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Title
Importance: High-sensitivity cardiac troponin I testing is widely used to evaluate patients with suspected acute coronary syndrome. A cardiac troponin concentration of less than 5 ng/L identifies patients at presentation as low risk, but the optimal ...
Bown, Matthew J.;Jones, Gregory T.;Harrison, Seamus C.;Wright, Benjamin J.;Bumpstead, Suzannah;Baas, Annette F.;Gretarsdottir, Solveig;Badger, Stephen A.;Bradley, Declan T.;Burnand, Kevin;Child, Anne H.;Clough, Rachel E.;Cockerill, Gillian;Hafez, Hany;Scott, D Julian A.;Futers, Simon;Johnson, Anne;Sohrabi, Soroush;Smith, Alberto;Thompson, Matthew M.;van Bockxmeer, Frank M.;Waltham, Matthew;Matthiasson, Stefan E.;Thorleifsson, Gudmar;Thorsteinsdottir, Unnur;Blankensteijn, Jan D.;Teijink, Joep A.W.;Wijmenga, Cisca;de Graaf, Jacqueline;Kiemeney, Lambertus A.;Assimes, Themistocles L.;McPherson, Ruth;Folkersen, Lasse;Franco-Cereceda, Anders;Palmen, Jutta;Smith, Andrew J.;Sylvius, Nicolas;Wild, John B.;Refstrup, Mette;Edkins, Sarah;Gwilliam, Rhian;Hunt, Sarah E.;Potter, Simon;Lindholt, Jes S.;Frikke-Schmidt, Ruth;Tybjærg-Hansen, Anne;Hughes, Anne E.;Golledge, Jonathan;Norman, Paul E.;van Rij, Andre;Powell, Janet T.;Eriksson, Per;Stefansson, Kari;Thompson, John R.;Humphries, Steve E.;Sayers, Robert D.;Deloukas, Panos;Samani, Nilesh J.;Schunkert, Heribert;König, Inke R.;Kathiresan, Sekar;Reilly, Muredach P.;Assimes, Themistocles L.;Holm, Hilma;Preuss, Michael;Stewart, Alexandre F. R.;Barbalic, Maja;Gieger, Christian;Absher, Devin;Aherrahrou, Zouhair;Allayee, Hooman;Altshuler, David;Anand, Sonia S.;Andersen, Karl;Anderson, Jeffrey L.;Ardissino, Diego;Ball, Stephen G.;Balmforth, Anthony J.;Barnes, Timothy A.;Becker, Diane M.;Becker, Lewis C.;Berger, Klaus;Bis, Joshua C.;Matthijs Boekholdt, S.;Boerwinkle, Eric;Braund, Peter S.;Brown, Morris J.;Susan Burnett, Mary;Buysschaert, Ian;Carlquist, John F.;Chen, Li;Cichon, Sven;Codd, Veryan;Davies, Robert W.;Dedoussis, George;Dehghan, Abbas;Demissie, Serkalem;Devaney, Joseph M.;Diemert, Patrick;Do, Ron;Doering, Angela;Eifert, Sandra;El Mokhtari, Nour Eddine;Ellis, Stephen G.;Elosua, Roberto;Engert, James C.;Epstein, Stephen E.;de Faire, Ulf;Fischer, Marcus;Folsom, Aaron R.;Freyer, Jennifer;Gigante, Bruna;Girelli, Domenico;Gretarsdottir, Solveig;Gudnason, Vilmundur;Gulcher, Jeffrey R.;Halperin, Eran;Hammond, Naomi;Hazen, Stanley L.;Hofman, Albert;Horne, Benjamin D.;Illig, Thomas;Iribarren, Carlos;Jones, Gregory T.;Wouter Jukema, J.;Kaiser, Michael A.;Kaplan, Lee M.;Kastelein, John J. P.;Khaw, Kay-Tee;Knowles, Joshua W.;Kolovou, Genovefa;Kong, Augustine;Laaksonen, Reijo;Lambrechts, Diether;Leander, Karin;Lettre, Guillaume;Li, Mingyao;Lieb, Wolfgang;Loley, Christina;Lotery, Andrew J.;Mannucci, Pier M.;Maouche, Seraya;Martinelli, Nicola;McKeown, Pascal P.;Meisinger, Christa;Meitinger, Thomas;Melander, Olle;Angelica Merlini, Pier;Mooser, Vincent;Morgan, Thomas;Mühleisen, Thomas W.;Muhlestein, Joseph B.;Münzel, Thomas;Musunuru, Kiran;Nahrstaedt, Janja;Nelson, Christopher P.;Nöthen, Markus M.;Olivieri, Oliviero;Patel, Riyaz S.;Patterson, Chris C.;Peters, Annette;Peyvandi, Flora;Qu, Liming;Quyyumi, Arshed A.;Rader, Daniel J.;Rallidis, Loukianos S.;Rice, Catherine;Rosendaal, Frits R.;Rubin, Diana;Salomaa, Veikko;Lourdes Sampietro, M.;Sandhu, Manj S.;Schadt, Eric;Schäfer, Arne;Schillert, Arne;Schreiber, Stefan;Schrezenmeir, Jürgen;Schwartz, Stephen M.;Siscovick, David S.;Sivananthan, Mohan;Sivapalaratnam, Suthesh;Smith, Albert;Smith, Tamara B.;Snoep, Jaapjan D.;Soranzo, Nicole;Spertus, John A.;Stark, Klaus;Stirrups, Kathy;Stoll, Monika;Wilson Tang, W. H.;Tennstedt, Stephanie;Thorgeirsson, Gudmundur;Thorleifsson, Gudmar;Tomaszewski, Maciej;Uitterlinden, Andre G.;van Rij, Andre M.;Voight, Benjamin F.;Wareham, Nick J.;Wells, George A.;Wichmann, H-Erich;Wild, Philipp S.;Willenborg, Christina;Witteman, Jaqueline C. M.;Wright, Benjamin J.;Ye, Shu;Zeller, Tanja;Ziegler, Andreas;Cambien, Francois;Goodall, Alison H.;Adrienne Cupples, L.;Quertermous, Thomas;März, Winfried;Hengstenberg, Christian;Blankenberg, Stefan;Ouwehand, Willem H.;Hall, Alistair S.;Deloukas, Panos;Thompson, John R.;Stefansson, Kari;Roberts, Robert;Thorsteinsdottir, Unnur;O'Donnell, Christopher J.;McPherson, Ruth;Erdmann, Jeanette;Samani, Nilesh J.;Newton-Cheh, Christopher;Johnson, Toby;Gateva, Vesela;Tobin, Martin D.;Bochud, Murielle;Coin, Lachlan;Najjar, Samer S.;Hua Zhao, Jing;Heath, Simon C.;Eyheramendy, Susana;Papadakis, Konstantinos;Voight, Benjamin F.;Scott, Laura J.;Zhang, Feng;Farrall, Martin;Tanaka, Toshiko;Wallace, Chris;Chambers, John C.;Khaw, Kay-Tee;Nilsson, Peter;van der Harst, Pim;Polidoro, Silvia;Grobbee, Diederick E.;Onland-Moret, N. Charlotte;Bots, Michiel L.;Wain, Louise V.;Elliott, Katherine S.;Teumer, Alexander;Luan, Jian'an;Lucas, Gavin;Kuusisto, Johanna;Burton, Paul R.;Hadley, David;McArdle, Wendy L.;Brown, Morris;Dominiczak, Anna;Newhouse, Stephen J.;Samani, Nilesh J.;Webster, John;Zeggini, Eleftheria;Beckmann, Jacques S.;Bergmann, Sven;Lim, Noha;Song, Kijoung;Vollenweider, Peter;Waeber, Gerard;Waterworth, Dawn M.;Yuan, Xin;Groop, Leif;Orho-Melander, Marju;Allione, Alessandra;Di Gregorio, Alessandra;Guarrera, Simonetta;Panico, Salvatore;Ricceri, Fulvio;Romanazzi, Valeria;Sacerdote, Carlotta;Vineis, Paolo;Barroso, Inês;Sandhu, Manjinder S.;Luben, Robert N.;Crawford, Gabriel J.;Jousilahti, Pekka;Perola, Markus;Boehnke, Michael;Bonnycastle, Lori L.;Collins, Francis S.;Jackson, Anne U.;Mohlke, Karen L.;Stringham, Heather M.;Valle, Timo T.;Willer, Cristen J.;Bergman, Richard N.;Morken, Mario A.;Döring, Angela;Gieger, Christian;Meitinger, Thomas;Org, Elin;Pfeufer, Arne;Wichmann, H. Erich;Kathiresan, Sekar;Marrugat, Jaume;O'Donnell, Christopher J.;Schwartz, Stephen M.;Siscovick, David S.;Subirana, Isaac;Freimer, Nelson B.;Hartikainen, Anna-Liisa;McCarthy, Mark I.;O'Reilly, Paul F.;Peltonen, Leena;Pouta, Anneli;de Jong, Paul E.;Snieder, Harold;van Gilst, Wiek H.;Clarke, Robert;Goel, Anuj;Hamsten, Anders;Peden, John F.;Seedorf, Udo;Syvänen, Ann-Christine;Tognoni, Giovanni;Lakatta, Edward G.;Sanna, Serena;Scheet, Paul;Schlessinger, David;Scuteri, Angelo;Dörr, Marcus;Ernst, Florian;Felix, Stephan B.;Homuth, Georg;Lorbeer, Roberto;Reffelmann, Thorsten;Rettig, Rainer;Völker, Uwe;Galan, Pilar;Gut, Ivo G.;Hercberg, Serge;Mark Lathrop, G.;Zelenika, Diana;Deloukas, Panos;Soranzo, Nicole;Williams, Frances M.;Zhai, Guangju;Salomaa, Veikko;Laakso, Markku;Elosua, Roberto;Forouhi, Nita G.;Völzke, Henry;Uiterwaal, Cuno S.;van der Schouw, Yvonne T.;Numans, Mattijs E.;Matullo, Giuseppe;Navis, Gerjan;Berglund, Göran;Bingham, Sheila A.;Kooner, Jaspal S.;Connell, John M.;Bandinelli, Stefania;Ferrucci, Luigi;Watkins, Hugh;Spector, Tim D.;Tuomilehto, Jaakko;Altshuler, David;Strachan, David P.;Laan, Maris;Meneton, Pierre;Wareham, Nicholas J.;Uda, Manuela;Jarvelin, Marjo-Riitta;Mooser, Vincent;Melander, Olle;Loos, Ruth J. F.;Elliott, Paul;Abecasis, Gonçalo R.;Caulfield, Mark;Munroe, Patricia B.;Voight, Benjamin F.;Scott, Laura J.;Steinthorsdottir, Valgerdur;Morris, Andrew P.;Dina, Christian;Welch, Ryan P.;Zeggini, Eleftheria;Zeggini, Eleftheria;Huth, Cornelia;Aulchenko, Yurii S.;Thorleifsson, Gudmar;McCulloch, Laura J.;Ferreira, Teresa;Grallert, Harald;Amin, Najaf;Wu, Guanming;Willer, Cristen J.;Raychaudhuri, Soumya;McCarroll, Steve A.;Langenberg, Claudia;Hofmann, Oliver M.;Dupuis, Josée;Qi, Lu;Segrè, Ayellet V.;van Hoek, Mandy;Navarro, Pau;Ardlie, Kristin;Balkau, Beverley;Benediktsson, Rafn;Bennett, Amanda J.;Blagieva, Roza;Boerwinkle, Eric;Bonnycastle, Lori L.;Bengtsson Boström, Kristina;Bravenboer, Bert;Bumpstead, Suzannah;Burtt, Noël P.;Charpentier, Guillaume;Chines, Peter S.;Cornelis, Marilyn;Couper, David J.;Crawford, Gabe;Doney, Alex S. F.;Elliott, Katherine S.;Elliott, Amanda L.;Erdos, Michael R.;Fox, Caroline S.;Franklin, Christopher S.;Ganser, Martha;Gieger, Christian;Grarup, Niels;Green, Todd;Griffin, Simon;Groves, Christopher J.;Guiducci, Candace;Hadjadj, Samy;Hassanali, Neelam;Herder, Christian;Isomaa, Bo;Jackson, Anne U.;Johnson, Paul R. V.;Jørgensen, Torben;Kao, Wen H. L.;Klopp, Norman;Kong, Augustine;Kraft, Peter;Lauritzen, Torsten;Li, Man;Lieverse, Aloysius;Lindgren, Cecilia M.;Lyssenko, Valeriya;Marre, Michel;Meitinger, Thomas;Midthjell, Kristian;Morken, Mario A.;Narisu, Narisu;Nilsson, Peter;Owen, Katharine R.;Payne, Felicity;Perry, John R. B.;Petersen, Ann-Kristin;Platou, Carl;Proença, Christine;Prokopenko, Inga;Rathmann, Wolfgang;William Rayner, N.;Robertson, Neil R.;Rocheleau, Ghislain;Roden, Michael;Sampson, Michael J.;Saxena, Richa;Shields, Beverley M.;Shrader, Peter;Sigurdsson, Gunnar;Sparsø, Thomas;Strassburger, Klaus;Stringham, Heather M.;Sun, Qi;Swift, Amy J.;Thorand, Barbara;Tichet, Jean;Tuomi, Tiinamaija;van Dam, Rob M.;van Haeften, Timon W.;van Herpt, Thijs;van Vliet-Ostaptchouk, Jana V.;Bragi Walters, G.;Weedon, Michael N.;Wijmenga, Cisca;Bergman, Richard N.;Cauchi, Stephane;Collins, Francis S.;Gloyn, Anna L.;Gyllensten, Ulf;Hansen, Torben;Hide, Winston A.;Hitman, Graham A.;Hofman, Albert;Hunter, David J.;Hveem, Kristian;Hveem, Kristian;Mohlke, Karen L.;Morris, Andrew D.;Palmer, Colin N. A.;Pramstaller, Peter P.;Rudan, Igor;Sijbrands, Eric;Stein, Lincoln D.;Tuomilehto, Jaakko;Uitterlinden, Andre;Walker, Mark;Wareham, Nicholas J.;Watanabe, Richard M.;Abecasis, Goncalo R.;Boehm, Bernhard O.;Campbell, Harry;Daly, Mark J.;Hattersley, Andrew T.;Hu, Frank B.;Meigs, James B.;Pankow, James S.;Pedersen, Oluf;Wichmann, H.-Erich;Barroso, Inês;Florez, Jose C.;Frayling, Timothy M.;Groop, Leif;Sladek, Rob;Thorsteinsdottir, Unnur;Wilson, James F.;Froguel, Philippe;van Duijn, Cornelia M.;Stefansson, Kari;Altshuler, David;Stefansson, Kari;Boehnke, Michael;McCarthy, Mark I.;Blair, Ross D.;Hill, Andrew A.;Gerry Hill, B.;Lewis, David R.;McNoe, Les A.;Merriman, Tony R.;Naik, Dilip K.;Vicky Phillips, L.;Thomson, Ian A.;Topless, Ruth;Vasudevan, Thodur M.;Yu, Grace
Abdominal aortic aneurysm (AAA) is a common cause of morbidity and mortality and has a significant heritability. We carried out a genome-wide association discovery study of 1866 patients with AAA and 5435 controls and replication of promising signals...
Background-Lipoprotein-associated phospholipase A2 (Lp-PLA(2)) levels are associated with coronary heart disease (CHD) in healthy individuals and in patients who have had ischemic events.
Zewinger, Stephen;Kleber, Marcus E;Tragante, Vinicius;McCubrey, Raymond O.;Schmidt, Amand F.;Direk, Kenan;Laufs, Ulrich;Werner, Christian;Koenig, Wolfgang;Rothenbacher, Dietrich;Mons, Ute;Breitling, Lutz P.;Brenner, Herrmann;Jennings, Richard T.;Petrakis, Ioannis;Triem, Sarah;Klug, Mira;Filips, Alexandra;Blankenberg, Stefan;Waldeyer, Christoph;Sinning, Christoph R.;Schnabel, Renate B;Lackner, Karl J.;Vlachopoulou, Efthymia;Nygård, Ottar;Svingen, Gard Frodahl Tveitevåg;Pedersen, Eva Ringdal;Tell, Grethe S.;Sinisalo, Juha;Nieminen, Markku S.;Laaksonen, Reijo;Trompet, Stella;Smit, Roelof A.J.;Sattar, Naveed;Jukema, J Wouter;Groesdonk, Heinrich V.;Delgado, Graciela;Stojakovic, Tatjana;Pilbrow, Anna P.;Cameron, Vicky A.;Richards, A. Mark;Doughty, Robert N.;Gong, Yan;Cooper-Dehoff, Rhonda M;Johnson, Julie A.;Scholz, Markus;Beutner, Frank;Thiery, Joachim;Smith, Gustav;Vilmundarson, Ragnar O.;McPherson, Ruth;Stewart, Alexandre F. R.;Cresci, Sharon;Lenzini, Petra A.;Spertus, John A.;Olivieri, Oliviero;Girelli, Domenico;Martinelli, Nicola I.;Leiherer, Andreas;Saely, Christoph H.;Drexel, Heinz;Mündlein, Axel;Braund, Peter S.;Nelson, Christopher P;Samani, Nilesh J.;Kofink, Daniel;Hoefer, Imo E;Pasterkamp, Gerard;Quyyumi, Arshed A.;Ko, Yi An;Hartiala, Jaana A.;Allayee, Hooman;Tang, W. H. Wilson;Hazen, Stanley L.;Eriksson, Niclas;Held, Claes;Hagström, Emil;Wallentin, Lars;Åkerblom, Axel;Siegbahn, Agneta;Karp, Igor;Labos, Christopher;Pilote, Louise;Engert, James C;Brophy, James M.;Thanassoulis, George;Bogaty, Peter;Szczeklik, Wojciech;Kaczor, Marcin;Sanak, Marek;Virani, Salim S.;Ballantyne, Christie M;Lee, Vei Vei;Boerwinkle, Eric;Holmes, Michael V;Horne, Benjamin D.;Hingorani, Aroon;Asselbergs, Folkert W.;Patel, Riyaz S.;Krämer, Bernhard K.;Scharnagl, Hubert;Fliser, Danilo;März, Winfried;Speer, Thimoteus
Background: Lipoprotein(a) concentrations in plasma are associated with cardiovascular risk in the general population. Whether lipoprotein(a) concentrations or LPA genetic variants predict long-term mortality in patients with established coronary hea...
Background Data are limited on genome-wide association studies (GWAS) for incident coronary heart disease (CHD). Moreover, it is not known whether genetic variants identified to date also associate with risk of CHD in a prospective setting. Methods W...
Bown, Matthew J.;Jones, Gregory T.;Harrison, Seamus C.;Wright, Benjamin J.;Bumpstead, Suzannah;Baas, Annette F.;Gretarsdottir, Solveig;Badger, Stephen A.;Bradley, Declan T.;Burnand, Kevin;Child, Anne H.;Clough, Rachel E.;Cockerill, Gillian;Hafez, Hany;Scott, D Julian A.;Futers, Simon;Johnson, Anne;Sohrabi, Soroush;Smith, Alberto;Thompson, Matthew M.;van Bockxmeer, Frank M.;Waltham, Matthew;Matthiasson, Stefan E.;Thorleifsson, Gudmar;Thorsteinsdottir, Unnur;Blankensteijn, Jan D.;Teijink, Joep A.W.;Wijmenga, Cisca;de Graaf, Jacqueline;Kiemeney, Lambertus A.;Assimes, Themistocles L.;McPherson, Ruth;Folkersen, Lasse;Franco-Cereceda, Anders;Palmen, Jutta;Smith, Andrew J.;Sylvius, Nicolas;Wild, John B.;Refstrup, Mette;Edkins, Sarah;Gwilliam, Rhian;Hunt, Sarah E.;Potter, Simon;Lindholt, Jes S.;Frikke-Schmidt, Ruth;Tybjærg-Hansen, Anne;Hughes, Anne E.;Golledge, Jonathan;Norman, Paul E.;van Rij, Andre;Powell, Janet T.;Eriksson, Per;Stefansson, Kari;Thompson, John R.;Humphries, Steve E.;Sayers, Robert D.;Deloukas, Panos;Samani, Nilesh J.;Schunkert, Heribert;König, Inke R.;Kathiresan, Sekar;Reilly, Muredach P.;Assimes, Themistocles L.;Holm, Hilma;Preuss, Michael;Stewart, Alexandre F. R.;Barbalic, Maja;Gieger, Christian;Absher, Devin;Aherrahrou, Zouhair;Allayee, Hooman;Altshuler, David;Anand, Sonia S.;Andersen, Karl;Anderson, Jeffrey L.;Ardissino, Diego;Ball, Stephen G.;Balmforth, Anthony J.;Barnes, Timothy A.;Becker, Diane M.;Becker, Lewis C.;Berger, Klaus;Bis, Joshua C.;Matthijs Boekholdt, S.;Boerwinkle, Eric;Braund, Peter S.;Brown, Morris J.;Susan Burnett, Mary;Buysschaert, Ian;Carlquist, John F.;Chen, Li;Cichon, Sven;Codd, Veryan;Davies, Robert W.;Dedoussis, George;Dehghan, Abbas;Demissie, Serkalem;Devaney, Joseph M.;Diemert, Patrick;Do, Ron;Doering, Angela;Eifert, Sandra;El Mokhtari, Nour Eddine;Ellis, Stephen G.;Elosua, Roberto;Engert, James C.;Epstein, Stephen E.;de Faire, Ulf;Fischer, Marcus;Folsom, Aaron R.;Freyer, Jennifer;Gigante, Bruna;Girelli, Domenico;Gretarsdottir, Solveig;Gudnason, Vilmundur;Gulcher, Jeffrey R.;Halperin, Eran;Hammond, Naomi;Hazen, Stanley L.;Hofman, Albert;Horne, Benjamin D.;Illig, Thomas;Iribarren, Carlos;Jones, Gregory T.;Wouter Jukema, J.;Kaiser, Michael A.;Kaplan, Lee M.;Kastelein, John J. P.;Khaw, Kay-Tee;Knowles, Joshua W.;Kolovou, Genovefa;Kong, Augustine;Laaksonen, Reijo;Lambrechts, Diether;Leander, Karin;Lettre, Guillaume;Li, Mingyao;Lieb, Wolfgang;Loley, Christina;Lotery, Andrew J.;Mannucci, Pier M.;Maouche, Seraya;Martinelli, Nicola;McKeown, Pascal P.;Meisinger, Christa;Meitinger, Thomas;Melander, Olle;Angelica Merlini, Pier;Mooser, Vincent;Morgan, Thomas;Mühleisen, Thomas W.;Muhlestein, Joseph B.;Münzel, Thomas;Musunuru, Kiran;Nahrstaedt, Janja;Nelson, Christopher P.;Nöthen, Markus M.;Olivieri, Oliviero;Patel, Riyaz S.;Patterson, Chris C.;Peters, Annette;Peyvandi, Flora;Qu, Liming;Quyyumi, Arshed A.;Rader, Daniel J.;Rallidis, Loukianos S.;Rice, Catherine;Rosendaal, Frits R.;Rubin, Diana;Salomaa, Veikko;Lourdes Sampietro, M.;Sandhu, Manj S.;Schadt, Eric;Schäfer, Arne;Schillert, Arne;Schreiber, Stefan;Schrezenmeir, Jürgen;Schwartz, Stephen M.;Siscovick, David S.;Sivananthan, Mohan;Sivapalaratnam, Suthesh;Smith, Albert;Smith, Tamara B.;Snoep, Jaapjan D.;Soranzo, Nicole;Spertus, John A.;Stark, Klaus;Stirrups, Kathy;Stoll, Monika;Wilson Tang, W. H.;Tennstedt, Stephanie;Thorgeirsson, Gudmundur;Thorleifsson, Gudmar;Tomaszewski, Maciej;Uitterlinden, Andre G.;van Rij, Andre M.;Voight, Benjamin F.;Wareham, Nick J.;Wells, George A.;Wichmann, H-Erich;Wild, Philipp S.;Willenborg, Christina;Witteman, Jaqueline C. M.;Wright, Benjamin J.;Ye, Shu;Zeller, Tanja;Ziegler, Andreas;Cambien, Francois;Goodall, Alison H.;Adrienne Cupples, L.;Quertermous, Thomas;März, Winfried;Hengstenberg, Christian;Blankenberg, Stefan;Ouwehand, Willem H.;Hall, Alistair S.;Deloukas, Panos;Thompson, John R.;Stefansson, Kari;Roberts, Robert;Thorsteinsdottir, Unnur;O'Donnell, Christopher J.;McPherson, Ruth;Erdmann, Jeanette;Samani, Nilesh J.;Newton-Cheh, Christopher;Johnson, Toby;Gateva, Vesela;Tobin, Martin D.;Bochud, Murielle;Coin, Lachlan;Najjar, Samer S.;Hua Zhao, Jing;Heath, Simon C.;Eyheramendy, Susana;Papadakis, Konstantinos;Voight, Benjamin F.;Scott, Laura J.;Zhang, Feng;Farrall, Martin;Tanaka, Toshiko;Wallace, Chris;Chambers, John C.;Khaw, Kay-Tee;Nilsson, Peter;van der Harst, Pim;Polidoro, Silvia;Grobbee, Diederick E.;Onland-Moret, N. Charlotte;Bots, Michiel L.;Wain, Louise V.;Elliott, Katherine S.;Teumer, Alexander;Luan, Jian'an;Lucas, Gavin;Kuusisto, Johanna;Burton, Paul R.;Hadley, David;McArdle, Wendy L.;Brown, Morris;Dominiczak, Anna;Newhouse, Stephen J.;Samani, Nilesh J.;Webster, John;Zeggini, Eleftheria;Beckmann, Jacques S.;Bergmann, Sven;Lim, Noha;Song, Kijoung;Vollenweider, Peter;Waeber, Gerard;Waterworth, Dawn M.;Yuan, Xin;Groop, Leif;Orho-Melander, Marju;Allione, Alessandra;Di Gregorio, Alessandra;Guarrera, Simonetta;Panico, Salvatore;Ricceri, Fulvio;Romanazzi, Valeria;Sacerdote, Carlotta;Vineis, Paolo;Barroso, Inês;Sandhu, Manjinder S.;Luben, Robert N.;Crawford, Gabriel J.;Jousilahti, Pekka;Perola, Markus;Boehnke, Michael;Bonnycastle, Lori L.;Collins, Francis S.;Jackson, Anne U.;Mohlke, Karen L.;Stringham, Heather M.;Valle, Timo T.;Willer, Cristen J.;Bergman, Richard N.;Morken, Mario A.;Döring, Angela;Gieger, Christian;Meitinger, Thomas;Org, Elin;Pfeufer, Arne;Wichmann, H. Erich;Kathiresan, Sekar;Marrugat, Jaume;O'Donnell, Christopher J.;Schwartz, Stephen M.;Siscovick, David S.;Subirana, Isaac;Freimer, Nelson B.;Hartikainen, Anna-Liisa;McCarthy, Mark I.;O'Reilly, Paul F.;Peltonen, Leena;Pouta, Anneli;de Jong, Paul E.;Snieder, Harold;van Gilst, Wiek H.;Clarke, Robert;Goel, Anuj;Hamsten, Anders;Peden, John F.;Seedorf, Udo;Syvänen, Ann-Christine;Tognoni, Giovanni;Lakatta, Edward G.;Sanna, Serena;Scheet, Paul;Schlessinger, David;Scuteri, Angelo;Dörr, Marcus;Ernst, Florian;Felix, Stephan B.;Homuth, Georg;Lorbeer, Roberto;Reffelmann, Thorsten;Rettig, Rainer;Völker, Uwe;Galan, Pilar;Gut, Ivo G.;Hercberg, Serge;Mark Lathrop, G.;Zelenika, Diana;Deloukas, Panos;Soranzo, Nicole;Williams, Frances M.;Zhai, Guangju;Salomaa, Veikko;Laakso, Markku;Elosua, Roberto;Forouhi, Nita G.;Völzke, Henry;Uiterwaal, Cuno S.;van der Schouw, Yvonne T.;Numans, Mattijs E.;Matullo, Giuseppe;Navis, Gerjan;Berglund, Göran;Bingham, Sheila A.;Kooner, Jaspal S.;Connell, John M.;Bandinelli, Stefania;Ferrucci, Luigi;Watkins, Hugh;Spector, Tim D.;Tuomilehto, Jaakko;Altshuler, David;Strachan, David P.;Laan, Maris;Meneton, Pierre;Wareham, Nicholas J.;Uda, Manuela;Jarvelin, Marjo-Riitta;Mooser, Vincent;Melander, Olle;Loos, Ruth J. F.;Elliott, Paul;Abecasis, Gonçalo R.;Caulfield, Mark;Munroe, Patricia B.;Voight, Benjamin F.;Scott, Laura J.;Steinthorsdottir, Valgerdur;Morris, Andrew P.;Dina, Christian;Welch, Ryan P.;Zeggini, Eleftheria;Zeggini, Eleftheria;Huth, Cornelia;Aulchenko, Yurii S.;Thorleifsson, Gudmar;McCulloch, Laura J.;Ferreira, Teresa;Grallert, Harald;Amin, Najaf;Wu, Guanming;Willer, Cristen J.;Raychaudhuri, Soumya;McCarroll, Steve A.;Langenberg, Claudia;Hofmann, Oliver M.;Dupuis, Josée;Qi, Lu;Segrè, Ayellet V.;van Hoek, Mandy;Navarro, Pau;Ardlie, Kristin;Balkau, Beverley;Benediktsson, Rafn;Bennett, Amanda J.;Blagieva, Roza;Boerwinkle, Eric;Bonnycastle, Lori L.;Bengtsson Boström, Kristina;Bravenboer, Bert;Bumpstead, Suzannah;Burtt, Noël P.;Charpentier, Guillaume;Chines, Peter S.;Cornelis, Marilyn;Couper, David J.;Crawford, Gabe;Doney, Alex S. F.;Elliott, Katherine S.;Elliott, Amanda L.;Erdos, Michael R.;Fox, Caroline S.;Franklin, Christopher S.;Ganser, Martha;Gieger, Christian;Grarup, Niels;Green, Todd;Griffin, Simon;Groves, Christopher J.;Guiducci, Candace;Hadjadj, Samy;Hassanali, Neelam;Herder, Christian;Isomaa, Bo;Jackson, Anne U.;Johnson, Paul R. V.;Jørgensen, Torben;Kao, Wen H. L.;Klopp, Norman;Kong, Augustine;Kraft, Peter;Lauritzen, Torsten;Li, Man;Lieverse, Aloysius;Lindgren, Cecilia M.;Lyssenko, Valeriya;Marre, Michel;Meitinger, Thomas;Midthjell, Kristian;Morken, Mario A.;Narisu, Narisu;Nilsson, Peter;Owen, Katharine R.;Payne, Felicity;Perry, John R. B.;Petersen, Ann-Kristin;Platou, Carl;Proença, Christine;Prokopenko, Inga;Rathmann, Wolfgang;William Rayner, N.;Robertson, Neil R.;Rocheleau, Ghislain;Roden, Michael;Sampson, Michael J.;Saxena, Richa;Shields, Beverley M.;Shrader, Peter;Sigurdsson, Gunnar;Sparsø, Thomas;Strassburger, Klaus;Stringham, Heather M.;Sun, Qi;Swift, Amy J.;Thorand, Barbara;Tichet, Jean;Tuomi, Tiinamaija;van Dam, Rob M.;van Haeften, Timon W.;van Herpt, Thijs;van Vliet-Ostaptchouk, Jana V.;Bragi Walters, G.;Weedon, Michael N.;Wijmenga, Cisca;Bergman, Richard N.;Cauchi, Stephane;Collins, Francis S.;Gloyn, Anna L.;Gyllensten, Ulf;Hansen, Torben;Hide, Winston A.;Hitman, Graham A.;Hofman, Albert;Hunter, David J.;Hveem, Kristian;Hveem, Kristian;Mohlke, Karen L.;Morris, Andrew D.;Palmer, Colin N. A.;Pramstaller, Peter P.;Rudan, Igor;Sijbrands, Eric;Stein, Lincoln D.;Tuomilehto, Jaakko;Uitterlinden, Andre;Walker, Mark;Wareham, Nicholas J.;Watanabe, Richard M.;Abecasis, Goncalo R.;Boehm, Bernhard O.;Campbell, Harry;Daly, Mark J.;Hattersley, Andrew T.;Hu, Frank B.;Meigs, James B.;Pankow, James S.;Pedersen, Oluf;Wichmann, H.-Erich;Barroso, Inês;Florez, Jose C.;Frayling, Timothy M.;Groop, Leif;Sladek, Rob;Thorsteinsdottir, Unnur;Wilson, James F.;Froguel, Philippe;van Duijn, Cornelia M.;Stefansson, Kari;Altshuler, David;Stefansson, Kari;Boehnke, Michael;McCarthy, Mark I.;Blair, Ross D.;Hill, Andrew A.;Gerry Hill, B.;Lewis, David R.;McNoe, Les A.;Merriman, Tony R.;Naik, Dilip K.;Vicky Phillips, L.;Thomson, Ian A.;Topless, Ruth;Vasudevan, Thodur M.;Yu, Grace
Abdominal aortic aneurysm (AAA) is a common cause of morbidity and mortality and has a significant heritability. We carried out a genome-wide association discovery study of 1866 patients with AAA and 5435 controls and replication of promising signals...
Background-Lipoprotein-associated phospholipase A2 (Lp-PLA(2)) levels are associated with coronary heart disease (CHD) in healthy individuals and in patients who have had ischemic events.
Genome-wide association studies (GWAS) yielded significant advances in defining the genetic architecture of complex traits and disease. Still, a major hurdle of GWAS is narrowing down multiple genetic associations to a few causal variants for functio...
Background--Lipoprotein-associated phospholipase A2 (Lp-PLA) levels are associated with coronary heart disease (CHD) in healthy individuals and in patients who have had ischemic events. Methods and Results--The Long-term Intervention with Pravastatin...
Aims We sought to determine the association between two major biomarkers, the inactive N-terminal fragment of brain natriuretic peptide (NT-proBNP) and tissue inhibitor of metalloproteinase-1 (TIMP-1) and long-term cardiovascular outcomes in a cohort...