ARTICLES
1,182 Article(s)
1, 2, 3, 4, 5, 6 >> >|
Document(s)
Title
Author Summary We explored the coding regions of 3,000 Finnish individuals with 3,000 non-Finnish Europeans (NFEs) using whole-exome sequence data, in order to understand how an individual from a bottlenecked population might differ from an individua...
Aims: In patients with stable coronary heart disease (CHD), we aimed to assess 1. the prognostic power of biomarkers reflecting haemodynamics, micronecrosis, inflammation, coagulation, lipids, neurohumoral activity, and renal function; 2. whether cha...
Scott, Robert A.;Freitag, Daniel F.;Li, Li;Chu, Audrey Y.;Surendran, Praveen;Young, Robin;Grarup, Niels;Stancáková, Alena;Chen, Yuning;Varga, Tibor V.;Yaghootkar, Hanieh;Luan, Jian'an;Zhao, Jing Hua;Willems, Sara M.;Wessel, Jennifer;Wang, Shuai;Maruthur, Nisa;Michailidou, Kyriaki;Pirie, Ailith;Van Der Lee, Sven J.;Gillson, Christopher;Al Olama, Ali Amin;Amouyel, Philippe;Arriola, Larraitz;Arveiler, Dominique;Aviles-Olmos, Iciar;Balkau, Beverley;Barricarte, Aurelio;Barroso, Inês;Garcia, Sara Benlloch;Bis, Joshua C.;Blankenberg, Stefan;Boehnke, Michael;Boeing, Heiner;Boerwinkle, Eric;Borecki, Ingrid B.;Bork-Jensen, Jette;Bowden, Sarah;Caldas, Carlos;Caslake, Muriel;Cupples, L. Adrienne;Cruchaga, Carlos;Czajkowski, Jacek;Den Hoed, Marcel;Dunn, Janet A.;Earl, Helena M.;Ehret, Georg B.;Ferrannini, Ele;Ferrieres, Jean;Foltynie, Thomas;Ford, Ian;Forouhi, Nita G.;Gianfagna, Francesco;Gonzalez, Carlos;Grioni, Sara;Hiller, Louise;Jansson, Jan Håkan;Jørgensen, Marit E.;Jukema, J. Wouter;Kaaks, Rudolf;Kee, Frank;Kerrison, Nicola D.;Key, Timothy J.;Kontto, Jukka;Kote-Jarai, Zsofia;Kraja, Aldi T.;Kuulasmaa, Kari;Kuusisto, Johanna;Linneberg, Allan;Liu, Chunyu;Marenne, Gaëlle;Mohlke, Karen L.;Morris, Andrew P.;Muir, Kenneth;Müller-Nurasyid, Martina;Munroe, Patricia B.;Navarro, Carmen;Nielsen, Sune F.;Nilsson, Peter M.;Nordestgaard, Børge G.;Packard, Chris J.;Palli, Domenico;Panico, Salvatore;Peloso, Gina M.;Perola, Markus;Peters, Annette;Poole, Christopher J.;Quirós, J. Ramón;Rolandsson, Olov;Sacerdote, Carlotta;Salomaa, Veikko;Sánchez, María José;Sattar, Naveed;Sharp, Stephen J.;Sims, Rebecca;Slimani, Nadia;Smith, Jennifer A.;Thompson, Deborah J.;Trompet, Stella;Tumino, Rosario;Van Der A, Daphne L.;Van Der Schouw, Yvonne T.;Virtamo, Jarmo;Walker, Mark;Walter, Klaudia;Abraham, Jean E.;Amundadottir, Laufey T.;Butterworth, Adam S.;Aponte, Jennifer L.;Dupuis, Josée;Easton, Douglas F.;Eeles, Rosalind A.;Erdmann, Jeanette;Franks, Paul W.;Frayling, Timothy M.;Hansen, Torben;Howson, Joanna M M;Jørgensen, Torben;Kooner, Jaspal;Laakso, Markku;McCarthy, Mark I.;Pankow, James S.;Pedersen, Oluf;Riboli, Elio;Rotter, Jerome I.;Saleheen, Danish;Samani, Nilesh J.;Schunkert, Heribert;Vollenweider, Peter;O'Rahilly, Stephen;Deloukas, Panos;Danesh, John;Goodarzi, Mark O.;Kathiresan, Sekar;Meigs, James B.;Ehm, Margaret G.;Wareham, Nicholas J.;Waterworth, Dawn M.
Regulatory authorities have indicated that new drugs to treat type 2 diabetes (T2D) should not be associated with an unacceptable increase in cardiovascular risk. Human genetics may be able to guide development of antidiabetic therapies by predicting...
Wild, Philipp S.;Felix, Janine F.;Schillert, Arne;Teumer, Alexander;Chen, Ming-Huei;Leening, Maarten J.G.;Völker, Uwe;Großmann, Vera;Brody, Jennifer A;Irvin, Marguerite R.;Shah, Sanjiv J.;Pramana, Setia;Lieb, Wolfgang;Schmidt, Reinhold;Stanton, Alice V;Malzahn, Dörthe;Smith, Albert Vernon;Sundström, Johan;Minelli, Cosetta;Ruggiero, Daniela;Lyytikäinen, Leo-Pekka;Tiller, Daniel;Smith, Gustav;Monnereau, Claire;Di Tullio, Marco R.;Musani, Solomon K;Morrison, Alanna C;Pers, Tune H.;Morley, Michael;Kleber, Marcus E;Aragam, Jayashri;Benjamin, Emelia J;Bis, Joshua C;Bisping, Egbert;Broeckel, Ulrich;Cheng, Susan;Deckers, Jaap W;Del Greco M, Fabiola;Edelmann, Frank;Fornage, Myriam;Franke, Lude;Friedrich, Nele;Harris, Tamara B;Hofer, Edith;Hofman, Albert;Huang, Jie;Hughes, Alun D.;Kähönen, Mika;Kruppa, Jochen;Lackner, Karl J.;Lannfelt, Lars;Laskowski, Rafael;Launer, Lenore J;Leosdottir, Margrét;Lin, Honghuang;Lindgren, Cecilia M.;Loley, Christina;MacRae, Calum A.;Mascalzoni, Deborah;Mayet, Jamil;Medenwald, Daniel;Morris, Andrew P;Müller, Christian;Müller-Nurasyid, Martina;Nappo, Stefania;Nilsson, Peter M.;Nuding, Sebastian;Nutile, Teresa;Peters, Annette;Pfeufer, Arne;Pietzner, Diana;Pramstaller, Peter P;Raitakari, Olli T;Rice, Kenneth M;Rivadeneira, Fernando;Rotter, Jerome I.;Ruohonen, Saku T.;Sacco, Ralph L.;Samdarshi, Tandaw E.;Schmidt, Helena;Sharp, Andrew S.P.;Shields, Denis C.;Sorice, Rossella;Sotoodehnia, Nona;Stricker, Bruno H;Surendran, Praveen;Thom, Simon;Töglhofer, Anna M.;Uitterlinden, André G;Wachter, Rolf;Völzke, Henry;Ziegler, Andreas;Münzel, Thomas;März, Winfried;Cappola, Thomas P;Hirschhorn, Joel N.;Mitchell, Gary F.;Smith, Nicholas L;Fox, Ervin R;Dueker, Nicole D.;Jaddoe, Vincent W. V.;Melander, Olle;Russ, Martin;Lehtimäki, Terho;Ciullo, Marina;Hicks, Andrew A;Lind, Lars;Gudnason, Vilmundur;Pieske, Burkert;Barron, Anthony J.;Zweiker, Robert;Schunkert, Heribert;Ingelsson, Erik;Liu, Kiang;Arnett, Donna K.;Psaty, Bruce M.;Blankenberg, Stefan;Larson, Martin G.;Felix, Stephan B;Franco, Oscar H.;Zeller, Tanja;Vasan, Ramachandran S.;Dörr, Marcus
BACKGROUND. Understanding the genetic architecture of cardiac structure and function may help to prevent and treat heart disease. This investigation sought to identify common genetic variations associated with inter-individual variability in cardiac ...
Voight, Benjamin F.;Peloso, Gina M.;Orho-Melander, Marju;Frikke-Schmidt, Ruth;Barbalic, Maja;Jensen, Majken K.;Hindy, George;Holm, Hilma;Ding, Eric L.;Johnson, Toby;Schunkert, Heribert;Samani, Nilesh J.;Clarke, Robert;Hopewell, Jemma C.;Thompson, John F.;Li, Mingyao;Thorleifsson, Gudmar;Newton-Cheh, Christopher;Musunuru, Kiran;Pirruccello, James P.;Saleheen, Danish;Chen, Li;Stewart, Alexandre F. R.;Schillert, Arne;Thorsteinsdottir, Unnur;Thorgeirsson, Gudmundur;Anand, Sonia;Engert, James C.;Morgan, Thomas;Spertus, John;Stoll, Monika;Berger, Klaus;Martinelli, Nicola;Girelli, Domenico;McKeown, Pascal P.;Patterson, Christopher C.;Epstein, Stephen E.;Devaney, Joseph;Burnett, Mary-Susan;Mooser, Vincent;Ripatti, Samuli;Surakka, Ida;Nieminen, Markku S.;Sinisalo, Juha;Lokki, Marja-Liisa;Perola, Markus;Havulinna, Aki;de Faire, Ulf;Gigante, Bruna;Ingelsson, Erik;Zeller, Tanja;Wild, Philipp;de Bakker, Paul I. W.;Klungel, Olaf H.;Maitland-van der Zee, Anke-Hilse;Peters, Bas J. M.;de Boer, Anthonius;Grobbee, Diederick E.;Kamphuisen, Pieter W.;Deneer, Vera H. M.;Elbers, Clara C.;Onland-Moret, N. Charlotte;Hofker, Marten H.;Wijmenga, Cisca;Verschuren, W. M. Monique;Boer, Jolanda M. A.;van der Schouw, Yvonne T.;Rasheed, Asif;Frossard, Philippe;Demissie, Serkalem;Willer, Cristen;Do, Ron;Ordovas, Jose M.;Abecasis, Goncalo R.;Boehnke, Michael;Mohlke, Karen L.;Daly, Mark J.;Guiducci, Candace;Burtt, Noel P.;Surti, Aarti;Gonzalez, Elena;Purcell, Shaun;Gabriel, Stacey;Marrugat, Jaume;Peden, John;Erdmann, Jeanette;Diemert, Patrick;Willenborg, Christina;Koenig, Inke R.;Fischer, Marcus;Hengstenberg, Christian;Ziegler, Andreas;Buysschaert, Ian;Lambrechts, Diether;Van de Werf, Frans;Fox, Keith A.;El Mokhtari, Nour Eddine;Rubin, Diana;Schrezenmeir, Juergen;Schreiber, Stefan;Schaefer, Arne;Danesh, John;Blankenberg, Stefan;Roberts, Robert;McPherson, Ruth;Watkins, Hugh;Hall, Alistair S.;Overvad, Kim;Rimm, Eric;Boerwinkle, Eric;Tybjaerg-Hansen, Anne;Cupples, L. Adrienne;Reilly, Muredach P.;Melander, Olle;Mannucci, Pier M.;Ardissino, Diego;Siscovick, David;Elosua, Roberto;Stefansson, Kari;O'Donnell, Christopher J.;Salomaa, Veikko;Rader, Daniel J.;Peltonen, Leena;Schwartz, Stephen M.;Altshuler, David;Kathiresan, Sekar
Background High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are randomly assigned at meiosis, are independent of non-genetic co...
PURPOSE: This paper describes the study design, methodology, cohort profile and self-reported diseases in the ophthalmological branch of the Gutenberg Health Study (GHS). METHODS: The GHS is an ongoing, prospective, interdisciplinary, single-center, ...
Background Coronary heart disease is a major cause of heart failure. Availability of risk-prediction models that include both clinical parameters and biomarkers is limited. We aimed to develop such a model for prediction of incident heart failure. Me...