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Winkler , Thomas W;Justice , Anne E;Graff , Mariaelisa;Barata , Llilda;Feitosa , Mary F;Chu , Su;Czajkowski , Jacek;Esko , Tõnu;Fall , Tove;Kilpeläinen , Tuomas O;Lu , Yingchang;Mägi , Reedik;Mihailov , Evelin;Pers , Tune H;Rüeger , Sina;Teumer , Alexander;Ehret , Georg B;Ferreira , Teresa;Heard-Costa , Nancy L;Karjalainen , Juha;Lagou , Vasiliki;Mahajan , Anubha;Neinast , Michael D;Prokopenko , Inga;Simino , Jeannette;Teslovich , Tanya M;Jansen , Rick;Westra , Harm-Jan;White , Charles C;Absher , Devin;Ahluwalia , Tarunveer S;Ahmad , Shafqat;Albrecht , Eva;Alves , Alexessander Couto;Bragg-Gresham , Jennifer L;de Craen , Anton J M;Bis , Joshua C;Bonnefond , Amélie;Boucher , Gabrielle;Cadby , Gemma;Cheng , Yu-Ching;Chiang , Charleston W K;Delgado , Graciela;Demirkan , Ayse;Dueker , Nicole;Eklund , Niina;Eiriksdottir , Gudny;Eriksson , Joel;Feenstra , Bjarke;Fischer , Krista;Frau , Francesca;Galesloot , Tessel E;Geller , Frank;Goel , Anuj;Gorski , Mathias;Grammer , Tanja B;Gustafsson , Stefan;Haitjema , Saskia;Hottenga , Jouke-Jan;Huffman , Jennifer E;Jackson , Anne U;Jacobs , Kevin B;Johansson , Åsa;Kaakinen , Marika;Kleber , Marcus E;Lahti , Jari;Mateo Leach , Irene;Lehne , Benjamin;Liu , Youfang;Lo , Ken Sin;Lorentzon , Mattias;Luan , Jian'An;Madden , Pamela A F;Mangino , Massimo;McKnight , Barbara;Medina-Gomez , Carolina;Monda , Keri L;Montasser , May E;Müller , Gabriele;Müller-Nurasyid , Martina;Nolte , Ilja M;Panoutsopoulou , Kalliope;Pascoe , Laura;Paternoster , Lavinia;Rayner , Nigel W;Renström , Frida;Rizzi , Federica;Rose , Lynda M;Ryan , Kathy A;Salo , Perttu;Sanna , Serena;Scharnagl , Hubert;Shi , Jianxin;Smith , Albert Vernon;Southam , Lorraine;Stančáková , Alena;Steinthorsdottir , Valgerdur;Strawbridge , Rona J;Sung , Yun Ju;Tachmazidou , Ioanna;Tanaka , Toshiko;Thorleifsson , Gudmar;Trompet , Stella;Pervjakova , Natalia;Tyrer , Jonathan P;Vandenput , Liesbeth;van der Laan , Sander W;van der Velde , Nathalie;van Setten , Jessica;Van Vliet-Ostaptchouk , Jana V;Verweij , Niek;Vlachopoulou , Efthymia;Waite , Lindsay L;Wang , Sophie R;Wang , Zhaoming;Wild , Sarah H;Willenborg , Christina;Wilson , James F;Wong , Andrew;Yang , Jian;Yengo , Loïc;Yerges-Armstrong , Laura M;Yu , Lei;Zhang , Weihua;Zhao , Jing Hua;Andersson , Ehm A;Bakker , Stephan J L;Baldassarre , Damiano;Banasik , Karina;Barcella , Matteo;Barlassina , Cristina;Bellis , Claire;Benaglio , Paola;Blangero , John;Blüher , Matthias;Bonnet , Fabrice;Bonnycastle , Lori L;Boyd , Heather A;Bruinenberg , Marcel;Buchman , Aron S;Campbell , Harry;Chen , Yii-Der Ida;Chines , Peter S;Claudi-Boehm , Simone;Cole , John;Collins , Francis S;de Geus , Eco J C;de Groot , Lisette C P G M;Dimitriou , Maria;Duan , Jubao;Enroth , Stefan;Eury , Elodie;Farmaki , Aliki-Eleni;Forouhi , Nita G;Friedrich , Nele;Gejman , Pablo V;Gigante , Bruna;Glorioso , Nicola;Go , Alan S;Gottesman , Omri;Gräßler , Jürgen;Grallert , Harald;Grarup , Niels;Gu , Yu-Mei;Broer , Linda;Ham , Annelies C;Hansen , Torben;Harris , Tamara B;Hartman , Catharina A;Hassinen , Maija;Hastie , Nicholas;Hattersley , Andrew T;Heath , Andrew C;Henders , Anjali K;Hernandez , Dena;Hillege , Hans;Holmen , Oddgeir;Hovingh , Kees G;Hui , Jennie;Husemoen , Lise L;Hutri-Kähönen , Nina;Hysi , Pirro G;Illig , Thomas;De Jager , Philip L;Jalilzadeh , Shapour;Jørgensen , Torben;Jukema , J Wouter;Juonala , Markus;Kanoni , Stavroula;Karaleftheri , Maria;Khaw , Kay Tee;Kinnunen , Leena;Kittner , Steven J;Koenig , Wolfgang;Kolcic , Ivana;Kovacs , Peter;Krarup , Nikolaj T;Kratzer , Wolfgang;Krüger , Janine;Kuh , Diana;Kumari , Meena;Kyriakou , Theodosios;Langenberg , Claudia;Lannfelt , Lars;Lanzani , Chiara;Lotay , Vaneet;Launer , Lenore J;Leander , Karin;Lindström , Jaana;Linneberg , Allan;Liu , Yan-Ping;Lobbens , Stéphane;Luben , Robert;Lyssenko , Valeriya;Männistö , Satu;Magnusson , Patrik K;McArdle , Wendy L;Menni , Cristina;Merger , Sigrun;Milani , Lili;Montgomery , Grant W;Morris , Andrew P;Narisu , Narisu;Nelis , Mari;Ong , Ken K;Palotie , Aarno;Pérusse , Louis;Pichler , Irene;Pilia , Maria G;Pouta , Anneli;Rheinberger , Myriam;Ribel-Madsen , Rasmus;Richards , Marcus;Rice , Kenneth M;Rice , Treva K;Rivolta , Carlo;Salomaa , Veikko;Sanders , Alan R;Sarzynski , Mark A;Scholtens , Salome;Scott , Robert A;Scott , William R;Sebert , Sylvain;Sengupta , Sebanti;Sennblad , Bengt;Seufferlein , Thomas;Silveira , Angela;Slagboom , P Eline;Smit , Jan H;Sparsø , Thomas H;Stirrups , Kathleen;Stolk , Ronald P;Stringham , Heather M;Swertz , Morris A;Swift , Amy J;Syvänen , Ann-Christine;Tan , Sian-Tsung;Thorand , Barbara;Tönjes , Anke;Tremblay , Angelo;Tsafantakis , Emmanouil;van der Most , Peter J;Völker , Uwe;Vohl , Marie-Claude;Vonk , Judith M;Waldenberger , Melanie;Walker , Ryan W;Wennauer , Roman;Widén , Elisabeth;Willemsen , Gonneke;Wilsgaard , Tom;Wright , Alan F;Zillikens , M Carola;van Dijk , Suzanne C;van Schoor , Natasja M;Asselbergs , Folkert W;de Bakker , Paul I W;Beckmann , Jacques S;Beilby , John;Bennett , David A;Bergman , Richard N;Bergmann , Sven;Böger , Carsten A;Boehm , Bernhard O;Boerwinkle , Eric;Boomsma , Dorret I;Bornstein , Stefan R;Bottinger , Erwin P;Bouchard , Claude;Chambers , John C;Chanock , Stephen J;Chasman , Daniel I;Cucca , Francesco;Cusi , Daniele;Dedoussis , George;Erdmann , Jeanette;Eriksson , Johan G;Evans , Denis A;de Faire , Ulf;Farrall , Martin;Ferrucci , Luigi;Ford , Ian;Franke , Lude;Franks , Paul W;Froguel , Philippe;Gansevoort , Ron T;Gieger , Christian;Grönberg , Henrik;Gudnason , Vilmundur;Gyllensten , Ulf;Hall , Per;Hamsten , Anders;van der Harst , Pim;Hayward , Caroline;Heliövaara , Markku;Hengstenberg , Christian;Hicks , Andrew A;Hingorani , Aroon;Hofman , Albert;Hu , Frank;Huikuri , Heikki V;Hveem , Kristian;James , Alan L;Jordan , Joanne M;Jula , Antti;Kähönen , Mika;Kajantie , Eero;Kathiresan , Sekar;Kiemeney , Lambertus A L M;Kivimaki , Mika;Knekt , Paul B;Koistinen , Heikki A;Kooner , Jaspal S;Koskinen , Seppo;Kuusisto , Johanna;Maerz , Winfried;Martin , Nicholas G;Laakso , Markku;Lakka , Timo A;Lehtimäki , Terho;Lettre , Guillaume;Levinson , Douglas F;Lind , Lars;Lokki , Marja-Liisa;Mäntyselkä , Pekka;Melbye , Mads;Metspalu , Andres;Mitchell , Braxton D;Moll , Frans L;Murray , Jeffrey C;Musk , Arthur W;Nieminen , Markku S;Njølstad , Inger;Ohlsson , Claes;Oldehinkel , Albertine J;Oostra , Ben A;Palmer , Lyle J;Pankow , James S;Pasterkamp , Gerard;Pedersen , Nancy L;Pedersen , Oluf;Penninx , Brenda W;Perola , Markus;Peters , Annette;Polašek , Ozren;Pramstaller , Peter P;Psaty , Bruce M;Qi , Lu;Quertermous , Thomas;Raitakari , Olli T;Rankinen , Tuomo;Rauramaa , Rainer;Ridker , Paul M;Rioux , John D;Rivadeneira , Fernando;Rotter , Jerome I;Rudan , Igor;den Ruijter , Hester M;Saltevo , Juha;Sattar , Naveed;Schunkert , Heribert;Schwarz , Peter E H;Shuldiner , Alan R;Sinisalo , Juha;Snieder , Harold;Sørensen , Thorkild I A;Spector , Tim D;Staessen , Jan A;Stefania , Bandinelli;Thorsteinsdottir , Unnur;Stumvoll , Michael;Tardif , Jean-Claude;Tremoli , Elena;Tuomilehto , Jaakko;Uitterlinden , André G;Uusitupa , Matti;Verbeek , André L M;Vermeulen , Sita H;Viikari , Jorma S;Vitart , Veronique;Völzke , Henry;Vollenweider , Peter;Waeber , Gérard;Walker , Mark;Wallaschofski , Henri;Wareham , Nicholas J;Watkins , Hugh;Zeggini , Eleftheria;Chakravarti , Aravinda;Clegg , Deborah J;Cupples , L Adrienne;Gordon-Larsen , Penny;Jaquish , Cashell E;Rao , D C;Abecasis , Goncalo R;Assimes , Themistocles L;Barroso , Inês;Berndt , Sonja I;Boehnke , Michael;Deloukas , Panos;Fox , Caroline S;Groop , Leif C;Hunter , David J;Ingelsson , Erik;Kaplan , Robert C;McCarthy , Mark I;Mohlke , Karen L;O'Connell , Jeffrey R;Schlessinger , David;Strachan , David P;Stefansson , Kari;van Duijn , Cornelia M;Hirschhorn , Joel N;Lindgren , Cecilia M;Heid , Iris M;North , Kari E;Borecki , Ingrid B;Kutalik , Zoltán;Loos , Ruth J F
International audience
Context: Plasma levels of C-reactive protein (CRP) are independently associated with risk of coronary heart disease, but whether CRP is causally associated with coronary heart disease or merely a marker of underlying atherosclerosis is uncertain. Obj...
Williams, Bryan;Mancia, Giuseppe;Spiering, Wilko;Agabiti Rosei, Enrico;Azizi, Michel;Burnier, Michel;Clement, Denis L;Coca, Antonio;de Simone, Giovanni;Dominiczak, Anna;Kahan, Thomas;Mahfoud, Felix;Redon, Josep;Ruilope, Luis;Zanchetti, Alberto;Kerins, Mary;Kjeldsen, Sverre E;Kreutz, Reinhold;Laurent, Stephane;Lip, Gregory Y H;McManus, Richard;Narkiewicz, Krzysztof;Ruschitzka, Frank;Schmieder, Roland E;Shlyakhto, Evgeny;Tsioufis, Costas;Aboyans, Victor;Desormais, Ileana;De Backer, Guy;Heagerty, Anthony M;Agewall, Stefan;Bochud, Murielle;Borghi, Claudio;Boutouyrie, Pierre;Brguljan, Jana;Bueno, Héctor;Caiani, Enrico G;Carlberg, Bo;Chapman, Neil;Cífková, Renata;Cleland, John G.F.;Collet, Jean-Philippe;Coman, Ioan Mircea;de Leeuw, Peter W;Delgado, Victoria;Dendale, Paul;Diener, Hans-Christoph;Dorobantu, Maria;Fagard, Robert;Farsang, Csaba;Ferrini, Marc;Graham, Ian M;Grassi, Guido;Haller, Hermann;Hobbs, F D Richard;Jelakovic, Bojan;Jennings, Catriona;Katus, Hugo A;Kroon, Abraham A;Leclercq, Christophe;Lovic, Dragan;Lurbe, Empar;Manolis, Athanasios J;McDonagh, Theresa A;Messerli, Franz;Muiesan, Maria Lorenza;Nixdorff, Uwe;Olsen, Michael Hecht;Parati, Gianfranco;Perk, Joep;Piepoli, Massimo Francesco;Polonia, Jorge;Ponikowski, Piotr;Richter, Dimitrios J;Rimoldi, Stefano F;Roffi, Marco;Sattar, Naveed;Seferovic, Petar M;Simpson, Iain A;Sousa-Uva, Miguel;Stanton, Alice V;van de Borne, Philippe;Vardas, Panos;Volpe, Massimo;Wassmann, Sven;Windecker, Stephan;Zamorano, Jose Luis;Windecker, Stephan;Aboyans, Victor;Agewall, Stefan;Barbato, Emanuele;Bueno, Héctor;Coca, Antonio;Collet, Jean-Philippe;Coman, Ioan Mircea;Dean, Veronica;Delgado, Victoria;Fitzsimons, Donna;Gaemperli, Oliver;Hindricks, Gerhard;Iung, Bernard;Jüni, Peter;Katus, Hugo A;Knuuti, Juhani;Lancellotti, Patrizio;Leclercq, Christophe;McDonagh, Theresa A;Piepoli, Massimo Francesco;Ponikowski, Piotr;Richter, Dimitrios J;Roffi, Marco;Shlyakhto, Evgeny;Simpson, Iain A;Sousa-Uva, Miguel;Zamorano, Jose Luis;Tsioufis, Costas;Lurbe, Empar;Kreutz, Reinhold;Bochud, Murielle;Rosei, Enrico Agabiti;Jelakovic, Bojan;Azizi, Michel;Januszewics, Andrzej;Kahan, Thomas;Polonia, Jorge;van de Borne, Philippe;Williams, Bryan;Borghi, Claudio;Mancia, Giuseppe;Parati, Gianfranco;Clement, Denis L;Coca, Antonio;Manolis, Athanasios;Lovic, Dragan;Benkhedda, Salim;Zelveian, Parounak;Siostrzonek, Peter;Najafov, Ruslan;Pavlova, Olga;De Pauw, Michel;Dizdarevic-Hudic, Larisa;Raev, Dimitar;Karpettas, Nikos;Linhart, Aleš;Olsen, Michael Hecht;Shaker, Amin Fouad;Viigimaa, Margus;Metsärinne, Kaj;Vavlukis, Marija;Halimi, Jean-Michel;Pagava, Zurab;Schunkert, Heribert;Thomopoulos, Costas;Páll, Dénes;Andersen, Karl;Shechter, Michael;Mercuro, Giuseppe;Bajraktari, Gani;Romanova, Tatiana;Trušinskis, Kārlis;Saade, Georges A;Sakalyte, Gintare;Noppe, Stéphanie;DeMarco, Daniela Cassar;Caraus, Alexandru;Wittekoek, Janneke;Aksnes, Tonje Amb;Jankowski, Piotr;Polonia, Jorge;Vinereanu, Dragos;Baranova, Elena I;Foscoli, Marina;Dikic, Ana Djordjevic;Filipova, Slavomira;Fras, Zlatko;Bertomeu-Martínez, Vicente;Carlberg, Bo;Burkard, Thilo;Sdiri, Wissem;Aydogdu, Sinan;Sirenko, Yuriy;Brady, Adrian;Weber, Thomas;Lazareva, Irina;Backer, Tine De;Sokolovic, Sekib;Jelakovic, Bojan;Widimsky, Jiri;Viigimaa, Margus;Pörsti, Ilkka;Denolle, Thierry;Krämer, Bernhard K;Stergiou, George S;Parati, Gianfranco;Trušinskis, Kārlis;Miglinas, Marius;Gerdts, Eva;Tykarski, Andrzej;de Carvalho Rodrigues, Manuel;Dorobantu, Maria;Chazova, Irina;Lovic, Dragan;Filipova, Slavomira;Brguljan, Jana;Segura, Julian;Gottsäter, Anders;Pechère-Bertschi, Antoinette;Erdine, Serap;Sirenko, Yuriy;Brady, Adrian
No abstract available.
Genome-wide association studies (GWAS) in coronary artery disease (CAD) had identified 66 loci at 'genome-wide significance' (P < 5 × 10 '8) at the time of this analysis, but a much larger number of putative loci at a false discovery rate (FDR) of 5%...
Autosomal recessive hypercholesterolemia is a rare inherited disorder, characterized by extremely high total and low-density lipoprotein cholesterol levels, that has been previously linked to mutations in LDLRAP1. We identified a family with autosoma...
Locke, Adam E;Kahali, Bratati;Berndt, Sonja I;Justice, Anne E;Pers, Tune H;Day, Felix R;Powell, Corey;Vedantam, Sailaja;Buchkovich, Martin L;Yang, Jian;Croteau-Chonka, Damien C;Esko, Tonu;Fall, Tove;Ferreira, Teresa;Gustafsson, Stefan;Kutalik, Zoltán;Luan, Jian'an;Mägi, Reedik;Randall, Joshua C;Winkler, Thomas W;Wood, Andrew R;Workalemahu, Tsegaselassie;Faul, Jessica D;Smith, Jennifer A;Hua Zhao, Jing;Zhao, Wei;Chen, Jin;Fehrmann, Rudolf;Hedman, Åsa K;Karjalainen, Juha;Schmidt, Ellen M;Absher, Devin;Amin, Najaf;Anderson, Denise;Beekman, Marian;Bolton, Jennifer L;Bragg-Gresham, Jennifer L;Buyske, Steven;Demirkan, Ayse;Deng, Guohong;Ehret, Georg B;Feenstra, Bjarke;Feitosa, Mary F;Fischer, Krista;Goel, Anuj;Gong, Jian;Jackson, Anne U;Kanoni, Stavroula;Kleber, Marcus E;Kristiansson, Kati;Lim, Unhee;Lotay, Vaneet;Mangino, Massimo;Mateo Leach, Irene;Medina-Gomez, Carolina;Medland, Sarah E;Nalls, Michael A;Palmer, Cameron D;Pasko, Dorota;Pechlivanis, Sonali;Peters, Marjolein J;Prokopenko, Inga;Shungin, Dmitry;Stančáková, Alena;Strawbridge, Rona J;Ju Sung, Yun;Tanaka, Toshiko;Teumer, Alexander;Trompet, Stella;van der Laan, Sander W;van Setten, Jessica;Van Vliet-Ostaptchouk, Jana V;Wang, Zhaoming;Yengo, Loïc;Zhang, Weihua;Isaacs, Aaron;Albrecht, Eva;Ärnlöv, Johan;Arscott, Gillian M;Attwood, Antony P;Bandinelli, Stefania;Barrett, Amy;Bas, Isabelita N;Bellis, Claire;Bennett, Amanda J;Berne, Christian;Blagieva, Roza;Blüher, Matthias;Böhringer, Stefan;Bonnycastle, Lori L;Böttcher, Yvonne;Boyd, Heather A;Bruinenberg, Marcel;Caspersen, Ida H;Ida Chen, Yii-Der;Clarke, Robert;Daw, E Warwick;de Craen, Anton J M;Delgado, Graciela;Dimitriou, Maria;Doney, Alex S F;Eklund, Niina;Estrada, Karol;Eury, Elodie;Folkersen, Lasse;Fraser, Ross M;Garcia, Melissa E;Geller, Frank;Giedraitis, Vilmantas;Gigante, Bruna;Go, Alan S;Golay, Alain;Goodall, Alison H;Gordon, Scott D;Gorski, Mathias;Grabe, Hans-Jörgen;Grallert, Harald;Grammer, Tanja B;Gräßler, Jürgen;Grönberg, Henrik;Groves, Christopher J;Gusto, Gaëlle;Haessler, Jeffrey;Hall, Per;Haller, Toomas;Hallmans, Goran;Hartman, Catharina A;Hassinen, Maija;Hayward, Caroline;Heard-Costa, Nancy L;Helmer, Quinta;Hengstenberg, Christian;Holmen, Oddgeir;Hottenga, Jouke-Jan;James, Alan L;Jeff, Janina M;Johansson, Åsa;Jolley, Jennifer;Juliusdottir, Thorhildur;Kinnunen, Leena;Koenig, Wolfgang;Koskenvuo, Markku;Kratzer, Wolfgang;Laitinen, Jaana;Lamina, Claudia;Leander, Karin;Lee, Nanette R;Lichtner, Peter;Lind, Lars;Lindström, Jaana;Sin Lo, Ken;Lobbens, Stéphane;Lorbeer, Roberto;Lu, Yingchang;Mach, François;Magnusson, Patrik K E;Mahajan, Anubha;McArdle, Wendy L;McLachlan, Stela;Menni, Cristina;Merger, Sigrun;Mihailov, Evelin;Milani, Lili;Moayyeri, Alireza;Monda, Keri L;Morken, Mario A;Mulas, Antonella;Müller, Gabriele;Müller-Nurasyid, Martina;Musk, Arthur W;Nagaraja, Ramaiah;Nöthen, Markus M;Nolte, Ilja M;Pilz, Stefan;Rayner, Nigel W;Renström, Frida;Rettig, Rainer;Ried, Janina S;Ripke, Stephan;Robertson, Neil R;Rose, Lynda M;Sanna, Serena;Scharnagl, Hubert;Scholtens, Salome;Schumacher, Fredrick R;Scott, William R;Seufferlein, Thomas;Shi, Jianxin;Vernon Smith, Albert;Smolonska, Joanna;Stanton, Alice V;Steinthorsdottir, Valgerdur;Stirrups, Kathleen;Stringham, Heather M;Sundström, Johan;Swertz, Morris A;Swift, Amy J;Syvänen, Ann-Christine;Tan, Sian-Tsung;Tayo, Bamidele O;Thorand, Barbara;Thorleifsson, Gudmar;Tyrer, Jonathan P;Uh, Hae-Won;Vandenput, Liesbeth;Verhulst, Frank C;Vermeulen, Sita H;Verweij, Niek;Vonk, Judith M;Waite, Lindsay L;Warren, Helen R;Waterworth, Dawn;Weedon, Michael N;Wilkens, Lynne R;Willenborg, Christina;Wilsgaard, Tom;Wojczynski, Mary K;Wong, Andrew;Wright, Alan F;Zhang, Qunyuan;Brennan, Eoin P;Choi, Murim;Dastani, Zari;Drong, Alexander W;Eriksson, Per;Franco-Cereceda, Anders;Gådin, Jesper R;Gharavi, Ali G;Goddard, Michael E;Handsaker, Robert E;Huang, Jinyan;Karpe, Fredrik;Kathiresan, Sekar;Keildson, Sarah;Kiryluk, Krzysztof;Kubo, Michiaki;Lee, Jong-Young;Liang, Liming;Lifton, Richard P;Ma, Baoshan;McCarroll, Steven A;McKnight, Amy J;Min, Josine L;Moffatt, Miriam F;Montgomery, Grant W;Murabito, Joanne M;Nicholson, George;Nyholt, Dale R;Okada, Yukinori;Perry, John R B;Dorajoo, Rajkumar;Reinmaa, Eva;Salem, Rany M;Sandholm, Niina;Scott, Robert A;Stolk, Lisette;Takahashi, Atsushi;Tanaka, Toshihiro;Van't Hooft, Ferdinand M;Vinkhuyzen, Anna A E;Westra, Harm-Jan;Zheng, Wei;Zondervan, Krina T;Heath, Andrew C;Arveiler, Dominique;Bakker, Stephan J L;Beilby, John;Bergman, Richard N;Blangero, John;Bovet, Pascal;Campbell, Harry;Caulfield, Mark J;Cesana, Giancarlo;Chakravarti, Aravinda;Chasman, Daniel I;Chines, Peter S;Collins, Francis S;Crawford, Dana C;Cupples, L Adrienne;Cusi, Daniele;Danesh, John;de Faire, Ulf;den Ruijter, Hester M;Dominiczak, Anna F;Erbel, Raimund;Erdmann, Jeanette;Eriksson, Johan G;Farrall, Martin;Felix, Stephan B;Ferrannini, Ele;Ferrières, Jean;Ford, Ian;Forouhi, Nita G;Forrester, Terrence;Franco, Oscar H;Gansevoort, Ron T;Gejman, Pablo V;Gieger, Christian;Gottesman, Omri;Gudnason, Vilmundur;Gyllensten, Ulf;Hall, Alistair S;Harris, Tamara B;Hattersley, Andrew T;Hicks, Andrew A;Hindorff, Lucia A;Hingorani, Aroon D;Hofman, Albert;Homuth, Georg;Hovingh, G Kees;Humphries, Steve E;Hunt, Steven C;Hyppönen, Elina;Illig, Thomas;Jacobs, Kevin B;Jarvelin, Marjo-Riitta;Jöckel, Karl-Heinz;Johansen, Berit;Jousilahti, Pekka;Jukema, J Wouter;Jula, Antti M;Kaprio, Jaakko;Kastelein, John J P;Keinanen-Kiukaanniemi, Sirkka M;Kiemeney, Lambertus A;Knekt, Paul;Kooner, Jaspal S;Kooperberg, Charles;Kovacs, Peter;Kraja, Aldi T;Kumari, Meena;Kuusisto, Johanna;Lakka, Timo A;Langenberg, Claudia;Le Marchand, Loic;Lehtimäki, Terho;Lyssenko, Valeriya;Männistö, Satu;Marette, André;Matise, Tara C;McKenzie, Colin A;McKnight, Barbara;Moll, Frans L;Morris, Andrew D;Morris, Andrew P;Murray, Jeffrey C;Nelis, Mari;Ohlsson, Claes;Oldehinkel, Albertine J;Ong, Ken K;Madden, Pamela A F;Pasterkamp, Gerard;Peden, John F;Peters, Annette;Postma, Dirkje S;Pramstaller, Peter P;Price, Jackie F;Qi, Lu;Raitakari, Olli T;Rankinen, Tuomo;Rao, D C;Rice, Treva K;Ridker, Paul M;Rioux, John D;Ritchie, Marylyn D;Rudan, Igor;Salomaa, Veikko;Samani, Nilesh J;Saramies, Jouko;Sarzynski, Mark A;Schunkert, Heribert;Schwarz, Peter E H;Sever, Peter;Shuldiner, Alan R;Sinisalo, Juha;Stolk, Ronald P;Strauch, Konstantin;Tönjes, Anke;Trégouët, David-Alexandre;Tremblay, Angelo;Tremoli, Elena;Virtamo, Jarmo;Vohl, Marie-Claude;Völker, Uwe;Waeber, Gérard;Willemsen, Gonneke;Witteman, Jacqueline C;Zillikens, M Carola;Adair, Linda S;Amouyel, Philippe;Asselbergs, Folkert W;Assimes, Themistocles L;Bochud, Murielle;Boehm, Bernhard O;Boerwinkle, Eric;Bornstein, Stefan R;Bottinger, Erwin P;Bouchard, Claude;Cauchi, Stéphane;Chambers, John C;Chanock, Stephen J;Cooper, Richard S;de Bakker, Paul I W;Dedoussis, George;Ferrucci, Luigi;Franks, Paul;Froguel, Philippe;Groop, Leif;Haiman, Christopher A;Hamsten, Anders;Hui, Jennie;Hunter, David J;Hveem, Kristian;Kaplan, Robert C;Kivimaki, Mika;Kuh, Diana;Laakso, Markku;Liu, Yongmei;Martin, Nicholas G;März, Winfried;Melbye, Mads;Metspalu, Andres;Moebus, Susanne;Munroe, Patricia B;Njølstad, Inger;Oostra, Ben A;Palmer, Colin N A;Pedersen, Nancy L;Perola, Markus;Pérusse, Louis;Peters, Ulrike;Power, Chris;Quertermous, Thomas;Rauramaa, Rainer;Rivadeneira, Fernando;Saaristo, Timo E;Saleheen, Danish;Sattar, Naveed;Schadt, Eric E;Schlessinger, David;Slagboom, P Eline;Snieder, Harold;Spector, Tim D;Thorsteinsdottir, Unnur;Stumvoll, Michael;Tuomilehto, Jaakko;Uitterlinden, André G;Uusitupa, Matti;van der Harst, Pim;Walker, Mark;Wallaschofski, Henri;Wareham, Nicholas J;Watkins, Hugh;Weir, David R;Wichmann, H-Erich;Wilson, James F;Zanen, Pieter;Borecki, Ingrid B;Deloukas, Panos;Fox, Caroline S;Heid, Iris M;O'Connell, Jeffrey R;Strachan, David P;Stefansson, Kari;van Duijn, Cornelia M;Abecasis, Gonçalo R;Franke, Lude;Frayling, Timothy M;McCarthy, Mark I;Visscher, Peter M;Scherag, André;Willer, Cristen J;Boehnke, Michael;Mohlke, Karen L;Lindgren, Cecilia M;Beckmann, Jacques S;Barroso, Inês;North, Kari E;Ingelsson, Erik;Hirschhorn, Joel N;Loos, Ruth J F;Speliotes, Elizabeth K
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity...
Background Plasma triglyceride levels are heritable and are correlated with the risk of coronary heart disease. Sequencing of the protein-coding regions of the human genome (the exome) has the potential to identify rare mutations that have a large ef...
Teslovich, Tanya M.;Musunuru, Kiran;Smith, Albert V.;Edmondson, Andrew C.;Stylianou, Ioannis M.;Koseki, Masahiro;Pirruccello, James P.;Ripatti, Samuli;Chasman, Daniel I.;Willer, Cristen J.;Johansen, Christopher T.;Fouchier, Sigrid W.;Isaacs, Aaron;Peloso, Gina M.;Barbalic, Maja;Ricketts, Sally L.;Bis, Joshua C.;Aulchenko, Yurii S.;Thorleifsson, Gudmar;Feitosa, Mary F.;Chambers, John;Orho-Melander, Marju;Melander, Olle;Johnson, Toby;Li, Xiaohui;Guo, Xiuqing;Li, Mingyao;Cho, Yoon Shin;Go, Min Jin;Kim, Young Jin;Lee, Jong-Young;Park, Taesung;Kim, Kyunga;Sim, Xueling;Ong, Rick Twee-Hee;Croteau-Chonka, Damien C.;Lange, Leslie A.;Smith, Joshua D.;Song, Kijoung;Zhao, Jing Hua;Yuan, Xin;Luan, Jian'an;Lamina, Claudia;Ziegler, Andreas;Zhang, Weihua;Zee, Robert Y. L.;Wright, Alan F.;Witteman, Jacqueline C. M.;Wilson, James F.;Willemsen, Gonneke;Wichmann, H. -Erich;Whitfield, John B.;Waterworth, Dawn M.;Wareham, Nicholas J.;Waeber, Gerard;Vollenweider, Peter;Voight, Benjamin F.;Vitart, Veronique;Uitterlinden, Andre G.;Uda, Manuela;Tuomilehto, Jaakko;Thompson, John R.;Tanaka, Toshiko;Surakka, Ida;Stringham, Heather M.;Spector, Tim D.;Soranzo, Nicole;Smit, Johannes H.;Sinisalo, Juha;Silander, Kaisa;Sijbrands, Eric J. G.;Scuteri, Angelo;Scott, James;Schlessinger, David;Sanna, Serena;Salomaa, Veikko;Saharinen, Juha;Sabatti, Chiara;Ruokonen, Aimo;Rudan, Igor;Rose, Lynda M.;Roberts, Robert;Rieder, Mark;Psaty, Bruce M.;Pramstaller, Peter P.;Pichler, Irene;Perola, Markus;Penninx, Brenda W. J. H.;Pedersen, Nancy L.;Pattaro, Cristian;Parker, Alex N.;Pare, Guillaume;Oostra, Ben A.;O'Donnell, Christopher J.;Nieminen, Markku S.;Nickerson, Deborah A.;Montgomery, Grant W.;Meitinger, Thomas;McPherson, Ruth;McCarthy, Mark I.;McArdle, Wendy;Masson, David;Martin, Nicholas G.;Marroni, Fabio;Mangino, Massimo;Magnusson, Patrik K. E.;Lucas, Gavin;Luben, Robert;Loos, Ruth J. F.;Lokki, Marja-Liisa;Lettre, Guillaume;Langenberg, Claudia;Launer, Lenore J.;Lakatta, Edward G.;Laaksonen, Reijo;Kyvik, Kirsten O.;Kronenberg, Florian;Koenig, Inke R.;Khaw, Kay-Tee;Kaprio, Jaakko;Kaplan, Lee M.;Johansson, Asa;Jarvelin, Marjo-Riitta;Janssens, A. Cecile J. W.;Ingelsson, Erik;Igi, Wilmar;Hovingh, G. Kees;Hottenga, Jouke-Jan;Hofman, Albert;Hicks, Andrew A.;Hengstenberg, Christian;Heid, Iris M.;Hayward, Caroline;Havulinna, Aki S.;Hastie, Nicholas D.;Harris, Tamara B.;Haritunians, Talin;Hall, Alistair S.;Gyllensten, Ulf;Guiducci, Candace;Groop, Leif;Gonzalez, Elena;Gieger, Christian;Freimer, Nelson B.;Ferrucci, Luigi;Erdmann, Jeanette;Elliott, Paul;Ejebe, Kenechi G.;Doering, Angela;Dominiczak, Anna F.;Demissie, Serkalem;Deloukas, Panagiotis;de Geus, Eco J. C.;de Faire, Ulf;Crawford, Gabriel;Collins, Francis S.;Chen, Yii-der I.;Caulfield, Mark J.;Campbell, Harry;Burtt, Noel P.;Bonnycastle, Lori L.;Boomsma, Dorret I.;Boekholdt, S. Matthijs;Bergman, Richard N.;Barroso, Ines;Bandinelli, Stefania;Ballantyne, Christie M.;Assimes, Themistocles L.;Quertermous, Thomas;Altshuler, David;Seielstad, Mark;Wong, Tien Y.;Tai, E-Shyong;Feranil, Alan B.;Kuzawa, Christopher W.;Adair, Linda S.;Taylor, Herman A., Jr.;Borecki, Ingrid B.;Gabriel, Stacey B.;Wilson, James G.;Holm, Hilma;Thorsteinsdottir, Unnur;Gudnason, Vilmundur;Krauss, Ronald M.;Mohlke, Karen L.;Ordovas, Jose M.;Munroe, Patricia B.;Kooner, Jaspal S.;Tall, Alan R.;Hegele, Robert A.;Kastelein, John J. P.;Schadt, Eric E.;Rotter, Jerome I.;Boerwinkle, Eric;Strachan, David P.;Mooser, Vincent;Stefansson, Kari;Reilly, Muredach P.;Samani, Nilesh J.;Schunkert, Heribert;Cupples, L. Adrienne;Sandhu, Manjinder S.;Ridker, Paul M.;Rader, Daniel J.;van Duijn, Cornelia M.;Peltonen, Leena;Abecasis, Goncalo R.;Boehnke, Michael;Kathiresan, Sekar
Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are targets for therapeutic interv...