteaux, Matthieu;Matullo, Giuseppe;McCarthy, Mark I.;Mueller, Christian;Navis, Gerjan;Numans, Mattijs E.;Nunez, Alejandro;Nyholt, Dale R.;Onland-Moret, Charlotte N.;Oostra, Ben A.;O;&;apos;Reilly, Paul F.;Palkovits, Miklos;Penninx, Brenda W.;Polidoro, Silvia;Pouta, Anneli;Prokopenko, Inga;Ricceri, Fulvio;Santos, Eugenio;Smit, Johannes H.;Soranzo, Nicole;Song, Kijoung;Sovio, Ulla;Stumvoll, Michael;Surakk, Ida;Thorgeirsson, Thorgeir E.;Thorsteinsdottir, Unnur;Troakes, Claire;Tyrfingsson, Thorarinn;Toenjes, Anke;Uiterwaal, Cuno S.;Uitterlinden, Andre G.;van der Harst, Pim;van der Schouw, Yvonne T.;Staehlin, Oliver;Vogelzangs, Nicole;Vollenweider, Peter;Waeber, Gerard;Wareham, Nicholas J.;Waterworth, Dawn M.;Whitfield, John B.;Wichmann, Erich H.;Willemsen, Gonneke;Witteman, Jacqueline C.;Yuan, Xin;Zhai, Guangju;Zhao, Jing H.;Zhang, Weihua;Martin, Nicholas G.;Metspalu, Andres;Doering, Angela;Scott, James;Spector, Tim D.;Loos, Ruth J.;Boomsma, Dorret I.;Mooser, Vincent;Peltonen, Leena;Stefansson, Kari;van Duijn, Cornelia M.;Vineis, Paolo;Sommer, Wolfgang H.;Kooner, Jaspal S.;Spanagel, Rainer;Heberlein, Ulrike A.;Jarvelin, Marjo-Riitta;Elliott, Paul
Alcohol consumption is a moderately heritable trait, but the genetic basis in humans is largely unknown, despite its clinical and societal importance. We report a genome-wide association study meta-analysis of similar to 2.5 million directly genotype...
We conducted a genome-wide association study for age at natural menopause in 2,979 European women and identified six SNPs in three loci associated with age at natural menopause: chromosome 19q13.4 (rs1172822; -0.4 year per T allele (39%); P = 6.3 x 1...
Di Angelantonio, Emanuele;Kaptoge, Stephen;Wormser, David;Willeit, Peter;Butterworth, Adam S;Bansal, Narinder;O'Keeffe, Linda M;Gao, Pei;Wood, Angela M;Burgess, Stephen;Freitag, Daniel F;Pennells, Lisa;Peters, Sanne A;Hart, Carole L;Håheim, Lise Lund;Gillum, Richard F;Nordestgaard, Børge G;Psaty, Bruce M;Yeap, Bu B;Knuiman, Matthew W;Nietert, Paul J;Kauhanen, Jussi;Salonen, Jukka T;Kuller, Lewis H;Simons, Leon A;van der Schouw, Yvonne T;Barrett-Connor, Elizabeth;Selmer, Randi;Crespo, Carlos J;Rodriguez, Beatriz;Verschuren, W M Monique;Salomaa, Veikko;Svärdsudd, Kurt;van der Harst, Pim;Björkelund, Cecilia;Wilhelmsen, Lars;Wallace, Robert B;Brenner, Hermann;Amouyel, Philippe;Barr, Elizabeth L M;Iso, Hiroyasu;Onat, Altan;Trevisan, Maurizio;D'Agostino, Ralph B;Cooper, Cyrus;Kavousi, Maryam;Welin, Lennart;Roussel, Ronan;Hu, Frank B;Sato, Shinichi;Davidson, Karina W;Howard, Barbara V;Leening, Maarten;Rosengren, Annika;Dörr, Marcus;Deeg, Dorly J H;Kiechl, Stefan;Stehouwer, Coen D A;Nissinen, Aulikki;Giampaoli, Simona;Donfrancesco, Chiara;Kromhout, Daan;Price, Jackie F;Peters, Annette;Meade, Tom W;Casiglia, Edoardo;Lawlor, Debbie A;Gallacher, John;Nagel, Dorothea;Franco, Oscar H;Assmann, Gerd;Dagenais, Gilles R;Jukema, J Wouter;Sundström, Johan;Woodward, Mark;Brunner, Eric J;Khaw, Kay-Tee;Wareham, Nicholas J;Whitsel, Eric A;Njølstad, Inger;Hedblad, Bo;Wassertheil-Smoller, Sylvia;Engström, Gunnar;Rosamond, Wayne D;Selvin, Elizabeth;Sattar, Naveed;Thompson, Simon G;Danesh, John
The prevalence of cardiometabolic multimorbidity is increasing.
Gaulton, Kyle J;Ferreira, Teresa;Lee, Yeji;Raimondo, Anne;Mägi, Reedik;Reschen, Michael E;Mahajan, Anubha;Locke, Adam;William Rayner, N;Robertson, Neil;Scott, Robert A;Prokopenko, Inga;Scott, Laura J;Green, Todd;Sparso, Thomas;Thuillier, Dorothee;Yengo, Loic;Grallert, Harald;Wahl, Simone;Frånberg, Mattias;Strawbridge, Rona J;Kestler, Hans;Chheda, Himanshu;Eisele, Lewin;Gustafsson, Stefan;Steinthorsdottir, Valgerdur;Thorleifsson, Gudmar;Qi, Lu;Karssen, Lennart C;van Leeuwen, Elisabeth M;Willems, Sara M;Li, Man;Chen, Han;Fuchsberger, Christian;Kwan, Phoenix;Ma, Clement;Linderman, Michael;Lu, Yingchang;Thomsen, Soren K;Rundle, Jana K;Beer, Nicola L;van de Bunt, Martijn;Chalisey, Anil;Kang, Hyun Min;Voight, Benjamin F;Abecasis, Gonçalo R;Almgren, Peter;Baldassarre, Damiano;Balkau, Beverley;Benediktsson, Rafn;Blüher, Matthias;Boeing, Heiner;Bonnycastle, Lori L;Bottinger, Erwin P;Burtt, Noël P;Carey, Jason;Charpentier, Guillaume;Chines, Peter S;Cornelis, Marilyn C;Couper, David J;Crenshaw, Andrew T;van Dam, Rob M;Doney, Alex S F;Dorkhan, Mozhgan;Edkins, Sarah;Eriksson, Johan G;Esko, Tonu;Eury, Elodie;Fadista, Joao;Flannick, Jason;Fontanillas, Pierre;Fox, Caroline;Franks, Paul;Gertow, Karl;Gieger, Christian;Gigante, Bruna;Gottesman, Omri;Grant, George B;Grarup, Niels;Groves, Christopher J;Hassinen, Maija;Have, Christian T;Herder, Christian;Holmen, Oddgeir L;Hreidarsson, Astradur B;Humphries, Steve E;Hunter, David J;Jackson, Anne U;Jonsson, Anna;Jørgensen, Marit E;Jørgensen, Torben;Kao, Wen-Hong L;Kerrison, Nicola D;Kinnunen, Leena;Klopp, Norman;Kong, Augustine;Kovacs, Peter;Kraft, Peter;Kravic, Jasmina;Langford, Cordelia;Leander, Karin;Liang, Liming;Lichtner, Peter;Lindgren, Cecilia M;Lindholm, Eero;Linneberg, Allan;Liu, Ching-Ti;Lobbens, Stéphane;Luan, Jian'an;Lyssenko, Valeriya;Männistö, Satu;McLeod, Olga;Meyer, Julia;Mihailov, Evelin;Mirza, Ghazala;Mühleisen, Thomas W;Müller-Nurasyid, Martina;Navarro, Carmen;Nöthen, Markus M;Oskolkov, Nikolay;Owen, Katharine R;Palli, Domenico;Pechlivanis, Sonali;Peltonen, Leena;Perry, John R B;Platou, Carl G P;Roden, Michael;Ruderfer, Douglas;Rybin, Denis;van der Schouw, Yvonne T;Sennblad, Bengt;Sigurðsson, Gunnar;Stančáková, Alena;Steinbach, Gerald;Storm, Petter;Strauch, Konstantin;Stringham, Heather M;Sun, Qi;Thorand, Barbara;Tikkanen, Emmi;Tonjes, Anke;Trakalo, Joseph;Tremoli, Elena;Tuomi, Tiinamaija;Wennauer, Roman;Wiltshire, Steven;Wood, Andrew R;Zeggini, Eleftheria;Dunham, Ian;Birney, Ewan;Pasquali, Lorenzo;Ferrer, Jorge;Loos, Ruth J F;Dupuis, Josée;Florez, Jose C;Boerwinkle, Eric;Pankow, James S;van Duijn, Cornelia;Sijbrands, Eric;Meigs, James B;Hu, Frank B;Thorsteinsdottir, Unnur;Stefansson, Kari;Lakka, Timo A;Rauramaa, Rainer;Stumvoll, Michael;Pedersen, Nancy L;Lind, Lars;Keinanen-Kiukaanniemi, Sirkka M;Korpi-Hyövälti, Eeva;Saaristo, Timo E;Saltevo, Juha;Kuusisto, Johanna;Laakso, Markku;Metspalu, Andres;Erbel, Raimund;Jöcke, Karl-Heinz;Moebus, Susanne;Ripatti, Samuli;Salomaa, Veikko;Ingelsson, Erik;Boehm, Bernhard O;Bergman, Richard N;Collins, Francis S;Mohlke, Karen L;Koistinen, Heikki;Tuomilehto, Jaakko;Hveem, Kristian;Njølstad, Inger;Deloukas, Panagiotis;Donnelly, Peter J;Frayling, Timothy M;Hattersley, Andrew T;de Faire, Ulf;Hamsten, Anders;Illig, Thomas;Peters, Annette;Cauchi, Stephane;Sladek, Rob;Froguel, Philippe;Hansen, Torben;Pedersen, Oluf;Morris, Andrew D;Palmer, Collin N A;Kathiresan, Sekar;Melander, Olle;Nilsson, Peter;Groop, Leif;Barroso, Inês;Langenberg, Claudia;Wareham, Nicholas J;O'Callaghan, Christopher A;Gloyn, Anna L;Altshuler, David;Boehnke, Michael;Teslovich, Tanya M;McCarthy, Mark I;Morris, Andrew P
We performed fine mapping of 39 established type 2 diabetes (T2D) loci in 27,206 cases and 57,574 controls of European ancestry. We identified 49 distinct association signals at these loci, including five mapping in or near KCNQ1. 'Credible sets' of ...
Aims: The hypothesis of 'metabolically healthy obesity' implies that, in the absence of metabolic dysfunction, individuals with excess adiposity are not at greater cardiovascular risk We tested this hypothesis in a large pan-European prospective stud...
Coviello, Andrea D.;Haring, Robin;Wellons, Melissa;Vaidya, Dhananjay;Lehtimaki, Terho;Keildson, Sarah;Lunetta, Kathryn L.;He, Chunyan;Fornage, Myriam;Lagou, Vasiliki;Mangino, Massimo;Onland-Moret, N. Charlotte;Chen, Brian;Eriksson, Joel;Garcia, Melissa;Mei, Yong;Koster, Annemarie;Lohman, Kurt;Lyytikainen, Leo-Pekka;Petersen, Ann-Kristin;Prescott, Jennifer;Stolk, Lisette;Vandenput, Liesbeth;Wood, Andrew R.;Zhuang, Wei Vivian;Ruokonen, Aimo;Hartikainen, Anna-Liisa;Pouta, Anneli;Bandinelli, Stefania;Biffar, Reiner;Brabant, Georg;Cox, David G.;Chen, Yuhui;Cummings, Steven;Ferrucci, Luigi;Gunter, Marc J.;Hankinson, Susan E.;Martikainen, Hannu;Hofman, Albert;Homuth, Georg;Illig, Thomas;Jansson, John-Olov;Johnson, Andrew D.;Karasik, David;Karlsson, Magnus;Kettunen, Johannes;Kiel, Douglas P.;Kraft, Peter;Liu, Jingmin;Ljunggren, Osten;Lorentzon, Mattias;Maggio, Marcello;Markus, Marcello R. P.;Mellstrom, Dan;Miljkovic, Iva;Mirel, Daniel;Nelson, Sarah;Papunen, Laure Morin;Peeters, Petra H. M.;Prokopenko, Inga;Raffel, Leslie;Reincke, Martin;Reiner, Alex P.;Rexrode, Kathryn;Rivadeneira, Fernando;Schwartz, Stephen M.;Siscovick, David;Soranzo, Nicole;Stockl, Doris;Tworoger, Shelley;Uitterlinden, Andre G.;van Gils, Carla H.;Vasan, Ramachandran S.;Wichmann, H. -Erich;Zhai, Guangju;Bhasin, Shalender;Bidlingmaier, Martin;Chanock, Stephen J.;De Vivo, Immaculata;Harris, Tamara B.;Hunter, David J.;Kahonen, Mika;Liu, Simin;Ouyang, Pamela;Spector, Tim D.;van der Schouw, Yvonne T.;Viikari, Jorma;Wallaschofski, Henri;McCarthy, Mark I.;Frayling, Timothy M.;Murray, Anna;Franks, Steve;Jarvelin, Marjo-Riitta;de Jong, Frank H.;Raitakari, Olli;Teumer, Alexander;Ohlsson, Claes;Murabito, Joanne M.;Perry, John R. B.
Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases including type 2 diabetes (T2D...
OBJECTIVEYounger age at menarche, a marker of pubertal timing in girls, is associated with higher risk of later type 2 diabetes. We aimed to confirm this association and to examine whether it is explained by adiposity.RESEARCH DESIGN AND METHODSThe p...
IMPORTANCE Low-density lipoprotein cholesterol (LDL-C)-lowering alleles in or near NPC1L1 or HMGCR, encoding the respective molecular targets of ezetimibe and statins, have previously been used as proxies to study the efficacy of these lipid-lowering...