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Title
Patient-derived xenografts (PDXs) have emerged as an important platform to elucidate new treatments and biomarkers in oncology. PDX models are used to address clinically relevant questions, including the contribution of tumour heterogeneity to therap...
Patient-derived xenografts (PDXs) have emerged as an important platform to elucidate new treatments and biomarkers in oncology. PDX models are used to address clinically relevant questions, including the contribution of tumour heterogeneity to therap...
Ghoussaini, Maya;Edwards, Stacey L.;Michailidou, Kyriaki;Nord, Silje;Cowper-Sal·lari, Richard;Desai, Kinjal;Kar, Siddhartha;Hillman, Kristine M.;Kaufmann, Susanne;Glubb, Dylan M.;Beesley, Jonathan;Dennis, Joe;Bolla, Manjeet K.;Wang, Qin;Dicks, Ed;Guo, Qi;Schmidt, Marjanka K.;Shah, Mitul;Luben, Robert;Brown, Judith;Czene, Kamila;Darabi, Hatef;Eriksson, Mikael;Klevebring, Daniel;Bojesen, Stig E.;Nordestgaard, Børge G.;Nielsen, Sune F.;Flyger, Henrik;Lambrechts, Diether;Thienpont, Bernard;Neven, Patrick;Wildiers, Hans;Broeks, Annegien;Van’t Veer, Laura J.;Th Rutgers, Emiel J.;Couch, Fergus J.;Olson, Janet E.;Hallberg, Emily;Vachon, Celine;Chang-Claude, Jenny;Rudolph, Anja;Seibold, Petra;Flesch-Janys, Dieter;Peto, Julian;dos-Santos-Silva, Isabel;Gibson, Lorna;Nevanlinna, Heli;Muranen, Taru A.;Aittomäki, Kristiina;Blomqvist, Carl;Hall, Per;Li, Jingmei;Liu, Jianjun;Humphreys, Keith;Kang, Daehee;Choi, Ji-Yeob;Park, Sue K.;Noh, Dong-Young;Matsuo, Keitaro;Ito, Hidemi;Iwata, Hiroji;Yatabe, Yasushi;Guénel, Pascal;Truong, Thérèse;Menegaux, Florence;Sanchez, Marie;Burwinkel, Barbara;Marme, Frederik;Schneeweiss, Andreas;Sohn, Christof;Wu, Anna H.;Tseng, Chiu-chen;Van Den Berg, David;Stram, Daniel O.;Benitez, Javier;Zamora, M. Pilar;Perez, Jose Ignacio Arias;Menéndez, Primitiva;Shu, Xiao-Ou;Lu, Wei;Gao, Yu-Tang;Cai, Qiuyin;Cox, Angela;Cross, Simon S.;Reed, Malcolm W. R.;Andrulis, Irene L.;Knight, Julia A.;Glendon, Gord;Tchatchou, Sandrine;Sawyer, Elinor J.;Tomlinson, Ian;Kerin, Michael J.;Miller, Nicola;Haiman, Christopher A.;Henderson, Brian E.;Schumacher, Fredrick;Le Marchand, Loic;Lindblom, Annika;Margolin, Sara;TEO, Soo Hwang;YIP, Cheng Har;Lee, Daphne S. C.;Wong, Tien Y.;Hooning, Maartje J.;Martens, John W. M.;Collée, J. Margriet;van Deurzen, Carolien H. M.;Hopper, John L.;Southey, Melissa C.;Tsimiklis, Helen;Kapuscinski, Miroslav K.;Shen, Chen-Yang;Wu, Pei-Ei;Yu, Jyh-Cherng;Chen, Shou-Tung;Alnæs, Grethe Grenaker;Borresen-Dale, Anne-Lise;Giles, Graham G.;Milne, Roger L.;McLean, Catriona;Muir, Kenneth;Lophatananon, Artitaya;Stewart-Brown, Sarah;Siriwanarangsan, Pornthep;Hartman, Mikael;Miao, Hui;Buhari, Shaik Ahmad Bin Syed;Teo, Yik Ying;Fasching, Peter A.;Haeberle, Lothar;Ekici, Arif B.;Beckmann, Matthias W.;Brenner, Hermann;Dieffenbach, Aida Karina;Arndt, Volker;Stegmaier, Christa;Swerdlow, Anthony;Ashworth, Alan;Orr, Nick;Schoemaker, Minouk J.;García-Closas, Montserrat;Figueroa, Jonine;Chanock, Stephen J.;Lissowska, Jolanta;Simard, Jacques;Goldberg, Mark S.;Labrèche, France;Dumont, Martine;Winqvist, Robert;Pylkäs, Katri;Jukkola-Vuorinen, Arja;Brauch, Hiltrud;Brüning, Thomas;Koto, Yon-Dschun;Radice, Paolo;Peterlongo, Paolo;Bonanni, Bernardo;Volorio, Sara;Dörk, Thilo;Bogdanova, Natalia V.;Helbig, Sonja;Mannermaa, Arto;Kataja, Vesa;Kosma, Veli-Matti;Hartikainen, Jaana M.;Devilee, Peter;Tollenaar, Robert A. E. M.;Seynaeve, Caroline;Van Asperen, Christi J.;Jakubowska, Anna;Lubinski, Jan;Jaworska-Bieniek, Katarzyna;Durda, Katarzyna;Slager, Susan;Toland, Amanda E.;Ambrosone, Christine B.;Yannoukakos, Drakoulis;Sangrajrang, Suleeporn;Gaborieau, Valerie;Brennan, Paul;McKay, James;Hamann, Ute;Torres, Diana;Zheng, Wei;Long, Jirong;Anton-Culver, Hoda;Neuhausen, Susan L.;Luccarini, Craig;Baynes, Caroline;Ahmed, Shahana;Maranian, Mel;Healey, Catherine S.;González-Neira, Anna;Pita, Guillermo;Alonso, M. Rosario;Álvarez, Nuria;Herrero, Daniel;Tessier, Daniel C.;Vincent, Daniel;Bacot, Francois;de Santiago, Ines;Carroll, Jason;Caldas, Carlos;Brown, Melissa A.;Lupien, Mathieu;Kristensen, Vessela N.;Pharoah, Paul D P;Chenevix-Trench, Georgia;French, Juliet D;Easton, Douglas F.;Dunning, Alison M.;Chenevix-Trench, Georgia;Webb, Penny;Bowtell, David;De Fazio, Anna
GWAS have identified a breast cancer susceptibility locus on 2q35. Here we report the fine mapping of this locus using data from 101,943 subjects from 50 case-control studies. We genotype 276 SNPs using the 'iCOGS' genotyping array and impute genotyp...
Pirie, Ailith;,;Guo, Qi;Kraft, Peter;Canisius, Sander;Eccles, Diana M;Rahman, Nazneen;Nevanlinna, Heli;Chen, Constance;Khan, Sofia;Tyrer, Jonathan;Bolla, Manjeet K;Wang, Qin;Dennis, Joe;Michailidou, Kyriaki;Lush, Michael;Dunning, Alison M;Shah, Mitul;Czene, Kamila;Darabi, Hatef;Eriksson, Mikael;Lambrechts, Dieter;Weltens, Caroline;Leunen, Karin;van Ongeval, Chantal;Nordestgaard, Børge G;Nielsen, Sune F;Flyger, Henrik;Rudolph, Anja;Seibold, Petra;Flesch-Janys, Dieter;Blomqvist, Carl;Aittomäki, Kristiina;Fagerholm, Rainer;Muranen, Taru A;Olsen, Janet E;Hallberg, Emily;Vachon, Celine;Knight, Julia A;Glendon, Gord;Mulligan, Anna Marie;Broeks, Annegien;Cornelissen, Sten;Haiman, Christopher A;Henderson, Brian E;Schumacher, Frederick;Le Marchand, Loic;Hopper, John L;Tsimiklis, Helen;Apicella, Carmel;Southey, Melissa C;Cross, Simon S;Reed, Malcolm WR;Giles, Graham G;Milne, Roger L;McLean, Catriona;Winqvist, Robert;Pylkäs, Katri;Jukkola-Vuorinen, Arja;Grip, Mervi;Hooning, Maartje J;Hollestelle, Antoinette;Martens, John WM;van den Ouweland, Ans MW;Marme, Federick;Schneeweiss, Andreas;Yang, Rongxi;Burwinkel, Barbara;Figueroa, Jonine;Chanock, Stephen J;Lissowska, Jolanta;Sawyer, Elinor J;Tomlinson, Ian;Kerin, Michael J;Miller, Nicola;Brenner, Hermann;Butterbach, Katja;Holleczek, Bernd;Kataja, Vesa;Kosma, Veli-Matti;Hartikainen, Jaana M;Li, Jingmei;Brand, Judith S;Humphreys, Keith;Devilee, Peter;Tollenaar, Robert AEM;Seynaeve, Caroline;Radice, Paolo;Peterlongo, Paolo;Manoukian, Siranoush;Ficarazzi, Filomena;Beckmann, Matthias W;Hein, Alexander;Ekici, Arif B;Balleine, Rosemary;Phillips, Kelly-Anne;Benitez, Javier;Zamora, M Pilar;Perez, Jose Ignacio Arias;Menéndez, Primitiva;Jakubowska, Anna;Lubinski, Jan;Gronwald, Jacek;Durda, Katarzyna;Hamann, Ute;Kabisch, Maria;Ulmer, Hans Ulrich;Rüdiger, Thomas;Margolin, Sara;Kristensen, Vessela;Nord, Siljie;Evans, D Gareth;Abraham, Jean;Earl, Helena;Poole, Christopher J;Hiller, Louise;Dunn, Janet A;Bowden, Sarah;Yang, Rose;Campa, Daniele;Diver, W Ryan;Gapstur, Susan M;Gaudet, Mia M;Hankinson, Susan;Hoover, Robert N;Hüsing, Anika;Kaaks, Rudolf;Machiela, Mitchell J;Willett, Walter;Barrdahl, Myrto;Canzian, Federico;Chin, Suet-Feung;Caldas, Carlos;Hunter, David J;Lindstrom, Sara;Garcia-Closas, Montserrat;Couch, Fergus J;Chenevix-Trench, Georgia;Mannermaa, Arto;Andrulis, Irene L;Hall, Per;Chang-Claude, Jenny;Easton, Douglas F;Bojesen, Stig E;Cox, Angela;Fasching, Peter A;Pharoah, Paul DP;Schmidt, Marjanka K;,
Introduction: Previous studies have identified common germline variants nominally associated with breast cancer survival. These associations have not been widely replicated in further studies. The purpose of this study was to evaluate the association...
Guo, Qi;Schmidt, Marjanka K.;Kraft, Peter;Canisius, Sander;Chen, Constance;Khan, Sofia;Tyrer, Jonathan;Bolla, Manjeet K.;Wang, Qin;Dennis, Joe;Michailidou, Kyriaki;Lush, Michael;Kar, Siddhartha;Beesley, Jonathan;Dunning, Alison M.;Shah, Mitul;Czene, Kamila;Darabi, Hatef;Eriksson, Mikael;Lambrechts, Diether;Weltens, Caroline;Leunen, Karin;Bojesen, Stig E.;Nordestgaard, Børge G.;Nielsen, Sune F.;Flyger, Henrik;Chang-Claude, Jenny;Rudolph, Anja;Seibold, Petra;Flesch-Janys, Dieter;Blomqvist, Carl;Aittomäki, Kristiina;Fagerholm, Rainer;Muranen, Taru A.;Couch, Fergus J.;Olson, Janet E.;Vachon, Celine;Andrulis, Irene L.;Knight, Julia A.;Glendon, Gord;Mulligan, Anna Marie;Broeks, Annegien;Hogervorst, Frans B.;Haiman, Christopher A.;Henderson, Brian E.;Schumacher, Fredrick;Le Marchand, Loic;Hopper, John L.;Tsimiklis, Helen;Apicella, Carmel;Southey, Melissa C.;Cox, Angela;Cross, Simon S.;Reed, Malcolm W. R.;Giles, Graham G.;Milne, Roger L.;McLean, Catriona;Winqvist, Robert;Pylkäs, Katri;Jukkola-Vuorinen, Arja;Grip, Mervi;Hooning, Maartje J.;Hollestelle, Antoinette;Martens, John W. M.;van den Ouweland, Ans M. W.;Marme, Federik;Schneeweiss, Andreas;Yang, Rongxi;Burwinkel, Barbara;Figueroa, Jonine;Chanock, Stephen J.;Lissowska, Jolanta;Sawyer, Elinor J.;Tomlinson, Ian;Kerin, Michael J.;Miller, Nicola;Brenner, Hermann;Dieffenbach, Aida Karina;Arndt, Volker;Holleczek, Bernd;Mannermaa, Arto;Kataja, Vesa;Kosma, Veli-Matti;Hartikainen, Jaana M.;Li, Jingmei;Brand, Judith S.;Humphreys, Keith;Devilee, Peter;Tollenaar, Rob A. E. M.;Seynaeve, Caroline;Radice, Paolo;Peterlongo, Paolo;Bonanni, Bernardo;Mariani, Paolo;Fasching, Peter A.;Beckmann, Matthias W.;Hein, Alexander;Ekici, Arif B.;Chenevix-Trench, Georgia;Balleine, Rosemary;Phillips, Kelly-Anne;Benitez, Javier;Zamora, M. Pilar;Arias Perez, Jose Ignacio;Menéndez, Primitiva;Jakubowska, Anna;Lubinski, Jan;Jaworska-Bieniek, Katarzyna;Durda, Katarzyna;Hamann, Ute;Kabisch, Maria;Ulmer, Hans Ulrich;Rüdiger, Thomas;Margolin, Sara;Kristensen, Vessela;Nord, Silje;Evans, D. Gareth;Abraham, Jean E.;Earl, Helena M.;Hiller, Louise;Dunn, Janet A.;Bowden, Sarah;Berg, Christine;Campa, Daniele;Diver, W. Ryan;Gapstur, Susan M.;Gaudet, Mia M.;Hankinson, Susan E.;Hoover, Robert N.;Hüsing, Anika;Kaaks, Rudolf;Machiela, Mitchell J.;Willett, Walter;Barrdahl, Myrto;Canzian, Federico;Chin, Suet-Feung;Caldas, Carlos;Hunter, David J.;Lindstrom, Sara;García-Closas, Montserrat;Hall, Per;Easton, Douglas F.;Eccles, Diana M.;Rahman, Nazneen;Nevanlinna, Heli;Pharoah, Paul D. P.
Background: Survival after a diagnosis of breast cancer varies considerably between patients, and some of this variation may be because of germline genetic variation. We aimed to identify genetic markers associated with breast cancer-specific surviva...