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614 Article(s)
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Document(s)
Title
Vijayakrishnan, Jayaram;Studd, James;Broderick, Peter;Kinnersley, Ben;Holroyd, Amy;Law, Philip J.;Kumar, Rajiv;Allan, James M.;Harrison, Christine J.;Moorman, Anthony V.;Vora, Ajay;Roman, Eve;Rachakonda, Sivaramakrishna;Kinsey, Sally E.;Sheridan, Eamonn;Thompson, Pamela D.;Irving, Julie A.;Koehler, Rolf;Hoffmann, Per;Nöthen, Markus M.;Heilmann-Heimbach, Stefanie;Jöckel, Karl-Heinz;Easton, Douglas F.;Pharaoh, Paul D.P.;Dunning, Alison M.;Peto, Julian;Canzian, Frederico;Swerdlow, Anthony;Eeles, Rosalind A.;Kote-Jarai, ZSofia;Muir, Kenneth;Pashayan, Nora;Greaves, Mel;Zimmerman, Martin;Bartram, Claus R.;Schrappe, Martin;Stanulla, Martin;Hemminki, Kari;Houlston, Richard S.;Henderson, Brian E.;Haiman, Christopher A.;Benlloch, Sara;Schumacher, Fredrick R.;Olama, Ali Amin Al;Berndt, Sonja I.;Conti, David V.;Wiklund, Fredrik;Chanock, Stephen;Stevens, Victoria L.;Tangen, Catherine M.;Batra, Jyotsna;Clements, Judith;Gronberg, Henrik;Schleutker, Johanna;Albanes, Demetrius;Weinstein, Stephanie;Wolk, Alicja;West, Catharine;Mucci, Lorelei;Cancel-Tassin, Géraldine;Koutros, Stella;Sorensen, Karina Dalsgaard;Maehle, Lovise;Neal, David E.;Travis, Ruth C.;Hamilton, Robert J.;Ingles, Sue Ann;Rosenstein, Barry;Lu, Yong-Jie;Giles, Graham G.;Kibel, Adam S.;Vega, Ana;Kogevinas, Manolis;Penney, Kathryn L.;Park, Jong Y.;Stanford, Janet L.;Cybulski, Cezary;Nordestgaard, Børge G.;Brenner, Hermann;Maier, Christiane;Kim, Jeri;John, Esther M.;Teixeira, Manuel R.;Neuhausen, Susan L.;De Ruyck, Kim;Razack, Azad;Newcomb, Lisa F.;Lessel, Davor;Kaneva, Radka;Usmani, Nawaid;Claessens, Frank;Townsend, Paul A.;Dominguez, Manuela Gago;Roobol, Monique J.;Menegaux, Florence
Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-...
Background: Kallikrein 15 (KLK15)/Prostinogen is a plausible candidate for prostate cancer susceptibility. Elevated KLK15 expression has been reported in prostate cancer and it has been described as an unfavorable prognostic marker for the disease. O...
Objectives: Prostate-specific-antigen (PSA) screening resulted in reduced prostate cancer (PCa) mortality in a large clinical trial, but due to many false positives and overdiagnosis of indolent disease, many guidelines do not endorse universal scree...
A recent genome-wide association study found that genetic variants on chromosomes 3, 6, 7, 10, 11, 19 and X were associated with prostate cancer risk. We evaluated the most significant single-nucleotide polymorphisms (SNP) in these loci using a world...
Circulating insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are associated with prostate cancer. Using genetic variants as instruments for IGF peptides, we investigated whether these associations are likely to be causal. We ide...
A variety of models have been proposed to explain regions of recurrent somatic copy number alteration (SCNA) in human cancer. Our study employs Whole Genome DNA Sequence (WGS) data from tumor samples (n=103) to comprehensively assess the role of the ...
Ionizing radiation is a potent carcinogen, inducing cancer through DNA damage. The signatures of mutations arising in human tissues following in vivo exposure to ionizing radiation have not been documented. Here, we searched for signatures of ionizin...
Whole genome DNA sequencing was used to decrypt the phylogeny of multiple samples from distinct areas of cancer and morphologically normal tissue taken from the prostates of three men. Mutations were present at high levels in morphologically normal t...
Objectives: Prostate-specific-antigen (PSA) screening resulted in reduced prostate cancer (PCa) mortality in a large clinical trial, but due to many false positives and overdiagnosis of indolent disease, many guidelines do not endorse universal scree...