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Title
The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentiall...
The QRS interval, from the beginning of the Q wave to the end of the S wave on an electrocardiogram, reflects ventricular depolarization and conduction time and is a risk factor for mortality, sudden death and heart failure. We performed a genome-wid...
Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure and death. We conducted a genome-wide association study (GWAS) in individuals of European ancestry, including 6,707 with and 52,426 without atrial ...
Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74...
Background and purpose Polymorphisms in coagulation genes have been associated with early-onset ischemic stroke. Here we pursue an a priori hypothesis that genetic variation in the endothelial-based receptors of the thrombomodulin-protein C system (T...
Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) i...
Anttila, Verneri;Bulik-Sullivan, Brendan;Finucane, Hilary K.;Walters, Raymond K.;Bras, Jose;Duncan, Laramie;Escott-Price, Valentina;Falcone, Guido J.;Gormley, Padhraig;Malik, Rainer;Patsopoulos, Nikolaos A.;Ripke, Stephan;Wei, Zhi;Yu, Dongmei;Lee, Phil H.;Turley, Patrick;Grenier-Boley, Benjamin;Chouraki, Vincent;Kamatani, Yoichiro;Berr, Claudine;Letenneur, Luc;Hannequin, Didier;Amouyel, Philippe;Boland, Anne;Deleuze, Jean-François;Duron, Emmanuelle;Vardarajan, Badri N.;Reitz, Christiane;Goate, Alison M.;Huentelman, Matthew J.;Kamboh, M. Ilyas;Larson, Eric B.;Rogaeva, Ekaterina;St George-Hyslop, Peter;Hakonarson, Hakon;Kukull, Walter A.;Farrer, Lindsay A.;Barnes, Lisa L.;Beach, Thomas G.;Demirci, F. Yesim;Head, Elizabeth;Hulette, Christine M.;Jicha, Gregory A.;Kauwe, John S.K.;Kaye, Jeffrey A.;Leverenz, James B.;Levey, Allan I.;Lieberman, Andrew P.;Pankratz, Vernon S.;Poon, Wayne W.;Quinn, Joseph F.;Saykin, Andrew J.;Schneider, Lon S.;Smith, Amanda G.;Sonnen, Joshua A.;Stern, Robert A.;Van Deerlin, Vivianna M.;Van Eldik, Linda J.;Harold, Denise;Russo, Giancarlo;Rubinsztein, David C.;Bayer, Anthony;Tsolaki, Magda;Proitsi, Petra;Fox, Nick C.;Hampel, Harald;Owen, Michael J.;Mead, Simon;Passmore, Peter;Morgan, Kevin;Nöthen, Markus M.;Schott, Jonathan M.;Rossor, Martin;Lupton, Michelle K.;Hoffmann, Per;Kornhuber, Johannes;Lawlor, Brian;McQuillin, Andrew;Al-Chalabi, Ammar;Bis, Joshua C;Ruiz, Agustin;Boada, Mercè;Seshadri, Sudha;Beiser, Alexa;Rice, Kenneth;van der Lee, Sven J.;De Jager, Philip L.;Geschwind, Daniel H.;Riemenschneider, Matthias;Riedel-Heller, Steffi;Rotter, Jerome I;Ransmayr, Gerhard;Hyman, Bradley T.;Cruchaga, Carlos;Alegret, Montserrat;Winsvold, Bendik;Palta, Priit;Farh, Kai-How;Cuenca-Leon, Ester;Furlotte, Nicholas;Kurth, Tobias;Ligthart, Lannie;Terwindt, Gisela M.;Freilinger, Tobias;Ran, Caroline;Gordon, Scott D.;Borck, Guntram;Adams, Hieab H.H.;Lehtimäki, Terho;Wedenoja, Juho;Buring, Julie E.;Schürks, Markus;Hrafnsdottir, Maria;Hottenga, Jouke-Jan;Penninx, Brenda;Artto, Ville;Kaunisto, Mari;Vepsäläinen, Salli;Martin, Nicholas G.;Montgomery, Grant W.;Kurki, Mitja I.;Hämäläinen, Eija;Huang, Hailiang;Huang, Jie;Sandor, Cynthia;Webber, Caleb;Muller-Myhsok, Bertram;Schreiber, Stefan;Salomaa, Veikko;Loehrer, Elizabeth;Göbel, Hartmut;Macaya, Alfons;Pozo-Rosich, Patricia;Hansen, Thomas;Werge, Thomas;Kaprio, Jaakko;Metspalu, Andres;Kubisch, Christian;Ferrari, Michel D.;Belin, Andrea C.;van den Maagdenberg, Arn M.J.M.;Zwart, John-Anker;Boomsma, Dorret;Eriksson, Nicholas;Olesen, Jes;Chasman, Daniel I.;Nyholt, Dale R.;Anney, Richard;Avbersek, Andreja;Baum, Larry;Berkovic, Samuel;Bradfield, Jonathan;Buono, Russell;Catarino, Claudia B.;Cossette, Patrick;De Jonghe, Peter;Depondt, Chantal;Dlugos, Dennis;Ferraro, Thomas N.;French, Jacqueline;Hjalgrim, Helle;Jamnadas-Khoda, Jennifer;Kälviäinen, Reetta;Kunz, Wolfram S.;Lerche, Holger;Leu, Costin;Lindhout, Dick;Lo, Warren;Lowenstein, Daniel;McCormack, Mark;Møller, Rikke S.;Molloy, Anne;Ng, Ping-Wing;Oliver, Karen;Privitera, Michael;Radtke, Rodney;Ruppert, Ann-Kathrin;Sander, Thomas;Schachter, Steven;Schankin, Christoph;Scheffer, Ingrid;Schoch, Susanne;Sisodiya, Sanjay M.;Smith, Philip;Sperling, Michael;Striano, Pasquale;Surges, Rainer;Thomas, G. Neil;Visscher, Frank;Whelan, Christopher D.;Zara, Federico;Heinzen, Erin L.;Marson, Anthony;Becker, Felicitas;Stroink, Hans;Zimprich, Fritz;Gasser, Thomas;Gibbs, Raphael;Heutink, Peter;Martinez, Maria;Morris, Huw R.;Sharma, Manu;Ryten, Mina;Mok, Kin Y.;Pulit, Sara;Bevan, Steve;Holliday, Elizabeth;Attia, John;Battey, Thomas;Boncoraglio, Giorgio;Thijs, Vincent;Chen, Wei-Min;Mitchell, Braxton;Rothwell, Peter;Sharma, Pankaj;Sudlow, Cathie;Vicente, Astrid;Markus, Hugh;Kourkoulis, Christina;Pera, Joana;Raffeld, Miriam;Silliman, Scott;Boraska Perica, Vesna;Thornton, Laura M.;Huckins, Laura M.;William Rayner, N.;Lewis, Cathryn M.;Gratacos, Monica;Rybakowski, Filip;Keski-Rahkonen, Anna;Raevuori, Anu;Hudson, James I.;Reichborn-Kjennerud, Ted;Monteleone, Palmiero;Karwautz, Andreas;Mannik, Katrin;Baker, Jessica H.;O’Toole, Julie K.;Trace, Sara E.;Davis, Oliver S. P.;Helder, Sietske G.;Ehrlich, Stefan;Herpertz-Dahlmann, Beate;Danner, Unna N.;van Elburg, Annemarie A.;Clementi, Maurizio;Forzan, Monica;Docampo, Elisa;Lissowska, Jolanta;Hauser, Joanna;Tortorella, Alfonso;Maj, Mario;Gonidakis, Fragiskos;Tziouvas, Konstantinos;Papezova, Hana;Yilmaz, Zeynep;Wagner, Gudrun;Cohen-Woods, Sarah;Herms, Stefan;Julià, Antonio;Rabionet, Raquel;Dick, Danielle M.;Ripatti, Samuli;Andreassen, Ole A.;Espeseth, Thomas;Lundervold, Astri J.;Steen, Vidar M.;Pinto, Dalila;Scherer, Stephen W.;Aschauer, Harald;Schosser, Alexandra;Alfredsson, Lars;Padyukov, Leonid;Halmi, Katherine A.;Mitchell, James;Strober, Michael;Bergen, Andrew W.;Kaye, Walter;Szatkiewicz, Jin Peng;Cormand, Bru;Ramos-Quiroga, Josep Antoni;Sánchez-Mora, Cristina;Ribasés, Marta;Casas, Miguel;Hervas, Amaia;Arranz, Maria Jesús;Haavik, Jan;Zayats, Tetyana;Johansson, Stefan;Williams, Nigel;Elia, Josephine;Dempfle, Astrid;Rothenberger, Aribert;Kuntsi, Jonna;Oades, Robert D.;Banaschewski, Tobias;Franke, Barbara;Buitelaar, Jan K.;Arias Vasquez, Alejandro;Doyle, Alysa E.;Reif, Andreas;Lesch, Klaus-Peter;Freitag, Christine;Rivero, Olga;Palmason, Haukur;Romanos, Marcel;Langley, Kate;Rietschel, Marcella;Witt, Stephanie H.;Dalsgaard, Soeren;Børglum, Anders D.;Waldman, Irwin;Wilmot, Beth;Molly, Nikolas;Bau, Claiton H.D.;Crosbie, Jennifer;Schachar, Russell;Loo, Sandra K.;McGough, James J.;Grevet, Eugenio H.;Medland, Sarah E.;Robinson, Elise;Weiss, Lauren A.;Bacchelli, Elena;Bailey, Anthony;Bal, Vanessa;Battaglia, Agatino;Betancur, Catalina;Bolton, Patrick;Cantor, Rita;Celestino-Soper, Patrícia;Dawson, Geraldine;De Rubeis, Silvia;Duque, Frederico;Green, Andrew;Klauck, Sabine M.;Leboyer, Marion;Levitt, Pat;Maestrini, Elena;Mane, Shrikant;De-Luca, Daniel Moreno-;Parr, Jeremy;Regan, Regina;Reichenberg, Abraham;Sandin, Sven;Vorstman, Jacob;Wassink, Thomas;Wijsman, Ellen;Cook, Edwin;Santangelo, Susan;Delorme, Richard;Rogé, Bernadette;Magalhaes, Tiago;Arking, Dan;Schulze, Thomas G.;Thompson, Robert C.;Strohmaier, Jana;Matthews, Keith;Melle, Ingrid;Morris, Derek;Blackwood, Douglas;McIntosh, Andrew;Bergen, Sarah E;Schalling, Martin;Jamain, Stéphane;Maaser, Anna;Fischer, Sascha B.;Reinbold, Céline S.;Fullerton, Janice M.;Grigoroiu-Serbanescu, Maria;Guzman-Parra, José;Mayoral, Fermin;Schofield, Peter R.;Cichon, Sven;Mühleisen, Thomas W.;Degenhardt, Franziska;Schumacher, Johannes;Bauer, Michael;Mitchell, Philip B.;Gershon, Elliot S.;Rice, John;Potash, James B.;Zandi, Peter P.;Craddock, Nick;Ferrier, I. Nicol;Alda, Martin;Rouleau, Guy A.;Turecki, Gustavo;Ophoff, Roel;Pato, Carlos;Anjorin, Adebayo;Stahl, Eli;Leber, Markus;Czerski, Piotr M.;Edenberg, Howard J.;Cruceanu, Cristiana;Jones, Ian R.;Posthuma, Danielle;Andlauer, Till F.M.;Forstner, Andreas J.;Streit, Fabian;Baune, Bernhard T.;Air, Tracy;Sinnamon, Grant;Wray, Naomi R.;MacIntyre, Donald J.;Porteous, David;Homuth, Georg;Rivera, Margarita;Grove, Jakob;Middeldorp, Christel M.;Hickie, Ian;Pergadia, Michele;Mehta, Divya;Smit, Johannes H.;Jansen, Rick;de Geus, Eco;Dunn, Erin;Li, Qingqin S.;Nauck, Matthias;Schoevers, Robert A.;Beekman, Aartjan TF;Knowles, James A.;Viktorin, Alexander;Arnold, Paul;Barr, Cathy L.;Bedoya-Berrio, Gabriel;Bienvenu, O. Joseph;Brentani, Helena;Burton, Christie;Camarena, Beatriz;Cappi, Carolina;Cath, Danielle;Cavallini, Maria;Cusi, Daniele;Darrow, Sabrina;Denys, Damiaan;Derks, Eske M.;Dietrich, Andrea;Fernandez, Thomas;Figee, Martijn;Freimer, Nelson;Gerber, Gloria;Grados, Marco;Greenberg, Erica;Hanna, Gregory L.;Hartmann, Andreas;Hirschtritt, Matthew E.;Hoekstra, Pieter J.;Huang, Alden;Huyser, Chaim;Illmann, Cornelia;Jenike, Michael;Kuperman, Samuel;Leventhal, Bennett;Lochner, Christine;Lyon, Gholson J.;Macciardi, Fabio;Madruga-Garrido, Marcos;Malaty, Irene A.;Maras, Athanasios;McGrath, Lauren;Miguel, Eurípedes C.;Mir, Pablo;Nestadt, Gerald;Nicolini, Humberto;Okun, Michael S.;Pakstis, Andrew;Paschou, Peristera;Piacentini, John;Pittenger, Christopher;Plessen, Kerstin;Ramensky, Vasily;Ramos, Eliana M.;Reus, Victor;Richter, Margaret A.;Riddle, Mark A.;Robertson, Mary M.;Roessner, Veit;Rosário, Maria;Samuels, Jack F.;Sandor, Paul;Stein, Dan J.;Tsetsos, Fotis;Van Nieuwerburgh, Filip;Weatherall, Sarah;Wendland, Jens R.;Wolanczyk, Tomasz;Worbe, Yulia;Zai, Gwyneth;Goes, Fernando S.;McLaughlin, Nicole;Nestadt, Paul S.;Grabe, Hans-Jorgen;Depienne, Christel;Konkashbaev, Anuar;Lanzagorta, Nuria;Valencia-Duarte, Ana;Bramon, Elvira;Buccola, Nancy;Cahn, Wiepke;Cairns, Murray;Chong, Siow A.;Cohen, David;Crespo-Facorro, Benedicto;Crowley, James;Davidson, Michael;DeLisi, Lynn;Dinan, Timothy;Donohoe, Gary;Drapeau, Elodie;Duan, Jubao;Haan, Lieuwe;Hougaard, David;Karachanak-Yankova, Sena;Khrunin, Andrey;Klovins, Janis;Kučinskas, Vaidutis;Lee Chee Keong, Jimmy;Limborska, Svetlana;Loughland, Carmel;Lönnqvist, Jouko;Maher, Brion;Mattheisen, Manuel;McDonald, Colm;Murphy, Kieran C.;Murray, Robin;Nenadic, Igor;van Os, Jim;Pantelis, Christos;Pato, Michele;Petryshen, Tracey;Quested, Digby;Roussos, Panos;Sanders, Alan R.;Schall, Ulrich;Schwab, Sibylle G.;Sim, Kang;So, Hon-Cheong;Stögmann, Elisabeth;Subramaniam, Mythily;Toncheva, Draga;Waddington, John;Walters, James;Weiser, Mark;Cheng, Wei;Cloninger, Robert;Curtis, David;Gejman, Pablo V.;Henskens, Frans;Mattingsdal, Morten;Oh, Sang-Yun;Scott, Rodney;Webb, Bradley;Breen, Gerome;Churchhouse, Claire;Bulik, Cynthia M.;Daly, Mark;Dichgans, Martin;Faraone, Stephen V.;Guerreiro, Rita;Holmans, Peter;Kendler, Kenneth S.;Koeleman, Bobby;Mathews, Carol A.;Price, Alkes;Scharf, Jeremiah;Sklar, Pamela;Williams, Julie;Wood, Nicholas W.;Cotsapas, Chris;Palotie, Aarno;Smoller, Jordan W.;Sullivan, Patrick;Rosand, Jonathan;Corvin, Aiden;Neale, Benjamin M.
INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed study of phenotypes with different ages of onset, severity, and presentation poses ...
Background and purpose Polymorphisms in coagulation genes have been associated with early-onset ischemic stroke. Here we pursue an a priori hypothesis that genetic variation in the endothelial-based receptors of the thrombomodulin-protein C system (T...
BACKGROUND AND PURPOSE: Polymorphisms in coagulation genes have been associated with early-onset ischemic stroke. Here we pursue an a priori hypothesis that genetic variation in the endothelial-based receptors of the thrombomodulin-protein C system (...
Hibar , Derrek P;Stein , Jason L;Renteria , Miguel E;Arias-Vasquez , Alejandro;Desrivières , Sylvane;Jahanshad , Neda;Toro , Roberto;Wittfeld , Katharina;Abramovic , Lucija;Andersson , Micael;Aribisala , Benjamin S;Armstrong , Nicola J;Bernard , Manon;Bohlken , Marc M;Boks , Marco P;Bralten , Janita;Brown , Andrew A;Chakravarty , M Mallar;Chen , Qiang;Ching , Christopher R K;Cuellar-Partida , Gabriel;den Braber , Anouk;Giddaluru , Sudheer;Goldman , Aaron L;Grimm , Oliver;Guadalupe , Tulio;Hass , Johanna;Woldehawariat , Girma;Holmes , Avram J;Hoogman , Martine;Janowitz , Deborah;Jia , Tianye;Kim , Sungeun;Klein , Marieke;Kraemer , Bernd;Lee , Phil H;Olde Loohuis , Loes M;Luciano , Michelle;Macare , Christine;Mather , Karen A;Mattheisen , Manuel;Milaneschi , Yuri;Nho , Kwangsik;Papmeyer , Martina;Ramasamy , Adaikalavan;Risacher , Shannon L;Roiz-Santiañez , Roberto;Rose , Emma J;Salami , Alireza;Sämann , Philipp G;Schmaal , Lianne;Schork , Andrew J;Shin , Jean;Strike , Lachlan T;Teumer , Alexander;van Donkelaar , Marjolein M J;van Eijk , Kristel R;Walters , Raymond K;Westlye , Lars T;Whelan , Christopher D;Winkler , Anderson M;Zwiers , Marcel P;Alhusaini , Saud;Athanasiu , Lavinia;Ehrlich , Stefan;Hakobjan , Marina M H;Hartberg , Cecilie B;Haukvik , Unn K;Heister , Angelien J G A M;Hoehn , David;Kasperaviciute , Dalia;Liewald , David C M;Lopez , Lorna M;Makkinje , Remco R R;Matarin , Mar;Naber , Marlies A M;McKay , D Reese;Needham , Margaret;Nugent , Allison C;Pütz , Benno;Royle , Natalie A;Shen , Li;Sprooten , Emma;Trabzuni , Daniah;van der Marel , Saskia S L;van Hulzen , Kimm J E;Walton , Esther;Wolf , Christiane;Almasy , Laura;Ames , David;Arepalli , Sampath;Assareh , Amelia A;Bastin , Mark E;Brodaty , Henry;Bulayeva , Kazima B;Carless , Melanie A;Cichon , Sven;Corvin , Aiden;Curran , Joanne E;Czisch , Michael;de Zubicaray , Greig I;Dillman , Allissa;Duggirala , Ravi;Dyer , Thomas D;Erk , Susanne;Fedko , Iryna O;Ferrucci , Luigi;Foroud , Tatiana M;Fox , Peter T;Fukunaga , Masaki;Gibbs , J Raphael;Göring , Harald H H;Green , Robert C;Guelfi , Sebastian;Hansell , Narelle K;Hartman , Catharina A;Hegenscheid , Katrin;Heinz , Andreas;Hernandez , Dena G;Heslenfeld , Dirk J;Hoekstra , Pieter J;Holsboer , Florian;Homuth , Georg;Hottenga , Jouke-Jan;Ikeda , Masashi;Jack , Clifford R;Jenkinson , Mark;Johnson , Robert;Kanai , Ryota;Keil , Maria;Kent , Jack W;Kochunov , Peter;Kwok , John B;Lawrie , Stephen M;Liu , Xinmin;Longo , Dan L;McMahon , Katie L;Meisenzahl , Eva;Melle , Ingrid;Mohnke , Sebastian;Montgomery , Grant W;Mostert , Jeanette C;Mühleisen , Thomas W;Nalls , Michael A;Nichols , Thomas E;Nilsson , Lars G;Nöthen , Markus M;Ohi , Kazutaka;Olvera , Rene L;Perez-Iglesias , Rocio;Pike , G Bruce;Potkin , Steven G;Reinvang , Ivar;Reppermund , Simone;Rietschel , Marcella;Romanczuk-Seiferth , Nina;Rosen , Glenn D;Rujescu , Dan;Schnell , Knut;Schofield , Peter R;Smith , Colin;Steen , Vidar M;Sussmann , Jessika E;Thalamuthu , Anbupalam;Toga , Arthur W;Traynor , Bryan J;Troncoso , Juan;Turner , Jessica A;Valdés Hernández , Maria C;van 't Ent , Dennis;van der Brug , Marcel;van der Wee , Nic J A;van Tol , Marie-Jose;Veltman , Dick J;Wassink , Thomas H;Westman , Eric;Zielke , Ronald H;Zonderman , Alan B;Ashbrook , David G;Hager , Reinmar;Lu , Lu;McMahon , Francis J;Morris , Derek W;Williams , Robert W;Brunner , Han G;Buckner , Randy L;Buitelaar , Jan K;Cahn , Wiepke;Calhoun , Vince D;Cavalleri , Gianpiero L;Crespo-Facorro , Benedicto;Dale , Anders M;Davies , Gareth E;Delanty , Norman;Depondt , Chantal;Djurovic , Srdjan;Drevets , Wayne C;Espeseth , Thomas;Gollub , Randy L;Ho , Beng-Choon;Hoffmann , Wolfgang;Hosten , Norbert;Kahn , René S;Le Hellard , Stephanie;Meyer-Lindenberg , Andreas;Müller-Myhsok , Bertram;Nauck , Matthias;Nyberg , Lars;Pandolfo , Massimo;Penninx , Brenda W J H;Roffman , Joshua L;Sisodiya , Sanjay M;Smoller , Jordan W;Van Bokhoven , Hans;van Haren , Neeltje E M;Völzke , Henry;Walter , Henrik;Weiner , Michael W;Wen , Wei;White , Tonya;Agartz , Ingrid;Andreassen , Ole A;Blangero , John;Boomsma , Dorret I;Brouwer , Rachel M;Cannon , Dara M;Cookson , Mark R;de Geus , Eco J C;Deary , Ian J;Donohoe , Gary;Fernández , Guillén;Fisher , Simon E;Francks , Clyde;Glahn , David C;Grabe , Hans J;Gruber , Oliver;Hardy , John;Hashimoto , Ryota;Hulshoff Pol , Hilleke E;Jönsson , Erik G;Kloszewska , Iwona;Lovestone , Simon;Mattay , Venkata S;Mecocci , Patrizia;McDonald , Colm;McIntosh , Andrew M;Ophoff , Roel A;Paus , Tomas;Pausova , Zdenka;Ryten , Mina;Sachdev , Perminder S;Saykin , Andrew J;Simmons , Andy;Singleton , Andrew;Soininen , Hilkka;Wardlaw , Joanna M;Weale , Michael E;Weinberger , Daniel R;Adams , Hieab H H;Launer , Lenore J;Seiler , Stephan;Schmidt , Reinhold;Chauhan , Ganesh;Satizabal , Claudia L;Becker , James T;Yanek , Lisa;van der Lee , Sven J;Ebling , Maritza;Fischl , Bruce;Longstreth , W T;Greve , Douglas;Schmidt , Helena;Nyquist , Paul;Vinke , Louis N;van Duijn , Cornelia M;Xue , Luting;Mazoyer , Bernard;Bis , Joshua C;Gudnason , Vilmundur;Seshadri , Sudha;Ikram , M Arfan;Martin , Nicholas G;Wright , Margaret J;Schumann , Gunter;Franke , Barbara;Thompson , Paul M;Medland , Sarah E
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