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Title
IMPORTANCE: High-sensitivity cardiac troponin I testing is widely used to evaluate patients with suspected acute coronary syndrome. A cardiac troponin concentration of less than 5 ng/L identifies patients at presentation as low risk, but the optimal ...
Background and Purpose- NT-proBNP (N-terminal pro-B-type natriuretic peptide) is a risk factor for atrial fibrillation and a marker of cardiac function used in the detection of heart failure. Given the link between cardiac dysfunction and stroke, NT-...
Surendran, Praveen;Drenos, Fotios;Young, Robin;Warren, Helen;Cook, James P;Manning, Alisa K;Grarup, Niels;Sim, Xueling;Barnes, Daniel R;Witkowska, Kate;Staley, James R;Tragante, Vinicius;Tukiainen, Taru;Yaghootkar, Hanieh;Masca, Nicholas;Freitag, Daniel F;Ferreira, Teresa;Giannakopoulou, Olga;Tinker, Andrew;Harakalova, Magdalena;Mihailov, Evelin;Liu, Chunyu;Kraja, Aldi T;Nielsen, Sune Fallgaard;Rasheed, Asif;Samue, Maria;Zhao, Wei;Bonnycastle, Lori L;Jackson, Anne U;Narisu, Narisu;Swift, Amy J;Southam, Lorraine;Marten, Jonathan;Huyghe, Jeroen R;Stancakova, Alena;Fava, Cristiano;Ohlsson, Therese;Matchan, Angela;Stirrups, Kathleen E;Bork-Jensen, Jette;Gjesing, Anette P;Kontto, Jukka;Perola, Markus;Shaw-Hawkins, Susan;Havulinna, Aki S;Zhang, He;Donnelly, Louise A;Groves, Christopher J;Rayner, N William;Neville, Matt J;Robertson, Neil R;Yiorkas, Andrianos M;Herzig, Karl-Heinz;Kajantie, Eero;Zhang, Weihua;Willems, Sara M;Lannfelt, Lars;Malerba, Giovanni;Soranzo, Nicole;Trabetti, Elisabetta;Verweij, Niek;Evangelou, Evangelos;Moayyeri, Alireza;Vergnaud, Anne-Claire;Nelson, Christopher P;Poveda, Alaitz;Varga, Tibor V;Caslake, Muriel;de Craen, Anton JM;Trompet, Stella;Luan, Jian'an;Scott, Robert A;Harris, Sarah E;Liewald, David CM;Marioni, Riccardo;Menni, Cristina;Farmaki, Aliki-Eleni;Hallmans, Goran;Renstrom, Frida;Huffman, Jennifer E;Hassinen, Maija;Burgess, Stephen;Vasan, Ramachandran S;Felix, Janine F;Uria-Nickelsen, Maria;Malarstign, Anders;Reilly, Dermot F;Hoek, Maarten;Vogt, Thomas F;Lin, Honghuang;Lieb, Wolfgang;Traylor, Matthew;Markus, Hugh S;Highland, Heather M;Justice, Anne E;Marouli, Eirini;Lindstrom, Jaana;Uusitupa, Matti;Komulainen, Pirjo;Lakka, Timo A;Rauramaa, Rainer;Polasek, Ozren;Rudan, Igor;Rolandsson, Olov;Franks, Paul W;Dedoussis, George;Spector, Timothy D;Jousilahti, Pekka;Mannisto, Satu;Deary, Ian J;Starr, John M;Langenberg, Claudia;Wareham, Nick J;Brown, Morris J;Dominiczak, Anna F;Connell, John M;Jukema, J Wouter;Sattar, Naveed;Ford, Ian;Packard, Chris J;Esko, Tonu;Magi, Reedik;Metspalu, Andres;de Boer, Rudolf A;van der Meer, Peter;van der Harst, Pim;Gambaro, Giovanni;Ingelsson, Erik;Lind, Lars;de Bakker, Paul IW;Numans, Mattijs E;Brandslund, Ivan;Christensen, Cramer;Petersen, Eva RB;Korpi-Hyovalti, Eeva;Oksa, Heikki;Chambers, John C;Kooner, Jaspal S;Blakemore, Alexandra IF;Franks, Steve;Jarvelin, Marjo-Riitta;Husemoen, Lise L;Linneberg, Allan;Skaaby, Tea;Thuesen, Betina;Karpe, Fredrik;Tuomilehto, Jaakko;Doney, Alex SF;Morris, Andrew D;Palmer, Colin NA;Holmen, Oddgeir Lingaas;Hveem, Kristian;Willer, Cristen J;Tuomi, Tiinamaija;Groop, Leif;Karajamaki, AnneMari;Palotie, Aarno;Ripatti, Samuli;Salomaa, Veikko;Alam, Dewan S;Majmnder, Abdulla Al Shafi;Di Angelantonio, Emanuele;Chowdhury, Rajiv;McCarthy, Mark I;Poulter, Neil;Stanton, Alice V;Sever, Peter;Amouyel, Philippe;Arveiler, Dominique;Blankenberg, Stefan;Ferrieres, Jean;Kee, Frank;Kuulasmaa, Kari;Muller-Nurasyid, Martina;Veronesi, Giovanni;Virtamo, Jarmo;Deloukas, Panos;Elliott, Paul;Zeggini, Eleftheria;Kathiresan, Sekar;Melander, Olle;Kuusisto, Johanna;Laakso, Markku;Padmanabhan, Sandosh;Porteous, David J;Hayward, Caroline;Scotland, Generation;Collins, Francis S;Mohlke, Karen L;Hansen, Torben;Pedersen, Oluf;Boehnke, Michael;Stringham, Heather M;Frossard, Philippe;Newton-Cheh, Christopher;Tobin, Martin D;Nordestgaard, Borge Gronne;Caulfield, Mark J;Mahajan, Anubha;Morris, Andrew P;Tomaszewski, Maciej;Samani, Nilesh J;Saleheen, Danish;Asselbergs, Folkert W;Lindgren, Cecilia M;Danesh, John;Wain, Louise V;Butterworth, Adam S;Howson, Joanna MM;Munroe, Patricia B;Consortiumm, CHARGE Heart Failure;Consortiumm, EchoGen;Consortiumm, Metastroke;Consortiumm, Giant;Consortium, EPIC-InterAct;Study, Lifelines Cohort;Consor, Wellcome Trust Case Control;Grp, Understanding Soc Sci;Consortium, EPIC-CVD;CHARGE, Exome Chip Blood Pressure C;Consortium, T2D-GENES;Consortium, GoT2DGenes;Consortium, ExomeBP;Consortium, CHD Exome
Background: Obesity, defined as pathologically increased body mass index (BMI), is strongly related to an increased risk for numerous common cardiovascular and metabolic diseases. It is particularly associated with insulin resistance, hyperglycemia, ...
International audience
International audience
Wild, Philipp S;Felix, Janine F;Schillert, Arne;Teumer, Alexander;Chen, Ming-Huei;Leening, Maarten JG;Voelker, Uwe;Grossmann, Vera;Brody, Jennifer A;Irvin, Marguerite R;Shah, Sanjiv J;Pramana, Setia;Lieb, Wolfgang;Schmidt, Reinhold;Stanton, Alice V;Malzahn, Doerthe;Smith, Albert Vernon;Sundstrom, Johan;Minelli, Cosetta;Ruggiero, Daniela;Lyytikainen, Leo-Pekka;Tiller, Daniel;Smith, J Gustav;Monnereau, Claire;Di Tullio, Marco R;Musani, Solomon K;Morrison, Alanna C;Pers, Tune H;Morley, Michael;Kleber, Marcus E;Aragam, Jayashri;Benjamin, Emelia J;Bis, Joshua C;Bisping, Egbert;Broeckel, Ulrich;Cheng, Susan;Deckers, Jaap W;Del Greco, Fabiola;Edelmann, Frank;Fornage, Myriam;Franke, Lude;Friedrich, Nele;Harris, Tamara B;Hofer, Edith;Hofman, Albert;Huang, Jie;Hughes, Alun D;Kahonen, Mika;Kruppa, Jochen;Lackner, Karl J;Lannfelt, Lars;Laskowski, Rafael;Launer, Lenore J;Leosdottir, Margret;Lin, Honghuang;Lindgren, Cecilia M;Loley, Christina;MacRae, Calum A;Mascalzoni, Deborah;Mayet, Jamil;Medenwald, Daniel;Morris, Andrew P;Mueller, Christian;Mueller-Nurasyid, Martina;Nappo, Stefania;Nilsson, Peter M;Nuding, Sebastian;Nutile, Teresa;Peters, Annette;Pfeufer, Arne;Pietzner, Diana;Pramstaller, Peter P;Raitakari, Olli T;Rice, Kenneth M;Rivadeneira, Fernando;Rotter, Jerome I;Ruohonen, Saku T;Sacco, Ralph L;Samdarshi, Tandaw E;Schmidt, Helena;Sharp, Andrew SP;Shields, Denis C;Sorice, Rossella;Sotoodehnia, Nona;Stricker, Bruno H;Surendran, Praveen;Thom, Simon;Toeglhofer, Anna M;Uitterlinden, Andre G;Wachter, Rolf;Voelzke, Henry;Ziegler, Andreas;Muenzel, Thomas;Maerz, Winfried;Cappola, Thomas P;Hirschhorn, Joel N;Mitchell, Gary F;Smith, Nicholas L;Fox, Ervin R;Dueker, Nicole D;Jaddoe, Vincent WV;Melander, Olle;Russ, Martin;Lehtimaki, Terho;Ciullo, Marina;Hicks, Andrew A;Lind, Lars;Gudnason, Vilmundur;Pieske, Burkert;Barron, Anthony J;Zweiker, Robert;Schunkert, Heribert;Ingelsson, Erik;Liu, Kiang;Arnett, Donna K;Psaty, Bruce M;Blankenberg, Stefan;Larson, Martin G;Felix, Stephan B;Franco, Oscar H;Zeller, Tanja;Vasan, Ramachandran S;Doerr, Marcus;Consortium, AortaGen;Consortium, CHARGE Heart Failure;Investigators, KNHI
International audience