ARTICLES
3,102 Article(s)
1, 2, 3, 4, 5, 6 >> >|
Document(s)
Title
Wood, Angela M;Kaptoge, Stephen;Butterworth, Adam S;Willeit, Peter;Warnakula, Samantha;Bolton, Thomas;Paige, Ellie;Paul, Dirk S;Sweeting, Michael;Burgess, Stephen;Bell, Steven;Astle, William;Stevens, David;Koulman, Albert;Selmer, Randi M;Verschuren, WM Monique;Sato, Shinichi;Njolstad, Inger;Woodward, Mark;Salomaa, Veikko;Nordestgaard, Borge G;Yeap, Bu B;Fletcher, Astrid;Melander, Olle;Kuller, Lewis H;Balkau, Beverley;Marmot, Michael;Koenig, Wolfgang;Casiglia, Edoardo;Cooper, Cyrus;Arndt, Volker;Franco, Oscar H;Wennberg, Patrik;Gallacher, John;de la Camara, Agustin Gomez;Volzke, Henry;Dahm, Christina C;Dale, Caroline E;Bergmann, Manuela M;Crespo, Carlos J;van der Schouw, Yvonne T;Kaaks, Rudolf;Simons, Leon A;Lagiou, Pagona;Schoufour, Josje D;Boer, Jolanda MA;Key, Timothy J;Rodriguez, Beatriz;Moreno-Iribas, Conchi;Davidson, Karina W;Taylor, James O;Sacerdote, Carlotta;Wallace, Robert B;Quiros, J Ramon;Tumino, Rosario;Blazer, Dan G;Linneberg, Allan;Daimon, Makoto;Panico, Salvatore;Howard, Barbara;Skeie, Guri;Strandberg, Timo;Weiderpass, Elisabete;Nietert, Paul J;Psaty, Bruce M;Kromhout, Daan;Salamanca-Fernandez, Elena;Kiechl, Stefan;Krumholz, Harlan M;Grioni, Sara;Palli, Domenico;Huerta, Jose M;Price, Jackie;Sundstrom, Johan;Arriola, Larraitz;Arima, Hisatomi;Travis, Ruth C;Panagiotakos, Demosthenes B;Karakatsani, Anna;Trichopoulou, Antonia;Kuhn, Tilman;Grobbee, Diederick E;Barrett-Connor, Elizabeth;van Schoor, Natasja;Boeing, Heiner;Overvad, Kim;Kauhanen, Jussi;Wareham, Nick;Langenberg, Claudia;Forouhi, Nita;Wennberg, Maria;Despres, Jean-Pierre;Cushman, Mary;Cooper, Jackie A;Rodriguez, Carlos J;Sakurai, Masaru;Shaw, Jonathan E;Knuiman, Matthew;Voortman, Trudy;Meisinger, Christa;Tjonneland, Anne;Brenner, Hermann;Palmieri, Luigi;Dallongeville, Jean;Brunner, Eric J;Assmann, Gerd;Trevisan, Maurizio;Gillum, Richard F;Ford, Ian;Sattar, Naveed;Lazo, Mariana;Thompson, Simon G;Ferrari, Pietro;Leon, David A;Smith, George Davey;Peto, Richard;Jackson, Rod;Banks, Emily;Di Angelantonio, Emanuele;Danesh, John
BACKGROUND:Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease, we studied individual-partici...
Pennells, Lisa Anne;Kaptoge, Stephen Kipkemoi;Wood, Angela Mary;Sweeting, Mike;Zhao, Xiaohui;White, Ian;Burgess, Stephen;Willeit, Peter;Bolton, Thomas Russell;Moons, Karel GM;van der Schouw, Yvonne T;Selmer, Randi;Khaw, Kay-Tee;Gudnason, Vilmundur;Assmann, Gerd;Amouyel, Philippe;Salomaa, Veikko;Kivimaki, Mika;Nordestgaard, Børge G;Blaha, Michael J;Kuller, Lewis H;Brenner, Hermann;Gillum, Richard F;Meisinger, Christa;Ford, Ian;Knuiman, Matthew W;Rosengren, Annika;Lawlor, Debbie A;Völzke, Henry;Cooper, Cyrus;Marín Ibañez, Alejandro;Casiglia, Edoardo;Kauhanen, Jussi;Cooper, Jackie A;Rodriguez, Beatriz;Sundström, Johan;Barrett-Connor, Elizabeth;Dankner, Rachel;Nietert, Paul J;Davidson, Karina W;Wallace, Robert B;Blazer, Dan G;Björkelund, Cecilia;Donfrancesco, Chiara;Krumholz, Harlan M;Nissinen, Aulikki;Davis, Barry R;Coady, Sean;Whincup, Peter H;Jørgensen, Torben;Ducimetiere, Pierre;Trevisan, Maurizio;Engström, Gunnar;Crespo, Carlos J;Meade, Tom W;Visser, Marjolein;Kromhout, Daan;Kiechl, Stefan;Daimon, Makoto;Price, Jackie F;Gómez de la Cámara, Agustin;Wouter Jukema, J;Lamarche, Benoît;Onat, Altan;Simons, Leon A;Kavousi, Maryam;Ben-Shlomo, Yoav;Gallacher, John;Dekker, Jacqueline M;Arima, Hisatomi;Shara, Nawar;Tipping, Robert W;Roussel, Ronan;Brunner, Eric J;Koenig, Wolfgang;Sakurai, Masaru;Pavlovic, Jelena;Gansevoort, Ron T;Nagel, Dorothea;Goldbourt, Uri;Barr, Elizabeth LM;Palmieri, Luigi;Njølstad, Inger;Sato, Shinichi;Monique Verschuren, WM;Varghese, Cherian V;Graham, Ian;Onuma, Oyere;Greenland, Philip;Woodward, Mark;Ezzati, Majid;Psaty, Bruce M;Sattar, Naveed;Jackson, Rod;Ridker, Paul M;Cook, Nancy R;D'Agostino, Ralph B;Thompson, Simon G;Danesh, John;Di Angelantonio, Emanuele;Emerging Risk Factors Collaboration,
Aims There is debate about the optimum algorithm for cardiovascular disease (CVD) risk estimation. We conducted head-to-head comparisons of four algorithms recommended by primary prevention guidelines, before and after “re-calibration”, a method that...
Wood, Angela M;Kaptoge, Stephen;Butterworth, Adam S;Willeit, Peter;Warnakula, Samantha;Bolton, Thomas;Paige, Ellie;Paul, Dirk S;Sweeting, Michael;Burgess, Stephen;Bell, Steven;van Schoor, Natasja;Boeing, Heiner;Overvad, Kim;Kauhanen, Jussi;Palmieri, Luigi;Wareham, Nick;Yeap, Bu B;Langenberg, Claudia;Forouhi, Nita;Rodriguez, Beatriz;Paige, Ellie;Wennberg, Maria;Després, Jean-Pierre;Cushman, Mary;Cooper, Jackie A;Rodriguez, Carlos J;Sakurai, Masaru;Dallongeville, Jean;Shaw, Jonathan E;Knuiman, Matthew;Fletcher, Astrid;Paul, Dirk S;Ford, Ian;Voortman, Trudy;Meisinger, Christa;Tjønneland, Anne;Brenner, Hermann;Palmieri, Luigi;Dallongeville, Jean-Pierre;Brunner, Eric J;Brunner, Eric J;Assmann, Gerd;Sweeting, Michael;Trevisan, Maurizio;Skeie, Guri;Gillumn, Richard F;Melander, Olle;Ford, Ian Ford;Sattar, Naveed;Lazo, Mariana;Thompson, Simon;Ferrari, Pietro;Leon, David A;Burgess, Stephen;Assmann, Gerd;Davey Smith, George;Moreno-Iribas, Conchi;Peto, Richard;Jackson, Rod;Banks, Emily;Kuller, Lewis H;Di Angelantonio, Emanuele;Danesh, John;Balkau, Beverley;Koulman, Albert;Marmot, Michael;Koenig, Wolfgang;Trevisan, Maurizio;Davidson, Karina W;Casiglia, Edoardo;Cooper, Cyrus;Arndt, Volker;Franco, Oscar H;Wennberg, Patrik;Gallacher, John;Bell, Steven;de la Cámara, Agustín Gómez;Völzke, Henry;Dahm, Christina C;Dale, Caroline E;Taylor, James O;Gillum, Richard F;Bergmann, Manuela M;Sacerdote, Carlotta;Wallace, Robert B;Quiros, J Ramon;Astle, William;Tumino, Rosario;Blazer, Dan G;Linneberg, Allan;Daimon, Makoto;Salomaa, Veikko;Sattar, Naveed;Panico, Salvatore;Howard, Barbara;Skeie, Guri;Strandberg, Timo;Stevens, David;Weiderpass, Elisabete;Nietert, Paul J;Psaty, Bruce M;Kromhout, Daan;Salamanca-Fernandez, Elena;Strandberg, Timo;Kiechl, Stefan;Astle, William;Krumholz, Harlan M;Grioni, Sara;Koulman, Albert;Palli, Domenico;Huerta, José M;Price, Jackie;Sundström, Johan;Arriola, Larraitz;Arima, Hisatomi;Weiderpass, Elisabete;Travis, Ruth C;Panagiotakos, Demosthenes B;Lazo, Mariana;Kiechl, Stefan;Karakatsani, Anna;Trichopoulou, Antonia;Kühn, Tilman;Grobbee, Diederick E;Barrett-Connor, Elizabeth;van Schoor, Natasja;Boeing, Heiner;Nietert, Paul J;Overvad, Kim;Kauhanen, Jussi;Crespo, Carlos J;Wareham, Nick;Thompson, Simon G;Langenberg, Claudia;Forouhi, Nita;Wennberg, Maria;Després, Jean-Pierre;Cushman, Mary;Cooper, Jackie A;Psaty, Bruce M;Rodriguez, Carlos J;Selmer, Randi M;Sakurai, Masaru;Shaw, Jonathan E;Knuiman, Matthew;Ferrari, Pietro;Voortman, Trudy;Meisinger, Christa;Leon, David A;Smith, George Davey;Peto, Richard;Kromhout, Daan;Verschuren, Monique;Jackson, Rod;Banks, Emily;Di Angelantonio, Emanuele;Danesh, John;Stevens, David;Wood, Angela M;Kaptoge, Stephen;Butterworth, Adam;Willeit, Peter;Warnakula, Samantha;Sato, Shinichi;Salamanca-Fernandez, Elena;Bolton, Thomas;Njølstad, Inger;Woodward, Mark;Veikko, Salomaa;Selmer, Randi M;Nordestgaard, Børge G;Yeap, Bu B;Flecther, Astrid;van der Schouw, Yvonne T;Salomaa, Veikko;Melander, Olle;Kuller, Lewis H;Balkau, Beverley;Marmot, Michael;Koenig, Wolfgang;Casiglia, Edoardo;Cooper, Cyrus;Verschuren, W M Monique;Arndt, Volker;Kaaks, Rudolf;Franco, Oscar H;Tjønneland, Anne;Wennberg, Patrik;Gallacher, John;Gómez de la Cámara, Agustín;Völzke, Henry;Dahm, Christina C;Dale, Caroline E;Bergmann, Manuela;Crespo, Carlos;Simons, Leon A;Sato, Shinichi;van der Schouw, Yvonne T;Krumholz, Harlan M;Kaaks, Rudolf;Simons, Leon A;Lagiou, Pagona;Schoufour, Josje D;Boer, Jolanda M.A;Key, Timothy J;Rodriguez, Beatriz;Lagiou, Pagona;Moreno-Iribas, Conchi;Davidson, Karina W;Njølstad, Inger;Grioni, Sara;Taylor, James O;Sacerdote, Carlotta;Wallace, Robert B;Quiros, J. Ramon;Rimm, Eric B;Tumino, Rosario;Schoufour, Josje D;Blazer III, Dan G;Linneberg, Allan;Daimon, Makoto;Panico, Salvatore;Palli, Domenico;Woodward, Mark;Howard, Barbara;Huerta, José M;Price, Jackie;Sundström, Johan;Boer, Jolanda M A;Arriola, Larraitz;Arima, Hisatomi;Travis, Ruth C;Panagiotakos, Demosthenes B;Brenner, Hermann;Nordestgaard, Børge G;Karakatsani, Anna;Trichopoulou, Antonia;Kühn, Tilman;Grobbee, Diederick E;Key, Timothy J;Barrett-Connor, Elizabeth
Background Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease, we studied individual-partici...
Locke, Adam E.;Kahali, Bratati;Berndt, Sonja I.;Justice, Anne E.;Pers, Tune H.;Day, Felix R.;Powell, Corey;Vedantam, Sailaja;Buchkovich, Martin L.;Yang, Jian;Croteau-Chonka, Damien C.;Esko, Tonu;Fall, Tove;Ferreira, Teresa;Gustafsson, Stefan;Kutalik, Zoltan;Luan, Jian'an;Maegi, Reedik;Randall, Joshua C.;Winkler, Thomas W.;Wood, Andrew R.;Workalemahu, Tsegaselassie;Faul, Jessica D.;Smith, Jennifer A.;Zhao, Jing Hua;Zhao, Wei;Chen, Jin;Fehrmann, Rudolf;Hedman, Asa K.;Karjalainen, Juha;Schmidt, Ellen M.;Absher, Devin;Amin, Najaf;Anderson, Denise;Beekman, Marian;Bolton, Jennifer L.;Bragg-Gresham, L.;Buyske, Steven;Demirkan, Ayse;Deng, Guohong;Ehret, Georg B.;Feenstra, Bjarke;Feitosa, Mary F.;Fischer, Krista;Goel, Anuj;Gong, Jian;Jackson, Anne U.;Kanoni, Stavroula;Kleber, Marcus E.;Kristiansson, Kati;Lim, Unhee;Lotay, Vaneet;Mangino, Massimo;Leach, Irene Mateo;Medina-Gomez, Carolina;Medland, Sarah E.;Nalls, Michael A.;Palmer, Cameron D.;Pasko, Dorota;Pechlivanis, Sonali;Peters, Marjolein J.;Prokopenko, Inga;Shungin, Dmitry;Stancakova, Alena;Strawbridge, Rona J.;Sung, Yun Ju;Tanaka, Toshiko;Teumer, Alexander;Trompet, Stella;van der Laan, Sander W.;van Setten, Jessica;Van Vliet-Ostaptchouk, Jana V.;Wang, Zhaoming;Yengo, Loic;Zhang, Weihua;Isaacs, Aaron;Albrecht, Eva;Arnlov, Johan;Arscott, Gillian M.;Attwood, Antony P.;Bandinelli, Stefania;Barrett, Amy;Bas, Isabelita N.;Bellis, Claire;Bennett, Amanda J.;Berne, Christian;Blagieva, Roza;Blueher, Matthias;Bohringer, Stefan;Bonnycastle, Lori L.;Boettcher, Yvonne;Boyd, Heather A.;Bruinenberg, Marcel;Caspersen, Ida H.;Chen, Yii-Der Ida;Clarke, Robert;Daw, E. Warwick;de Craen, Anton J. M.;Delgado, Graciela;Dimitriou, Maria;Doney, Alex S. F.;Eklund, Niina;Estrada, Karol;Eury, Elodie;Folkersen, Lasse;Fraser, Ross M.;Garcia, Melissa E.;Geller, Frank;Giedraitis, Vilmantas;Gigante, Bruna;Go, Alan S.;Golay, Alain;Goodall, Alison H.;Gordon, Scott D.;Gorski, Mathias;Grabe, Hans-Joergen;Grallert, Harald;Grammer, Tanja B.;Graessler, Jurgen;Gronberg, Henrik;Groves, Christopher J.;Gusto, Gaeelle;Haessler, Jeffrey;Hall, Per;Haller, Toomas;Hallmans, Goran;Hartman, Catharina A.;Hassinen, Maija;Hayward, Caroline;Heard-Costa, Nancy L.;Helmer, Qinta;Hengstenberg, Christian;Holmen, Oddgeir;Hottenga, Jouke-Jan;James, Alan L.;Jeff, Janina M.;Johansson, Asa;Jolley, Jennifer;Juliusdottir, Thorhildur;Kinnunen, Leena;Koenig, Wolfgang;Koskenvuo, Markku;Kratzer, Wolfgang;Laitinen, Jaana;Lamina, Claudia;Leander, Karin;Lee, Nanette R.;Lichtner, Peter;Lind, Lars;Lindstrom, Jaana;Lo, Ken Sin;Lobbens, Stephane;Lorbeer, Roberto;Lu, Yingchang;Mach, Francois;Magnusson, Patrik K. E.;Mahajan, Anubha;McArdle, Wendy L.;McLachlan, Stela;Menni, Cristina;Merger, Sigrun;Mihailov, Evelin;Milani, Lili;Moayyeri, Alireza;Monda, Keri L.;Morken, Mario A.;Mulas, Antonella;Mueller, Gabriele;Mueller-Nurasyid, Martina;Musk, Arthur W.;Nagaraja, Ramaiah;Noethen, Markus M.;Nolte, Ilja M.;Pilz, Stefan;Rayner, Nigel W.;Renstrom, Frida;Rettig, Rainer;Ried, Janina S.;Ripke, Stephan;Robertson, Neil R.;Rose, Lynda M.;Sanna, Serena;Scharnagl, Hubert;Scholtens, Salome;Schumacher, Fredrick R.;Scott, William R.;Seufferlein, Thomas;Shi, Jianxin;Smith, Albert Vernon;Smolonska, Joanna;Stanton, Alice V.;Steinthorsdottir, Valgerdur;Stirrups, Kathleen;Stringham, Heather M.;Sundstrom, Johan;Swertz, Morris A.;Swift, Amy J.;Syvanen, Ann-Christine;Tan, Sian-Tsung;Tayo, Bamidele O.;Thorand, Barbara;Thorleifsson, Gudmar;Tyrer, Jonathan P.;Uh, Hae-Won;Vandenput, Liesbeth;Verhulst, Frank C.;Vermeulen, Sita H.;Verweij, Niek;Vonk, Judith M.;Waite, Lindsay L.;Warren, Helen R.;Waterworth, Dawn;Weedon, Michael N.;Wilkens, Lynne R.;Willenborg, Christina;Wilsgaard, Tom;Wojczynski, Mary K.;Wong, Andrew;Wrightl, Alan F.;Zhang, Qunyuan;Brennan, Eoin P.;Choi, Murim;Dastani, Zari;Drong, Alexander W.;Eriksson, Per;Franco-Cereceda, Anders;Gadin, Jesper R.;Gharavi, Ali G.;Goddard, Michael E.;Handsaker, Robert E.;Huang, Jinyan;Karpe, Fredrik;Kathiresan, Sekar;Keildson, Sarah;Kiryluk, Krzysztof;Kubo, Michiaki;Lee, Jong-Young;Liang, Liming;Lifton, Richard P.;Ma, Baoshan;McCarroll, Steven A.;McKnight, Amy J.;Min, Josine L.;Moffatt, Miriam F.;Montgomery, Grant W.;Murabito, Joanne M.;Nicholson, George;Nyholt, Dale R.;Okada, Yukinori;Perry, John R. B.;Dorajoo, Rajkumar;Reinmaa, Eva;Salem, Rany M.;Sandholm, Niina;Scott, Robert A.;Stolk, Lisette;Takahashi, Atsushi;Tanaka, Toshihiro;van 't Hooft, Ferdinand M.;Vinkhuyzen, Anna A. E.;Westra, Harm-Jan;Zheng, Wei;Zondervan, Krina T.;Heath, Andrew C.;Arveiler, Dominique;Bakker, Stephan J. L.;Beilby, John;Bergman, Richard N.;Blangero, John;Bovet, Pascal;Campbell, Harry;Caulfield, Mark J.;Cesana, Giancarlo;Chakravarti, Aravinda;Chasman, Daniel I.;Chines, Peter S.;Collins, Francis S.;Crawford, Dana C.;Cupples, L. Adrienne;Cusi, Daniele;Danesh, John;de Faire, Ulf;den Ruijter, Hester M.;Dominiczak, Anna F.;Erbel, Raimund;Erdmann, Jeanette;Eriksson, Johan G.;Farrall, Martin;Felix, Stephan B.;Ferrannini, Ele;Ferrieres, Jean;Ford, Ian;Forouhi, Nita G.;Forrester, Terrence;Franco, Oscar H.;Gansevoort, Ron T.;Gejman, Pablo V.;Gieger, Christian;Gottesman, Omri;Gudnason, Vilmundur;Gyllensten, Ulf;Hall, Alistair S.;Harris, Tamara B.;Hattersley, Andrew T.;Hicks, Andrew A.;Hindorff, Lucia A.;Hingorani, Aroon D.;Hofman, Albert;Homuth, Georg;Hovingh, G. Kees;Humphries, Steve E.;Hunt, Steven C.;Hypponen, Elina;Illig, Thomas;Jacobs, Kevin B.;Jarvelin, Marjo-Riitta;Joeckel, Karl-Heinz;Johansen, Berit;Jousilahti, Pekka;Jukema, J. Wouter;Jula, Antti M.;Kaprio, Jaakko;Kastelein, John J. P.;Keinanen-Kiukaanniemi, Sirkka M.;Kiemeney, Lambertus A.;Knekt, Paul;Kooner, Jaspal S.;Kooperberg, Charles;Kovacs, Peter;Kraja, Aldi T.;Kumari, Meena;Kuusisto, Johanna;Lakka, Timo A.;Langenberg, Claudia;Le Marchand, Laic;Lehtimaki, Terho;Lyssenko, Valeriya;Mannisto, Satu;Marette, Andre;Matise, Tara C.;McKenzie, Colin A.;McKnight, Barbara;Moll, Frans L.;Morris, Andrew D.;Morris, Andrew P.;Murray, Jeffrey C.;Nelis, Mari;Ohlsson, Claes;Oldehinkel, Albertine J.;Ong, Ken K.;Madden, Pamela A. F.;Pasterkamp, Gerard;Peden, John F.;Peters, Annette;Postma, Dirkje S.;Pramstaller, Peter P.;Price, Jackie F.;Qi, Lu;Raitakari, Olli T.;Rankinen, Tuomo;Rao, D. C.;Rice, Treva K.;Ridker, Paul M.;Rioux, John D.;Ritchie, Marylyn D.;Rudan, Igor;Salomaa, Veikko;Samani, Nilesh J.;Saramines, Jouko;Sarzynski, Mark A.;Schunkert, Heribert;Schwarz, Peter E. H.;Sever, Peter;Shuldiner, Alan R.;Sinisalo, Juha;Stolk, Ronald P.;Strauch, Konstantin;Toenjes, Anke;Tregouet, David-Alexandre;Tremblay, Angelo;Tremoli, Elena;Virtamo, Jarmo;Vohl, Marie-Claude;Voelker, Uwe;Waeber, Gerard;Willemsen, Gonneke;Witteman, Jacqueline C.;Zillikens, M. Carola;Adair, Linda S.;Amouyel, Philippe;Asselbergs, Folkert W.;Assimes, Themistocles L.;Bochud, Murielle;Boehm, Bernhard O.;Boerwinkle, Eric;Bornstein, Stefan R.;Bottinger, Erwin P.;Bouchard, Claude;Cauchi, Stephane;Chambers, John C.;Chanock, Stephen J.;Cooper, Richard S.;de Bakker, Paul I. W.;Dedoussis, George;Ferrucci, Luigi;Franks, Paul W.;Froguel, Philippe;Groop, Leif C.;Haiman, Christopher A.;Hamsten, Anders;Hui, Jennie;Hunter, David J.;Hveem, Kristian;Kaplan, Robert C.;Kivimaki, Mika;Kuh, Diana;Laakso, Markku;Liu, Yongmei;Martin, Nicholas G.;Maerz, Winfried;Melbve, Mads;Metspalu, Andres;Moebus, Susanne;Munroe, Patricia B.;Njolstad, Inger;Oostra, Ben A.;Palmer, Colin N. A.;Pedersen, Nancy L.;Perola, Markus;Perusse, Louis;Peters, Ulrike;Power, Chris;Quertermous, Thomas;Rauramaa, Rainer;Rivadeneira, Fernando;Saaristo, Timo E.;Saleheen, Danish;Sattar, Naveed;Schadt, Eric E.;Schlessinger, David;Slagboom, P. Eline;Snieder, Harold;Spector, Tim D.;Thorsteinsdottir, Unnu R.;Stumvoll, Michael;Tuomilehto, Jaakko;Uitterlinden, Andre G.;Uusitupa, Matti;van der Harst, Pim;Walker, Mark;Wallaschofski, Henri;Wareham, Nicholas J.;Watkins, Hugh;Weir, David R.;Wichmann, H-Erich;Wilson, James F.;Zanen, Pieter;Borecki, Ingrid B.;Deloukas, Panos;Fox, Caroline S.;Heid, Iris M.;O'Connell, Jeffrey R.;Strachan, David P.;Stefansson, Kari;van Duijri, Cornelia M.;Abecasis, Goncalo R.;Franke, Lude;Frayling, Timothy M.;McCarthy, Mark I.;Visscher, Peter M.;Scherag, Andre;Willer, Cristen J.;Boehnke, Michael;Mohlke, Karen L.;Lindgren, Cecilia M.;Beckmann, Jacques S.;Barroso, Ines;North, Kari E.;Ingelsson, Erik;Hirschhorn, Joel N.;Loos, Ruth J. F.;Speliotes, Elizabeth K.;Peeters, P;Broekmans, FJM;van Gils, CH;van der Schouw, YT;Fauser, BCJM;Uiterwaal, C.S.P.M.;Bots, Michael L
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity...
Swerdlow, Daniel I.;Preiss, David;Kuchenbaecker, Karoline B.;Holmes, Michael V.;Engmann, Jorgen E L;Shah, Tina;Sofat, Reecha;Stender, Stefan;Johnson, Paul C D;Scott, Robert A.;Leusink, Maarten;Verweij, Niek;Sharp, Stephen J.;Guo, Yiran;Giambartolomei, Claudia;Chung, Christina;Peasey, Anne;Amuzu, Antoinette;Li, Kawah;Palmen, Jutta;Howard, Philip;Cooper, Jackie A.;Drenos, Fotios;Li, Yun R.;Lowe, Gordon;Gallacher, John;Stewart, Marlene C W;Tzoulaki, Ioanna;Buxbaum, Sarah G.;Van Der A, Daphne L.;Forouhi, Nita G.;Onland-Moret, N. Charlotte;Van Der Schouw, Yvonne T.;Schnabel, Renate B.;Hubacek, Jaroslav A.;Kubinova, Ruzena;Baceviciene, Migle;Tamosiunas, Abdonas;Pajak, Andrzej;Topor-Madry, Romanvan;Stepaniak, Urszula;Malyutina, Sofia;Baldassarre, Damiano;Sennblad, Bengt;Tremoli, Elena;De Faire, Ulf;Veglia, Fabrizio;Ford, Ian;Jukema, J. Wouter;Westendorp, Rudi G J;De Borst, Gert Jan;De Jong, Pim A.;Algra, Ale;Spiering, Wilko;Der Zee, Anke H Maitland Van;Klungel, Olaf H.;De Boer, Anthonius;Doevendans, Pieter A.;Eaton, Charles B.;Robinson, Jennifer G.;Duggan, David;Kjekshus, John;Downs, John R.;Gotto, Antonio M.;Keech, Anthony C.;Marchioli, Roberto;Tognoni, Gianni;Sever, Peter S.;Poulter, Neil R.;Waters, David D.;Pedersen, Terje R.;Amarenco, Pierre;Nakamura, Haruo;McMurray, John J V;Lewsey, James D.;Chasman, Daniel I.;Ridker, Paul M.;Maggioni, Aldo P.;Tavazzi, Luigi;Ray, Kausik K.;Seshasai, Sreenivasa Rao Kondapally;Manson, Joann E.;Price, Jackie F.;Whincup, Peter H.;Morris, Richard W.;Lawlor, Debbie A.;Smith, George Davey;Ben-Shlomo, Yoav;Schreiner, Pamela J.;Fornage, Myriam;Siscovick, David S.;Cushman, Mary;Kumari, Meena;Wareham, Nick J.;Verschuren, W. M Monique;Redline, Susan;Patel, Sanjay R.;Whittaker, John C.;Hamsten, Anders;Delaney, Joseph A.;Dale, Caroline;Gaunt, Tom R.;Wong, Andrew;Kuh, Diana;Hardy, Rebecca;Kathiresan, Sekar;Castillo, Berta A.;Van Der Harst, Pim;Brunner, Eric J.;Tybjaerg-Hansen, Anne;Marmot, Michael G.;Krauss, Ronald M.;Tsai, Michael;Coresh, Josef;Hoogeveen, Ronald C.;Psaty, Bruce M.;Lange, Leslie A.;Hakonarson, Hakon;Dudbridge, Frank;Humphries, Steve E.;Talmud, Philippa J.;Kivimäki, Mika;Timpson, Nicholas J.;Langenberg, Claudia;Asselbergs, Folkert W.;Voevoda, Mikhail;Bobak, Martin;Pikhart, Hynek;Wilson, James G.;Reiner, Alex P.;Keating, Brendan J.;Hingorani, Aroon D.;Sattar, Naveed
Background Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the intended drug target. Methods We used...
Winkler, Thomas W.;Justice, Anne E.;Graff, Mariaelisa;Barata, Llilda;Feitosa, Mary F.;Chu, Su;Czajkowski, Jacek;Esko, Tonu;Fall, Tove;Kilpelainen, Tuomas O.;Lu, Yingchang;Magi, Reedik;Mihailov, Evelin;Pers, Tune H.;Rueeger, Sina;Teumer, Alexander;Ehret, Georg B.;Ferreira, Teresa;Heard-Costa, Nancy L.;Karjalainen, Juha;Lagou, Vasiliki;Mahajan, Anubha;Neinast, Michael D.;Prokopenko, Inga;Simino, Jeannette;Teslovich, Tanya M.;Jansen, Rick;Westra, Harm-Jan;White, Charles C.;Absher, Devin;Ahluwalia, Tarunveer S.;Ahmad, Shafqat;Albrecht, Eva;Alves, Alexessander Couto;Bragg-Gresham, Jennifer L.;de Craen, Anton J. M.;Bis, Joshua C.;Bonnefond, Amelie;Boucher, Gabrielle;Cadby, Gemma;Cheng, Yu-Ching;Chiang, Charleston W. K.;Delgado, Graciela;Demirkan, Ayse;Dueker, Nicole;Eklund, Niina;Eiriksdottir, Gudny;Eriksson, Joel;Feenstra, Bjarke;Fischer, Krista;Frau, Francesca;Galesloot, Tessel E.;Geller, Frank;Goel, Anuj;Gorski, Mathias;Grammer, Tanja B.;Gustafsson, Stefan;Haitjema, Saskia;Hottenga, Jouke-Jan;Huffman, Jennifer E.;Jackson, Anne U.;Jacobs, Kevin B.;Johansson, Asa;Kaakinen, Marika;Kleber, Marcus E.;Lahti, Jari;Leach, Irene Mateo;Lehne, Benjamin;Liu, Youfang;Lo, Ken Sin;Lorentzon, Mattias;Luan, Jian'an;Madden, Pamela A. F.;Mangino, Massimo;McKnight, Barbara;Medina-Gomez, Carolina;Monda, Keri L.;Montasser, May E.;Mueller, Gabriele;Mueller-Nurasyid, Martina;Nolte, Ilja M.;Panoutsopoulou, Kalliope;Pascoe, Laura;Paternoster, Lavinia;Rayner, Nigel W.;Renstrom, Frida;Rizzi, Federica;Rose, Lynda M.;Ryan, Kathy A.;Salo, Perttu;Sanna, Serena;Scharnagl, Hubert;Shi, Jianxin;Smith, Albert Vernon;Southam, Lorraine;Stancakova, Alena;Steinthorsdottir, Valgerdur;Strawbridge, Rona J.;Sung, Yun Ju;Tachmazidou, Ioanna;Tanaka, Toshiko;Thorleifsson, Gudmar;Trompet, Stella;Pervjakova, Natalia;Tyrer, Jonathan P.;Vandenput, Liesbeth;van der Laan, Sander W.;van der Velde, Nathalie;van Setten, Jessica;van Vliet-Ostaptchouk, Jana V.;Verweij, Niek;Vlachopoulou, Efthymia;Waite, Lindsay L.;Wang, Sophie R.;Wang, Zhaoming;Wild, Sarah H.;Willenborg, Christina;Wilson, James F.;Wong, Andrew;Yang, Jian;Yengo, Loic;Yerges-Armstrong, Laura M.;Yu, Lei;Zhang, Weihua;Zhao, Jing Hua;Andersson, Ehm A.;Bakker, Stephan J. L.;Baldassarre, Damiano;Banasik, Karina;Barcella, Matteo;Barlassina, Cristina;Bellis, Claire;Benaglio, Paola;Blangero, John;Blueher, Matthias;Bonnet, Fabrice;Bonnycastle, Lori L.;Boyd, Heather A.;Bruinenberg, Marcel;Buchman, Aron S.;Campbell, Harry;Chen, Yii-Der Ida;Chines, Peter S.;Claudi-Boehm, Simone;Cole, John;Collins, Francis S.;de Geus, Eco J. C.;de Groot, Lisette C. P. G. M.;Dimitriou, Maria;Duan, Jubao;Enroth, Stefan;Eury, Elodie;Farmaki, Aliki-Eleni;Forouhi, Nita G.;Friedrich, Nele;Gejman, Pablo V.;Gigante, Bruna;Glorioso, Nicola;Go, Alan S.;Gottesman, Omri;Graessler, Juergen;Grallert, Harald;Grarup, Niels;Gu, Yu-Mei;Broer, Linda;Ham, Annelies C.;Hansen, Torben;Harris, Tamara B.;Hartman, Catharina A.;Hassinen, Maija;Hastie, Nicholas;Hattersley, Andrew T.;Heath, Andrew C.;Henders, Anjali K.;Hernandez, Dena;Hillege, Hans;Holmen, Oddgeir;Hovingh, Kees G.;Hui, Jennie;Husemoen, Lise L.;Hutri-Kahonen, Nina;Hysi, Pirro G.;Illig, Thomas;De Jager, Philip L.;Jalilzadeh, Shapour;Jorgensen, Torben;Jukema, J. Wouter;Juonala, Markus;Kanoni, Stavroula;Karaleftheri, Maria;Khaw, Kay Tee;Kinnunen, Leena;Kittner, Steven J.;Koenig, Wolfgang;Kolcic, Ivana;Kovacs, Peter;Krarup, Nikolaj T.;Kratzer, Wolfgang;Krueger, Janine;Kuh, Diana;Kumari, Meena;Kyriakou, Theodosios;Langenberg, Claudia;Lannfelt, Lars;Lanzani, Chiara;Lotay, Vaneet;Launer, Lenore J.;Leander, Karin;Lindstrom, Jaana;Linneberg, Allan;Liu, Yan-Ping;Lobbens, Stephane;Luben, Robert;Lyssenko, Valeriya;Mannisto, Satu;Magnusson, Patrik K.;McArdle, Wendy L.;Menni, Cristina;Merger, Sigrun;Milani, Lili;Montgomery, Grant W.;Morris, Andrew P.;Narisu, Narisu;Nelis, Mari;Ong, Ken K.;Palotie, Aarno;Perusse, Louis;Pichler, Irene;Pilia, Maria G.;Pouta, Anneli;Rheinberger, Myriam;Ribel-Madsen, Rasmus;Richards, Marcus;Rice, Kenneth M.;Rice, Treva K.;Rivolta, Carlo;Salomaa, Veikko;Sanders, Alan R.;Sarzynski, Mark A.;Scholtens, Salome;Scott, Robert A.;Scott, William R.;Sebert, Sylvain;Sengupta, Sebanti;Sennblad, Bengt;Seufferlein, Thomas;Silveira, Angela;Slagboom, P. Eline;Smit, Jan H.;Sparso, Thomas H.;Stirrups, Kathleen;Stolk, Ronald P.;Stringham, Heather M.;Swertz, Morris A.;Swift, Amy J.;Syvanen, Ann-Christine;Tan, Sian-Tsung;Thorand, Barbara;Toenjes, Anke;Tremblay, Angelo;Tsafantakis, Emmanouil;van der Most, Peter J.;Voelker, Uwe;Vohl, Marie-Claude;Vonk, Judith M.;Waldenberger, Melanie;Walker, Ryan W.;Wennauer, Roman;Widen, Elisabeth;Willemsen, Gonneke;Wilsgaard, Tom;Wright, Alan F.;Zillikens, M. Carola;van Dijk, Suzanne C.;van Schoor, Natasja M.;Asselbergs, Folkert W.;de Bakker, Paul I. W.;Beckmann, Jacques S.;Beilby, John;Bennett, David A.;Bergman, Richard N.;Bergmann, Sven;Boeger, Carsten A.;Boehm, Bernhard O.;Boerwinkle, Eric;Boomsma, Dorret I.;Bornstein, Stefan R.;Bottinger, Erwin P.;Bouchard, Claude;Chambers, John C.;Chanock, Stephen J.;Chasman, Daniel I.;Cucca, Francesco;Cusi, Daniele;Dedoussis, George;Erdmann, Jeanette;Eriksson, Johan G.;Evans, Denis A.;de Faire, Ulf;Farrall, Martin;Ferrucci, Luigi;Ford, Ian;Franke, Lude;Franks, Paul W.;Froguel, Philippe;Gansevoort, Ron T.;Gieger, Christian;Gronberg, Henrik;Gudnason, Vilmundur;Gyllensten, Ulf;Hall, Per;Hamsten, Anders;van der Harst, Pim;Hayward, Caroline;Heliovaara, Markku;Hengstenberg, Christian;Hicks, Andrew A.;Hingorani, Aroon;Hofman, Albert;Hu, Frank;Huikuri, Heikki V.;Hveem, Kristian;James, Alan L.;Jordan, Joanne M.;Jula, Antti;Kaehoenen, Mika;Kajantie, Eero;Kathiresan, Sekar;Kiemeney, Lambertus A. L. M.;Kivimaki, Mika;Knekt, Paul B.;Koistinen, Heikki A.;Kooner, Jaspal S.;Koskinen, Seppo;Kuusisto, Johanna;Maerz, Winfried;Martin, Nicholas G.;Laakso, Markku;Lakka, Timo A.;Lehtimaki, Terho;Lettre, Guillaume;Levinson, Douglas F.;Lind, Lars;Lokki, Marja-Liisa;Mantyselka, Pekka;Melbye, Mads;Metspalu, Andres;Mitchell, Braxton D.;Moll, Frans L.;Murray, Jeffrey C.;Musk, Arthur W.;Nieminen, Markku S.;Njolstad, Inger;Ohlsson, Claes;Oldehinkel, Albertine J.;Oostra, Ben A.;Palmer, Lyle J.;Pankow, James S.;Pasterkamp, Gerard;Pedersen, Nancy L.;Pedersen, Oluf;Penninx, Brenda W.;Perola, Markus;Peters, Annette;Polasek, Ozren;Pramstaller, Peter P.;Psaty, Bruce M.;Qi, Lu;Quertermous, Thomas;Raitakari, Olli T.;Rankinen, Tuomo;Rauramaa, Rainer;Ridker, Paul M.;Rioux, John D.;Rivadeneira, Fernando;Rotter, Jerome I.;Rudan, Igor;den Ruijter, Hester M.;Saltevo, Juha;Sattar, Naveed;Schunkert, Heribert;Schwarz, Peter E. H.;Shuldiner, Alan R.;Sinisalo, Juha;Snieder, Harold;Sorensen, Thorkild I. A.;Spector, Tim D.;Staessen, Jan A.;Stefania, Bandinelli;Thorsteinsdottir, Unnur;Stumvoll, Michael;Tardif, Jean-Claude;Tremoli, Elena;Tuomilehto, Jaakko;Uitterlinden, Andre G.;Uusitupa, Matti;Verbeek, Andre L. M.;Vermeulen, Sita H.;Viikari, Jorma S.;Vitart, Veronique;Voelzke, Henry;Vollenweider, Peter;Waeber, Gerard;Walker, Mark;Wallaschofski, Henri;Wareham, Nicholas J.;Watkins, Hugh;Zeggini, Eleftheria;Chakravarti, Aravinda;Clegg, Deborah J.;Cupples, L. Adrienne;Gordon-Larsen, Penny;Jaquish, Cashell E.;Rao, D. C.;Abecasis, Goncalo R.;Assimes, Themistocles L.;Barroso, Ines;Berndt, Sonja I.;Boehnke, Michael;Deloukas, Panos;Fox, Caroline S.;Groop, Leif C.;Hunter, David J.;Ingelsson, Erik;Kaplan, Robert C.;McCarthy, Mark I.;Mohlke, Karen L.;O'Connell, Jeffrey R.;Schlessinger, David;Strachan, David P.;Stefansson, Kari;van Duijn, Cornelia M.;Hirschhorn, Joel N.;Lindgren, Cecilia M.;Heid, Iris M.;North, Kari E.;Borecki, Ingrid B.;Kutalik, Zoltan;Loos, Ruth J. F.;CHARGE Consortium;DIAGRAM Consortium;GLGC Consortium;Global-BPGen Consortium;ICBP Consortium;MAGIC Consortium
Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow...
Background: Both statins and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors lower blood low-density lipoprotein cholesterol levels to reduce risk of cardiovascular events. To assess potential differences between metabolic effects of...
Pennells, Lisa;Kaptoge, Stephen;Wood, Angela;Sweeting, Mike;Zhao, Xiaohui;White, Ian;Burgess, Stephen;Willeit, Peter;Bolton, Thomas;Moons, Karel G M;van der Schouw, Yvonne T;Selmer, Randi;Khaw, Kay-Tee;Gudnason, Vilmundur;Assmann, Gerd;Amouyel, Philippe;Salomaa, Veikko;Kivimaki, Mika;Nordestgaard, Børge G;Blaha, Michael J;Kuller, Lewis H;Brenner, Hermann;Gillum, Richard F;Meisinger, Christa;Ford, Ian;Knuiman, Matthew W;Rosengren, Annika;Lawlor, Debbie A;Völzke, Henry;Cooper, Cyrus;Marín Ibañez, Alejandro;Casiglia, Edoardo;Kauhanen, Jussi;Cooper, Jackie A;Rodriguez, Beatriz;Sundström, Johan;Barrett-Connor, Elizabeth;Dankner, Rachel;Nietert, Paul J;Davidson, Karina W;Wallace, Robert B;Blazer, Dan G;Björkelund, Cecilia;Donfrancesco, Chiara;Krumholz, Harlan M;Nissinen, Aulikki;Davis, Barry R;Coady, Sean;Whincup, Peter H;Jørgensen, Torben;Ducimetiere, Pierre;Trevisan, Maurizio;Engström, Gunnar;Crespo, Carlos J;Meade, Tom W;Visser, Marjolein;Kromhout, Daan;Kiechl, Stefan;Daimon, Makoto;Price, Jackie F;Gómez de la Cámara, Agustin;Wouter Jukema, J;Lamarche, Benoît;Onat, Altan;Simons, Leon A;Kavousi, Maryam;Ben-Shlomo, Yoav;Gallacher, John;Dekker, Jacqueline M;Arima, Hisatomi;Shara, Nawar;Tipping, Robert W;Roussel, Ronan;Brunner, Eric J;Koenig, Wolfgang;Sakurai, Masaru;Pavlovic, Jelena;Gansevoort, Ron T;Nagel, Dorothea;Goldbourt, Uri;Barr, Elizabeth L M;Palmieri, Luigi;Njølstad, Inger;Sato, Shinichi;Monique Verschuren, W M;Varghese, Cherian V;Graham, Ian;Onuma, Oyere;Greenland, Philip;Woodward, Mark;Ezzati, Majid;Psaty, Bruce M;Sattar, Naveed;Jackson, Rod;Ridker, Paul M;Cook, Nancy R;D'Agostino, Ralph B;Thompson, Simon G;Danesh, John;Di Angelantonio, Emanuele
Aims: There is debate about the optimum algorithm for cardiovascular disease (CVD) risk estimation. We conducted head-to-head comparisons of four algorithms recommended by primary prevention guidelines, before and after 'recalibration', a method that...