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Title
OBJECTIVE: Meat intake has been consistently shown to be positively associated with incident type 2 diabetes. Part of that association may be mediated by body iron status, which is influenced by genetic factors. We aimed to test for interactions of g...
We aimed to investigate the causal effect of circulating uric acid concentrations on type 2 diabetes risk. A Mendelian randomization study was performed using a genetic score with 24 uric acid associated loci. We used data of the EPIC-InterAct case-c...
The aims of this study were to investigate the association between smoking and incident type 2 diabetes, accounting for a large number of potential confounding factors, and to explore potential effect modifiers and intermediate factors.
We aimed to validate genetic variants as instruments for insulin resistance and secretion, to characterise their association with intermediate phenotypes, and to investigate their role in T2D risk among normal-weight, overweight and obese individuals...
We examined the associations of intake of vegetables, legumes and fruit with all-cause and cause-specific mortality in a population with prevalent diabetes in Europe. A cohort of 10,449 participants with self-reported diabetes within the European Pro...
Background: The higher risk of death resulting from excess adiposity may be attenuated by physical activity (PA). However, the theoretical number of deaths reduced by eliminating physical inactivity compared with overall and abdominal obesity remains...
Scott, Robert A.;Freitag, Daniel F.;Li, Li;Chu, Audrey Y.;Surendran, Praveen;Young, Robin;Grarup, Niels;Stancáková, Alena;Chen, Yuning;Varga, Tibor V.;Yaghootkar, Hanieh;Luan, Jian'an;Zhao, Jing Hua;Willems, Sara M.;Wessel, Jennifer;Wang, Shuai;Maruthur, Nisa;Michailidou, Kyriaki;Pirie, Ailith;Van Der Lee, Sven J.;Gillson, Christopher;Al Olama, Ali Amin;Amouyel, Philippe;Arriola, Larraitz;Arveiler, Dominique;Aviles-Olmos, Iciar;Balkau, Beverley;Barricarte, Aurelio;Barroso, Inês;Garcia, Sara Benlloch;Bis, Joshua C.;Blankenberg, Stefan;Boehnke, Michael;Boeing, Heiner;Boerwinkle, Eric;Borecki, Ingrid B.;Bork-Jensen, Jette;Bowden, Sarah;Caldas, Carlos;Caslake, Muriel;Cupples, L. Adrienne;Cruchaga, Carlos;Czajkowski, Jacek;Den Hoed, Marcel;Dunn, Janet A.;Earl, Helena M.;Ehret, Georg B.;Ferrannini, Ele;Ferrieres, Jean;Foltynie, Thomas;Ford, Ian;Forouhi, Nita G.;Gianfagna, Francesco;Gonzalez, Carlos;Grioni, Sara;Hiller, Louise;Jansson, Jan Håkan;Jørgensen, Marit E.;Jukema, J. Wouter;Kaaks, Rudolf;Kee, Frank;Kerrison, Nicola D.;Key, Timothy J.;Kontto, Jukka;Kote-Jarai, Zsofia;Kraja, Aldi T.;Kuulasmaa, Kari;Kuusisto, Johanna;Linneberg, Allan;Liu, Chunyu;Marenne, Gaëlle;Mohlke, Karen L.;Morris, Andrew P.;Muir, Kenneth;Müller-Nurasyid, Martina;Munroe, Patricia B.;Navarro, Carmen;Nielsen, Sune F.;Nilsson, Peter M.;Nordestgaard, Børge G.;Packard, Chris J.;Palli, Domenico;Panico, Salvatore;Peloso, Gina M.;Perola, Markus;Peters, Annette;Poole, Christopher J.;Quirós, J. Ramón;Rolandsson, Olov;Sacerdote, Carlotta;Salomaa, Veikko;Sánchez, María José;Sattar, Naveed;Sharp, Stephen J.;Sims, Rebecca;Slimani, Nadia;Smith, Jennifer A.;Thompson, Deborah J.;Trompet, Stella;Tumino, Rosario;Van Der A, Daphne L.;Van Der Schouw, Yvonne T.;Virtamo, Jarmo;Walker, Mark;Walter, Klaudia;Abraham, Jean E.;Amundadottir, Laufey T.;Butterworth, Adam S.;Aponte, Jennifer L.;Dupuis, Josée;Easton, Douglas F.;Eeles, Rosalind A.;Erdmann, Jeanette;Franks, Paul W.;Frayling, Timothy M.;Hansen, Torben;Howson, Joanna M M;Jørgensen, Torben;Kooner, Jaspal;Laakso, Markku;McCarthy, Mark I.;Pankow, James S.;Pedersen, Oluf;Riboli, Elio;Rotter, Jerome I.;Saleheen, Danish;Samani, Nilesh J.;Schunkert, Heribert;Vollenweider, Peter;O'Rahilly, Stephen;Deloukas, Panos;Danesh, John;Goodarzi, Mark O.;Kathiresan, Sekar;Meigs, James B.;Ehm, Margaret G.;Wareham, Nicholas J.;Waterworth, Dawn M.
Regulatory authorities have indicated that new drugs to treat type 2 diabetes (T2D) should not be associated with an unacceptable increase in cardiovascular risk. Human genetics may be able to guide development of antidiabetic therapies by predicting...
Endometrial cancer risk has been associated with reproductive factors (age at menarche, age at menopause, parity, age at first and last birth, time since last birth and use of oral contraceptives (OCs)]. However, these factors are closely interrelate...
We aimed to validate genetic variants as instruments for insulin resistance and secretion, to characterise their association with intermediate phenotypes, and to investigate their role in T2D risk among normal-weight, overweight and obese individuals...
Observational studies show an association between ferritin and type 2 diabetes (T2D), suggesting a role of high iron stores in T2D development. However, ferritin is influenced by factors other than iron stores, which is less the case for other biomar...