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Wood, Angela M;Kaptoge, Stephen;Butterworth, Adam S;Willeit, Peter;Warnakula, Samantha;Bolton, Thomas;Paige, Ellie;Paul, Dirk S;Sweeting, Michael;Burgess, Stephen;Bell, Steven;Astle, William;Stevens, David;Koulman, Albert;Selmer, Randi M;Verschuren, WM Monique;Sato, Shinichi;Njolstad, Inger;Woodward, Mark;Salomaa, Veikko;Nordestgaard, Borge G;Yeap, Bu B;Fletcher, Astrid;Melander, Olle;Kuller, Lewis H;Balkau, Beverley;Marmot, Michael;Koenig, Wolfgang;Casiglia, Edoardo;Cooper, Cyrus;Arndt, Volker;Franco, Oscar H;Wennberg, Patrik;Gallacher, John;de la Camara, Agustin Gomez;Volzke, Henry;Dahm, Christina C;Dale, Caroline E;Bergmann, Manuela M;Crespo, Carlos J;van der Schouw, Yvonne T;Kaaks, Rudolf;Simons, Leon A;Lagiou, Pagona;Schoufour, Josje D;Boer, Jolanda MA;Key, Timothy J;Rodriguez, Beatriz;Moreno-Iribas, Conchi;Davidson, Karina W;Taylor, James O;Sacerdote, Carlotta;Wallace, Robert B;Quiros, J Ramon;Tumino, Rosario;Blazer, Dan G;Linneberg, Allan;Daimon, Makoto;Panico, Salvatore;Howard, Barbara;Skeie, Guri;Strandberg, Timo;Weiderpass, Elisabete;Nietert, Paul J;Psaty, Bruce M;Kromhout, Daan;Salamanca-Fernandez, Elena;Kiechl, Stefan;Krumholz, Harlan M;Grioni, Sara;Palli, Domenico;Huerta, Jose M;Price, Jackie;Sundstrom, Johan;Arriola, Larraitz;Arima, Hisatomi;Travis, Ruth C;Panagiotakos, Demosthenes B;Karakatsani, Anna;Trichopoulou, Antonia;Kuhn, Tilman;Grobbee, Diederick E;Barrett-Connor, Elizabeth;van Schoor, Natasja;Boeing, Heiner;Overvad, Kim;Kauhanen, Jussi;Wareham, Nick;Langenberg, Claudia;Forouhi, Nita;Wennberg, Maria;Despres, Jean-Pierre;Cushman, Mary;Cooper, Jackie A;Rodriguez, Carlos J;Sakurai, Masaru;Shaw, Jonathan E;Knuiman, Matthew;Voortman, Trudy;Meisinger, Christa;Tjonneland, Anne;Brenner, Hermann;Palmieri, Luigi;Dallongeville, Jean;Brunner, Eric J;Assmann, Gerd;Trevisan, Maurizio;Gillum, Richard F;Ford, Ian;Sattar, Naveed;Lazo, Mariana;Thompson, Simon G;Ferrari, Pietro;Leon, David A;Smith, George Davey;Peto, Richard;Jackson, Rod;Banks, Emily;Di Angelantonio, Emanuele;Danesh, John
BACKGROUND:Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease, we studied individual-partici...
Background - The aim of this paper is to investigate the causality of the inverse association between cigarette smoking and Parkinson’s disease (PD). The main suggested alternatives include a delaying effect of smoking, reverse causality, or an unmea...
Wood, Angela M;Kaptoge, Stephen;Butterworth, Adam S;Willeit, Peter;Warnakula, Samantha;Bolton, Thomas;Paige, Ellie;Paul, Dirk S;Sweeting, Michael;Burgess, Stephen;Bell, Steven;van Schoor, Natasja;Boeing, Heiner;Overvad, Kim;Kauhanen, Jussi;Palmieri, Luigi;Wareham, Nick;Yeap, Bu B;Langenberg, Claudia;Forouhi, Nita;Rodriguez, Beatriz;Paige, Ellie;Wennberg, Maria;Després, Jean-Pierre;Cushman, Mary;Cooper, Jackie A;Rodriguez, Carlos J;Sakurai, Masaru;Dallongeville, Jean;Shaw, Jonathan E;Knuiman, Matthew;Fletcher, Astrid;Paul, Dirk S;Ford, Ian;Voortman, Trudy;Meisinger, Christa;Tjønneland, Anne;Brenner, Hermann;Palmieri, Luigi;Dallongeville, Jean-Pierre;Brunner, Eric J;Brunner, Eric J;Assmann, Gerd;Sweeting, Michael;Trevisan, Maurizio;Skeie, Guri;Gillumn, Richard F;Melander, Olle;Ford, Ian Ford;Sattar, Naveed;Lazo, Mariana;Thompson, Simon;Ferrari, Pietro;Leon, David A;Burgess, Stephen;Assmann, Gerd;Davey Smith, George;Moreno-Iribas, Conchi;Peto, Richard;Jackson, Rod;Banks, Emily;Kuller, Lewis H;Di Angelantonio, Emanuele;Danesh, John;Balkau, Beverley;Koulman, Albert;Marmot, Michael;Koenig, Wolfgang;Trevisan, Maurizio;Davidson, Karina W;Casiglia, Edoardo;Cooper, Cyrus;Arndt, Volker;Franco, Oscar H;Wennberg, Patrik;Gallacher, John;Bell, Steven;de la Cámara, Agustín Gómez;Völzke, Henry;Dahm, Christina C;Dale, Caroline E;Taylor, James O;Gillum, Richard F;Bergmann, Manuela M;Sacerdote, Carlotta;Wallace, Robert B;Quiros, J Ramon;Astle, William;Tumino, Rosario;Blazer, Dan G;Linneberg, Allan;Daimon, Makoto;Salomaa, Veikko;Sattar, Naveed;Panico, Salvatore;Howard, Barbara;Skeie, Guri;Strandberg, Timo;Stevens, David;Weiderpass, Elisabete;Nietert, Paul J;Psaty, Bruce M;Kromhout, Daan;Salamanca-Fernandez, Elena;Strandberg, Timo;Kiechl, Stefan;Astle, William;Krumholz, Harlan M;Grioni, Sara;Koulman, Albert;Palli, Domenico;Huerta, José M;Price, Jackie;Sundström, Johan;Arriola, Larraitz;Arima, Hisatomi;Weiderpass, Elisabete;Travis, Ruth C;Panagiotakos, Demosthenes B;Lazo, Mariana;Kiechl, Stefan;Karakatsani, Anna;Trichopoulou, Antonia;Kühn, Tilman;Grobbee, Diederick E;Barrett-Connor, Elizabeth;van Schoor, Natasja;Boeing, Heiner;Nietert, Paul J;Overvad, Kim;Kauhanen, Jussi;Crespo, Carlos J;Wareham, Nick;Thompson, Simon G;Langenberg, Claudia;Forouhi, Nita;Wennberg, Maria;Després, Jean-Pierre;Cushman, Mary;Cooper, Jackie A;Psaty, Bruce M;Rodriguez, Carlos J;Selmer, Randi M;Sakurai, Masaru;Shaw, Jonathan E;Knuiman, Matthew;Ferrari, Pietro;Voortman, Trudy;Meisinger, Christa;Leon, David A;Smith, George Davey;Peto, Richard;Kromhout, Daan;Verschuren, Monique;Jackson, Rod;Banks, Emily;Di Angelantonio, Emanuele;Danesh, John;Stevens, David;Wood, Angela M;Kaptoge, Stephen;Butterworth, Adam;Willeit, Peter;Warnakula, Samantha;Sato, Shinichi;Salamanca-Fernandez, Elena;Bolton, Thomas;Njølstad, Inger;Woodward, Mark;Veikko, Salomaa;Selmer, Randi M;Nordestgaard, Børge G;Yeap, Bu B;Flecther, Astrid;van der Schouw, Yvonne T;Salomaa, Veikko;Melander, Olle;Kuller, Lewis H;Balkau, Beverley;Marmot, Michael;Koenig, Wolfgang;Casiglia, Edoardo;Cooper, Cyrus;Verschuren, W M Monique;Arndt, Volker;Kaaks, Rudolf;Franco, Oscar H;Tjønneland, Anne;Wennberg, Patrik;Gallacher, John;Gómez de la Cámara, Agustín;Völzke, Henry;Dahm, Christina C;Dale, Caroline E;Bergmann, Manuela;Crespo, Carlos;Simons, Leon A;Sato, Shinichi;van der Schouw, Yvonne T;Krumholz, Harlan M;Kaaks, Rudolf;Simons, Leon A;Lagiou, Pagona;Schoufour, Josje D;Boer, Jolanda M.A;Key, Timothy J;Rodriguez, Beatriz;Lagiou, Pagona;Moreno-Iribas, Conchi;Davidson, Karina W;Njølstad, Inger;Grioni, Sara;Taylor, James O;Sacerdote, Carlotta;Wallace, Robert B;Quiros, J. Ramon;Rimm, Eric B;Tumino, Rosario;Schoufour, Josje D;Blazer III, Dan G;Linneberg, Allan;Daimon, Makoto;Panico, Salvatore;Palli, Domenico;Woodward, Mark;Howard, Barbara;Huerta, José M;Price, Jackie;Sundström, Johan;Boer, Jolanda M A;Arriola, Larraitz;Arima, Hisatomi;Travis, Ruth C;Panagiotakos, Demosthenes B;Brenner, Hermann;Nordestgaard, Børge G;Karakatsani, Anna;Trichopoulou, Antonia;Kühn, Tilman;Grobbee, Diederick E;Key, Timothy J;Barrett-Connor, Elizabeth
Background Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease, we studied individual-partici...
OBJECTIVE: Meat intake has been consistently shown to be positively associated with incident type 2 diabetes. Part of that association may be mediated by body iron status, which is influenced by genetic factors. We aimed to test for interactions of g...
Objective: Observational studies show an association between ferritin and type 2 diabetes (T2D), suggesting a role of high iron stores for T2D development. However, ferritin is influenced by factors other than iron stores, which is less the case for ...
ABSTRACT Objective To investigate the association between alcohol consumption (at baseline and over lifetime) and non-fatal and fatal coronary heart disease (CHD) and stroke. Design Multicentre case-cohort study. Setting A study of cardiovascular dis...
We aimed to validate genetic variants as instruments for insulin resistance and secretion, to characterise their association with intermediate phenotypes, and to investigate their role in T2D risk among normal-weight, overweight and obese individuals...
Scott, Robert;Freitag, Daniel F;Li, Li;Chu, Audrey Y;Surendran, Praveen;Young, Robin;Grarup, Niels;Stancáková, Alena;Chen, Yuning;Varga, Tibor V;Yaghootkar, Hanieh;Luan, Jian'an;Zhao, Jing Hua;Willems, Sara Marie;Wessel, Jennifer;Wang, Shuai;Maruthur, Nisa;Michailidou, Kyriaki;Pirie, Ailith;van, der Lee Sven J;Gillson, Christopher;Al, Olama Ali Amin;Amouyel, Philippe;Arriola, Larraitz;Arveiler, Dominique;Aviles-Olmos, Iciar;Balkau, Beverley;Barricarte, Aurelio;Barroso, Ines;Garcia, Sara Benlloch;Bis, Joshua C;Blankenberg, Stefan;Boehnke, Michael;Boeing, Heiner;Boerwinkle, Eric;Borecki, Ingrid B;Bork-Jensen, Jette;Bowden, Sarah;Caldas, Carlos Manuel;Caslake, Muriel;Cupples, L Adrienne;Cruchaga, Carlos;Czajkowski, Jacek;den, Hoed Marcel;Dunn, Janet A;Earl, Helena Margaret;Ehret, Georg B;Ferrannini, Ele;Ferrieres, Jean;Foltynie, Thomas;Ford, Ian;Forouhi, Nita Gandhi;Gianfagna, Francesco;Gonzalez, Carlos;Grioni, Sara;Hiller, Louise;Jansson, Jan-Håkan;Jørgensen, Marit E;Jukema, J Wouter;Kaaks, Rudolf;Kee, Frank;Kerrison, Nicola D;Key, Timothy J;Kontto, Jukka;Kote-Jarai, Zsofia;Kraja, Aldi T;Kuulasmaa, Kari;Kuusisto, Johanna;Linneberg, Allan;Liu, Chunyu;Marenne, Gaëlle;Mohlke, Karen L;Morris, Andrew P;Muir, Kenneth;Müller-Nurasyid, Martina;Munroe, Patricia B;Navarro, Carmen;Nielsen, Sune F;Nilsson, Peter M;Nordestgaard, Børge G;Packard, Chris J;Palli, Domenico;Panico, Salvatore;Peloso, Gina M;Perola, Markus;Peters, Annette;Poole, Christopher J;Quirós, J Ramón;Rolandsson, Olov;Sacerdote, Carlotta;Salomaa, Veikko;Sánchez, María-José;Sattar, Naveed;Sharp, Stephen John;Sims, Rebecca;Slimani, Nadia;Smith, Jennifer A;Thompson, Deborah Jane;Trompet, Stella;Tumino, Rosario;van, der A Daphne L;van, der Schouw Yvonne T;Virtamo, Jarmo;Walker, Mark;Walter, Klaudia;Abraham, Jean Elizabeth;Amundadottir, Laufey T;Aponte, Jennifer L;Butterworth, Adam Stuart;Dupuis, Josée;Easton, Douglas Frederick;Eeles, Rosalind A;Erdmann, Jeanette;Franks, Paul W;Frayling, Timothy M;Hansen, Torben;Howson, Joanna McCammond;Jørgensen, Torben;Kooner, Jaspal;Laakso, Markku;Langenberg, Claudia;McCarthy, Mark I;Pankow, James S;Pedersen, Oluf;Riboli, Elio;Rotter, Jerome I;Saleheen, Danish;Samani, Nilesh J;Schunkert, Heribert;Vollenweider, Peter;O’Rahilly, Stephen;Deloukas, Panos;Danesh, John;Goodarzi, Mark O;Kathiresan, Sekar;Meigs, James B;Ehm, Margaret G;Wareham, Nicholas J;Waterworth, Nicholas John
Regulatory authorities have indicated that new drugs to treat type 2 diabetes (T2D) should not be associated with an unacceptable increase in cardiovascular risk. Human genetics may be able to guide development of antidiabetic therapies by predicting...
Background: The higher risk of death resulting from excess adiposity may be attenuated by physical activity (PA). However, the theoretical number of deaths reduced by eliminating physical inactivity compared with overall and abdominal obesity remains...